FB2025_01 , released February 20, 2025
Allele: Dmel\raspT802
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General Information
Symbol
Dmel\raspT802
Species
D. melanogaster
Name
FlyBase ID
FBal0126334
Feature type
allele
Associated gene
Dmel\rasp
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Deletion of 10bps TGTGATGCAA causes a frame shift at N156, followed by 17 extraneous amino acids and a stop codon.

    (Lee and Treisman, 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3L:3,162,666..3,162,675 [+]
    Comment:

    Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Deletion of 10bp TGTGATGCAA causes a frame shift at N156, followedby 17 extraneous amino acids and a stop codon.

    (Lee and Treisman, 2001)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        raspT802 mutant eye disc clones fail to differentiate photoreceptors R1-R7, although R8 appears normal.

        (Steinhauer et al., 2013)

        The eggshells of eggs formed from raspT802 homozygous germline clones are partially ventralized, as shown by the fusion of the two dorsal appendages in all resulting eggshells.

        (Miura et al., 2006)

        raspT392/raspT802 eye discs are smaller than wild-type. Homozygous clones in the eye disc show a reduction in photoreceptors that is pronounced near the centre of the clones.

        (Lee and Treisman, 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT suppressed by
        Statement
        Reference

        raspT802 has photoreceptor cell R1 phenotype, non-suppressible by rho7M43/ru1

        (Steinhauer et al., 2013)

        raspT802 has photoreceptor cell R2 phenotype, non-suppressible by rho7M43/ru1

        (Steinhauer et al., 2013)

        raspT802 has photoreceptor cell R3 phenotype, non-suppressible by rho7M43/ru1

        (Steinhauer et al., 2013)

        raspT802 has photoreceptor cell R4 phenotype, non-suppressible by rho7M43/ru1

        (Steinhauer et al., 2013)

        raspT802 has photoreceptor cell R5 phenotype, non-suppressible by rho7M43/ru1

        (Steinhauer et al., 2013)

        raspT802 has photoreceptor cell R6 phenotype, non-suppressible by rho7M43/ru1

        (Steinhauer et al., 2013)

        raspT802 has photoreceptor cell R7 phenotype, non-suppressible by rho7M43/ru1

        (Steinhauer et al., 2013)
        Suppressor of
        NOT Suppressor of
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        A ru1 rho7M43 double mutant background fails to suppress the R1-R7 photoreceptor differentiation defects seen in raspT802 mutant eye disc clones.

        (Steinhauer et al., 2013)

        Most ectopic photoreceptor differentiation caused by ptcS2 homozygous clones in the eye disc is suppressed in a raspT392/raspT802 background, with most of the remaining photoreceptors having R8 identity.

        The ectopic photoreceptor differentiation induced by somatic clones of Scer\GAL4Act5C.PP cells in the eye disc in animals carrying rhoScer\UAS.cGa and spis.Scer\UAS or spiScer\UAS.s.T:Avic\GFP is completely suppressed by raspT392/raspT802. However, the ectopic photoreceptor differentiation caused by somatic clones of Scer\GAL4Act5C.PP cells in the eye disc in animals carrying btl::EgfrScer\UAS.T:λ\cI-DD is not suppressed by raspT392/raspT802.

        (Miura et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        raspT802
        (Steinhauer et al., 2013, Miura et al., 2006)
        sitT802
        (Lee and Treisman, 2001)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)