Allele Dmel\osa^4H

General Information
Symbol	Dmel\osa^4H	Species	D. melanogaster
Name		FlyBase ID	FBal0126349
Feature type	allele	Associated gene	Dmel\osa

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Kaminker et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:13,520,781..13,520,781 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The mutation was reported at Gln 1281 but there is no glutamine at that position. The mutation was inferred to be at Gln 1282 in the reported sequence which translates to Gln 1283 in the reference sequence. evidence=experimental na_change=C13520781T pr_change=Q1283\|osa-PB,Q1270\|osa-PA reported_pr_change=Q1281@ (Heitzler et al., 2003)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q1281@. (Heitzler et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Kaminker et al., 2001)
Phenotype Manifest In
	dorsocentral bristle \| supernumerary (with osa¹⁴⁰⁶⁰) (Heitzler et al., 2003) external sensory organ precursor cell \| supernumerary (with osa¹⁴⁰⁶⁰) (Heitzler et al., 2003)
Detailed Description
	Statement Reference Homozygous mutant adults exhibit about 2.50 dorsocentral bristle per heminotum (compared to 2.00 in wild-type). osa^4H/osa¹⁴⁰⁶⁰ mutant adults exhibit about 4.17 dorsocentral bristle per heminotum (compared to 2.00 in wild-type). Excess dorsocentral bristle precursors are seen in imaginal discs. (Heitzler et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference osa^4H/osa[+] is an enhancer of visible \| heat sensitive phenotype of lz^ts1 (Kaminker et al., 2001)
Phenotype Manifest In
Enhancer of
Statement Reference osa^4H/osa[+] is an enhancer of eye phenotype of lz^ts1 (Kaminker et al., 2001) osa^4H is an enhancer of thorax phenotype of Chi^E (Heitzler et al., 2003)
Suppressor of
Statement Reference osa^4H is a suppressor of dorsocentral bristle phenotype of Chi^E (Heitzler et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Separable from: An unknown separable lethal on the original osa^4H chromosome. (Heitzler et al., 2003) Selected as: an enhancer of the lz^ts1 eye phenotype. (Kaminker et al., 2001)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	en(lz)4H (Kaminker et al., 2001) osa^4H (Carrera et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Carrera et al., 2008, Mol. Cell. Biol. 28(17): 5238--5250 Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development. [FBrf0207089] Heitzler et al., 2003, Genes Dev. 17(5): 591--596 Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by Osa. [FBrf0157156] Kaminker et al., 2001, Development 128(14): 2639--2648 Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development. [FBrf0138356]

Allele Dmel\osa4H

Allele Dmel\osa^4H