Allele Dmel\fry²

General Information
Symbol	Dmel\fry²	Species	D. melanogaster
Name		FlyBase ID	FBal0126391
Feature type	allele	Associated gene	Dmel\fry

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Cong et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:9,630,011..9,630,011 comment=Position of mutation on reference sequence inferred by FlyBase curator based on author statement evidence=experimental pr_change=Q2244\|fry-PC,Q2299\|fry-PB reported_pr_change=?2299@ na_change=G9630011T (Cong et al., 2001)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: ?2299@. (Cong et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| recessive (Cong et al., 2001) sterile, with Scer\GAL4^Act.PU, fry¹, fry^{Scer\UAS.T:Hsap\MYC.T:Avic\GFP} (Fang et al., 2010) sterile, with Scer\GAL4^Act.PU, fry¹/fry^{Scer\UAS.T:Hsap\MYC.T:Avic\GFP} (Fang et al., 2010) sterile (with fry^{Scer\UAS.T:Hsap\MYC.T:Avic\GFP}), with Scer\GAL4^Act.PU, fry¹ (Fang et al., 2010, Fang et al., 2010) visible \| cell autonomous \| recessive \| somatic clone (Cong et al., 2001)
Phenotype Manifest In
	egg, with Scer\GAL4^Act.PU, fry¹, fry^{Scer\UAS.T:Hsap\MYC.T:Avic\GFP} (Fang et al., 2010) egg (with fry^{Scer\UAS.T:Hsap\MYC.T:Avic\GFP}), with Scer\GAL4^Act.PU, fry¹ (Fang et al., 2010, Fang et al., 2010) ovary, with Scer\GAL4^Act.PU, fry¹, fry^{Scer\UAS.T:Hsap\MYC.T:Avic\GFP} (Fang et al., 2010) ovary (with fry^{Scer\UAS.T:Hsap\MYC.T:Avic\GFP}), with Scer\GAL4^Act.PU, fry¹ (Fang et al., 2010, Fang et al., 2010) wing cell (with fry¹) (Fang et al., 2010) wing hair \| cell autonomous \| somatic clone \| supernumerary (Cong et al., 2001) wing hair \| ectopic (with fry¹) (Fang et al., 2010)
Detailed Description
	Statement Reference fry[1]/fry[2] flies are lethal. Wing cells from these flies often exhibit more than four hairs per cell. Wing cells in adult wings from these flies display (in 99% of cases) a single hair compared to the more than four hairs per cell seen in fry[1]/fry[2] mutants. These flies are both male and female sterile. The paired ovaries of rescued females are often of different sizes, and the eggs produced are rounded than normal and are rarely laid. (Fang et al., 2010) Cells in homozygous clones in the wing form a cluster of hairs. The phenotype is cell autonomous. (Cong et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference fry²/fry[+], mats^e235, trc¹/trc[+] has visible \| dominant phenotype (He et al., 2005) fry²/fry[+], mats^e03077, trc¹/trc[+] has visible \| dominant phenotype (He et al., 2005)
Phenotype Manifest In
Other
Statement Reference fry²/fry[+], mats^e235, trc¹/trc[+] has wing hair \| supernumerary phenotype (He et al., 2005) fry²/fry[+], mats^e03077, trc¹/trc[+] has wing hair \| supernumerary phenotype (He et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference fry² trc¹ mats^e235 triple heterozygotes have a weak multiple wing hair phenotype in 48% of wings. (He et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	fry²/fry¹ is rescued by Scer\GAL4^Act.PU/fry^{Scer\UAS.T:Hsap\MYC.T:Avic\GFP} (Fang et al., 2010)
Not rescued by	fry²/fry¹ is not rescued by Scer\GAL4^Act.PU/fry^{1637.Scer\UAS.T:Hsap\MYC} (Fang et al., 2010)
Comments	Expression of fry[Scer\UAS.T:Hsap\MYC.T:Avic\GFP] under the control of Scer\GAL4[Act] completely rescues the lethality seen in fry[1]/fry[2] mutants. Wing cells in adult wings from these flies display (in 99% of cases) a single hair compared to the more than four hairs per cell seen in fry[1]/fry[2] mutants. These flies are both male and female sterile. The paired ovaries of rescued females are often of different sizes, and the eggs produced are rounded than normal and are rarely laid. (Fang et al., 2010)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	fry² (He et al., 2005, Fang et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Fang et al., 2010, BMC Dev. Biol. 10: 40 The Drosophila Fry protein interacts with Trc and is highly mobile in vivo. [FBrf0210776] He et al., 2005, Mol. Biol. Cell 16(9): 4139--4152 Drosophila mob family proteins interact with the related tricornered (trc) and warts (wts) kinases. [FBrf0188034] Cong et al., 2001, Development 128(14): 2793--2802 The furry gene of Drosophila is important for maintaining the integrity of cellular extensions during morphogenesis. [FBrf0138360]

Allele Dmel\fry2

Allele Dmel\fry²