Allele Dmel\dome^{Scer\UAS.cCGHa}

General Information
Symbol	Dmel\dome^{Scer\UAS.cCGHa}	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Castelli-Gair Hombria	FlyBase ID	FBal0126400
Feature type	allele	Associated gene	Dmel\dome

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Castelli-Gair Hombria, 2001.9.19)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of LD32858 is governed by Scer\UAS regulatory sequences. (Castelli-Gair Hombria, 2001.9.19)
Carried in construct	P{UAS-dome.CGH} (Medioni and Noselli, 2005, Castelli-Gair Hombria, 2001.9.19, Bach et al., 2003, Ghiglione et al., 2002, Brown et al., 2001, Tsai and Sun, 2004, Makki et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile, with Scer\GAL4^slbo.2.6 (Ghiglione et al., 2002) visible, with Scer\GAL4^dpp.blk1 (Bach et al., 2003) visible, with Scer\GAL4^ey.PH (Bach et al., 2003)
Phenotype Manifest In
	border follicle cell, with Scer\GAL4^slbo.2.6 (Ghiglione et al., 2002, Medioni and Noselli, 2005) eye, with Scer\GAL4^dpp.blk1 (Bach et al., 2003) eye, with Scer\GAL4^ey.PH (Bach et al., 2003, Tsai and Sun, 2004)
Detailed Description
	Statement Reference Scer\GAL4[dome-PG125]-driven expression of two copies of dome[Scer\UAS.cCGHa] results in early larval lethality. (Makki et al., 2010) Expression of dome^{Scer\UAS.cCGHa} in border cells, driven by Scer\GAL4^slbo.2.6, inhibits the migration of border cell clusters to the oocyte. However, the apical cap of these egg chambers forms and is shed normally. (Medioni and Noselli, 2005) Expression of dome[Scer\UAS.cCGHa] under the control of Scer\GAL4[ey.PH] results in a small-eye phenotype. (Tsai and Sun, 2004) Expression of dome^{Scer\UAS.cCGHa} under the control of Scer\GAL4^ey.PH or Scer\GAL4^dpp.blk1 results in flies with smaller eyes than normal. Expression of dome^{Scer\UAS.cCGHa} under the control of Scer\GAL4^GMR.PF does not result in flies with enlarged eyes. (Bach et al., 2003) Expression of dome^{Scer\UAS.cCGHa} under the control of Scer\GAL4^slbo.2.6 results in a failure of border follicle cell migration. (Ghiglione et al., 2002)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference dome^{Scer\UAS.cCGHa}/Scer\GAL4^ey.PH is an enhancer of visible phenotype of os^unspecified/Df(1)os1A2 (Bach et al., 2003)
Phenotype Manifest In
Enhancer of
Statement Reference dome^{Scer\UAS.cCGHa}/Scer\GAL4^ey.PH is an enhancer of eye phenotype of os^unspecified/Df(1)os1A2 (Bach et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference The small eye phenotype of os^unspecified/Df(1)os1A2 flies is enhanced by expression of dome^{Scer\UAS.cCGHa} under the control of Scer\GAL4^ey.PH. (Bach et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	dome^{Scer\UAS.cCGHa} Dome^WT (Medioni and Noselli, 2005)
Name Synonym	Saccharomyces cerevisiae UAS construct a of Castelli-Gair Hombria (Castelli-Gair Hombria, 2001.9.19)
Secondary FlyBase IDs

References ( 7 )
Research paper	Makki et al., 2010, PLoS Biol. 8(8): e1000441 A short receptor downregulates Jak/STAT signalling to control the Drosophila cellular immune response. [FBrf0211466] Medioni and Noselli, 2005, Development 132(13): 3069--3077 Dynamics of the basement membrane in invasive epithelial clusters in Drosophila. [FBrf0187473] Tsai and Sun, 2004, genesis 39(2): 141--153 Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development. [FBrf0179489] Bach et al., 2003, Genetics 165(3): 1149--1166 A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. [FBrf0167623] Ghiglione et al., 2002, Development 129(23): 5437--5447 The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis. [FBrf0151938] Brown et al., 2001, Curr. Biol. 11(21): 1700--1705 Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. [FBrf0141438]
Personal communication to FlyBase	Castelli-Gair Hombria, 2001.9.19, domeless. domeless. [FBrf0138617]

Allele Dmel\domeScer\UAS.cCGHa

Allele Dmel\dome^{Scer\UAS.cCGHa}