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General Information
Symbol
Dmel\domeG0468
Species
D. melanogaster
Name
FlyBase ID
FBal0126401
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dome468
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{lacW} insertion is at nucleotide +268 of the 4.8kb dome transcript.

P{lacW} insertion in the 5' UTR, at nucleotide position 268 of dome EST LD32858.

Insertion of P{lacW} into 5' UTR of dome, at position of 268bp with respect to the start of LD32858.

Insertion components
P{lacW}domeG0468
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

domeG0468 mutants exhibit abnormal spiracles due to a lack of cell elongation.

Mutant animals are lethal at the first instar larval stage and show a phenotype in the gastrointestinal tract indicate by a block of food passage at the defective proventriculus organ. A failure of ectodermal cells to invaginate and a disorganised endodermal layer of the proventriculus is seen.

Lethality occurs during the first larval instar.

The shape of the posterior spiracles is abnormal in mutants; the stigmatophore does not protrude and only the most external part of the filzkorper is formed.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

domeG0468 is a suppressor | partially of visible phenotype of upd1GMR.PB

Phenotype Manifest In
Suppressor of
Statement
Reference

domeG0468 is a suppressor | partially of eye phenotype of upd1GMR.PB

Other
Additional Comments
Genetic Interactions
Statement
Reference

In ctdb7, domeG0468, Df(2L)32FP-5 (deficiency for sal) triple mutants, no obvious spiracle structures remain, but the trachea still joins to the outside.

Quadruple ctdb7, Df(2L)32FP-5 (deficiency for sal), ems2, domeG0468 mutants are missing spiracle structures completely.

The enlarged eye phenotype seen in flies carrying one copy of upd1GMR.PB is moderately suppressed by domeG0468.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Mobilisation of the P-element reverts both the lethality and posterior spiracle phenotype.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (3)
References (12)