Allele Dmel\Tak1⁴

General Information
Symbol	Dmel\Tak1⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0126472
Feature type	allele	Associated gene	Dmel\Tak1

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Vidal et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation X:20,393,388..20,393,388 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=G20393388A pr_change=R257H\|Tak1-PA reported_pr_change=R257H (Vidal et al., 2001)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The lesion is in the kinase domain and results in a dominant-negative protein being produced. (Geuking et al., 2005) Amino acid replacement: R257H. (Vidal et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	immune response defective (Vidal et al., 2001)
Phenotype Manifest In

Detailed Description
	Statement Reference Tak1[4] mutant larvae do not exhibit a melanotic phenotype in the posterior hindgut either under normal food conditions or when raised on food containing 0.1M or 0.2M NaCl. (Seisenbacher et al., 2011) Flies are susceptible to Gram-negative bacterial infection. (Vidal et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Tak1[+]/Tak1⁴ is a suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^Scer\UAS.cMa (Geuking et al., 2005) Tak1⁴ is a suppressor \| partially of melanotic mass phenotype \| larval stage \| nutrition conditional phenotype of MAPk-Ak2^Δ43 (Seisenbacher et al., 2011)
Phenotype Manifest In
Suppressor of
Statement Reference Tak1[+]/Tak1⁴ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^Scer\UAS.cMa (Geuking et al., 2005) Tak1⁴ is a suppressor \| partially of embryonic/larval hindgut \| posterior \| larval stage \| nutrition conditional phenotype of MAPk-Ak2^Δ43 (Seisenbacher et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference Tak1[4] partially suppresses the "black dot" phenotype seen in the hindgut of MAPk-Ak2[Δ43] larvae raised on either 0.1M or 0.2M NaCl. (Seisenbacher et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	dTAK1⁴ (Geuking et al., 2005) Tak1⁴ TAK1⁴ (Seisenbacher et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Seisenbacher et al., 2011, PLoS Genet. 7(8): e1002168 MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic Stress. [FBrf0214607] Geuking et al., 2005, Genetics 171(4): 1683--1694 A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. [FBrf0190722] Vidal et al., 2001, Genes Dev. 15(15): 1900--1912 Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-B-dependent innate immune responses. [FBrf0137242]

Allele Dmel\Tak14

Allele Dmel\Tak1⁴