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General Information
Symbol
Dmel\Rab11ETo3
Species
D. melanogaster
Name
FlyBase ID
FBal0126495
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Rab11E(To)3
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Females carrying homozygous germline clones are sterile.

Homozygous clones in the adult germ cells result in defective fusomes. Germline stem cell clones show an approximately 4-fold reduction in half-life compared to control clones.

Testes from Rab1193Bi/Rab11ETo3 larvae have spermatids composed of an abnormally large Nebenkern associated with multiple nuclei.

Rab1193Bi/Rab11ETo3 brains do not exhibit polyploid mitoses.

Rab11ETo3/+ flies show no eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Other
Phenotype Manifest In
Enhancer of
Statement
Reference

Rab11[+]/Rab11ETo3 is an enhancer of spermatid phenotype of brunZ3358/Df(2L)pr2b

Rab11[+]/Rab11ETo3 is an enhancer of embryonic abdominal segment phenotype of Tm1el4/Tm1eg9, osk[+]/osk1

Additional Comments
Genetic Interactions
Statement
Reference

Flies homozygous for bruZ3358 and transheterozygous for Rab1193Bi/Rab11ETo3 die in early larval stages at 25[o]C.

Testes from bruZ3358/Df(2L)pr2b;Rab11ETo3 males raised at 25[o]C exhibit a 4.5-fold increase in the percentage of tetranucleate early spermatids relative to testes from bruZ3358/Df(2L)pr2b males.

Rab11ETo3 heterozygotes act as dominant enhancers of the Scer\GAL4GMR.PF>bchsEP2299 eye phenotype, resulting in adults with severely reduced eyes.

Dominantly increases the penetrance of the "posterior group" phenotype of embryos derived from Tm1eg9 +/Tm1el4 osk1 females to 98.0%.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Rab1193Bi/Rab11ETo3 flies carrying Rab11T:Avic\GFP are fully viable and testes from larvae of these genotypes do not exhibit abnormal spermatids.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a dominant enhancer of the Tm1eg9 +/Tm1el4 osk1 phenotype. Separable from: a mutation (lethal or female sterile) on the 2nd chromosome.

Comments
Comments

Order of alleles (based on transheterozygous sterile phenotype): Rab1193Bi < Rab11j2D1 < Rab11EP3017 = Rab11ETo11 = Rab11ETo3 < Df(3R)e-N19.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)