FlyBase Allele Report: Hsap\MAPT[R406W.UAS]

General Information

Symbol

Hsap\MAPT^R406W.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0126527

Feature type

allele

Associated gene

Hsap\MAPT

Associated Insertion(s)

Carried in Construct

P{UAS-Hsap\MAPT.R406W}

Also Known As

UAS-tau^R406W, UAS-hTau^R406W, tau^R406W, UAS-R406W tau, tau R406W, UAS-tau(R406W), uas-tau-R406W, uas-tau R406W, UAS-tau.R406W, UAS-TauR406W

Key Links

Transgenic product class

missense_variant

(Wittmann et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Wittmann et al., 2001)

Mutagen

in vitro construct

(Wittmann et al., 2001)

Progenitor genotype

Carried in construct

P{UAS-Hsap\MAPT.R406W}

Cytology

Description

UAS regulatory sequences drive expression of a mutant form of Hsap\MAPT (carries the amino acid replacement R406W).

(Wittmann et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\MAPT

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Alzheimer's disease

CEA

(Haddadi et al., 2016, Frost et al., 2014, Ryoo et al., 2007)

model of tauopathy

CEA

(Amini et al., 2024, Nair et al., 2024, Ortiz-Vega et al., 2024, Pragati and Sarkar, 2024, Zuniga et al., 2024, Beckmann et al., 2023, Ochoa et al., 2023, Schulz et al., 2023, Zuniga et al., 2023, Farrell et al., 2022, Shafik et al., 2022, Sun et al., 2022, Zhang et al., 2022, Abreha et al., 2021, Li et al., 2021, Nikookar et al., 2021, Abtahi et al., 2020, Krishnaswamy et al., 2020, Lohr et al., 2020, Ma et al., 2020, Mahoney et al., 2020, Cornelison et al., 2019, He et al., 2019, Kadas et al., 2019, Park et al., 2019, Guo et al., 2018, Kim et al., 2018, Berson et al., 2017, Dräger et al., 2017, Tsuda et al., 2017, Zhou et al., 2017, Bernstein et al., 2016, Frost et al., 2016, Haddadi et al., 2016, Huang et al., 2014, Povellato et al., 2014, Ali et al., 2012, Duboff et al., 2012, Feuillette et al., 2010, Kosmidis et al., 2010, Bilen and Bonini, 2007, Dias-Santagata et al., 2007, Fulga et al., 2007, Khurana et al., 2006, Mershin et al., 2004, Nishimura et al., 2004, Scherzer et al., 2003, Wittmann et al., 2001)

model of amnestic disorder

CEA

(Mershin et al., 2004)

model of neurodegenerative disease

CEA

(Berger et al., 2006, Bilen et al., 2006, Khurana et al., 2006, Nishimura et al., 2004)

model of frontotemporal dementia

CEA

(Nitta et al., 2023, Zhang et al., 2022, Guo et al., 2018, Ali et al., 2012)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of tauopathy

is exacerbated by Trxr1^Δ1

(Dias-Santagata et al., 2007)

is exacerbated by Sod2ⁿ²⁸³

(Dias-Santagata et al., 2007)

is ameliorated by Sod2^UAS.cMa

(Dias-Santagata et al., 2007)

is ameliorated by Gtpx^UAS.cMa

(Dias-Santagata et al., 2007)

is ameliorated by Dcr-2^UAS.cDa

(Ochoa et al., 2023)

is ameliorated by Arc1^JF01974

(Schulz et al., 2023)

is ameliorated by Arc1^esm113

(Schulz et al., 2023)

is ameliorated by Imp^EP1433

(Bilen and Bonini, 2007)

is ameliorated by Acox1^B227.2

(Bilen and Bonini, 2007)

is ameliorated by CG11700^EP1384

(Bilen and Bonini, 2007)

is ameliorated by Tpr2^EB7-1A

(Bilen and Bonini, 2007)

is ameliorated by wech^JM265

(Bilen and Bonini, 2007)

is exacerbated by par-1^UAS.cSa

(Nishimura et al., 2004)

is exacerbated by f^+t13

(Duboff et al., 2012)

is ameliorated by Gel^UAS.cDa

(Frost et al., 2016, Duboff et al., 2012)

is ameliorated by Opa1^s3475

(Duboff et al., 2012)

is ameliorated by Marf^JF01650

(Duboff et al., 2012)

is exacerbated by Marf^UAS.cDa

(Duboff et al., 2012)

is ameliorated by Drp1^UAS.cDb

(Duboff et al., 2012)

is exacerbated by WASp^UAS.cBa

(Duboff et al., 2012)

is exacerbated by sqh^AX3

(Duboff et al., 2012)

is exacerbated by Drp1^GD10456

(Duboff et al., 2012)

is exacerbated by zip¹

(Duboff et al., 2012)

is exacerbated by Upf2^E801R.UAS

(Zuniga et al., 2023)

is ameliorated by Upf2^UAS.cAa

(Zuniga et al., 2024, Zuniga et al., 2023)

is exacerbated by Upf3^HMJ22158

(Zuniga et al., 2023)

is ameliorated by sbr^HMS00273

(Zuniga et al., 2023)

is ameliorated by Nxt1^GD17336

(Zuniga et al., 2023, Cornelison et al., 2019)

is exacerbated by Smg5^HMC05268

(Zuniga et al., 2023)

is exacerbated by Upf1^GL01485

(Zuniga et al., 2023)

is ameliorated by Upf1^UASp.GFP

(Zuniga et al., 2023)

is ameliorated by Zzzz\scFv^{235.UAS.Tag:polyHis,Tag:HA}

(Krishnaswamy et al., 2020)

is ameliorated by Nmnat^UAS.PD

(Ma et al., 2020)

is ameliorated by Nmnat^WR.UAS.PD

(Ma et al., 2020)

is exacerbated by Ggal\MLCK^{CaMBP4.UAS.Tag:MYC}

(Mahoney et al., 2020)

is exacerbated by slo¹

(Mahoney et al., 2020)

is exacerbated by slo^HMC04093

(Mahoney et al., 2020)

is exacerbated by Smvt^HMJ30134

(Lohr et al., 2020)

is exacerbated by Smvt^MB04530

(Lohr et al., 2020)

is ameliorated by Btnd^GD5654

(Lohr et al., 2020)

is ameliorated by Btnd^PL59

(Lohr et al., 2020)

is exacerbated by Hcs^UAS.cLa

(Lohr et al., 2020)

is ameliorated by Hsap\HSPB1^UAS.cZa

(Zhang et al., 2022)

is ameliorated by Moe^HMS00886

(Beckmann et al., 2023)

is exacerbated by Moe^{K.T559D.UAS.Tag:MYC}

(Beckmann et al., 2023)

is exacerbated by Lam^GL00577

(Frost et al., 2016)

is ameliorated by Zzzz\scFv^{T1.UAS.Tag:FLAG}

(Li et al., 2021)

is ameliorated by Amph^GD1311

(Dräger et al., 2017)

is ameliorated by Amph^HMS01933

(Dräger et al., 2017)

is exacerbated by Hsap\TBK1^UAS.Tag:HA

(Abreha et al., 2021)

is ameliorated by IKKε^GL00160

(Abreha et al., 2021)

is exacerbated by IKKε^{UAS.ORF.Tag:HA}

(Abreha et al., 2021)

is exacerbated by Zzzz\GGGGCC^30.UAS.EGFP

(He et al., 2019)

is ameliorated by Kdm3^HMJ22328

(Park et al., 2019)

is ameliorated by Kdm2^KK101783

(Park et al., 2019)

is ameliorated by Kdm4A^GD9133

(Park et al., 2019)

is ameliorated by Kdm4B^KK102089

(Park et al., 2019)

is ameliorated by sbr¹

(Cornelison et al., 2019)

is ameliorated by sbr^KK100882

(Cornelison et al., 2019)

is exacerbated by Amph^A.UAS

(Bernstein et al., 2016)

is exacerbated by Hsap\CELF1^UAS.cdHa

(Bernstein et al., 2016)

is exacerbated by Rbp^MB02027

(Bernstein et al., 2016)

is ameliorated by Set^EY09821

(Bernstein et al., 2016)

is exacerbated by bru1^BG01566

(Bernstein et al., 2016)

is ameliorated by bru2^G5819

(Bernstein et al., 2016)

is ameliorated by ema^HMC03234

(Bernstein et al., 2016)

is exacerbated by msn^HMJ02084

(Bernstein et al., 2016)

is exacerbated by msn^JF03219

(Bernstein et al., 2016)

is exacerbated by rno^HMC04968

(Farrell et al., 2022)

is exacerbated by rno^HMJ24120

(Farrell et al., 2022)

is exacerbated by Hsap\APP^{Arctic.Aβ42.UAS.cUa}

(Sun et al., 2022)

is ameliorated by Trmt61^GD8364

(Shafik et al., 2022)

is ameliorated by rswl^GD12447

(Shafik et al., 2022)

is ameliorated by scu^GD1528

(Shafik et al., 2022)

is ameliorated by InR^HMS03166

(Pragati and Sarkar, 2024)

is exacerbated by Klc^8ex94

(Falzone et al., 2010)

is exacerbated by Clc^DG23206

(Merlo et al., 2014)

is exacerbated by Chc¹

(Merlo et al., 2014)

is exacerbated by Amph^EY09339

(Merlo et al., 2014)

is exacerbated by Chc⁴

(Merlo et al., 2014)

is ameliorated by Rab26^UAS.YFP

(Merlo et al., 2014)

is exacerbated by Rab26^{T204N.UAS.YFP}

(Merlo et al., 2014)

is exacerbated by Rab26^GD9927

(Merlo et al., 2014)

is exacerbated by p53^5A-1-4

(Merlo et al., 2014)

is exacerbated by p53^11-1B-1

(Merlo et al., 2014)

is exacerbated by Amph^GD1311

(Merlo et al., 2014)

is exacerbated by Sytβ^DG10711

(Merlo et al., 2014)

is exacerbated by Sytβ^JF02593

(Merlo et al., 2014)

is exacerbated by Hsap\SOD1^A4V.UAS

(Huang et al., 2015)

is exacerbated by Hsap\SOD1^UAS.cWa

(Huang et al., 2015)

is exacerbated by Lerp^GD306

(Butzlaff et al., 2015)

is exacerbated by Dhc93AB^GD11054

(Butzlaff et al., 2015)

is exacerbated by Cwc25^GD9830

(Butzlaff et al., 2015)

is exacerbated by Vha16-1^GD4523

(Butzlaff et al., 2015)

is exacerbated by Trmt2a^GD11081

(Butzlaff et al., 2015)

is exacerbated by snRNP-U1-C^GD11660

(Butzlaff et al., 2015)

is exacerbated by CG5986^GD9900

(Butzlaff et al., 2015)

is exacerbated by fzy^GD11268

(Butzlaff et al., 2015)

is exacerbated by Gdi^GD11312

(Butzlaff et al., 2015)

is exacerbated by par-6^GD4048

(Butzlaff et al., 2015)

is exacerbated by Arv1^GD1675

(Butzlaff et al., 2015)

is exacerbated by αTub84B^GD17779

(Butzlaff et al., 2015)

is exacerbated by Scamp^GD3371

(Butzlaff et al., 2015)

is exacerbated by g^GD7158

(Butzlaff et al., 2015)

is exacerbated by CG8664^GD3411

(Butzlaff et al., 2015)

is exacerbated by EloB^GD4863

(Butzlaff et al., 2015)

is exacerbated by Spp^GD786

(Butzlaff et al., 2015)

is exacerbated by CG8785^GD1961

(Butzlaff et al., 2015)

is exacerbated by Nedd8^GD12964

(Butzlaff et al., 2015)

is exacerbated by Fer1^GD13372

(Butzlaff et al., 2015)

is exacerbated by CG10979^GD7154

(Butzlaff et al., 2015)

is exacerbated by CG17327^GD9348

(Butzlaff et al., 2015)

is exacerbated by Hipk^GD9283

(Butzlaff et al., 2015)

is exacerbated by Drak^GD9422

(Butzlaff et al., 2015)

is exacerbated by CG6330^GD11891

(Butzlaff et al., 2015)

is exacerbated by Usp10^GD5121

(Butzlaff et al., 2015)

is exacerbated by Su(z)2^GD16388

(Butzlaff et al., 2015)

is exacerbated by Snp^GD11912

(Butzlaff et al., 2015)

is exacerbated by Flo2^GD7328

(Butzlaff et al., 2015)

is ameliorated by CG42788^GD8865

(Butzlaff et al., 2015)

is ameliorated by CG18508^GD6805

(Butzlaff et al., 2015)

is exacerbated by CG7896^GD20

(Butzlaff et al., 2015)

is exacerbated by Datp^GD15139

(Butzlaff et al., 2015)

is exacerbated by CG7896^GD2516

(Butzlaff et al., 2015)

is ameliorated by nord^GD5955

(Butzlaff et al., 2015)

is ameliorated by Mad1^GD9715

(Butzlaff et al., 2015)

is ameliorated by Shrm^GD13983

(Butzlaff et al., 2015)

is ameliorated by CG6418^GD11919

(Butzlaff et al., 2015)

is exacerbated by Vha16-1^GD17431

(Butzlaff et al., 2015)

is ameliorated by smash^GD10286

(Butzlaff et al., 2015)

is ameliorated by S-Lap2^GD10864

(Butzlaff et al., 2015)

is ameliorated by CG31259^GD2862

(Butzlaff et al., 2015)

is ameliorated by CG5500^GD4790

(Butzlaff et al., 2015)

is exacerbated by Vha36-1^GD17846

(Butzlaff et al., 2015)

is ameliorated by CG14621^GD3713

(Butzlaff et al., 2015)

is ameliorated by Nuf2^GD14063

(Butzlaff et al., 2015)

is exacerbated by Dab^GD4886

(Butzlaff et al., 2015)

is ameliorated by Tet^GD14834

(Butzlaff et al., 2015)

is ameliorated by Tet^GD14330

(Butzlaff et al., 2015)

is ameliorated by CG15629^GD890

(Butzlaff et al., 2015)

is exacerbated by T3dh^GD10964

(Butzlaff et al., 2015)

is ameliorated by CG15629^GD17179

(Butzlaff et al., 2015)

is exacerbated by DCTN4-p62^GD7465

(Butzlaff et al., 2015)

is ameliorated by CG32809^GD11076

(Butzlaff et al., 2015)

is exacerbated by T3dh^GD16513

(Butzlaff et al., 2015)

is exacerbated by Arp10^GD7542

(Butzlaff et al., 2015)

is exacerbated by CG3500^GD2177

(Butzlaff et al., 2015)

is exacerbated by GstS1^GD16335

(Butzlaff et al., 2015)

is exacerbated by Cyp301a1^GD13977

(Butzlaff et al., 2015)

is exacerbated by DCTN1-p150^GD1455

(Butzlaff et al., 2015)

is exacerbated by Cwc25^GD17298

(Butzlaff et al., 2015)

is exacerbated by DCTN2-p50^GD13758

(Butzlaff et al., 2015)

is exacerbated by αTub84B^GD9679

(Butzlaff et al., 2015)

is exacerbated by αTub67C^GD13885

(Butzlaff et al., 2015)

is exacerbated by Prosα7^GD3491

(Butzlaff et al., 2015)

is exacerbated by krz^GD8470

(Butzlaff et al., 2015)

is ameliorated by S-Lap2^GD16773

(Butzlaff et al., 2015)

is ameliorated by Tet^GD9718

(Butzlaff et al., 2015)

is exacerbated by Su(z)2^GD4494

(Butzlaff et al., 2015)

is exacerbated by Gabat^GD12238

(Butzlaff et al., 2015)

is exacerbated by ttv^GD1993

(Butzlaff et al., 2015)

is exacerbated by CG7896^GD14469

(Butzlaff et al., 2015)

is ameliorated by Shrm^GD16363

(Butzlaff et al., 2015)

is ameliorated by hep^GD1461

(Butzlaff et al., 2015)

is ameliorated by CG32809^GD11060

(Butzlaff et al., 2015)

is exacerbated by Snp^GD10043

(Butzlaff et al., 2015)

is ameliorated by CG3511^GD11160

(Butzlaff et al., 2015)

is exacerbated by DCTN5-p25^GD3469

(Butzlaff et al., 2015)

is exacerbated by Lamtor1^GD12840

(Butzlaff et al., 2015)

is ameliorated by PICK1^KK109273

(McGurk and Bonini, 2012)

is exacerbated by Lkb1^UAS.cWa

(Wang et al., 2007)

is exacerbated by cathD¹

(Khurana et al., 2010)

is ameliorated by rad50^EP1

(Tuxworth et al., 2019)

model of neurodegenerative disease

is exacerbated by par-1^UAS.cSa

(Nishimura et al., 2004)

is exacerbated by loqs^f00791

(Bilen et al., 2006)

is exacerbated by Hsap\APP^695.T.UAS

(Wang et al., 2007)

is ameliorated by MRG15^GD11902

(Voßfeldt et al., 2012)

is exacerbated by CG2887^GD9842

(Voßfeldt et al., 2012)

is exacerbated by CG6873^GD12062

(Voßfeldt et al., 2012)

is ameliorated by CG16890^GD9226

(Voßfeldt et al., 2012)

is exacerbated by Vha100-1^GD12710

(Williamson and Hiesinger, 2010)

exacerbates neurodegenerative disease

modeled by Hsap\APP^695.T.UAS

(Wang et al., 2007)

model of Alzheimer's disease

is exacerbated by Su(var)3-9¹

(Frost et al., 2014)

is exacerbated by Su(var)205^MB11439

(Frost et al., 2014)

is ameliorated by AGO3^GL00117

(Frost et al., 2014)

is ameliorated by AGO3^HMS00125

(Frost et al., 2014)

is exacerbated by Su(var)3-9²

(Frost et al., 2014)

is exacerbated by Su(var)205⁵

(Frost et al., 2014)

is ameliorated by Nurf-38^JF01299

(Frost et al., 2014)

is ameliorated by E(bx)^JF01709

(Frost et al., 2014)

is ameliorated by ash1^B1

(Frost et al., 2014)

is ameliorated by ash1^RNAi.UAS.cUa

(Frost et al., 2014)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.Aβ42.UAS.cUa}

(Sun et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Wittmann et al., 2001)

MAPT:p.Arg723Trp

(FlyBase curators, 2019-)

Variants Synonym(s)

MAPT:p.Arg406Trp

MAPT:p.Arg798Trp

MAPT:p.Arg317Trp

MAPT:p.Arg348Trp

MAPT:p.Arg377Trp

Associated human disease model(s)

External database links

ClinVar: MAPT_14247

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal cell cycle, with Scer\GAL4^elav.PU

(Duboff et al., 2012)

abnormal cell cycle, with Scer\GAL4^elav-C155

(Loewen and Feany, 2010)

abnormal cell death, with Scer\GAL4^elav.PU

(Duboff et al., 2012)

abnormal learning | adult stage, with Scer\GAL4^elav.PU

(Ali et al., 2012)

abnormal locomotor behavior, with Scer\GAL4^elav.PLu

(Merlo et al., 2014)

abnormal locomotor behavior, with Scer\GAL4^elav.PU

(Huang et al., 2015, Frost et al., 2014)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav.PU

(Ali et al., 2012)

abnormal memory | adult stage, with Scer\GAL4^c739

(Haddadi et al., 2016)

abnormal memory | adult stage, with Scer\GAL4^elav.PU

(Ali et al., 2012)

abnormal mitotic cell cycle, with Scer\GAL4^elav.PLu

(Merlo et al., 2014)

abnormal neuroanatomy, with Scer\GAL4^ChAT.7.4

(Nishimura et al., 2004)

abnormal neuroanatomy, with Scer\GAL4^elav.PU

(Huang et al., 2015, Duboff et al., 2012, Kosmidis et al., 2010, Papanikolopoulou et al., 2010)

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Loewen and Feany, 2010)

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Williamson and Hiesinger, 2010)

abnormal neuroanatomy, with Scer\GAL4^hs.2sev

(Nishimura et al., 2004)

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

abnormal neuroanatomy | day 60 of adulthood, with Scer\GAL4^c492b

(Mershin et al., 2004)

abnormal neuroanatomy | progressive, with Scer\GAL4^elav.PU

(Ali et al., 2012)

abnormal neurophysiology, with Scer\GAL4^GMR.PF

(Williamson and Hiesinger, 2010)

decreased cell number | adult stage, with Scer\GAL4^GMR.PF

(Wang et al., 2007)

decreased rate of adult locomotory behavior, with Scer\GAL4^elav-C155

(Schulz et al., 2023)

increased cell death, with Scer\GAL4^elav.PLu

(Merlo et al., 2014, Fulga et al., 2007)

increased cell death, with Scer\GAL4^elav.PU

(Frost et al., 2014, Ali et al., 2012)

increased cell death, with Scer\GAL4^elav-C155

(Khurana et al., 2010, Loewen and Feany, 2010)

increased cell death, with Scer\GAL4^GMR.PF

(Bilen et al., 2006)

increased cell death | adult stage, with Scer\GAL4^elav.PU

(Ojelade et al., 2019, Dias-Santagata et al., 2007)

increased cell death | adult stage, with Scer\GAL4^elav-C155

(Schulz et al., 2023, Abreha et al., 2021)

increased cell death | conditional, with Scer\GAL4^elav.PLu

(Khurana et al., 2006)

increased occurrence of cell division, with Scer\GAL4^elav-C155

(Khurana et al., 2010)

increased occurrence of cell division | adult stage, with Scer\GAL4^elav.PLu

(Khurana et al., 2006)

partially lethal, with Scer\GAL4^Appl.G1a

(Falzone et al., 2010)

short lived

(Huang et al., 2014)

short lived, with Scer\GAL4^elav.PU

(Kim et al., 2015)

short lived, with Scer\GAL4^elav-C155

(Haddadi et al., 2016, Khurana et al., 2010)

short lived | nutrition conditional

(Huang et al., 2014)

visible, with Scer\GAL4^GMR.PF

(Povellato et al., 2014, Feuillette et al., 2010)

visible, with Scer\GAL4^GMR.PU

(Huang et al., 2015, McGurk and Bonini, 2012, Bilen and Bonini, 2007)

visible, with Scer\GAL4^hs.2sev

(Nishimura et al., 2004)

visible | adult stage, with Scer\GAL4^elav-C155

(Schulz et al., 2023)

visible | adult stage, with Scer\GAL4^GMR.PF

(Wang et al., 2007)

visible | adult stage, with Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Phenotype Manifest In

adult brain, with Scer\GAL4^elav.PLu

(Wittmann et al., 2001)

adult brain, with Scer\GAL4^elav.PU

(Ojelade et al., 2019, Duboff et al., 2012)

adult brain, with Scer\GAL4^elav-C155

(Schulz et al., 2023, Abreha et al., 2021, Khurana et al., 2010)

adult brain | conditional, with Scer\GAL4^elav.PLu

(Khurana et al., 2006)

adult brain cell body rind, with Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

adult central complex, with Scer\GAL4^ChAT.7.4

(Wittmann et al., 2001)

adult CNS neuron | decreased number, with Scer\GAL4^elav-C155

(Schulz et al., 2023)

adult mushroom body, with Scer\GAL4^elav.PU

(Kosmidis et al., 2010, Papanikolopoulou et al., 2010)

adult mushroom body | day 60 of adulthood, with Scer\GAL4^c492b

(Mershin et al., 2004)

axon | larval stage, with Scer\GAL4^Appl.G1a

(Falzone et al., 2010)

brain, with Scer\GAL4^elav.PLu

(Merlo et al., 2014)

brain, with Scer\GAL4^elav.PU

(Huang et al., 2015, Ali et al., 2012)

eye, with Scer\GAL4^elav-C155

(Schulz et al., 2023)

eye, with Scer\GAL4^ey.PB

(Berger et al., 2006)

eye, with Scer\GAL4^GMR.PF

(Butzlaff et al., 2015, Povellato et al., 2014, Feuillette et al., 2010, Yeh et al., 2010, Mallik and Lakhotia, 2009, Ryoo et al., 2007, Wang et al., 2007, Bilen et al., 2006)

eye, with Scer\GAL4^GMR.PU

(Shafik et al., 2022, Huang et al., 2015, McGurk and Bonini, 2012, Bilen and Bonini, 2007)

eye, with Scer\GAL4^hs.2sev

(Nishimura et al., 2004)

eye photoreceptor cell & neuron, with Scer\GAL4^hs.2sev

(Nishimura et al., 2004)

lamina, with Scer\GAL4^ChAT.7.4

(Wittmann et al., 2001)

lamina | conditional, with Scer\GAL4^elav.PLu

(Khurana et al., 2006)

macrochaeta, with Scer\GAL4^Eq

(Yeh et al., 2010)

mitochondrion, with Scer\GAL4^elav.PU

(Duboff et al., 2012)

neuromuscular junction | larval stage, with Scer\GAL4^elav-C155

(Butzlaff et al., 2015)

neuron, with Scer\GAL4^ChAT.7.4

(Nishimura et al., 2004)

neuron, with Scer\GAL4^elav.PU

(Huang et al., 2015, Frost et al., 2014)

neuron | adult stage, with Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

neuron | adult stage, with Scer\GAL4^elav-C155

(Khurana et al., 2010)

neuropil | adult stage, with Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

ommatidium, with Scer\GAL4^GMR.PU

(Huang et al., 2015)

photoreceptor, with Scer\GAL4^GMR.PF

(Wang et al., 2007)

photoreceptor neuron, with Scer\GAL4^GMR.PF

(Williamson and Hiesinger, 2010)

retina, with Scer\GAL4^GMR.PF

(Bilen et al., 2006)

sensory organ cell, with Scer\GAL4^Eq

(Yeh et al., 2010)

vesicle | larval stage, with Scer\GAL4^Appl.G1a

(Falzone et al., 2010)

Detailed Description

Statement

Reference

The expression of Hsap\MAPT^R406W.UAS under the control of Scer\GAL4^GMR.PU induces a rough eye phenotype.

(Shafik et al., 2022)

10-day old adults expressing Hsap\MAPT^R406W.UAS under the control of Scer\GAL4^elav-C155 show elevated apoptosis in the brain.

(Abreha et al., 2021)

Expression of Hsap\MAPT^R406W.UAS under the control of Scer\GAL4^elav.PU increases apoptosis (TUNEL) in the adult brain, compared to controls.

(Ojelade et al., 2019)

Expression of Hsap\MAPT^{R406W.Scer\UAS} driven pan-neuronally by Scer\GAL4^elav-C155 leads to a significantly shortened lifespan compared to control flies and flies with expression of Hsap\MAPT^{V337M.Scer\UAS}. Scer\GAL4^elav-C155>Hsap\MAPT^{R406W.Scer\UAS} flies show significant changes in the activity of antioxidant enzymes.

Expression of Hsap\MAPT^{R406W.Scer\UAS} driven in mushroom bodies by Scer\GAL4^c739 leads to a significant impairment in middle-term and long-term olfactory memory compared to controls.

(Haddadi et al., 2016)

Scer\GAL4^GMR.PF-mediated expression of Hsap\MAPT^{R406W.Scer\UAS} results in a rough eye.

Scer\GAL4^elav-C155-mediated expression of Hsap\MAPT^{R406W.Scer\UAS} results in a significant decrease in synaptic vesicles at larval neuromuscular junctions, but only minor changes in its overall appearance.

Scer\GAL4^elav-C155-mediated expression of Hsap\MAPT^{R406W.Scer\UAS} has no apparent effect on larval motor coordination or locomotion, or on eclosion rates.

(Butzlaff et al., 2015)

Expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU results in a reduction in adult lifespan compared to controls.

(Kim et al., 2015)

Transgenic flies expressing Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS} show reduced locomotor activity compared with control flies.

(Frost et al., 2014)

Feeding flies ZnCl[[2]] enhances the toxicity seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU, further reducing lifespan. Feeding the flies CQ (a hydrophobic metal chelator) partially rescues the toxicity, elongating the lifespan. No changes in lifespan are observed when wild type flies are fed the same levels of metals.

(Huang et al., 2014)

Expression of Hsap\MAPT^{R406W.Scer\UAS} using Scer\GAL4^elav.PLu induces neuronal cell death and abnormal cell cycle reactivation. The transgenic flies expressing Hsap\MAPT^{R406W.Scer\UAS} display locomotor defect as assayed by measuring walking speed.

(Merlo et al., 2014)

Flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU exhibit normal learning and memory in an aversive phototaxis assay at two days after eclosion. Learning and memory are both significantly reduced at 20 days post-eclosion.

Expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU results in an age-dependent decrease in locomotor activity as measured by climbing performance.

Vacuolisation is observed in the brains of 2 day old flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU. By 20 days multiple large vacuoles can be observed and an increased number of apoptotic cells (caspase 3 positive) is seen in the mid brain compared to controls.

(Ali et al., 2012)

The mitochondria in the neurons of adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU are markedly elongated. Mitochondria length is on average greater than twice that of controls. Neuron death (assayed by TUNEL staining) is also observed. An increase in cell cycle activation (assayed by PCNA) is also seen compared to controls.

The brains of animals expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU show a significant increase in superoxide production (assayed using dihydroethidium) compared to controls.

(Duboff et al., 2012)

Expression of Hsap\MAPT^{R406W.Scer\UAS} driven by Scer\GAL4^Appl.G1a induces substantial axonal vesicle accumulations in larvae and results in increased lethality during development, as compared to controls.

(Falzone et al., 2010)

Neuronal expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav-C155 results in reduced adult lifespan and results in adult brains presenting increases in both apoptosis {as visualised with TUNEL) and DNA replication (as visualized with PCNA) and vacuolar degeneration, compared to wild-type controls.

(Khurana et al., 2010)

Pan-neuronal expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU results in severe mushroom body (MB) defects that are generally bilateral. The brain defects are restricted to the MBs.

(Kosmidis et al., 2010)

Expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav-C155 increases the level of apoptosis in the nervous system.

(Loewen and Feany, 2010)

Flies expressing Hsap\MAPT^{R406W.Scer\UAS} in neurons under the control of Scer\GAL4^elav.PU show mushroom body aberrations.

(Papanikolopoulou et al., 2010)

Expression of Hsap\MAPT^{R406W.Scer\UAS} in the developing eye under the control of Scer\GAL4^GMR.PF generates a severe rough eye phenotype. The orderly ommatidial architecture is disorganized and photoreceptors are fused with missing mechanosensory bristles.

Expression of Hsap\MAPT^{R406W.Scer\UAS} in the developing external sensory organs under the control of Scer\GAL4^Eq1 generates a severe bristle loss phenotype.

(Yeh et al., 2010)

Expression of Hsap\MAPT^{R406W.Scer\UAS} using Scer\GAL4^GMR.PF produces a rough and reduced eye.

(Mallik and Lakhotia, 2009)

Expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU results in neurodegeneration of both the cortex and neuropil in 10-day old flies, with these regions exhibiting vacuolization and an increase in neuron apoptosis, as compared to controls.

(Dias-Santagata et al., 2007)

Expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu results in increased levels of neuronal cell death.

(Fulga et al., 2007)

Expression of Hsap\MAPT^{R406W.Scer\UAS} driven by Scer\GAL4^GMR.PF results in ablation of the adult eye.

(Ryoo et al., 2007)

Expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in a rough eye phenotype and mild photoreceptor loss.

(Wang et al., 2007)

Expression of Scer\GAL4^ey.PB>Hsap\MAPT^{R406W.Scer\UAS} leads to the formation of abnormal eyes or no eyes. Rapamycin treatment ameliorates the eye phenotype.

(Berger et al., 2006)

Expression of Hsap\MAPT^{R406W.Scer\UAS} in the developing eye (under the control of Scer\GAL4^GMR.PF) induces severe neurodegeneration, reflected by a severely disrupted eye phenotype.

(Bilen et al., 2006)

Adult brains from newly-eclosed animals expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu appear morphologically normal, but by 10 days neurodegeneration is observed, and vacuolar degeneration of the lamina is observed. Increased rates of cell division are also observed in these mutant brains.

(Khurana et al., 2006)

21 day old flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^c492b do not exhibit obvious degeneration or vacuoles in the mushroom body. Severe neurodegeneration and large vacuoles are observed in the mushroom bodies of 60 day old flies expressing Hsap\MAPT^{R406W.Scer\UAS} using Scer\GAL4^c492b. Degenerating neurons and vacuoles are observed in the mushroom body, but not in the ellipsoid body where the Scer\GAL4^c492b driver is inactive.

(Mershin et al., 2004)

Flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^hs.2sev show a moderate eye degeneration phenotype. A 6% loss in photoreceptor neurons is seen. Expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^Cha.7.4 results in mild vacuole formation in the cell bodies of the cholinergic neurons. About 13% of neurons stain positive in a TUNEL assay in clones expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^hs.2sev in the brain, significantly more than in control clones.

(Nishimura et al., 2004)

Expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu results in a severe reduction in adult life span. The effect on life span is dosage sensitive. 1 day old adults has no brain abnormalities. Aged flies show neurodegeneration; vacuolisation and degeneration of cells in the cortex is seen. There is also a modest increase in neuropil vacuolisation. The degeneration is progressive and the phenotype is fully penetrant. No evidence of large filamentous aggregates (neurofibrillary tangles) is seen in the brains of adults expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu or Scer\GAL4^Cha.7.4. Cholinergic neurons of the optic lamina appear normal in 1 day old adults expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^Cha.7.4. However, 30 day old flies show widespread vacuolization and loss of cholinergic neurons in the optic lamina. Loss of cholinergic neurons is also seen in the central body complex. 1 day old adults expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu have a normal number of cholinergic terminals in the brain. The number of acetylcholine-positive terminals is strongly reduced in aged flies.

(Wittmann et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by rswl^GD12447, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by scu^GD1528, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Trmt61^GD8364, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death | adult stage phenotype, enhanceable by Hsap\TBK1^UAS.Tag:HA, Scer\GAL4^elav-C155

(Abreha et al., 2021)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death | adult stage phenotype, enhanceable by IKKε^{UAS.ORF.Tag:HA}, Scer\GAL4^elav-C155

(Abreha et al., 2021)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death | adult stage phenotype, enhanceable by cindr¹/Df(3R)Exel6217

(Ojelade et al., 2019)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death | adult stage phenotype, enhanceable by cindr¹/cindr¹

(Ojelade et al., 2019)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Hsap\SOD1^UAS.cWa, Scer\GAL4^GMR.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Hsap\SOD1^A4V.UAS, Scer\GAL4^GMR.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior phenotype, enhanceable by Hsap\SOD1^UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, enhanceable by Hsap\SOD1^UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior phenotype, enhanceable by Hsap\SOD1^A4V.UAS, Scer\GAL4^elav.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, enhanceable by Hsap\SOD1^A4V.UAS, Scer\GAL4^elav.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, enhanceable by Su(var)205⁵/Su(var)205[+]

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior phenotype, enhanceable by Su(var)205⁵/Su(var)205[+]

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, enhanceable by Su(var)205^MB11439/Su(var)205[+]

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, enhanceable by Su(var)3-9¹/Su(var)3-9[+]

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, enhanceable by Su(var)3-9[+]/Su(var)3-9²

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior phenotype, enhanceable by Su(var)3-9[+]/Su(var)3-9²

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has visible phenotype, enhanceable by Zip42C.1^UAS.cLa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has short lived phenotype, enhanceable by Zip42C.1^UAS.cLa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, enhanceable by Zip42C.1^UAS.cLa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has visible phenotype, enhanceable by ZnT63C^RNAi.UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has short lived phenotype, enhanceable by ZnT63C^RNAi.UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, enhanceable by ZnT63C^RNAi.UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by Sytβ^DG10711, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Sytβ^JF02593

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by Sytβ^JF02593

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by p53^11-1B-1

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by p53^11-1B-1

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal locomotor behavior phenotype, enhanceable by p53^11-1B-1

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by p53^5A-1-4

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by p53^5A-1-4

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Amph^EY09339

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by Amph^EY09339

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Amph^GD1311, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by Amph^GD1311, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Clc^DG23206

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by Clc^DG23206

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Chc¹

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by Chc¹

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Chc⁴

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by Chc⁴

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Rab26^{T204N.UAS.YFP}, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by Rab26^{T204N.UAS.YFP}, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Rab26^GD9927, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, enhanceable by Rab26^GD9927, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Sytβ^DG10711, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, enhanceable by Marf^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell death phenotype, enhanceable by Marf^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell cycle phenotype, enhanceable by Marf^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, enhanceable by Drp1^GD10456, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell death phenotype, enhanceable by Drp1^GD10456, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell cycle phenotype, enhanceable by Drp1^GD10456, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, enhanceable by Drp1^T26

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell death phenotype, enhanceable by Drp1^T26

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG6873^GD12062, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG2887^GD9842, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^Appl.G1a has partially lethal phenotype, enhanceable by Klc[+]/Klc^8ex94

(Falzone et al., 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased occurrence of cell division phenotype, enhanceable by cathD¹/cathD¹

(Khurana et al., 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by cathD¹

(Khurana et al., 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death phenotype, enhanceable by cathD¹

(Khurana et al., 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has abnormal cell cycle phenotype, enhanceable by Xbp1^GD4745, Scer\GAL4^elav-C155

(Loewen and Feany, 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death phenotype, enhanceable by Xbp1^GD4745, Scer\GAL4^elav-C155

(Loewen and Feany, 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, enhanceable by Xbp1^GD4745, Scer\GAL4^elav-C155

(Loewen and Feany, 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death phenotype, enhanceable by Xbp1^k13803

(Loewen and Feany, 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, enhanceable by Xbp1^k13803

(Loewen and Feany, 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Vha100-1^GD12710, Scer\GAL4^GMR.PF

(Williamson and Hiesinger, 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has abnormal neurophysiology phenotype, enhanceable by Vha100-1^GD12710, Scer\GAL4^GMR.PF

(Williamson and Hiesinger, 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by emb^E2-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy | adult stage phenotype, enhanceable by Trxr-1[+]/Trxr1^Δ1

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death | adult stage phenotype, enhanceable by Trxr-1[+]/Trxr1^Δ1

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy | adult stage phenotype, enhanceable by Sod2ⁿ²⁸³/Sod2[+]

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death | adult stage phenotype, enhanceable by Sod2ⁿ²⁸³/Sod2[+]

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, enhanceable by Act5C^UAS.GFP, Scer\GAL4^elav.PLu

(Fulga et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Hsap\APP^695.T.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Lkb1^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has decreased cell number | adult stage phenotype, enhanceable by Lkb1^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has increased cell death phenotype, enhanceable by loqs^f00791, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death | conditional phenotype, enhanceable by CycA^UAS.cWa, Scer\GAL4^elav.PLu

(Khurana et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^hs.2sev has visible phenotype, enhanceable by par-1^UAS.cSa, Scer\GAL4^hs.2sev

(Nishimura et al., 2004)

Hsap\MAPT^R406W.UAS, Scer\GAL4^ChAT.7.4 has abnormal neuroanatomy phenotype, enhanceable by par-1^UAS.cSa, Scer\GAL4^ChAT.7.4

(Nishimura et al., 2004)

NOT Enhanced by

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has visible | adult stage phenotype, non-enhanceable by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior phenotype, non-enhanceable by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death | adult stage phenotype, non-enhanceable by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has visible | adult stage phenotype, non-enhanceable by Arc1^esm113

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-enhanceable by Trmt6^KK109131, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-enhanceable by mldr^KK108043, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Scer\GAL4^GMR.PF

(Feuillette et al., 2010)

Suppressed by

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has visible | adult stage phenotype, suppressible | partially by Arc1^JF01974, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Arc1^esm113

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Arc1^JF01974, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death | adult stage phenotype, suppressible | partially by Arc1^esm113

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death | adult stage phenotype, suppressible | partially by Arc1^JF01974, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death | adult stage phenotype, suppressible by IKKε^GL00160, Scer\GAL4^elav-C155

(Abreha et al., 2021)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible by POLDIP2^EY08866

(Kim et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, suppressible by ash1^B1/ash1[+]

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, suppressible by ash1^RNAi.UAS.cUa, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, suppressible by Nurf-38^JF01299, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, suppressible by E(bx)^JF01709, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior phenotype, suppressible by ash1^RNAi.UAS.cUa, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior phenotype, suppressible by E(bx)^JF01709, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, suppressible by AGO3^GL00117, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior phenotype, suppressible by AGO3^GL00117, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, suppressible by AGO3^HMS00125, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has visible phenotype, suppressible by ZnT63C^UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible by ZnT63C^UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by ZnT63C^UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has visible phenotype, suppressible by Zip42C.1^RNAi.UAS, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible by Zip42C.1^RNAi.UAS, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by Zip42C.1^RNAi.UAS, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, suppressible by Rab26^UAS.YFP, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has abnormal mitotic cell cycle phenotype, suppressible by Rab26^UAS.YFP, Scer\GAL4^elav.PLu

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal learning | adult stage phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal memory | adult stage phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy | progressive phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal learning | adult stage phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal memory | adult stage phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy | progressive phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by Drp1^UAS.cDb, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell death phenotype, suppressible by Drp1^UAS.cDb, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell cycle phenotype, suppressible by Drp1^UAS.cDb, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by Marf^JF01650, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell death phenotype, suppressible by Marf^JF01650, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell cycle phenotype, suppressible by Marf^JF01650, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by Opa1^s3475

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell death phenotype, suppressible by Opa1^s3475

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by Df(1)Exel6239

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell death phenotype, suppressible by Df(1)Exel6239

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by PICK1^KK109273, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has visible phenotype, suppressible by CG16890^GD9226, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has visible phenotype, suppressible by MRG15^GD11902, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Tpr2^EB7-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by CG11700^EP1384, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Acox1^B227.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by wech^JM265, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Imp^EP1433, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Gtpx^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death | adult stage phenotype, suppressible by Gtpx^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Sod2^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has increased cell death | adult stage phenotype, suppressible by Sod2^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death phenotype, suppressible by tsr^{UAS.Tag:polyHis}, Scer\GAL4^elav.PLu

(Fulga et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death | conditional phenotype, suppressible by dap^UAS.cdNa/Rbf^UAS.cDa, Scer\GAL4^elav.PLu

(Khurana et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death | conditional phenotype, suppressible by dap^UAS.cdNa/Cdk1^E51Q.UAS, Scer\GAL4^elav.PLu

(Khurana et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has increased cell death | conditional phenotype, suppressible by gig^{ΔAkt-P.UAS.Tag:FLAG}, Scer\GAL4^elav.PLu

(Khurana et al., 2006)

NOT suppressed by

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has visible | adult stage phenotype, non-suppressible by Arc1^esm113

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has visible | adult stage phenotype, non-suppressible by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has decreased rate of adult locomotory behavior phenotype, non-suppressible by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has increased cell death | adult stage phenotype, non-suppressible by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Trmt6^KK109131, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by mldr^KK108043, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, non-suppressible by Drp1^{Tag:FLAG,Tag:CALI(TC),Tag:HA}

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell death phenotype, non-suppressible by Drp1^{Tag:FLAG,Tag:CALI(TC),Tag:HA}

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, non-suppressible by Gel^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has abnormal cell death phenotype, non-suppressible by Gel^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Scer\GAL4^GMR.PF

(Feuillette et al., 2010)

Enhancer of

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU is an enhancer of abnormal neuroanatomy phenotype of Marf^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU is an enhancer of abnormal cell death phenotype of Marf^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Other

Statement

Reference

Hsap\MAPT^R406W.UAS, Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb, Scer\GAL4^elav-C155 has lethal phenotype

(Ordonez et al., 2018)

Cwc25^GD9830, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has lethal phenotype

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF, Trmt2a^GD11081 has lethal phenotype

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF, snRNP-U1-C^GD11660 has lethal phenotype

(Butzlaff et al., 2015)

CG5986^GD9900, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has lethal phenotype

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF, fzy^GD11268 has lethal phenotype

(Butzlaff et al., 2015)

Gdi^GD11312, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has lethal phenotype

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF, par-6^GD4048 has lethal phenotype

(Butzlaff et al., 2015)

Arv1^GD1675, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has lethal phenotype

(Butzlaff et al., 2015)

DCTN2-p50^GD13758, Hsap\MAPT^R406W.UAS, Scer\GAL4^Toll-6-D42 has abnormal locomotor behavior | progressive phenotype

(Butzlaff et al., 2015)

DCTN1-p150^GD1455, Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has partially lethal phenotype

(Butzlaff et al., 2015)

DCTN2-p50^GD13758, Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has partially lethal phenotype

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Lerp^GD306, Scer\GAL4^GMR.PF has lethal phenotype

(Butzlaff et al., 2015)

Dhc93AB^GD11054, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has lethal phenotype

(Butzlaff et al., 2015)

Cwc25^GD17298, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has lethal phenotype

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Hsap\SOD1^UAS.cWa, Scer\GAL4^elav.PU has short lived phenotype

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Hsap\SOD1^A4V.UAS, Scer\GAL4^elav.PU has short lived phenotype

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Nmnat^unspecified, Scer\GAL4^elav.PU has abnormal learning | adult stage phenotype

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Nmnat^unspecified, Scer\GAL4^elav.PU has abnormal memory | adult stage phenotype

(Ali et al., 2012)

HisRS^GD1599, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Prosβ2^GD10938, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Nrx-IV^GD2436, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, RpS10a^GD7556, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long, brun^GD5423 has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, MED14^GD4081, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Prp8^GD6578, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long, Uck^GD229 has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long, vnc^GD7454 has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Nelf-E^GD9903, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long, bic^GD5037 has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Rab30^GD14116, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Ciz1^GD12382, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

CG8086^GD12374, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Rpn9^GD6909, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long, Sf3b5^GD12979 has lethal phenotype

(Voßfeldt et al., 2012)

CycJ^GD6936, Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

CycD^UAS.cMa, Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has partially lethal - majority die phenotype

(Khurana et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by rswl^GD12447, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by scu^GD1528, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Trmt61^GD8364, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has adult brain phenotype, enhanceable by Hsap\TBK1^UAS.Tag:HA, Scer\GAL4^elav-C155

(Abreha et al., 2021)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has adult brain phenotype, enhanceable by IKKε^{UAS.ORF.Tag:HA}, Scer\GAL4^elav-C155

(Abreha et al., 2021)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, enhanceable by cindr¹/Df(3R)Exel6217

(Ojelade et al., 2019)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, enhanceable by cindr¹/cindr¹

(Ojelade et al., 2019)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by DCTN1-p150^GD1455, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by DCTN2-p50^GD13758, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by αTub84B^GD9679, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by αTub84B^GD17779, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by αTub67C^GD13885, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Scamp^GD3371, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by g^GD7158, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by EloB^GD4863, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Spp^GD786, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Prosα7^GD3491, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Nedd8^GD12964, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Fer1^GD13372, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG10979^GD7154, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG17327^GD9348, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hipk^GD9283, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Drak^GD9422, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG6330^GD11891, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Su(z)2^GD16388, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Su(z)2^GD4494, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Flo2^GD7328, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG7896^GD20, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG7896^GD14469, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG7896^GD2516, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG8664^GD3411, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Snp^GD11912, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Snp^GD10043, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Datp^GD15139, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Vha16-1^GD4523, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Vha16-1^GD17431, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Vha36-1^GD17846, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by krz^GD8470, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Dab^GD4886, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by T3dh^GD10964, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by T3dh^GD16513, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG3500^GD2177, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by GstS1^GD16335, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Gabat^GD12238, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Cyp301a1^GD13977, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by ttv^GD1993, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG8785^GD1961, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Usp10^GD5121, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by DCTN4-p62^GD7465, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by DCTN5-p25^GD3469, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Arp10^GD7542, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Lamtor1^GD12840, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Hsap\SOD1^UAS.cWa, Scer\GAL4^GMR.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by Hsap\SOD1^A4V.UAS, Scer\GAL4^GMR.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has brain phenotype, enhanceable by Hsap\SOD1^UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, enhanceable by Hsap\SOD1^UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has brain phenotype, enhanceable by Hsap\SOD1^A4V.UAS, Scer\GAL4^elav.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, enhanceable by Hsap\SOD1^A4V.UAS, Scer\GAL4^elav.PU

(Huang et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, enhanceable by Su(var)205⁵/Su(var)205[+]

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, enhanceable by Su(var)205^MB11439/Su(var)205[+]

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, enhanceable by Su(var)3-9¹/Su(var)3-9[+]

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, enhanceable by Su(var)3-9[+]/Su(var)3-9²

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has eye phenotype, enhanceable by ZnT63C^UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has eye phenotype, enhanceable by Zip42C.1^UAS.cLa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has brain phenotype, enhanceable by p53^11-1B-1

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has brain phenotype, enhanceable by p53^5A-1-4

(Merlo et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, enhanceable by Marf^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, enhanceable by Marf^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, enhanceable by Drp1^GD10456, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, enhanceable by Drp1^GD10456, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, enhanceable by Drp1^T26

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, enhanceable by Drp1^T26

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, enhanceable by WASp^UAS.cBa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, enhanceable by WASp^UAS.cBa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, enhanceable by f^+t13

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, enhanceable by f^+t13

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, enhanceable by zip[+]/zip¹

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, enhanceable by zip[+]/zip¹

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, enhanceable by sqh^AX3/sqh[+]

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, enhanceable by sqh^AX3/sqh[+]

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG6873^GD12062, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG2887^GD9842, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has adult brain phenotype, enhanceable by cathD¹/cathD¹

(Khurana et al., 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has neuron | adult stage phenotype, enhanceable by cathD¹/cathD¹

(Khurana et al., 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has photoreceptor neuron phenotype, enhanceable by Vha100-1^GD12710, Scer\GAL4^GMR.PF

(Williamson and Hiesinger, 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by emb^E2-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain cell body rind phenotype, enhanceable by Trxr-1[+]/Trxr1^Δ1

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuropil | adult stage phenotype, enhanceable by Trxr-1[+]/Trxr1^Δ1

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron | adult stage phenotype, enhanceable by Trxr-1[+]/Trxr1^Δ1

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain cell body rind phenotype, enhanceable by Sod2ⁿ²⁸³/Sod2[+]

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuropil | adult stage phenotype, enhanceable by Sod2ⁿ²⁸³/Sod2[+]

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron | adult stage phenotype, enhanceable by Sod2ⁿ²⁸³/Sod2[+]

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsap\APP^695.T.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Lkb1^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, enhanceable by Lkb1^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by loqs^f00791, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by loqs^f00791, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has adult brain | conditional phenotype, enhanceable by CycA^UAS.cWa, Scer\GAL4^elav.PLu

(Khurana et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has lamina | conditional phenotype, enhanceable by CycA^UAS.cWa, Scer\GAL4^elav.PLu

(Khurana et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by par-1^UAS.cSa, Scer\GAL4^hs.2sev

(Nishimura et al., 2004)

Hsap\MAPT^R406W.UAS, Scer\GAL4^hs.2sev has eye photoreceptor cell & neuron phenotype, enhanceable by par-1^UAS.cSa, Scer\GAL4^hs.2sev

(Nishimura et al., 2004)

Hsap\MAPT^R406W.UAS, Scer\GAL4^ChAT.7.4 has neuron phenotype, enhanceable by par-1^UAS.cSa, Scer\GAL4^ChAT.7.4

(Nishimura et al., 2004)

NOT Enhanced by

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has eye phenotype, non-enhanceable by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has adult CNS neuron | decreased number phenotype, non-enhanceable by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has eye phenotype, non-enhanceable by Arc1^esm113

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Trmt6^KK109131, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by mldr^KK108043, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has neuromuscular junction | larval stage phenotype, non-enhanceable by DCTN2-p50^GD13758, Scer\GAL4^elav-C155

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Scer\GAL4^GMR.PF

(Feuillette et al., 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by lncRNA:Hsrω^EP3037, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by lncRNA:Hsrω^EP93D, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Suppressed by

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has eye phenotype, suppressible | partially by Arc1^JF01974, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has adult CNS neuron | decreased number phenotype, suppressible | partially by Arc1^esm113

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has adult CNS neuron | decreased number phenotype, suppressible | partially by Arc1^JF01974, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has adult brain phenotype, suppressible by IKKε^GL00160, Scer\GAL4^elav-C155

(Abreha et al., 2021)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG42788^GD8865, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG18508^GD6805, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by nord^GD5955, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Mad1^GD9715, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Shrm^GD16363, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Shrm^GD13983, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG31259^GD2862, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG5500^GD4790, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by hep^GD1461, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG6418^GD11919, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by smash^GD10286, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by S-Lap2^GD10864, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by S-Lap2^GD16773, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG14621^GD3713, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Nuf2^GD14063, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Tet^GD9718, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Tet^GD14834, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Tet^GD14330, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG32809^GD11076, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG32809^GD11060, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG3511^GD11160, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG15629^GD890, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by CG15629^GD17179, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, suppressible by ash1^B1/ash1[+]

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, suppressible by ash1^RNAi.UAS.cUa, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, suppressible by Nurf-38^JF01299, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, suppressible by E(bx)^JF01709, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, suppressible by AGO3^GL00117, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron phenotype, suppressible by AGO3^HMS00125, Scer\GAL4^elav.PU

(Frost et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has eye phenotype, suppressible by ZnT63C^UAS.cWa, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has eye phenotype, suppressible by Zip42C.1^RNAi.UAS, Scer\GAL4^elav.PU

(Huang et al., 2014)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has brain phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has brain phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^elav.PU

(Ali et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, suppressible by Opa1^s3475

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, suppressible by Opa1^s3475

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, suppressible by Df(1)Exel6239

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, suppressible by Df(1)Exel6239

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, suppressible by Gel^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, suppressible by Gel^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, suppressible by Drp1^UAS.cDb, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, suppressible by Drp1^UAS.cDb, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, suppressible by Marf^JF01650, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, suppressible by Marf^JF01650, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by PICK1^KK109273, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by CG16890^GD9226, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by MRG15^GD11902, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by EloA^GD1290, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by ppk14^GD947, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by bwa^GD3476, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by CG17048^GD3783, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Mal-A1^GD5459, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Polr2I^GD4234, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by aux^GD7187, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by trbd^GD14218, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by 5PtaseI^GD8685, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsc70-4^GD11264, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsc70-4^GD16584, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Gβ13F^GD7011, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by CG5687^GD2255, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Scer\GAL4^GMR.long/Trmt2a^GD11081

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Herc4^GD2240, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Usp2^GD5229, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by THADA^GD9074, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Prim1^GD4566, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsc70-1^GD13532, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by CG17919^GD17025, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Cad88C^GD2653, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Dab^GD4886, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hrb27C^GD6964, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Doa^GD8588, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by LanB1^GD13179, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Droj2^GD14050, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by roq^GD9209, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Isha^GD11266, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Stip1^GD9818, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Fbxo42^GD12027, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Tpr2^EB7-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG11700^EP1384, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Acox1^B227.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^JM265, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Imp^EP1433, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain cell body rind phenotype, suppressible by Gtpx^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuropil | adult stage phenotype, suppressible by Gtpx^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron | adult stage phenotype, suppressible by Gtpx^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain cell body rind phenotype, suppressible by Sod2^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuropil | adult stage phenotype, suppressible by Sod2^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has neuron | adult stage phenotype, suppressible by Sod2^UAS.cMa, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has adult brain | conditional phenotype, suppressible by dap^UAS.cdNa/Rbf^UAS.cDa, Scer\GAL4^elav.PLu

(Khurana et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has lamina | conditional phenotype, suppressible by dap^UAS.cdNa/Rbf^UAS.cDa, Scer\GAL4^elav.PLu

(Khurana et al., 2006)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PLu has adult brain | conditional phenotype, suppressible by dap^UAS.cdNa/Cdk1^E51Q.UAS, Scer\GAL4^elav.PLu

(Khurana et al., 2006)

NOT suppressed by

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has eye phenotype, non-suppressible by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has eye phenotype, non-suppressible by Arc1^esm113

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has adult CNS neuron | decreased number phenotype, non-suppressible by Arc1^UAS.cMb, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Trmt6^KK109131, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by mldr^KK108043, Scer\GAL4^GMR.PU

(Shafik et al., 2022)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, non-suppressible by Drp1^{Tag:FLAG,Tag:CALI(TC),Tag:HA}

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, non-suppressible by milt⁹²

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, non-suppressible by milt⁹²

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU has adult brain phenotype, non-suppressible by Drp1^{Tag:FLAG,Tag:CALI(TC),Tag:HA}

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Scer\GAL4^GMR.PF

(Feuillette et al., 2010)

Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Enhancer of

Statement

Reference

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU is an enhancer of adult brain phenotype of Marf^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU is an enhancer of mitochondrion phenotype of Marf^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

NOT Enhancer of

Statement

Reference

Scer\GAL4^ninaE.PU/Hsap\MAPT^R406W.UAS is a non-enhancer of lipid droplet | adult stage | increased number phenotype of ND-42^ninaE.GD6220

(Goodman et al., 2024)

Scer\GAL4^ninaE.PU/Hsap\MAPT^R406W.UAS is a non-enhancer of ommatidium | adult stage phenotype of ND-42^ninaE.GD6220

(Goodman et al., 2024)

Suppressor of

Statement

Reference

Scer\GAL4^54C/Hsap\MAPT^R406W.UAS is a suppressor of lipid droplet | increased number | adult stage phenotype of ND-42^ninaE.GD6220

(Goodman et al., 2024)

Scer\GAL4^54C/Hsap\MAPT^R406W.UAS is a suppressor of ommatidium | adult stage phenotype of ND-42^ninaE.GD6220

(Goodman et al., 2024)

NOT Suppressor of

Statement

Reference

Scer\GAL4^ninaE.PU/Hsap\MAPT^R406W.UAS is a non-suppressor of lipid droplet | increased number | adult stage phenotype of ND-42^ninaE.GD6220

(Goodman et al., 2024)

Scer\GAL4^ninaE.PU/Hsap\MAPT^R406W.UAS is a non-suppressor of ommatidium | adult stage phenotype of ND-42^ninaE.GD6220

(Goodman et al., 2024)

Scer\GAL4^elav.PU/Hsap\MAPT^R406W.UAS is a non-suppressor of adult brain phenotype of milt⁹²

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU is a non-suppressor of mitochondrion phenotype of Scer\GAL4^elav.PU, milt⁹²

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU is a non-suppressor of adult brain phenotype of Gel^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU is a non-suppressor of mitochondrion phenotype of Gel^UAS.cDa, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Other

Statement

Reference

DCTN1-p150^GD1455, Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has axon | larval stage phenotype

(Butzlaff et al., 2015)

DCTN2-p50^GD13758, Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155 has axon | larval stage phenotype

(Butzlaff et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav-C155 and Hsap\SNCA^{Ncra\QUAS.cOa} under the control of Ncra\QF^QF2.nSyb induces lethality.

(Ordonez et al., 2018)

DCTN2-p50 silencing (DCTN2-p50^GD13758, Scer\GAL4^elav-C155) in combination with Hsap\MAPT^{R406W.Scer\UAS} expression does not result in any obvious changes to the microtubule network in larval segmental nerves.

Scer\GAL4^elav-C155-mediated expression of Hsap\MAPT^{R406W.Scer\UAS} in combination with silencing of DCTN1-p150 (DCTN1-p150^GD1455) or DCTN2-p50 (DCTN2-p50^GD13758) results in axonal swellings in larval segmental nerves.

Scer\GAL4^elav-C155-mediated co-expression of Hsap\MAPT^{R406W.Scer\UAS} and DCTN2-p50^GD13758 has no apparent effect on larval motor coordination or locomotion.

Scer\GAL4^elav-C155-mediated co-expression of Hsap\MAPT^{R406W.Scer\UAS} with DCTN1-p150^GD1455 or DCTN2-p50^GD13758 strongly reduces eclosion rates.

Scer\GAL4^D42-mediated co-expression of Hsap\MAPT^{R406W.Scer\UAS} with DCTN2-p50^GD13758 has no impact on viability but an age-dependent decline in locomotion skills is observed.

(Butzlaff et al., 2015)

Co-expression of Hsap\SOD1^A4V.Scer\UAS enhances the toxicity of Scer\GAL4^GMR.PU>Hsap\MAPT^{R406W.Scer\UAS} in Drosophila compound eyes. The rough eye phenotype caused by Hsap\MAPT^{R406W.Scer\UAS}-expression becomes more severe, and the ommatidia are more severely fused and irregular.

Co-expression of Hsap\SOD1^Scer\UAS.cWa enhances the toxicity of Scer\GAL4^GMR.PU>Hsap\MAPT^{R406W.Scer\UAS} in Drosophila compound eyes. The rough eye phenotype caused by Hsap\MAPT^{R406W.Scer\UAS}-expression becomes more severe, and the ommatidia are more severely fused and irregular.

Co-expression of Hsap\SOD1^Scer\UAS.cWa shortens the lifespan of files expressing Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS} and exacerbates their movement impairment.

Co-expression of Hsap\SOD1^A4V.Scer\UAS shortens the lifespan of files expressing Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS} and exacerbates their movement impairment.

Co-expression of Hsap\SOD1^Scer\UAS.cWa exacerbates the brain damage caused by the expression of Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS}. The number of vacuoles is significantly increased in the double-transgenic flies compared with Hsap\MAPT^{R406W.Scer\UAS}-expression alone.

Co-expression of Hsap\SOD1^A4V.Scer\UAS exacerbates the brain damage caused by the expression of Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS}. The number of vacuoles is significantly increased in the double-transgenic flies compared with Hsap\MAPT^{R406W.Scer\UAS}-expression alone.

(Huang et al., 2015)

The decreased lifespan resulting from the expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU is suppressed by POLDIP2^EY08866.

(Kim et al., 2015)

Co-expression of Scer\GAL4^elav.PU>AGO3^HMS00125 suppresses the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS}-induced neuronal apoptosis.

Co-expression of Scer\GAL4^elav.PU>AGO3^GL00117 suppresses the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS}-induced neuronal apoptosis and locomotory defects.

Heterozygous Su(var)3-9² enhances the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS} induced neuronal apoptosis and locomotory defects.

Heterozygous Su(var)3-9¹ enhances the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS} induced neuronal apoptosis.

Heterozygous Su(var)205^MB11439 enhances the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS} induced neuronal apoptosis.

Heterozygous Su(var)205⁵ enhances the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS} induced neuronal apoptosis and locomotory defects.

Co-expression of Scer\GAL4^elav.PU>E(bx)^JF01709 suppresses the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS}-induced neuronal apoptosis and locomotory defects.

Co-expression of Scer\GAL4^elav.PU>Nurf-38^JF01299 suppresses the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS}-induced neuronal apoptosis.

Heterozygous ash1^B1 suppresses the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS}-induced neuronal apoptosis.

Co-expression of Scer\GAL4^elav.PU>ash1^{dsRNA.Scer\UAS.cUa} suppresses the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS}-induced neuronal apoptosis and locomotory defects.

(Frost et al., 2014)

Expression of ZnT63C^Scer\UAS.cWa partially suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU. Lifespan is also increased. The number of brain vacuoles in reduced.

Expression of Zip42C.1^{dsRNA.Scer\UAS} partially suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU. Lifespan is also increased. The number of brain vacuoles in reduced.

Expression of ZnT63C^{dsRNA.Scer\UAS.cWa} enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU. Lifespan is also further shortened. The level of vacuolisation in the CNS is exacerbated.

Expression of Zip42C.1^Scer\UAS.cLa enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU. Lifespan is also further shortened. The level of vacuolisation in the CNS is exacerbated.

(Huang et al., 2014)

p53^11-1B-1 enhances the neurodegeneration phenotype induced by expression of Scer\GAL4^elav.PLu>Hsap\MAPT^{R406W.Scer\UAS}.

p53^5A-1-4 enhances the neurodegeneration phenotype induced by expression of Scer\GAL4^elav.PLu>Hsap\MAPT^{R406W.Scer\UAS}.

(Merlo et al., 2014)

One copy of Nmnat^unspecified significantly impairs the learning and memory abilities of two day old flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU.

Expression of Nmnat^Scer\UAS.cZa suppresses the learning and memory deficits seen in 20 day old flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU. The climbing defects are also suppressed to near wild type levels. The brain vacuolisation seen at 20 days post eclosion is almost completely suppressed and fewer apoptotic cells are seen in the midbrain.

Expression of Nmnat^WR.Scer\UAS suppresses the learning and memory deficits seen in 20 day old flies expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU. The climbing defects are also suppressed. The brain vacuolisation seen at 20 days post eclosion is almost completely suppressed and fewer apoptotic cells are seen in the midbrain.

(Ali et al., 2012)

milt⁹² has no effect on the mitochondrial elongation defect seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU, however, as in milt⁹² single mutants, the overall number of mitochondria is increased, with an elevated number of both elongated and normal mitochondria.

Expression of Drp1^Scer\UAS.cDb significantly suppresses the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU. The increases in neurotoxicity and cell cycle activation are also significantly rescued.

Expression of Marf^JF01650 significantly suppresses the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU. The increases in neurotoxicity and cell cycle activation are also significantly rescued.

The increase in mitochondria length seen when either Marf^Scer\UAS.cDa or Hsap\MAPT^{R406W.Scer\UAS} are expressed under the control of Scer\GAL4^elav.PU is enhanced when the two constructs are co-expressed. Increased levels of neurodegeneration and cell cycle activation are also seen.

Expression of Drp1^GD10456 enhances the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU. Increased levels of neurodegeneration and cell cycle activation are also seen.

Expression of opa1-like^s3475 significantly suppresses the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU. The increased neurotoxicity is also significantly rescued.

Drp1^T26 enhances the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU. Increased levels of neurotoxicity are also seen.

Df(1)Exel6239 significantly suppresses the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU. The increase in neurotoxicity is also significantly rescued.

Expression of Drp1^Scer\UAS.cDb suppresses the increase in superoxide production seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

Expression of Marf^JF01650 suppresses the increase in superoxide production seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

Expression of Marf^Scer\UAS.cDa enhances the increase in superoxide production seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

Expression of Drp1^GD10456 enhances the increase in superoxide production seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

Expression of Drp1^{T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1} has no effect on the increase in mitochondria length or neurotoxicity seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

Expression of WASp^Scer\UAS.cBa enhances the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

Expression of f^+t13 enhances the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

Expression of Gel^Scer\UAS.cDa significantly suppresses the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU, with the rescue flies having a mitochondrial length similar to expression of Gel^Scer\UAS.cDa alone. The increases in neurotoxicity and superoxide production are also significantly rescued.

One copy of zip¹ enhances the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

One copy of sqh^AX3 enhances the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

(Duboff et al., 2012)

Klc^8ex94/+ enhances the partial lethality induced by the expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^Appl.G1a.

(Falzone et al., 2010)

A cathD¹ homozygous background further reduces the lifespan of Hsap\MAPT^{R406W.Scer\UAS} (Scer\GAL4^elav-C155) flies by almost 50%.

Flies expressing Hsap\MAPT^{R406W.Scer\UAS} neuronally (under the control of Scer\GAL4^elav-C155) in a cathD¹ null background exhibit an almost 3-fold increase in apoptotic cell death (as visualized with TUNEL). A similar effect is seen on neurodegeneration, with an increase in vacuolar degeneration in aged double mutant flies.

(Khurana et al., 2010)

A heterozygous Xbp1^k13803 background significantly increases the level of apoptosis mediated by expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Co-expression of Xbp1^GD4745 with Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav-C155 significantly increases the level of cell death seen in the nervous system.

(Loewen and Feany, 2010)

Co-expression of Hsap\MAPT^{R406W.Scer\UAS} with Vha100-1^GD12710 in developing eyes exposed to two days of intense light stimulation accelerates the degenerative photoreceptor phenotype.

(Williamson and Hiesinger, 2010)

Trxr-1^Δ1/+ or Sod2ⁿ²⁸³/+ enhances the neurodegeneration of the cortex and neuropil seen in adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU, as evidenced by increased vacuolization and neuron apoptosis in these regions.

Co-expression of PHGPx^Scer\UAS.cMa or Sod2^Scer\UAS.cMa partially suppresses the neuron apoptosis in the cortex and neuropil of adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU.

(Dias-Santagata et al., 2007)

Expression of tsr^{Scer\UAS.T:Zzzz\His6} in animals expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu suppresses neuronal cell death.

Expression of Act5C^{Scer\UAS.T:Avic\GFP} in animals expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu enhances neuronal cell death.

(Fulga et al., 2007)

Expression of Hsap\APP^{695.T.Scer\UAS} enhances the rough eye phenotype seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of lkb1^Scer\UAS.cWa enhances the eye phenotypes seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF, resulting in severe disorganisation of the eye and drastic loss of photoreceptor neurons and surrounding cells.

(Wang et al., 2007)

Eye degeneration due to expression of Hsap\MAPT^{R406W.Scer\UAS} in the eye (under the control of Scer\GAL4^GMR.PF) is enhanced in a loqs^f00791 background.

(Bilen et al., 2006)

Co-expression of dap^{Scer\UAS.cdNa} and Rbf^Scer\UAS.cDa in adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu significantly reduces the number of dying cells observed. Vacuolar degeneration of the lamina is rescued in these animals.

Co-expression of dap^{Scer\UAS.cdNa} and cdc2^{E51Q.Scer\UAS} in adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu significantly reduces the number of dying cells observed.

Expression of CycA^Scer\UAS.cWa in adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu significantly increases the number of dying cells observed. Vacuolar degeneration of the lamina is enhanced in these animals.

Expression of CycD^Scer\UAS.cMa in adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu results in semi-lethality.

Expression of gig^{ΔAkt-P.Scer\UAS.T:Zzzz\FLAG} in adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PLu suppresses increased cell death.

(Khurana et al., 2006)

Co-expression of a weak par-1^Scer\UAS.cSa expression line enhances the eye phenotype caused by expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^hs.2sev, resulting in smaller eyes. A 15% loss in photoreceptor neurons is seen in these flies. Co-expression of par-1^Scer\UAS.cSa and Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^Cha.7.4 results in profound vacuole formation in the cell bodies and neuronal processes of the cholinergic neurons.

(Nishimura et al., 2004)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Hsap\MAPT^{R406W.Scer\UAS}

Hsap\MAPT^R406W.UAS

Tau^R406W

(Bernstein et al., 2016)

hMAPT^R406W

(Haddadi et al., 2016)

tau^R406W

(Frost et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (88)

Report Sections

Open Close