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General Information
Symbol
Hsap\MAPTR406W.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0126527
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-tauR406W, tauR406W, UAS-R406W tau, UAS-hTauR406W, UAS-tau(R406W), UAS-tau.R406W
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of a mutant form of Hsap\MAPT (carries the amino acid replacement R406W).
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
model of  tauopathy
is exacerbated by f+t13
is ameliorated by GelUAS.cDa
is exacerbated by MarfUAS.cDa
is ameliorated by Drp1UAS.cDb
is ameliorated by Opa1s3475
is ameliorated by MarfJF01650
is exacerbated by WASpUAS.cBa
is exacerbated by sqhAX3
is exacerbated by zip1
is exacerbated by Drp1GD10456
is exacerbated by Klc8ex94
is exacerbated by AmphEY09339
is exacerbated by ClcDG23206
is exacerbated by Chc1
is exacerbated by Chc4
is ameliorated by Rab26UAS.YFP
is exacerbated by Rab26GD9927
is exacerbated by AmphGD1311
is exacerbated by p535A-1-4
is exacerbated by p5311-1B-1
is exacerbated by SytβDG10711
is exacerbated by SytβJF02593
is exacerbated by LerpGD306
is exacerbated by gGD7158
is exacerbated by SppGD786
is exacerbated by DabGD4886
is ameliorated by hepGD1461
is exacerbated by krzGD8470
is exacerbated by ttvGD1993
is ameliorated by TetGD9718
is exacerbated by Lkb1UAS.cWa
is exacerbated by cathD1
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
eye photoreceptor cell & neuron, with Scer\GAL4hs.2sev
Detailed Description
Statement
Reference
Expression of Hsap\MAPTR406W.Scer\UAS driven pan-neuronally by Scer\GAL4elav-C155 leads to a significantly shortened lifespan compared to control flies and flies with expression of Hsap\MAPTV337M.Scer\UAS. Scer\GAL4elav-C155>Hsap\MAPTR406W.Scer\UAS flies show significant changes in the activity of antioxidant enzymes. Expression of Hsap\MAPTR406W.Scer\UAS driven in mushroom bodies by Scer\GAL4c739 leads to a significant impairment in middle-term and long-term olfactory memory compared to controls.
Scer\GAL4GMR.PF-mediated expression of Hsap\MAPTR406W.Scer\UAS results in a rough eye. Scer\GAL4elav-C155-mediated expression of Hsap\MAPTR406W.Scer\UAS results in a significant decrease in synaptic vesicles at larval neuromuscular junctions, but only minor changes in its overall appearance. Scer\GAL4elav-C155-mediated expression of Hsap\MAPTR406W.Scer\UAS has no apparent effect on larval motor coordination or locomotion, or on eclosion rates.
Expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU results in a reduction in adult lifespan compared to controls.
Transgenic flies expressing Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS show reduced locomotor activity compared with control flies.
Feeding flies ZnCl[[2]] enhances the toxicity seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU, further reducing lifespan. Feeding the flies CQ (a hydrophobic metal chelator) partially rescues the toxicity, elongating the lifespan. No changes in lifespan are observed when wild type flies are fed the same levels of metals.
Expression of Hsap\MAPTR406W.Scer\UAS using Scer\GAL4elav.PLu induces neuronal cell death and abnormal cell cycle reactivation. The transgenic flies expressing Hsap\MAPTR406W.Scer\UAS display locomotor defect as assayed by measuring walking speed.
Flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU exhibit normal learning and memory in an aversive phototaxis assay at two days after eclosion. Learning and memory are both significantly reduced at 20 days post-eclosion. Expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU results in an age-dependent decrease in locomotor activity as measured by climbing performance. Vacuolisation is observed in the brains of 2 day old flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. By 20 days multiple large vacuoles can be observed and an increased number of apoptotic cells (caspase 3 positive) is seen in the mid brain compared to controls.
The mitochondria in the neurons of adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU are markedly elongated. Mitochondria length is on average greater than twice that of controls. Neuron death (assayed by TUNEL staining) is also observed. An increase in cell cycle activation (assayed by PCNA) is also seen compared to controls. The brains of animals expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU show a significant increase in superoxide production (assayed using dihydroethidium) compared to controls.
Expression of Hsap\MAPTR406W.Scer\UAS driven by Scer\GAL4Appl.G1a induces substantial axonal vesicle accumulations in larvae and results in increased lethality during development, as compared to controls.
Neuronal expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav-C155 results in reduced adult lifespan and results in adult brains presenting increases in both apoptosis {as visualised with TUNEL) and DNA replication (as visualized with PCNA) and vacuolar degeneration, compared to wild-type controls.
Pan-neuronal expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU results in severe mushroom body (MB) defects that are generally bilateral. The brain defects are restricted to the MBs.
Expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav-C155 increases the level of apoptosis in the nervous system.
Flies expressing Hsap\MAPTR406W.Scer\UAS in neurons under the control of Scer\GAL4elav.PU show mushroom body aberrations.
Expression of Hsap\MAPTR406W.Scer\UAS in the developing eye under the control of Scer\GAL4GMR.PF generates a severe rough eye phenotype. The orderly ommatidial architecture is disorganized and photoreceptors are fused with missing mechanosensory bristles. Expression of Hsap\MAPTR406W.Scer\UAS in the developing external sensory organs under the control of Scer\GAL4Eq1 generates a severe bristle loss phenotype.
Expression of Hsap\MAPTR406W.Scer\UAS using Scer\GAL4GMR.PF produces a rough and reduced eye.
Expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU results in neurodegeneration of both the cortex and neuropil in 10-day old flies, with these regions exhibiting vacuolization and an increase in neuron apoptosis, as compared to controls.
Expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu results in increased levels of neuronal cell death.
Expression of Hsap\MAPTR406W.Scer\UAS driven by Scer\GAL4GMR.PF results in ablation of the adult eye.
Expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4GMR.PF results in a rough eye phenotype and mild photoreceptor loss.
Expression of Scer\GAL4ey.PB>Hsap\MAPTR406W.Scer\UAS leads to the formation of abnormal eyes or no eyes. Rapamycin treatment ameliorates the eye phenotype.
Expression of Hsap\MAPTR406W.Scer\UAS in the developing eye (under the control of Scer\GAL4GMR.PF) induces severe neurodegeneration, reflected by a severely disrupted eye phenotype.
Adult brains from newly-eclosed animals expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu appear morphologically normal, but by 10 days neurodegeneration is observed, and vacuolar degeneration of the lamina is observed. Increased rates of cell division are also observed in these mutant brains.
21 day old flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4c492b do not exhibit obvious degeneration or vacuoles in the mushroom body. Severe neurodegeneration and large vacuoles are observed in the mushroom bodies of 60 day old flies expressing Hsap\MAPTR406W.Scer\UAS using Scer\GAL4c492b. Degenerating neurons and vacuoles are observed in the mushroom body, but not in the ellipsoid body where the Scer\GAL4c492b driver is inactive.
Flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4hs.2sev show a moderate eye degeneration phenotype. A 6% loss in photoreceptor neurons is seen. Expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4Cha.7.4 results in mild vacuole formation in the cell bodies of the cholinergic neurons. About 13% of neurons stain positive in a TUNEL assay in clones expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4hs.2sev in the brain, significantly more than in control clones.
Expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu results in a severe reduction in adult life span. The effect on life span is dosage sensitive. 1 day old adults has no brain abnormalities. Aged flies show neurodegeneration; vacuolisation and degeneration of cells in the cortex is seen. There is also a modest increase in neuropil vacuolisation. The degeneration is progressive and the phenotype is fully penetrant. No evidence of large filamentous aggregates (neurofibrillary tangles) is seen in the brains of adults expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu or Scer\GAL4Cha.7.4. Cholinergic neurons of the optic lamina appear normal in 1 day old adults expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4Cha.7.4. However, 30 day old flies show widespread vacuolization and loss of cholinergic neurons in the optic lamina. Loss of cholinergic neurons is also seen in the central body complex. 1 day old adults expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu have a normal number of cholinergic terminals in the brain. The number of acetylcholine-positive terminals is strongly reduced in aged flies.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Enhancer of
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU has neuron phenotype, enhanceable by Su(var)2055/Su(var)205[+]
Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU has neuron phenotype, enhanceable by Su(var)205MB11439/Su(var)205[+]
Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU has neuron phenotype, enhanceable by Su(var)3-91/Su(var)3-9[+]
Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU has neuron phenotype, enhanceable by Su(var)3-9[+]/Su(var)3-92
Hsap\MAPTR406W.UAS, Scer\GAL4hs.2sev has eye photoreceptor cell & neuron phenotype, enhanceable by par-1UAS.cSa, Scer\GAL4hs.2sev
NOT Enhanced by
Suppressed by
Statement
Reference
Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU has neuron phenotype, suppressible by ash1B1/ash1[+]
NOT suppressed by
Enhancer of
NOT Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Co-expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav-C155 and Hsap\SNCANcra\QUAS.cOa under the control of Ncra\QFQF2.nSyb induces lethality.
DCTN2-p50 silencing (DCTN2-p50GD13758, Scer\GAL4elav-C155) in combination with Hsap\MAPTR406W.Scer\UAS expression does not result in any obvious changes to the microtubule network in larval segmental nerves. Scer\GAL4elav-C155-mediated expression of Hsap\MAPTR406W.Scer\UAS in combination with silencing of DCTN1-p150 (DCTN1-p150GD1455) or DCTN2-p50 (DCTN2-p50GD13758) results in axonal swellings in larval segmental nerves. Scer\GAL4elav-C155-mediated co-expression of Hsap\MAPTR406W.Scer\UAS and DCTN2-p50GD13758 has no apparent effect on larval motor coordination or locomotion. Scer\GAL4elav-C155-mediated co-expression of Hsap\MAPTR406W.Scer\UAS with DCTN1-p150GD1455 or DCTN2-p50GD13758 strongly reduces eclosion rates. Scer\GAL4D42-mediated co-expression of Hsap\MAPTR406W.Scer\UAS with DCTN2-p50GD13758 has no impact on viability but an age-dependent decline in locomotion skills is observed.
Co-expression of Hsap\SOD1A4V.Scer\UAS enhances the toxicity of Scer\GAL4GMR.PU>Hsap\MAPTR406W.Scer\UAS in Drosophila compound eyes. The rough eye phenotype caused by Hsap\MAPTR406W.Scer\UAS-expression becomes more severe, and the ommatidia are more severely fused and irregular. Co-expression of Hsap\SOD1Scer\UAS.cWa enhances the toxicity of Scer\GAL4GMR.PU>Hsap\MAPTR406W.Scer\UAS in Drosophila compound eyes. The rough eye phenotype caused by Hsap\MAPTR406W.Scer\UAS-expression becomes more severe, and the ommatidia are more severely fused and irregular. Co-expression of Hsap\SOD1Scer\UAS.cWa shortens the lifespan of files expressing Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS and exacerbates their movement impairment. Co-expression of Hsap\SOD1A4V.Scer\UAS shortens the lifespan of files expressing Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS and exacerbates their movement impairment. Co-expression of Hsap\SOD1Scer\UAS.cWa exacerbates the brain damage caused by the expression of Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS. The number of vacuoles is significantly increased in the double-transgenic flies compared with Hsap\MAPTR406W.Scer\UAS-expression alone. Co-expression of Hsap\SOD1A4V.Scer\UAS exacerbates the brain damage caused by the expression of Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS. The number of vacuoles is significantly increased in the double-transgenic flies compared with Hsap\MAPTR406W.Scer\UAS-expression alone.
The decreased lifespan resulting from the expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU is suppressed by POLDIP2EY08866.
Co-expression of Scer\GAL4elav.PU>AGO3HMS00125 suppresses the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS-induced neuronal apoptosis. Co-expression of Scer\GAL4elav.PU>AGO3GL00117 suppresses the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS-induced neuronal apoptosis and locomotory defects. Heterozygous Su(var)3-92 enhances the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS induced neuronal apoptosis and locomotory defects. Heterozygous Su(var)3-91 enhances the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS induced neuronal apoptosis. Heterozygous Su(var)205MB11439 enhances the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS induced neuronal apoptosis. Heterozygous Su(var)2055 enhances the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS induced neuronal apoptosis and locomotory defects. Co-expression of Scer\GAL4elav.PU>E(bx)JF01709 suppresses the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS-induced neuronal apoptosis and locomotory defects. Co-expression of Scer\GAL4elav.PU>Nurf-38JF01299 suppresses the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS-induced neuronal apoptosis. Heterozygous ash1B1 suppresses the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS-induced neuronal apoptosis. Co-expression of Scer\GAL4elav.PU>ash1dsRNA.Scer\UAS.cUa suppresses the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS-induced neuronal apoptosis and locomotory defects.
Expression of ZnT63CScer\UAS.cWa partially suppresses the rough eye phenotype seen in flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. Lifespan is also increased. The number of brain vacuoles in reduced. Expression of Zip42C.1dsRNA.Scer\UAS partially suppresses the rough eye phenotype seen in flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. Lifespan is also increased. The number of brain vacuoles in reduced. Expression of ZnT63CdsRNA.Scer\UAS.cWa enhances the rough eye phenotype seen in flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. Lifespan is also further shortened. The level of vacuolisation in the CNS is exacerbated. Expression of Zip42C.1Scer\UAS.cLa enhances the rough eye phenotype seen in flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. Lifespan is also further shortened. The level of vacuolisation in the CNS is exacerbated.
p5311-1B-1 enhances the neurodegeneration phenotype induced by expression of Scer\GAL4elav.PLu>Hsap\MAPTR406W.Scer\UAS. p535A-1-4 enhances the neurodegeneration phenotype induced by expression of Scer\GAL4elav.PLu>Hsap\MAPTR406W.Scer\UAS.
One copy of Nmnatunspecified significantly impairs the learning and memory abilities of two day old flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. Expression of NmnatScer\UAS.cZa suppresses the learning and memory deficits seen in 20 day old flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. The climbing defects are also suppressed to near wild type levels. The brain vacuolisation seen at 20 days post eclosion is almost completely suppressed and fewer apoptotic cells are seen in the midbrain. Expression of NmnatWR.Scer\UAS suppresses the learning and memory deficits seen in 20 day old flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. The climbing defects are also suppressed. The brain vacuolisation seen at 20 days post eclosion is almost completely suppressed and fewer apoptotic cells are seen in the midbrain.
milt92 has no effect on the mitochondrial elongation defect seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU, however, as in milt92 single mutants, the overall number of mitochondria is increased, with an elevated number of both elongated and normal mitochondria. Expression of Drp1Scer\UAS.cDb significantly suppresses the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. The increases in neurotoxicity and cell cycle activation are also significantly rescued. Expression of MarfJF01650 significantly suppresses the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. The increases in neurotoxicity and cell cycle activation are also significantly rescued. The increase in mitochondria length seen when either MarfScer\UAS.cDa or Hsap\MAPTR406W.Scer\UAS are expressed under the control of Scer\GAL4elav.PU is enhanced when the two constructs are co-expressed. Increased levels of neurodegeneration and cell cycle activation are also seen. Expression of Drp1GD10456 enhances the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Increased levels of neurodegeneration and cell cycle activation are also seen. Expression of opa1-likes3475 significantly suppresses the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. The increased neurotoxicity is also significantly rescued. Drp1T26 enhances the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Increased levels of neurotoxicity are also seen. Df(1)Exel6239 significantly suppresses the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. The increase in neurotoxicity is also significantly rescued. Expression of Drp1Scer\UAS.cDb suppresses the increase in superoxide production seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Expression of MarfJF01650 suppresses the increase in superoxide production seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Expression of MarfScer\UAS.cDa enhances the increase in superoxide production seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Expression of Drp1GD10456 enhances the increase in superoxide production seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Expression of Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1 has no effect on the increase in mitochondria length or neurotoxicity seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Expression of WASpScer\UAS.cBa enhances the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Expression of f+t13 enhances the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Expression of GelScer\UAS.cDa significantly suppresses the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU, with the rescue flies having a mitochondrial length similar to expression of GelScer\UAS.cDa alone. The increases in neurotoxicity and superoxide production are also significantly rescued. One copy of zip1 enhances the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. One copy of sqhAX3 enhances the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU.
Klc8ex94/+ enhances the partial lethality induced by the expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4Appl.G1a.
A cathD1 homozygous background further reduces the lifespan of Hsap\MAPTR406W.Scer\UAS (Scer\GAL4elav-C155) flies by almost 50%. Flies expressing Hsap\MAPTR406W.Scer\UAS neuronally (under the control of Scer\GAL4elav-C155) in a cathD1 null background exhibit an almost 3-fold increase in apoptotic cell death (as visualized with TUNEL). A similar effect is seen on neurodegeneration, with an increase in vacuolar degeneration in aged double mutant flies.
A heterozygous Xbp1k13803 background significantly increases the level of apoptosis mediated by expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav-C155. Co-expression of Xbp1GD4745 with Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav-C155 significantly increases the level of cell death seen in the nervous system.
Co-expression of Hsap\MAPTR406W.Scer\UAS with Vha100-1GD12710 in developing eyes exposed to two days of intense light stimulation accelerates the degenerative photoreceptor phenotype.
Trxr-1Δ1/+ or Sod2n283/+ enhances the neurodegeneration of the cortex and neuropil seen in adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU, as evidenced by increased vacuolization and neuron apoptosis in these regions. Co-expression of PHGPxScer\UAS.cMa or Sod2Scer\UAS.cMa partially suppresses the neuron apoptosis in the cortex and neuropil of adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU.
Expression of tsrScer\UAS.T:Zzzz\His6 in animals expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu suppresses neuronal cell death. Expression of Act5CScer\UAS.T:Avic\GFP in animals expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu enhances neuronal cell death.
Expression of Hsap\APP695.T.Scer\UAS enhances the rough eye phenotype seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF. Expression of lkb1Scer\UAS.cWa enhances the eye phenotypes seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF, resulting in severe disorganisation of the eye and drastic loss of photoreceptor neurons and surrounding cells.
Eye degeneration due to expression of Hsap\MAPTR406W.Scer\UAS in the eye (under the control of Scer\GAL4GMR.PF) is enhanced in a loqsf00791 background.
Co-expression of dapScer\UAS.cdNa and RbfScer\UAS.cDa in adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu significantly reduces the number of dying cells observed. Vacuolar degeneration of the lamina is rescued in these animals. Co-expression of dapScer\UAS.cdNa and cdc2E51Q.Scer\UAS in adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu significantly reduces the number of dying cells observed. Expression of CycAScer\UAS.cWa in adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu significantly increases the number of dying cells observed. Vacuolar degeneration of the lamina is enhanced in these animals. Expression of CycDScer\UAS.cMa in adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu results in semi-lethality. Expression of gigΔAkt-P.Scer\UAS.T:Zzzz\FLAG in adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu suppresses increased cell death.
Co-expression of a weak par-1Scer\UAS.cSa expression line enhances the eye phenotype caused by expression of Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4hs.2sev, resulting in smaller eyes. A 15% loss in photoreceptor neurons is seen in these flies. Co-expression of par-1Scer\UAS.cSa and Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4Cha.7.4 results in profound vacuole formation in the cell bodies and neuronal processes of the cholinergic neurons.
Complementation and Rescue Data
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Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Hsap\MAPTR406W.Scer\UAS
Hsap\MAPTR406W.UAS
Name Synonyms
Secondary FlyBase IDs
    References (42)