Open Close
General Information
Symbol
Dmel\Tre1ΔEP5
Species
D. melanogaster
Name
FlyBase ID
FBal0127254
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

2492 bp deletion associated with the imprecise excision of P{EP}Tre1EP496 (GB:AB066611).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Distal breakpoint falls in the first intron of Tre1. Proximal breakpoint lies within the first Gr5a intron, which lies 3' to the codon specifying Arg 36. The translation initiation codon of Gr5a is removed.

Imprecise excision of the progenitor insertion, resulting in a 2.5kb deletion of genomic sequences uncovering 0.9kb towards Gr5a (removing the promoter, 5' leader sequences and sequences to 133bp downstream of the start codon) and 1.6b towards Tre1 (removing the promoter, exon 1 and part of intron 1).

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos derived from mutant mothers are defective in the first active step of germ cell migration, the transepithelial migration through the posterior midgut (PMG). Germ cells in mutant embryos do not transmigrate the PMG, but remain clumped together within midgut pocket. At the end of embryogenesis, mutant embryos have on average one or two germ cells per gonad, compared to the 12-15 seen in wild-type. The overall number of germ cells seems unaffected. This phenotype is fully penetrant. This phenotype does not seem to be due to a defect in germ cell mobility. When mutant mothers are mated with wild-type males a weaker germ-cell migration phenotype is seen than when both parents are mutant. Embryos mutant only in zygotic Tre1 have no germ cell migration phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)