Allele Dmel\Poxm^Scer\UAS.cJa

General Information
Symbol	Dmel\Poxm^Scer\UAS.cJa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Jiao	FlyBase ID	FBal0127289
Feature type	allele	Associated gene	Dmel\Poxm

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Jiao et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of the 2.6kb Poxm P29c1 cDNA. (Jiao et al., 2001)
Carried in construct	P{UAS-Poxm.J} (Jiao et al., 2001, Duan et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^ey.PH (Jiao et al., 2001)
Phenotype Manifest In
	A1-7 dorsal acute muscle 1, with Scer\GAL4^how-24B (Duan et al., 2007) A1-7 dorsal oblique muscle 4, with Scer\GAL4^how-24B (Duan et al., 2007) A1-7 dorsal oblique muscle 5, with Scer\GAL4^how-24B (Duan et al., 2007) A1-7 lateral longitudinal muscle 1, with Scer\GAL4^how-24B (Duan et al., 2007) abdominal dorsal adult muscle precursor cell \| ectopic, with Scer\GAL4^how-24B (Duan et al., 2007) abdominal lateral adult muscle precursor cell, with Scer\GAL4^how-24B (Duan et al., 2007) adult head, with Scer\GAL4^ey.PH (Jiao et al., 2001) antenna, with Scer\GAL4^ey.PH (Jiao et al., 2001) embryonic/larval somatic muscle \| dorsal \| ectopic, with Scer\GAL4^how-24B (Duan et al., 2007) embryonic/larval somatic muscle \| dorso-lateral \| ectopic, with Scer\GAL4^how-24B (Duan et al., 2007) eye, with Scer\GAL4^ey.PH (Jiao et al., 2001)
Detailed Description
	Statement Reference Expression of Poxm[Scer\UAS.cJa] under the control of Scer\GAL4[how-24B] results in a severely altered muscle pattern in the embryo, which varies among different segments and embryos. The most striking defects are seen in the dorsal and dorsolateral muscles. Ectopic muscles are generated in most segments in the dorsal region. Ectopic muscles similar in shape and orientation to muscle DA3 are found in the dorsolateral region, which is largely free of muscles in wild-type embryos. Several muscles of abnormal shape are generally seen at the position where muscle DA1 is normally found. Muscles LL1, DO4 and DO5 have aberrant shapes or are missing in some segments. Some of the lateral muscles are abnormally shaped. The ventral muscles remain largely unaffected, although some muscle fibres appear enlarged. Expression of Poxm[Scer\UAS.cJa] under the control of Scer\GAL4[how-24B] affects the number of adult muscle precursors in stage 14 embryos; in the lateral mesoderm, in most segments the dorsolateral DLaPs are missing and only one of the two lateral LaPs is present. In the dorsal region, two dorsal DaPs instead of one are present in approximately half of the segments. In the ventral region, the number of ventral VaPs is unaffected. (Duan et al., 2007) Pharate adults expressing Poxm^Scer\UAS.cJa under the control of Scer\GAL4^ey.PH show a headless phenotype. Three classes of phenotype are seen; class I pharate adults lack all head structures derived from the eye-antennal discs, class II consists of eyeless flies which lack most head structures and both antennae and class III consists of eyeless animals with large parts of the head missing but one or both antennae present. (Jiao et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Poxm^Scer\UAS.cJa, Scer\GAL4^ey.PH has visible phenotype, suppressible \| partially by dm^Scer\UAS.cZa, Scer\GAL4^ey.PH (Jiao et al., 2001) Poxm^Scer\UAS.cJa, Scer\GAL4^ey.PH has visible phenotype, suppressible by CycE^Scer\UAS.cLa, Scer\GAL4^ey.PH (Jiao et al., 2001)
Phenotype Manifest In
Suppressed by
Statement Reference Poxm^Scer\UAS.cJa, Scer\GAL4^ey.PH has adult head phenotype, suppressible \| partially by dm^Scer\UAS.cZa, Scer\GAL4^ey.PH (Jiao et al., 2001) Poxm^Scer\UAS.cJa, Scer\GAL4^ey.PH has adult head phenotype, suppressible by CycE^Scer\UAS.cLa, Scer\GAL4^ey.PH (Jiao et al., 2001)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Pox-m^Scer\UAS.cJa Poxm^Scer\UAS.cJa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Jiao (Jiao et al., 2001)
Secondary FlyBase IDs

References ( 2 )
Research paper	Duan et al., 2007, Development 134(22): 3985--3997 A key role of Pox meso in somatic myogenesis of Drosophila. [FBrf0201381] Jiao et al., 2001, Development 128(17): 3307--3319 Headless flies generated by developmental pathway interference. [FBrf0138373]

Allele Dmel\PoxmScer\UAS.cJa

Allele Dmel\Poxm^Scer\UAS.cJa