FlyBase Allele Report: Hsap\HTT[Q93.ex1.UAS]

General Information

Symbol

Hsap\HTT^Q93.ex1.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0127292

Feature type

allele

Associated gene

Hsap\HTT

Associated Insertion(s)

Carried in Construct

P{UAS-HTT.ex1.Q93}

Also Known As

UAS-Httex1p Q93, Httex1p Q93, UAS-Httex1pQ93, Htt93Q, UAS-Htt93Q, UAS-Httex1p-Q93, UAS-htt exon-1-Q93, P{UAS-Httex1p Q93}, UAS-htt-exon1-Q93, Httex1-93Q

Key Links

Transgenic product class

inframe_deletion

(Steffan et al., 2001)

trinucleotide_repeat_expansion

(Steffan et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Steffan et al., 2001)

trinucleotide_repeat_expansion

(Steffan et al., 2001)

Mutagen

in vitro construct

(Steffan et al., 2001)

Progenitor genotype

Carried in construct

P{UAS-HTT.ex1.Q93}

Cytology

Description

UASt sequences drive expression of Hsap\HTT exon 1 with an extended polyglutamine repeat of 93 residues.

(Steffan et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\HTT

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Huntington's disease

CEA

(Twyning et al., 2024, Aditi et al., 2022, Dhankhar et al., 2022, Nandi et al., 2022, Rai and Tapadia, 2022, Singh and Agrawal, 2022, Xu et al., 2022, Khyati et al., 2021, Singh and Agrawal, 2021, Delfino et al., 2020, Lin et al., 2019, Raj and Sarkar, 2019, Aron et al., 2018, Calpena et al., 2018, Dubey and Tapadia, 2018, Song et al., 2018, Zhang et al., 2018, Raj and Sarkar, 2017, Singh et al., 2017, Aditi et al., 2016, Breda et al., 2016, Chongtham and Agrawal, 2016, Ruetenik et al., 2016, Vicente Miranda et al., 2016, Besson et al., 2015, Varadarajan et al., 2015, Kumar et al., 2014, Maheshwari et al., 2014, Smith et al., 2014, O'Rourke et al., 2013, Xiao et al., 2013, Dupont et al., 2012, Steinert et al., 2012, Campesan et al., 2011, Maher et al., 2011, Sleiman et al., 2011, Besson et al., 2010, Luthi-Carter et al., 2010, Menzies et al., 2010, Zhang et al., 2009, McLear et al., 2008, Mugat et al., 2008, Slepko et al., 2006, Agrawal et al., 2005, Lievens et al., 2005, Wolfgang et al., 2005, Steffan et al., 2001)

model of neurodegenerative disease

CEA

(Richards et al., 2011, Mallik and Lakhotia, 2009, Liévens et al., 2008, Pallos et al., 2008, Wolfgang et al., 2005, Gunawardena et al., 2003, Steffan et al., 2001)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Huntington's disease

is ameliorated by Sirt2^5B-2-35

(Luthi-Carter et al., 2010)

is ameliorated by Hsap\SLC8B1^UAS.cTa

(Twyning et al., 2024)

is exacerbated by Itpr^90B.0

(Twyning et al., 2024)

is ameliorated by MCU¹

(Twyning et al., 2024)

is ameliorated by pan²

(Dupont et al., 2012)

is ameliorated by wg¹

(Dupont et al., 2012)

is ameliorated by arm³

(Dupont et al., 2012)

is ameliorated by wg^Sp-1

(Dupont et al., 2012)

is ameliorated by Wnt2^O

(Dupont et al., 2012)

is ameliorated by Wnt2^I

(Dupont et al., 2012)

is ameliorated by Wnt2^RJ

(Dupont et al., 2012)

is ameliorated by pan³

(Dupont et al., 2012)

is ameliorated by arm^G0192

(Dupont et al., 2012)

is exacerbated by arm^{S10.UAS.Tag:MYC}

(Dupont et al., 2012)

is ameliorated by Apc2^UAS.cUa

(Dupont et al., 2012)

is ameliorated by Axn^UAS.cUa

(Dupont et al., 2012)

is exacerbated by sgg^UAS.cBa

(Dupont et al., 2012)

is exacerbated by sgg^S9A.UAS

(Dupont et al., 2012)

is ameliorated by sgg^Y214F.UAS

(Dupont et al., 2012)

is ameliorated by Hsap\SLC2A3^UAS.cBa

(Besson et al., 2015)

is ameliorated by G6pd^UAS.cLa

(Besson et al., 2015)

is ameliorated by Pfk^UAS.cTa

(Besson et al., 2015)

is ameliorated by jp^UAS

(Calpena et al., 2018)

is exacerbated by jp^KK107921

(Calpena et al., 2018)

is ameliorated by Sirt1¹⁷

(Smith et al., 2014)

is exacerbated by Sirt1¹⁷

(Smith et al., 2014)

is ameliorated by htt^81aa.UAS

(Mugat et al., 2008)

is ameliorated by Hsap\HTT^N548.Q0.UAS

(Mugat et al., 2008)

is ameliorated by cd¹

(Campesan et al., 2011)

is ameliorated by cn³

(Campesan et al., 2011)

is ameliorated by cn^KK101938

(Campesan et al., 2011)

is ameliorated by v^KK108195

(Campesan et al., 2011)

is ameliorated by v^36f

(Campesan et al., 2011)

is exacerbated by htt^98E2

(Zhang et al., 2009)

is exacerbated by Hsap\HTT^Q20.ex1.UAS

(Slepko et al., 2006)

is ameliorated by Hsap\HTT^{C4sFv.UAS.Tag:HA}

(Wolfgang et al., 2005)

is ameliorated by Zzzz\scFv^{C4.UAS.Tag:HA}

(McLear et al., 2008, Wolfgang et al., 2005)

is ameliorated by Bmcp^UAS.cBa

(Besson et al., 2010)

is ameliorated by Hsap\UCP2^UAS.cFa

(Besson et al., 2010)

is ameliorated by Glut1^UAS.cBa

(Besson et al., 2010)

is ameliorated by Ctr1B^NIG.7459R

(Xiao et al., 2013)

is ameliorated by ATP7^EY07895

(Xiao et al., 2013, Cao et al., 2008)

is exacerbated by ATP7^GD3322

(Xiao et al., 2013)

is ameliorated by Rab11^UAS.EGFP

(Steinert et al., 2012)

is ameliorated by Psa^UAS.cSa

(Menzies et al., 2010)

is exacerbated by Psa^NIG.1009R

(Menzies et al., 2010)

is ameliorated by mav^GL01025

(Varadarajan et al., 2015)

is exacerbated by Hsf^GD16368

(Maheshwari et al., 2014)

is ameliorated by Hsap\KYAT1^{IVS.10xUAS.GFP}

(Breda et al., 2016)

is exacerbated by v^36f

(Breda et al., 2016)

is ameliorated by InR^UAS.Exel

(Raj and Sarkar, 2019)

is ameliorated by Rab8^{Q67L.UASp.YFP}

(Delfino et al., 2020)

is exacerbated by Rab8^{T22N.UASp.YFP}

(Delfino et al., 2020)

is ameliorated by Rab8^UASp.YFP

(Delfino et al., 2020)

is exacerbated by Usp12-46^KK108313

(Aron et al., 2018)

is ameliorated by Usp12-46^UAS.cAa

(Aron et al., 2018)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(McLear et al., 2008)

is ameliorated by Su(var)2-10^zimp-2

(O'Rourke et al., 2013)

is ameliorated by srl^UAS.cTa

(Ruetenik et al., 2016)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Steffan et al., 2001)

is ameliorated by Kdm4A^KG04636

(Song et al., 2018)

is exacerbated by E(z)⁶³

(Song et al., 2018)

is exacerbated by E(z)⁷³¹

(Song et al., 2018)

is ameliorated by Jarid2^MB00996

(Song et al., 2018)

is ameliorated by Set2^RNAi.UAS

(Song et al., 2018)

is ameliorated by Utx¹

(Song et al., 2018)

is ameliorated by Utx²

(Song et al., 2018)

is exacerbated by ash1²²

(Song et al., 2018)

is exacerbated by esc⁵

(Song et al., 2018)

is exacerbated by gpp^XXV

(Song et al., 2018)

is exacerbated by gpp^X

(Song et al., 2018)

is ameliorated by trr¹

(Song et al., 2018)

is ameliorated by trr³

(Song et al., 2018)

is ameliorated by trx¹

(Song et al., 2018)

is ameliorated by Kdm2^DG12810

(Song et al., 2018)

is ameliorated by Su(var)3-3^GD9296

(Song et al., 2018)

is exacerbated by Hsap\PPM1B^UAS.Tag:HA

(Nandi et al., 2022)

is ameliorated by Nil^HMC06011

(Nandi et al., 2022)

is exacerbated by Glo1^KK109109

(Vicente Miranda et al., 2016)

is exacerbated by Tpi^GD10138

(Vicente Miranda et al., 2016)

is ameliorated by Hsap\MYC^UAS.1

(Raj and Sarkar, 2017)

is ameliorated by Hsap\MYC^UAS.2

(Raj and Sarkar, 2017)

is ameliorated by Hsap\MYC^UAS.S

(Raj and Sarkar, 2017)

is ameliorated by Hsc70-4^HMS00152

(Rai and Tapadia, 2022)

is ameliorated by Hsc70-4^JF03136

(Rai and Tapadia, 2022)

is exacerbated by Hsc70-4^UAS.cEa

(Rai and Tapadia, 2022)

is ameliorated by Glut1^d05758

(Vittori et al., 2014)

is exacerbated by Glut1^17J

(Vittori et al., 2014)

is exacerbated by Glut1^KK108683

(Vittori et al., 2014)

is ameliorated by svr^EP356

(Cao et al., 2008)

is ameliorated by MESR4^EP386

(Cao et al., 2008)

is exacerbated by Tl^EP1051

(Cao et al., 2008)

is exacerbated by SNF4Aγ^EP3015b

(Cao et al., 2008)

is ameliorated by g^EP514

(Cao et al., 2008)

is exacerbated by SNF4Aγ^KG10152

(Cao et al., 2008)

is ameliorated by mub^EP3108

(Cao et al., 2008)

is ameliorated by Pink1^UAS.Tag:HA

(Khalil et al., 2015)

is exacerbated by Drp1^UAS.cDa

(Khalil et al., 2015)

is NOT ameliorated by Gcn5^UAS.cBa

(Bodai et al., 2012)

is exacerbated by Gcn5^E333st

(Bodai et al., 2012)

is exacerbated by nej³

(Bodai et al., 2012)

is NOT exacerbated by mof²

(Bodai et al., 2012)

is NOT exacerbated by enok²

(Bodai et al., 2012)

is ameliorated by Mmus\Gpx1^UAS.cMa

(Mason et al., 2013)

is ameliorated by Sumo^unspecified

(Steffan et al., 2004)

is exacerbated by Ubi-p63E^unspecified

(Steffan et al., 2004)

is ameliorated by Mmus\Bag1^UAS.Tag:FLAG

(Sroka et al., 2009)

is ameliorated by Kdm5¹⁰⁴²⁴

(Vashishtha et al., 2013)

is ameliorated by Hsap\HTT^P42.UAS.GFP

(Arribat et al., 2013)

is ameliorated by Hsap\HTT^{P42.UAS.Tag:MYC}

(Arribat et al., 2013)

model of neurodegenerative disease

is ameliorated by Hsap\HTT^{C4sFv.UAS.Tag:HA}

(Wolfgang et al., 2005)

is ameliorated by Zzzz\scFv^{C4.UAS.Tag:HA}

(Wolfgang et al., 2005)

is exacerbated by Khc⁹

(Gunawardena et al., 2003)

is ameliorated by lncRNA:Hsrω^RNAi.Sym.UAS

(Mallik and Lakhotia, 2009)

is ameliorated by Sirt1¹⁷

(Pallos et al., 2008)

is ameliorated by HDAC1^5-5

(Pallos et al., 2008)

is ameliorated by Sirt2^5B-2-35

(Pallos et al., 2008)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Steffan et al., 2001)

is ameliorated by Tpr2^UAS.cKa

(Liévens et al., 2008)

is ameliorated by DnaJ-1^UAS.cKa

(Liévens et al., 2008)

is ameliorated by mrj^UAS.cFa

(Liévens et al., 2008)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Liévens et al., 2008)

is ameliorated by Akt^UAS.Exel

(Liévens et al., 2008)

is NOT ameliorated by rl^Sem.C.UAS

(Liévens et al., 2008)

is ameliorated by Rab11^UAS.EGFP

(Richards et al., 2011)

is ameliorated by DJ-1α^UAS.cMa

(Sajjad et al., 2014)

is exacerbated by Hsp110⁰⁰⁰⁸²

(Zhang et al., 2010)

is exacerbated by Hsp110^S064906

(Zhang et al., 2010)

is ameliorated by Hsp110^UAS.cZa

(Zhang et al., 2010)

is exacerbated by Hsp110^S031820

(Zhang et al., 2010)

is exacerbated by Hsp110^S004112

(Zhang et al., 2010)

is exacerbated by Nipped-A^NC116

(Zhang et al., 2010)

is exacerbated by Nipped-A^NC186

(Zhang et al., 2010)

is exacerbated by lncRNA:Hsrω⁰⁵²⁴¹

(Sengupta and Lakhotia, 2006)

is ameliorated by yki^UAS.cHa

(Dubey and Tapadia, 2018)

is exacerbated by yki^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

The progressive degeneration seen in Hsap\HTT^{Q93.ex1p.Scer\UAS} flies is significantly relieved when flies are fed the C2-8 compound.

(Zhang et al., 2005)

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Steffan et al., 2001)

HTT:p.Gln18[93]

(FlyBase curators, 2019-)

Variants Synonym(s)

HTT:p.Gln18[93Gln]

HTT, (CAG)n REPEAT EXPANSION

Associated human disease model(s)

Huntington disease

External database links

ClinVar: HTT_409

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal body size | adult stage, with Scer\GAL4^elav-C155

(Aditi et al., 2016)

abnormal eye color, with Scer\GAL4^GMR.PF

(Nandi et al., 2022)

abnormal eye color, with Scer\GAL4^GMR.PU

(Xiao et al., 2013)

abnormal eye color | progressive, with Scer\GAL4^GMR.PU

(Calpena et al., 2018, Liévens et al., 2008)

abnormal feeding behavior | adult stage, with Scer\GAL4^elav-C155

(Aditi et al., 2016)

abnormal locomotor behavior, with Scer\GAL4^elav-C155

(Besson et al., 2015, Smith et al., 2014, Besson et al., 2010, Zhang et al., 2009)

abnormal locomotor behavior, with Scer\GAL4^repo

(Besson et al., 2010)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

(Maheshwari et al., 2014, Xiao et al., 2013, Dupont et al., 2012)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav-C155

(Mason et al., 2013, Liévens et al., 2008)

abnormal locomotor behavior | adult stage, with Scer\GAL4^repo.PU

(Dupont et al., 2012, Liévens et al., 2008)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^C164

(Steinert et al., 2012)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^elav-C155

(Chongtham and Agrawal, 2016)

abnormal locomotor rhythm, with Scer\GAL4^Pdf.PU

(Delfino et al., 2020)

abnormal neuroanatomy, with Hsap\HTT^Q20.ex1.UAS, Scer\GAL4^ninaE.PD

(Slepko et al., 2006)

abnormal neuroanatomy, with Scer\GAL4^elav.PU

(Khalil et al., 2015)

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Besson et al., 2015, Sajjad et al., 2014, Smith et al., 2014, Vittori et al., 2014, Steinert et al., 2012, Bortvedt et al., 2010, Pallos et al., 2008, Wolfgang et al., 2005)

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Mugat et al., 2008)

abnormal neuroanatomy, with Scer\GAL4^ninaE.PD

(Slepko et al., 2006)

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav-C155

(Xu et al., 2022, Chongtham and Agrawal, 2016, Liévens et al., 2008)

abnormal neuroanatomy | adult stage, with Scer\GAL4^P2.4.Pdf

(Mason et al., 2013)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^GMR.PU

(Maheshwari et al., 2014)

abnormal neuroanatomy | chemical conditional, with Scer\GAL4^elav-C155

(Pallos et al., 2008)

abnormal neuroanatomy | progressive, with Scer\GAL4^elav-C155

(Steffan et al., 2001)

abnormal neuroanatomy | progressive, with Scer\GAL4^GMR.PF

(Nandi et al., 2014)

abnormal neurophysiology | adult stage, with Scer\GAL4^repo.PU

(Dupont et al., 2012)

abnormal neurophysiology | progressive, with Scer\GAL4^GMR.PF

(Nandi et al., 2014)

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^elav-C155

(Steinert et al., 2012)

abnormal oxidative stress response, with Scer\GAL4^elav-C155

(Besson et al., 2015)

abnormal phototaxis, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

abnormal visual behavior | adult stage | progressive, with Scer\GAL4^GMR.PU

(Maheshwari et al., 2014)

bang sensitive, with Scer\GAL4^repo.PU

(Dupont et al., 2012)

bang sensitive, with Scer\GAL4^repo

(Besson et al., 2010)

bang sensitive | adult stage, with Scer\GAL4^repo.PU

(Liévens et al., 2008)

decreased cell number | adult stage, with Scer\GAL4^elav.PU

(Dupont et al., 2012)

decreased cell number | adult stage, with Scer\GAL4^elav-C155

(Xu et al., 2022, Liévens et al., 2008)

decreased cell number | adult stage | progressive, with Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

decreased rate of movement | adult stage, with Scer\GAL4^Eaat1.PR

(Lievens et al., 2005)

increased cell death, with Hsap\HTT^Q20.ex1.UAS, Scer\GAL4^ninaE.PD

(Slepko et al., 2006)

increased cell death, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

increased cell death, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

increased cell death, with Scer\GAL4^elav.PU

(Khalil et al., 2015)

increased cell death, with Scer\GAL4^ninaE.PD

(Slepko et al., 2006)

increased mortality, with Scer\GAL4^elav-C155

(Pallos et al., 2008)

lethal, with Scer\GAL4^elav-C155

(Maher et al., 2011)

partially lethal, with Scer\GAL4^elav.PU

(Xiao et al., 2013)

partially lethal, with Scer\GAL4^elav-C155

(Steffan et al., 2001)

partially lethal - majority die, with Scer\GAL4^elav.PU

(Vashishtha et al., 2013)

partially lethal - majority die, with Scer\GAL4^elav-C155

(Delfino et al., 2020, Vittori et al., 2014, Wolfgang et al., 2005)

short lived, with Scer\GAL4^Appl.PU

(Heidari et al., 2015)

short lived, with Scer\GAL4^Eaat1.PR

(Dupont et al., 2012, Besson et al., 2010, Liévens et al., 2008, Lievens et al., 2005)

short lived, with Scer\GAL4^elav.PU

(Khalil et al., 2015, Maheshwari et al., 2014, Xiao et al., 2013, Dupont et al., 2012)

short lived, with Scer\GAL4^elav-C155

(Delfino et al., 2020, Aditi et al., 2016, Besson et al., 2015, Vittori et al., 2014, Richards et al., 2011, Besson et al., 2010, Menzies et al., 2010, Mallik and Lakhotia, 2009, Zhang et al., 2009, Liévens et al., 2008)

short lived, with Scer\GAL4^repo.PU

(Heidari et al., 2015, Liévens et al., 2008)

short lived, with Scer\GAL4^repo

(Besson et al., 2010)

short lived | calorie restriction conditional, with Scer\GAL4^elav-C155

(Pallos et al., 2008)

some die during pharate adult stage, with Scer\GAL4^elav-C155

(Wolfgang et al., 2005)

some die during pupal stage, with Scer\GAL4^elav-C155

(Richards et al., 2011)

visible, with Scer\GAL4^GMR.PU

(Liévens et al., 2008)

visible | adult stage, with Scer\GAL4^GMR.PF

(Nandi et al., 2022)

visible | adult stage | progressive, with Scer\GAL4^GMR.PF

(Chongtham and Agrawal, 2016)

visible | adult stage | progressive, with Scer\GAL4^GMR.PU

(Calpena et al., 2018)

visible | progressive, with Scer\GAL4^GMR.PF

(Mugat et al., 2008)

visible | progressive, with Scer\GAL4^GMR.PU

(Zhang et al., 2010)

Phenotype Manifest In

adult antennal lobe, with Scer\GAL4^elav.PU

(Khalil et al., 2015)

adult heart | RU486 conditional, with Scer\GAL4^{Hand.ΔVM.Switch}

(Heidari et al., 2015)

adult median bundle, with Scer\GAL4^ey-OK107

(Agrawal et al., 2005)

adult mushroom body, with Scer\GAL4^elav-C155

(Agrawal et al., 2005)

adult mushroom body, with Scer\GAL4^ey-OK107

(Agrawal et al., 2005)

adult mushroom body alpha'-lobe, with Scer\GAL4^ey-OK107

(Agrawal et al., 2005)

adult mushroom body beta'-lobe, with Scer\GAL4^ey-OK107

(Agrawal et al., 2005)

adult mushroom body gamma-lobe, with Scer\GAL4^elav-C155

(Liévens et al., 2008)

adult mushroom body gamma-lobe, with Scer\GAL4^ey-OK107

(Besson et al., 2010)

adult optic lobe neuron, with Scer\GAL4^elav-C155

(Wolfgang et al., 2005)

adult s-LNv neuron, with Scer\GAL4^P2.4.Pdf

(Mason et al., 2013)

axon, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

axon, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

dendrite | larval stage, with Scer\GAL4²²¹

(Chen et al., 2012)

dorsal longitudinal indirect flight muscle cell, with Scer\GAL4^repo.PU

(Dupont et al., 2012)

eye, with Scer\GAL4^elav-C155

(Delfino et al., 2020, Steffan et al., 2004)

eye, with Scer\GAL4^GMR.PF

(Nandi et al., 2022, Sengupta and Lakhotia, 2006)

eye, with Scer\GAL4^GMR.PU

(Xiao et al., 2013, Cao et al., 2008)

eye | adult stage, with Scer\GAL4^GMR.PU

(Liévens et al., 2008)

eye | adult stage | progressive, with Scer\GAL4^GMR.PF

(Chongtham and Agrawal, 2016)

eye | progressive, with Scer\GAL4^GMR.PF

(Mugat et al., 2008)

eye | progressive, with Scer\GAL4^GMR.PU

(Kumar et al., 2014, Zhang et al., 2010)

eye | progressive | nutrition conditional, with Scer\GAL4^GMR.PU

(Kumar et al., 2014)

eye disc | larval stage, with Scer\GAL4^GMR.PU

(Maheshwari et al., 2014)

eye photoreceptor cell, with Scer\GAL4^elav.PU

(Khalil et al., 2015, Dupont et al., 2012)

eye photoreceptor cell, with Scer\GAL4^elav-C155

(Besson et al., 2015, Maher et al., 2011, Pollitt et al., 2003)

eye photoreceptor cell | adult stage | decreased number, with Scer\GAL4^elav-C155

(Xu et al., 2022)

eye photoreceptor cell | adult stage | progressive, with Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

fat body | larval stage, with Scer\GAL4^elav-C155

(Aditi et al., 2016)

giant fiber neuron, with Scer\GAL4^repo.PU

(Dupont et al., 2012)

gnathal ganglion, with Scer\GAL4^ey-OK107

(Agrawal et al., 2005)

Kenyon cell, with Scer\GAL4^ey-OK107

(Agrawal et al., 2005)

lamellar body, with Scer\GAL4^elav-C155

(Steinert et al., 2012)

larval dorsal multidendritic neuron ddaE | larval stage, with Scer\GAL4²²¹

(Chen et al., 2012)

microtubule | larval stage, with Scer\GAL4²²¹

(Chen et al., 2012)

mitochondrion, with Scer\GAL4^elav.PU

(Khalil et al., 2015)

multivesicular body, with Scer\GAL4^elav-C155

(Steinert et al., 2012)

NMJ bouton, with Scer\GAL4^elav-C155

(Steinert et al., 2012)

ommatidium, with Scer\GAL4^elav-C155

(Besson et al., 2015)

ommatidium, with Scer\GAL4^GMR.PF

(Mugat et al., 2008, Sengupta and Lakhotia, 2006)

photoreceptor, with Scer\GAL4^elav-C155

(Steffan et al., 2004)

photoreceptor | adult stage, with Scer\GAL4^elav-C155

(Liévens et al., 2008)

photoreceptor neuron, with Hsap\HTT^Q20.ex1.UAS, Scer\GAL4^ninaE.PD

(Slepko et al., 2006)

photoreceptor neuron, with Scer\GAL4^elav-C155

(Pallos et al., 2008, Wolfgang et al., 2005)

photoreceptor neuron, with Scer\GAL4^GMR.PF

(Nandi et al., 2014)

photoreceptor neuron, with Scer\GAL4^ninaE.PD

(Slepko et al., 2006)

photoreceptor neuron | adult stage, with Scer\GAL4^elav-C155

(Bortvedt et al., 2010)

pigment granule, with Scer\GAL4^GMR.PF

(Sengupta and Lakhotia, 2006)

retina, with Scer\GAL4^elav-C155

(Smith et al., 2014)

retina | adult stage | progressive, with Scer\GAL4^GMR.PU

(Maheshwari et al., 2014)

rhabdomere, with Hsap\HTT^Q20.ex1.UAS, Scer\GAL4^ninaE.PD

(Slepko et al., 2006)

rhabdomere, with Scer\GAL4^elav.PU

(Vashishtha et al., 2013)

rhabdomere, with Scer\GAL4^elav-C155

(Sajjad et al., 2014, Vittori et al., 2014, Richards et al., 2011, Zhang et al., 2009, Pallos et al., 2008, Wolfgang et al., 2005, Pollitt et al., 2003, Steffan et al., 2001)

rhabdomere, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

rhabdomere, with Scer\GAL4^GMR.PU

(Xiao et al., 2013)

rhabdomere, with Scer\GAL4^ninaE.PD

(Slepko et al., 2006)

rhabdomere | adult stage, with Scer\GAL4^elav-C155

(Chongtham and Agrawal, 2016)

rhabdomere | decreased number, with Scer\GAL4^elav-C155

(Delfino et al., 2020)

rhabdomere | progressive, with Scer\GAL4^elav.PU

(Sroka et al., 2009)

rhabdomere | progressive, with Scer\GAL4^elav-C155

(Mason et al., 2013)

rhabdomere | progressive, with Scer\GAL4^GMR.PU

(Kumar et al., 2014)

rhabdomere | progressive | nutrition conditional, with Scer\GAL4^GMR.PU

(Kumar et al., 2014)

rhabdomere of eye photoreceptor cell, with Scer\GAL4^elav.PU

(Luthi-Carter et al., 2010)

rhabdomere of eye photoreceptor cell | adult stage | progressive, with Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

synaptic vesicle, with Scer\GAL4^elav-C155

(Steinert et al., 2012)

Detailed Description

Statement

Reference

The expression of Hsap\HTT^Q93.ex1.UAS under the control of Scer\GAL4^GMR.PF induces a degeneration, reflected by depigmentation of the adult eye.

(Nandi et al., 2022)

Expression of Hsap\HTT^Q93.ex1.UAS under the control of Scer\GAL4^Pdf.PU leads to arrhythmicity in majority of adults and the period of those remaining rhythmic ones is more than 1 hour shorter.

(Delfino et al., 2020)

Flies expressing Hsap\HTT^{Q93.ex1.Scer\UAS} under the control of Scer\GAL4^GMR.PU have normal external morphology of the eye at day 1 post-eclosion but suffer progressive degeneration of the underlying retina resulting in patchy depigmentation as the flies age.

(Calpena et al., 2018)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 results in adult weight alteration, as measured by fresh weight, dry weight and water content, with a small but significant decrease in weight at 0 days post eclosion, significantly increased weight at 3-9 days, no significant difference in weight at 11 days, and decreased weight at 13 days post-eclosion, as compared to controls. These flies do not survive beyond day 13 post eclosion. As compared to controls, flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 also exhibit arrhythmic feeding; significantly increased levels of trehalose and glycogen at 3 and 5 days, but not at 0, 7, 9, 11, or 13 days post-eclosion; significantly increased protein content at 7 and 9 days, decreased protein content at 13 days, but no difference at 0, 3, 5, or 11 days post-eclosion; significantly decreased lipid content at 0, 11 and 13 days, significantly increased lipid content at 3, 5, and 7 days, but no significant difference in lipid content 9 days post-eclosion. Lipid droplet size in the larval fat body is unaltered, but lipid droplets in the adult abdominal fat body are increased in size at 3-7 days and decreased in size by day 11-13 post-eclosion.

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^Ilp2.PR in adults results in significantly decreased adult weight at 0, 7 and 13 days, but not at 3, 5, 9 or 11 days post-eclosion; significantly increased lipid content at 5 and 9 days, but not at 0, 3, 7, 11 and 13 days post-eclosion; significantly decreased glycogen content 0, 3 and 7 days, significantly increased glycogen content at 5 and 11 days, but no significant difference at 9 or 13 days post-eclosion; significantly increased trehalose content at 0 and 11 days, significantly decreased trehalose content at 3 and 5 days, but no significant difference at 7, 9 and 13 days post-eclosion.

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^Akh.PL in adults results in significantly decreased adult weight at 5-13 days, but not 0-3 days post-eclosion; significantly decreased lipid content at 0 days, significantly increased at 3, 5, 7 and 11 days, but no significant difference at 9 or 13 days post-eclosion; significantly decreased glycogen at 3 days, significantly increased glycogen content at 5, 6, 11 and 13 days, but no significant difference at 0 or 9 days post-eclosion; significantly increased trehalose content at 0-5 days, significantly decreased trehalose content at 11 days, but no significant difference at 7, 9 or 13 days post-eclosion.

(Aditi et al., 2016)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 result in photoreceptor neurodegeneration in the adult eye at 7 days post-eclosion and reduced crawling ability in third instar larvae; expression under Scer\GAL4^GMR.PF induces an age-progressive rough eye phenotype.

(Chongtham and Agrawal, 2016)

Compared with wild-type, expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} in neuronal cells using Scer\GAL4^elav-C155 reduces fly longevity.

Flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS} display defects in their negative geotaxis response.

Expression of Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS} leads to an obvious loss of one or more photoreceptors leading to a disorganization of ommatidia.

6-day old flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS} are insensitive to oxidative stress generated by hydrogen peroxide treatment. It is noteworthy, that these flies do not yet present pathological symptoms.

(Besson et al., 2015)

The end-systolic diameter (ESD) and end-diastolic diameter (EDD) of 5-day old flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^{Hand.ΔVM.Switch} (limited to the adult stages using 100ug/ml RU486) are similar to controls. No significant changes are seen in the ESD at 19 days, but the EDD is modestly but significantly increased.

When flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^{Hand.ΔVM.Switch} are raised on medium containing 2ug/ml RU486 adults are produced adults are produced but the hearts are severely impaired. When raised on a lower RU485 concentration (20ng/ml) the flies could be seen to have dilated hearts, with increases in ESD and EDD that are more severe than those seen when expression is limited to adulthood. Feeding the flies Methylene blue along with RU486 significantly rescues the heart dilatation at 19 days.

Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} either in neurons under the control of Scer\GAL4^Appl.PU or in glia under the control of Scer\GAL4^repo.PU show a strong deficit in mean lifespan compared to controls. This reduction in lifespan is not rescued by feeding the flies Methylene Blue, and is aggravated when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed in neurons.

(Heidari et al., 2015)

1-day old flies expressing Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} show neurodegeneration in the retina. Neurodegeneration is moderate at this age, although some photoreceptors start to display rhabdomere atrophy or cytoplasmic condensation typical of apoptosis. Non-apoptotic photoreceptors contain two types of mitochondria: typical round-shaped mitochondria, and, unexpectedly, mitochondrial tubules that seem to bend and often fuse at their extremities to adopt a ring-shaped structure. Sometimes those bended mitochondria engulf cytoplasmic components such as pigment granules.

12-day old flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} in postmitotic neurons in the central brain display neurodegeneration. About 7% of degenerative neurons show cytoplasmic vacuolization in the olfactory lobes.

(Khalil et al., 2015)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 results in a progressive loss of rhabdomeres and photoreceptor cells during their lifespan.

(Varadarajan et al., 2015)

The external eye morphology and vision of freshly-eclosed Scer\GAL4^GMR.PU-->Hsap\HTT^{Q93.ex1p.Scer\UAS} flies are near normal. However, these flies show a progressive age-dependent degeneration, becoming almost completely blind by 10 days. The eye surface of these flies do not show any appreciable change with age in any of the feeding regimes. The pseudopupil images of rhabdomeres of 1-day-old Scer\GAL4^GMR.PU-->Hsap\HTT^{Q93.ex1p.Scer\UAS} flies fed on a normal diet show severely degenerated rhabdomeres so that, unlike the stereotyped pattern of rhabdomeres in pseudopupil image of eyes of wild-type flies, no distinct rhabdomeres are seen in their eyes. Scer\GAL4^GMR.PU-->Hsap\HTT^{Q93.ex1p.Scer\UAS} flies fed on azaserine-supplemented food display at least some organised rhabdomere-like structures in approximately 60% of flies.

Scer\GAL4^GMR.PU-->Hsap\HTT^{Q93.ex1p.Scer\UAS} flies reared on normal food exhibit a progressive loss of vision such that the proportion of flies selecting the lighted chamber in a phototaxis assay declines with age. By day 10, these flies become nearly blind and move at random between dark and light chambers. Significantly, a greater proportion of Scer\GAL4^GMR.PU-->Hsap\HTT^{Q93.ex1p.Scer\UAS} flies reared on azaserine-supplemented food continue to move to the illuminated chamber even on day 15. Thus, azaserine feeding partially restores vision in these flies.

Scer\GAL4^GMR.PU-driven expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} leads to the accumulation of polyQ inclusion bodies posterior to the morphogenetic furrow in late third instar larval eye discs. Feeding these larvae with azaserine substantially reduces the accumulation of Hsap\HTT aggregates, such that in 57% of eye discs from azaserine-fed larvae, the aggregates are nearly absent behind the morphogenetic furrow, although in the remaining discs immunostaining is less than in the eye discs from larvae fed a normal diet.

(Kumar et al., 2014)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU results in the formation of aggregates in larval eye imaginal discs and subsequent age-dependent retinal degeneration and visual impairment measured by phototaxic response, as compared to wild type.

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU results in climbing defects and a dramatic reduction in lifespan.

(Maheshwari et al., 2014)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} in photoreceptor cells under the control of Scer\GAL4^GMR.PF triggers strong neuronal degeneration, with only a small detectable depolarization remaining after 1 week.

(Nandi et al., 2014)

Pan-neuronal expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 leads to robust degeneration of photoreceptor neurons.

(Sajjad et al., 2014)

Animals expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 exhibit loss of retinal neurons and impaired motor function.

At 10 microM, selisistat is able to rescue degeneration to at least the same level as genetic loss of one copy of the Sir2 gene.

(Smith et al., 2014)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 results in progressive degeneration of photoreceptor rhabdomeres in the eye. This phenotype can be partially suppressed by feeding the flies ebselen.

Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 show reduced locomotor activity compared to wild type.

Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^P2.4.Pdf show loss of the small lateral ventral neurons compared to wild type.

(Mason et al., 2013)

Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU show loss of photoreceptor rhabdomeres.

(Vashishtha et al., 2013)

Adults expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU show reduced mobility in a climbing assay.

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU results in loss of eye pigmentation and progressive loss of rhabdomeres.

The survival rate of animals expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU is significantly increased by dietary copper chelation (0.05mM bathocuproine disulfonate) or 0.00625mM clioquinol and is significantly reduced by addition of 0.25mM CuCl[[2]].

(Xiao et al., 2013)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 results in a reduced eclosion rate.

(Bodai et al., 2012)

Larval ddaE neurons expressing Hsap\HTT^Q93.ex1.UAS under the control of Scer\GAL4²²¹ show a significant increase in growing microtubules within dendrites, as compared to neurons in controls.

(Chen et al., 2012)

Flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU or Scer\GAL4^Eaat1.PR have a shorter lifespan compared to controls. Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies have locomotor impairments (significant reduction in climbing performance) and have photoreceptor loss in the ommatidia of the retina. Scer\GAL4^repo.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies have locomotor impairments (significant reduction in climbing performance) and more than a third of flies are bang sensitive at 12 days of age. Scer\GAL4^repo.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies show normal baseline electrophysiological recordings in response to a single-pulse stimulus in the giant fiber pathway (recording from dorsal longitudinal muscle), but 12 day old flies show significant defects in response to high frequency stimulation (at 200Hz the number of delayed discharges is significantly enhanced and delay discharge timing is significantly delayed).

(Dupont et al., 2012)

Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 show reduced evoked excitatory junction potential (eEJP) amplitudes recorded at the third instar larval neuromuscular junction at 0.6 or 1.5 mM Ca[2+] concentrations compared to controls. Miniature excitatory junction potential (mEJP) amplitude is also reduced. mEJP decay kinetics, mEJP frequency, mean resting membrane potential and quantal content are all unaffected.

The average synaptic vesicle diameter in larvae expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 is smaller than in controls in both 1s and 1b boutons. NMJ boutons expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} also show increased numbers of vacuoles, multi-lammelar bodies and multivesicular bodies. The number of active zones is comparable to controls.

Larvae expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^C164 perform significantly fewer turns than controls in a crawling assay. The distance travelled is also significantly increased.

(Steinert et al., 2012)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 results a 2 to 3 fold increase in the 3-hydroxykynurenine (3-HK)/kynurenic acid (KYNA) ratio as compared to controls at day one and day 7 post-eclosion.

Treating flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 with the KMO inhibitors UPF648, JM6 or Ro 61-8048 produces suppression of the rhabdomere degeneration seen at seven days post eclosion. 3-hydroxykynurenine (3-HK) feeding significantly potentiates the rhabdomere loss. Conversely feeding the flies with kynurenic acid (KYNA) confers a significant but modest increase in rhabdomere number and an associated reduction in the 3-HK/KYNA ratio.

(Campesan et al., 2011)

Expression of Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 results in photoreceptor neuron degeneration, and a decrease in photoreceptor cell number is observed. This phenotype is suppressed in a dose-dependent manner by increasing concentrations of fisetin in the fly food medium, rescuing the number of photoreceptor cells observed in the eye. The number of adult flies surviving to 7-days post-eclosion also increases in a dose-dependent manner in the presence of fisetin.

(Maher et al., 2011)

Pan-neuronal expression of Hsap\HTT^{Q93.ex1.Scer\UAS}, under the control of Scer\GAL4^elav-C155 results in some pupal lethality, with approximately 40% of flies emerging as adults. These surviving adults are short lived as compared to controls.

Pan-neuronal expression of Hsap\HTT^{Q93.ex1.Scer\UAS}, under the control of Scer\GAL4^elav-C155 results in rhabdomere degeneration.

(Richards et al., 2011)

At 12 days post-eclosion, only 26% of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^repo reach the top of a column after a startle and >46% remain at the bottom. This is in contrast to control flies which all reach the top of the column.

At 12 days post-eclosion, ~40% of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^repo are bang sensitive.

>70% of adult flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^repo are dead at 16 days.

Adult flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^Eaat1.PR die early.

Only 59% of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 reach the top of a column after a startle. This is in contrast to control flies where 90% reach the top of the column.

Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 die early and do not survive beyond 28 days post eclosion.

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} using Scer\GAL4^ey-OK107 results in loss of mushroom body gamma lobes in 12 day old flies, whereas the alpha and beta lobes remain intact.

(Besson et al., 2010)

Adult flies expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 treated continuously wth 100υM cystamine alone over a 6 day period produces a significant 17% rescue of photoreceptors compared to no-drug controls, while treatment with 50 and 250υM doses has no significant effects.

In Hsap\HD^{Q93.ex1p.Scer\UAS}-expressing flies expressing the Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} transgene, both under the control of Scer\GAL4^elav-C155, photoreceptors are significantly rescued by 48% compared to no intrabody controls. The combination of Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} and postsymptomatic 100υM cystamine treatment rescues 66% of photoreceptors compared to Hsap\HD^{Q93.ex1p.Scer\UAS} controls undergoing neither treatment. Neither the 50&ugrM nor the 250υM cystamine dose combined with the Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} intrabody treatment show any significant difference from intrabody treatment alone.

Feeding cystamine throughout larval and adult stages does not affect photoreceptor neurodegeneration in flies expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Feeding of cystamine to adult flies expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 does not significantly improve survival. A higher dose of 250υM produces a small yet significant decrease in survival. Co-expression of Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} produces a significant increase in mean survival, by almost three days. Combination of either a 50υM or 250υM dose of cystamine with Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} expression leads to significantly decreased survival compared to Hsap\HD^{Q93.ex1p.Scer\UAS}-expressing flies co-expressing Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} alone. Combination of Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} expression with 100υM postsymptomatic cystamine treatment does not change survival times compared to Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} expression alone.

Treatment of Hsap\HD^{Q93.ex1p.Scer\UAS} expressing flies (under the control of Scer\GAL4^elav-C155) presymptomatically with 100υM cystamine at the larval as well as adult stages significantly increases survival, relative to no-drug Hsap\HD^{Q93.ex1p.Scer\UAS} flies. Co-expression of Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} confers significantly improved survival on Hsap\HD^{Q93.ex1p.Scer\UAS} flies. Administration of 50υM or 100υM doses of cystamine at larval and adult stages in Hsap\HD^{Q93.ex1p.Scer\UAS} flies co-expressing Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} results in an additional improvement in survival (this is not seen with a 250υM dose of cystamine).

(Bortvedt et al., 2010)

The expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU results in decreased average rhabdomere number in the adult eye.

(Luthi-Carter et al., 2010)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} in the brain under the control of Scer\GAL4^elav-C155 reduces the lifespan of the mutants relative to wild-type.

(Menzies et al., 2010)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU results in progressive degeneration in the eye.

(Zhang et al., 2010)

Expression of Hsap\HD^{Q93.ex1p.Scer\UAS} using Scer\GAL4^GMR.PF results in normal ommatidial morphology in freshly emerged flies, but rhabdomere degeneration is seen in 10-day old flies.

10-day old flies expressing Hsap\HD^{Q93.ex1p.Scer\UAS} using Scer\GAL4^GMR.PF fail to detect light.

Expression of Hsap\HTT^{Q93.ex1.Scer\UAS} using Scer\GAL4^GMR.PF also results in decreased adult lifespan, as compared to controls.

(Mallik and Lakhotia, 2009)

Scer\GAL4^elav.PU-mediated expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} leads to a marked disruption of the number as well as the arrangement of rhabdomeres 10 days post-eclosion.

(Sroka et al., 2009)

Adults expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 are initially hyperactive and then show a gradual loss of coordination and a decline in locomotor activity. These animals die at around 20 days of age. Progressive degeneration of the photoreceptors is also seen.

(Zhang et al., 2009)

Expression with Scer\GAL4^GMR.PU causes a rough eye phenotype accompanied by a 'glassy' appearance.

(Cao et al., 2008)

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU leads to late-onset eye depigmentation.

Expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 disrupts the regular arrangement of the retina, progressively decreasing the number of photoreceptors in each ommatidium as observed by pseudopupil analysis.

Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} in neurons under the control of Scer\GAL4^elav-C155 die between days 8 and 28 of adult age. A similar phenotype is seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed in glia under the control of Scer\GAL4^repo.PU. Lifespan is unaffected when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed in the surface or peripheral glia (under the control of Scer\GAL4^moody.PS and Scer\GAL4^Gli.PS respectively) but expression under the control of Scer\GAL4^Eaat1.PR, which expresses in CNS cortex glia and PNS perisynaptic glia, results in lethality as early as 12 days.

Adult flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^repo.PU show locomotor defects in a negative geotaxis test. Walking speed is also reduced. Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^repo.PU also exhibit a bang sensitive phenotype. No locomotor defects are seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^Eaat1.PR.

Pan-neuronal expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 results in degeneration of the kenyon cells that comprise the γ-lobe of the mushroom body.

(Liévens et al., 2008)

Flies expressing Scer\GAL4^GMR.PF>Hsap\HTT^{Q93.ex1p.Scer\UAS} display age-dependent eye depigmentation as well as disorganization of ommatidial arrays. The eye pigmentation and ommatidial defects are not observed when Hsap\HTT^Q0.Scer\UAS is co-expressed with Hsap\HTT^{Q93.ex1p.Scer\UAS}

(Mugat et al., 2008)

Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 do not exhibit changes in lifespan when reared on diluted food (while control flies display increased longevity). There is also no change in photoreceptor neuron survival in these flies.

Addition of resveratrol to food fed to flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 can rescue neuronal degeneration in a dose-dependent manner, although it does not alter the early death phenotype of these flies.

(Pallos et al., 2008)

Expression of Hsap\HD^{Q93.ex1p.Scer\UAS} in the developing eye disc, under the control of Scer\GAL4^GMR.PF results in a loss of pigmentation and disruption of the regular ordered arrays of ommatidia in adult eyes without affecting the eye size.

(Sengupta and Lakhotia, 2006)

Five days after overexpression of Hsap\HD^{Q93.ex1p.Scer\UAS} in photoreceptor neurons, under the control of Scer\GAL4^ninaE.PD, the protein is found primarily in the cytosol in multiple, small aggregates. Twenty-four hours later, at day 6, nuclear aggregates begin to appear. By day ten, most nuclei contain nuclear inclusions.

By as late as 8 days after inclusion, flies expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^ninaE.PD exhibit seven intact rhabdomeres, similar to wild-type flies. By day 12, the average n umber of rhabdomeres per ommatidium decreases to 5.8, indicating mild degeneration.

(Slepko et al., 2006)

When Hsap\HD^{Q93.ex1p.Scer\UAS} is driven by Scer\GAL4^OK107 changes in the structure of the mushroom body are apparent. The alpha'-lobes and beta'-lobes are mostly missing, the number of fibres in the gamma-lobe is reduced ,and Kenyon cell bodies responsible for these fibres are also reduced. The number of cells in the median bundle cluster is reduced from ~20 to ~8. In addition, the cells of the ventral ganglia show a reduced number of cell bodies and the projections reveal clear dismorphology. Cells in the abdominal region of the ventral ganglia show changes in neuronal morphology with loss of projections and rounded (rather than stellate) shape. When Hsap\HD^{Q93.ex1p.Scer\UAS} is driven by Scer\GAL4^elav-C155, an approximately 24% volume reduction is seen the mushroom body 10 days after eclosion.

(Agrawal et al., 2005)

Flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^Eaat1.PR have a shortened lifespan compared to wild type and are found to be lethargic a few days before dying.

(Lievens et al., 2005)

Expression of Hsap\HTT^Q93.ex1.UAS at 25[o]C, under the regulation of Scer\GAL4^elav-C155 results in 23% eclosion from the pupal case. Most Hsap\HTT^Q93.ex1.UAS flies dies as externally normal adults (pharate adults) trapped in the pupal case unable to act out the stereotypic eclosion behaviour required to emerge.

Flies expressing Hsap\HTT^Q93.ex1.UAS under the control of Scer\GAL4^elav-C155 exhibit an age-dependent loss of photoreceptor cells.

(Wolfgang et al., 2005)

Photoreceptor neurons are progressively lost and the integrity of the eye is compromised.

(Steffan et al., 2004)

When Hsap\HD^{Q93.ex1p.Scer\UAS} is driven by Scer\GAL4^179Y or Scer\GAL4^Appl.G1a accumulations of organelles are seen in neurons, characteristic of a defect in axonal transport. When Hsap\HD^{Q93.ex1p.Scer\UAS} is overexpressed in neurons, increased cell death is seen.

(Gunawardena et al., 2003)

Mutant flies have eyes that have reduced numbers of rhabdomeres, caused by progressive neurodegeneration of photoreceptor neurons. Feeding the flies Y-27632 slows the loss of photoreceptor neurons.

(Pollitt et al., 2003)

When Hsap\HD^{Q93.ex1p.Scer\UAS} is driven by Scer\GAL4^elav-C155, a progressive loss of rhabdomeres is seen. Rather than the normal seven visible rhabdomeres, the number progressively declines from an average of 6.35 at day 1 to 5.13 and 4.66 at days 6 and 12 after eclosion respectively. Expression of Hsap\HD^{Q93.ex1p.Scer\UAS} leads to 70% lethality and early adult death. Suberoylanilide hydroxamic acid (SAHA) suppresses the lethality to 45% and reduces the level of degeneration seen in the eye.

(Steffan et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, enhanceable by jp^KK107921, Scer\GAL4^GMR.PU

(Calpena et al., 2018)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, enhanceable by jp^KK107921, Scer\GAL4^GMR.PU

(Calpena et al., 2018)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, enhanceable by Drp1^UAS.cDa, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has abnormal neuroanatomy | progressive phenotype, enhanceable by Acn^KK111555, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has abnormal neurophysiology | progressive phenotype, enhanceable by Acn^KK111555, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, enhanceable by Sirt1¹⁷

(Smith et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, enhanceable by Sirt1¹⁷

(Smith et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, enhanceable by Glut1^17J

(Vittori et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, enhanceable by Glut1^KK108683, Scer\GAL4^elav-C155

(Vittori et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by Glut1^KK108683, Scer\GAL4^elav-C155

(Vittori et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has abnormal eye color phenotype, enhanceable by ATP7^GD3322, Scer\GAL4^GMR.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has partially lethal phenotype, enhanceable by ATP7^GD3322, Scer\GAL4^elav.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage phenotype, enhanceable by ATP7^GD3322, Scer\GAL4^elav.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, enhanceable by ATP7^GD3322, Scer\GAL4^elav.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, enhanceable by Df(3L)iro-2/+

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, enhanceable by nej[+]/nej³

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, enhanceable by Pcaf[+]/Gcn5^E333st

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has lethal phenotype, enhanceable by Dsor1^G42/Dsor1[+]

(Maher et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by Psa^NIG.1009R, Scer\GAL4^elav-C155

(Menzies et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible | progressive phenotype, enhanceable by Hsp110⁰⁰⁰⁸²/Hsc70Cb[+]

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible | progressive phenotype, enhanceable by Hsp110^S031820/Hsc70Cb[+]

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible | progressive phenotype, enhanceable by Hsc70Cb[+]/Hsp110^S064906

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible | progressive phenotype, enhanceable by Hsc70Cb[+]/Hsp110^S004112

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible | progressive phenotype, enhanceable by Nipped-A^NC116/Nipped-A[+]

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible | progressive phenotype, enhanceable by Nipped-A[+]/Nipped-A^NC186

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, enhanceable by htt^98E2

(Zhang et al., 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by htt^98E2

(Zhang et al., 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by lncRNA:Hsrω⁰⁵²⁴¹/lncRNA:Hsrω⁰⁵²⁴¹

(Sengupta and Lakhotia, 2006)

NOT Enhanced by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has abnormal eye color phenotype, non-enhanceable by Hsap\PPM1B^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-enhanceable by Hsap\PPM1B^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by Hap40^ko3

(Xu et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has decreased cell number | adult stage phenotype, non-enhanceable by Hap40^ko3

(Xu et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-enhanceable by Rab8^UASp.YFP, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-enhanceable by Rab8^{T22N.UASp.YFP}, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, non-enhanceable by Pink1[+]/Pink1^B9

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, non-enhanceable by park^UAS.Tag:MYC, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has abnormal neuroanatomy | progressive phenotype, non-enhanceable by Acn^{D527A.Tag:MYC}

(Nandi et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has abnormal neurophysiology | progressive phenotype, non-enhanceable by Acn^{D527A.Tag:MYC}

(Nandi et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, non-enhanceable by Glut1^17J

(Vittori et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-enhanceable by enok[+]/enok²

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-enhanceable by mof[+]/mof²

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-enhanceable by Df(3R)Exel6259/+

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, non-enhanceable by Bmcp^BG02446/Bmcp[+]

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, non-enhanceable by HDAC3^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived | calorie restriction conditional phenotype, non-enhanceable by HDAC3^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, non-enhanceable by HDAC4^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived | calorie restriction conditional phenotype, non-enhanceable by HDAC4^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, non-enhanceable by HDAC11^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived | calorie restriction conditional phenotype, non-enhanceable by HDAC11^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Suppressed by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Nil^HMC06011, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has abnormal eye color phenotype, suppressible by Nil^HMC06011, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Pdf.PU has abnormal locomotor rhythm phenotype, suppressible | partially by Rab8^UASp.YFP, Scer\GAL4^Pdf.PU

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has increased mortality during development phenotype, suppressible by Rab8^{Q67L.UASp.YFP}, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Rab8^{Q67L.UASp.YFP}, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Rab8^UASp.YFP, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, suppressible by jp^UAS, Scer\GAL4^GMR.PU

(Calpena et al., 2018)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, suppressible by jp^UAS, Scer\GAL4^GMR.PU

(Calpena et al., 2018)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, suppressible by Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by G6pd^UAS.cLa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by G6pd^UAS.cLa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by dhd^UAS.cUa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Prx2^UAS.cHa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible | partially by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by mav^GL01025, Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has decreased cell number | adult stage | progressive phenotype, suppressible by mav^GL01025, Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by Sirt1¹⁷/Sir2[+]

(Smith et al., 2014, Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by DJ-1α^UAS.cMa, Scer\GAL4^elav-C155

(Sajjad et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by dj-1β^UAS.cMa, Scer\GAL4^elav-C155

(Sajjad et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, suppressible by Sirt1¹⁷/Sir2[+]

(Smith et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by Glut1^d05758, Scer\GAL4^elav-C155

(Vittori et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage phenotype, suppressible by Mmus\Gpx1^UAS.cMa, Scer\GAL4^elav-C155

(Mason et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, suppressible by Mmus\Gpx1^UAS.cMa, Scer\GAL4^P2.4.Pdf

(Mason et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has partially lethal - majority die phenotype, suppressible | partially by lid[+]/Kdm5¹⁰⁴²⁴

(Vashishtha et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has abnormal eye color phenotype, suppressible by Ctr1B^NIG.7459R, Scer\GAL4^GMR.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has abnormal eye color phenotype, suppressible by ATP7^EY07895, Scer\GAL4^GMR.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has partially lethal phenotype, suppressible | partially by Ctr1B^NIG.7459R, Scer\GAL4^elav.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has partially lethal phenotype, suppressible | partially by ATP7^EY07895, Scer\GAL4^elav.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Ctr1B^NIG.7459R, Scer\GAL4^elav.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Ctr1B^NIG.7459R, Scer\GAL4^elav.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by ATP7^EY07895, Scer\GAL4^elav.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by arm³/arm[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by arm^G0192/arm[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible | partially by arm³/arm[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible | partially by arm^G0192/arm[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by wg^Sp-1/wg[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by wg¹/wg[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Wnt2^O/Wnt2[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Wnt2[+]/Wnt2^I

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Wnt2[+]/Wnt2^RJ

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by pan[+]/pan³

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Apc2^UAS.cUa, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Axn^UAS.cUa, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by sgg^Y214F.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible | partially by pan[+]/pan³

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible | partially by pan[+]/pan²

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible | partially by Axn^UAS.cUa, Scer\GAL4^Eaat1.PR

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage phenotype, suppressible by Axn^UAS.cUa, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has decreased cell number | adult stage phenotype, suppressible | partially by Axn^UAS.cUa, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has decreased cell number | adult stage phenotype, suppressible | partially by arm³/arm[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has abnormal locomotor behavior | adult stage phenotype, suppressible by Axn^UAS.cUa, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has abnormal locomotor behavior | adult stage phenotype, suppressible by arm³/arm[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has bang sensitive phenotype, suppressible by Axn^UAS.cUa, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has bang sensitive phenotype, suppressible by arm³/arm[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has abnormal neurophysiology | adult stage phenotype, suppressible by Axn^UAS.cUa, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Steinert et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neurophysiology phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Steinert et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^C164 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by Scer\GAL4^elav-C155/Rab11^UAS.EGFP

(Steinert et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, suppressible by cn³

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, suppressible by v^36f

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, suppressible by cn^KK101938, Scer\GAL4^elav-C155

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, suppressible by v^KK108195, Scer\GAL4^elav-C155

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, suppressible by cd¹

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has lethal phenotype, suppressible by PTP-ER^XE-2776

(Maher et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has some die during pupal stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Richards et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Richards et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Sod2^+t9/Cat^{Tag:Mito(Oat)}

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo has abnormal locomotor behavior phenotype, suppressible | partially by Bmcp^UAS.cBa, Scer\GAL4^repo

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo has bang sensitive phenotype, suppressible | partially by Bmcp^UAS.cBa, Scer\GAL4^repo

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo has short lived phenotype, suppressible by Bmcp^UAS.cBa, Scer\GAL4^repo

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible by Bmcp^UAS.cBa, Scer\GAL4^Eaat1.PR

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo has abnormal locomotor behavior phenotype, suppressible | partially by Hsap\UCP2^UAS.cFa, Scer\GAL4^repo

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo has bang sensitive phenotype, suppressible | partially by Hsap\UCP2^UAS.cFa, Scer\GAL4^repo

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo has short lived phenotype, suppressible by Hsap\UCP2^UAS.cFa, Scer\GAL4^repo

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible by Hsap\UCP2^UAS.cFa, Scer\GAL4^Eaat1.PR

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo has abnormal locomotor behavior phenotype, suppressible | partially by Glut1^UAS.cBa, Scer\GAL4^repo

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo has short lived phenotype, suppressible by Glut1^UAS.cBa, Scer\GAL4^repo

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Psa^UAS.cSa, Scer\GAL4^elav-C155

(Menzies et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible | progressive phenotype, suppressible by Hsp110^UAS.cZa, Scer\GAL4^GMR.PU

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^elav-C155

(Mallik and Lakhotia, 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has abnormal phototaxis phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has decreased cell number phenotype, suppressible by Akt^UAS.Exel, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has decreased cell number phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Akt^UAS.Exel, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, suppressible by Akt^UAS.Exel, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Akt^UAS.Exel, Scer\GAL4^repo.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible | partially by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Eaat1.PR

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has short lived phenotype, suppressible | partially by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^repo.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible | partially by DnaJ-1^UAS.cKa, Scer\GAL4^Eaat1.PR

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, suppressible | partially by mrj^UAS.cFa, Scer\GAL4^Eaat1.PR

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has visible | progressive phenotype, suppressible by htt^81aa.UAS, Scer\GAL4^GMR.PF

(Mugat et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has increased mortality phenotype, suppressible by HDAC1^5-5/Rpd3[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by HDAC1^5-5/Rpd3[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has increased mortality phenotype, suppressible by Sirt1¹⁷/Sir2[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by Sirt2^5B-2-35/Sirt2[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, suppressible by Zzzz\scFv^{C4.UAS.Tag:HA}, Scer\GAL4^elav-C155

(Wolfgang et al., 2005)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Zzzz\scFv^{C4.UAS.Tag:HA}, Scer\GAL4^elav-C155

(Wolfgang et al., 2005)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal phenotype, suppressible by Sin3A[+]/Sin3A⁰⁸²⁶⁹

(Steffan et al., 2001)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | progressive phenotype, suppressible by Sin3A[+]/Sin3A⁰⁸²⁶⁹

(Steffan et al., 2001)

NOT suppressed by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has abnormal eye color phenotype, non-suppressible by Hsap\PPM1B^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-suppressible by Hsap\PPM1B^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Hap40^ko3

(Xu et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has decreased cell number | adult stage phenotype, non-suppressible by Hap40^ko3

(Xu et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-suppressible by Rab8^UASp.YFP, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-suppressible by Rab8^{T22N.UASp.YFP}, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by Rab8^{T22N.UASp.YFP}, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by Pfk^UAS.cTa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, non-suppressible by Pfk^UAS.cTa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by G6pd^UAS.cLa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, park¹/park[+] has short lived phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, park¹/park[+] has abnormal neuroanatomy phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, non-suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Marf^RNAi.cUa.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, porin[+]/porin^k05123 has short lived phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, non-suppressible by park^UAS.Tag:MYC, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-suppressible by Glut1^d05758, Scer\GAL4^elav-C155

(Vittori et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-suppressible by Gcn5^UAS.cBa

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has short lived phenotype, non-suppressible by shg[+]/shg^k03401

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, non-suppressible by shg[+]/shg^k03401

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has lethal phenotype, non-suppressible by rl[+]/rl^10a

(Maher et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, non-suppressible by Bmcp^BG02446/Bmcp[+]

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, non-suppressible by Sod2^+t9/Cat^{Tag:Mito(Oat)}

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, non-suppressible by Bmcp^UAS.cBa, Scer\GAL4^elav-C155

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by Bmcp^UAS.cBa, Scer\GAL4^elav-C155

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has short lived phenotype, non-suppressible by Akt^UAS.Exel, Scer\GAL4^repo.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, non-suppressible by Akt^UAS.Exel, Scer\GAL4^Eaat1.PR

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has short lived phenotype, non-suppressible by rl^Sem.C.UAS, Scer\GAL4^repo.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by Akt^UAS.Exel, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Akt^UAS.Exel, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Akt^UAS.Exel, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by rl^Sem.C.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by rl^Sem.C.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, non-suppressible by rl^Sem.C.UAS, Scer\GAL4^Eaat1.PR

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR has short lived phenotype, non-suppressible by Tpr2^UAS.cKa, Scer\GAL4^Eaat1.PR

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by rl^Sem.C.UAS, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, non-suppressible by rl^Sem.C.UAS, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, non-suppressible by HDAC3^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived | calorie restriction conditional phenotype, non-suppressible by HDAC3^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, non-suppressible by HDAC4^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived | calorie restriction conditional phenotype, non-suppressible by HDAC4^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, non-suppressible by HDAC11^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived | calorie restriction conditional phenotype, non-suppressible by HDAC11^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has short lived | calorie restriction conditional phenotype, non-suppressible by HDAC1^5-5/Rpd3[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has increased mortality phenotype, non-suppressible by Sirt2^5B-2-35/Sirt2[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has increased mortality phenotype, non-suppressible by Sirt1^EP2300, Scer\GAL4^elav-C155

(Pallos et al., 2008)

NOT Suppressor of

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 is a non-suppressor of abnormal oxidative stress response phenotype of G6pd^UAS.cLa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Other

Statement

Reference

Cul1^GD9650, Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible phenotype

(Bhutani et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU, SkpA^GD16179 has lethal phenotype

(Bhutani et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU, SkpA^GD16179 has visible phenotype

(Bhutani et al., 2012)

Cul1^KK100827, Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has lethal phenotype

(Bhutani et al., 2012)

Cul1^KK100827, Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has visible phenotype

(Bhutani et al., 2012)

Cul1^GD9650, Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has lethal phenotype

(Bhutani et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, sgg^UAS.cBa has lethal phenotype

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, sgg^S9A.UAS has lethal phenotype

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU, esg^EP684 has lethal phenotype

(Cao et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere | decreased number phenotype, enhanceable by Rab8^{T22N.UASp.YFP}, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye phenotype, enhanceable by Rab8^{T22N.UASp.YFP}, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by jp^KK107921, Scer\GAL4^GMR.PU

(Calpena et al., 2018)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye disc | larval stage phenotype, enhanceable by Hsf^GD16368, Scer\GAL4^GMR.PU

(Maheshwari et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has photoreceptor neuron phenotype, enhanceable by Acn^KK111555, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has retina phenotype, enhanceable by Sirt1¹⁷

(Smith et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, enhanceable by Glut1^KK108683, Scer\GAL4^elav-C155

(Vittori et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by ATP7^GD3322, Scer\GAL4^GMR.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has rhabdomere phenotype, enhanceable by ATP7^GD3322, Scer\GAL4^GMR.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has ommatidium phenotype, enhanceable by Df(3L)iro-2/+

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, enhanceable by Df(3L)iro-2/+

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has ommatidium phenotype, enhanceable by Pcaf[+]/Gcn5^E333st

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, enhanceable by Pcaf[+]/Gcn5^E333st

(Bodai et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by Hsp110⁰⁰⁰⁸²/Hsc70Cb[+]

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by Hsp110^S031820/Hsc70Cb[+]

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by Hsc70Cb[+]/Hsp110^S064906

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by Hsc70Cb[+]/Hsp110^S004112

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by Nipped-A^NC116/Nipped-A[+]

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by Nipped-A[+]/Nipped-A^NC186

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, enhanceable by lncRNA:Hsrω^EP3037, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Dsp1^EP355, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Tl^EP1051, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by SNF4Aγ^EP3015b, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by P{EP}Pus7^EP595b, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by lncRNA:Hsrω⁰⁵²⁴¹/lncRNA:Hsrω⁰⁵²⁴¹

(Sengupta and Lakhotia, 2006)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye phenotype, enhanceable by Ubi-p63E[+]/Ubi-p63E^unspecified

(Steffan et al., 2004)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor phenotype, enhanceable by Ubi-p63E[+]/Ubi-p63E^unspecified

(Steffan et al., 2004)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^179Y has axon phenotype, enhanceable by Df(2R)k10408

(Gunawardena et al., 2003)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Appl.G1a has axon phenotype, enhanceable by Df(2R)k10408

(Gunawardena et al., 2003)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Appl.G1a has axon phenotype, enhanceable by Khc⁹

(Gunawardena et al., 2003)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^179Y has axon phenotype, enhanceable by Khc⁹

(Gunawardena et al., 2003)

NOT Enhanced by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Hsap\PPM1B^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye photoreceptor cell | adult stage | decreased number phenotype, non-enhanceable by Hap40^ko3

(Xu et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has photoreceptor neuron phenotype, non-enhanceable by Acn^{D527A.Tag:MYC}

(Nandi et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, non-enhanceable by Glut1^17J

(Vittori et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, non-enhanceable by htt^98E2

(Zhang et al., 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by EP1318^EP1318, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by EP1504^EP1504, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by CG2924[+]/CG2924^EY02142

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Sap130⁰⁶⁹²⁴/l(3)06924[+]

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Dyro^EP3405, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by cwo^EP3470, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Nep2^EP3549, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by P{EP}ckd^EP3041, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, non-enhanceable by HDAC3^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, non-enhanceable by HDAC3^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, non-enhanceable by HDAC4^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, non-enhanceable by HDAC4^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, non-enhanceable by HDAC11^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, non-enhanceable by HDAC11^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Suppressed by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Nil^HMC06011, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere | decreased number phenotype, suppressible by Rab8^UASp.YFP, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye phenotype, suppressible by Rab8^UASp.YFP, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere | decreased number phenotype, suppressible by Rab8^{Q67L.UASp.YFP}, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye phenotype, suppressible by Rab8^{Q67L.UASp.YFP}, Scer\GAL4^elav-C155

(Delfino et al., 2020)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | progressive phenotype, suppressible by jp^UAS, Scer\GAL4^GMR.PU

(Calpena et al., 2018)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has ommatidium phenotype, suppressible by Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has ommatidium phenotype, suppressible by Pfk^UAS.cTa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye photoreceptor cell phenotype, suppressible by Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye photoreceptor cell phenotype, suppressible by G6pd^UAS.cLa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has eye photoreceptor cell phenotype, suppressible | partially by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has mitochondrion phenotype, suppressible | partially by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has adult antennal lobe phenotype, suppressible | partially by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype, suppressible by mav^GL01025, Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye photoreceptor cell | adult stage | progressive phenotype, suppressible by mav^GL01025, Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by DJ-1α^UAS.cMa, Scer\GAL4^elav-C155

(Sajjad et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by dj-1β^UAS.cMa, Scer\GAL4^elav-C155

(Sajjad et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has retina phenotype, suppressible by Sirt1¹⁷/Sir2[+]

(Smith et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by Glut1^d05758, Scer\GAL4^elav-C155

(Vittori et al., 2014)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere | progressive phenotype, suppressible by Mmus\Gpx1^UAS.cMa, Scer\GAL4^elav-C155

(Mason et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^P2.4.Pdf has adult s-LNv neuron phenotype, suppressible by Mmus\Gpx1^UAS.cMa, Scer\GAL4^P2.4.Pdf

(Mason et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has rhabdomere phenotype, suppressible | partially by lid[+]/Kdm5¹⁰⁴²⁴

(Vashishtha et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ctr1B^NIG.7459R, Scer\GAL4^GMR.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by ATP7^EY07895, Scer\GAL4^GMR.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has rhabdomere phenotype, suppressible by Ctr1B^NIG.7459R, Scer\GAL4^GMR.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has rhabdomere phenotype, suppressible by ATP7^EY07895, Scer\GAL4^GMR.PU

(Xiao et al., 2013)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has eye photoreceptor cell phenotype, suppressible | partially by Axn^UAS.cUa, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has eye photoreceptor cell phenotype, suppressible | partially by arm³/arm[+]

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has dorsal longitudinal indirect flight muscle cell phenotype, suppressible by Axn^UAS.cUa, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU has giant fiber neuron phenotype, suppressible by Axn^UAS.cUa, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has NMJ bouton phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Steinert et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has synaptic vesicle phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Steinert et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by cn³

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by v^36f

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by cn^KK101938, Scer\GAL4^elav-C155

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by v^KK108195, Scer\GAL4^elav-C155

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by cb¹

(Campesan et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye photoreceptor cell phenotype, suppressible by PTP-ER^XE-2776

(Maher et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Richards et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has rhabdomere of eye photoreceptor cell phenotype, suppressible | partially by Sirt2^5B-2-35/Sirt2^5B-2-35

(Luthi-Carter et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has rhabdomere of eye photoreceptor cell phenotype, suppressible | partially by Sirt2^5B-2-35/Sirt2[+]

(Luthi-Carter et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | progressive phenotype, suppressible by Hsp110^UAS.cZa, Scer\GAL4^GMR.PU

(Zhang et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU has rhabdomere | progressive phenotype, suppressible by Mmus\Bag1^UAS.Tag:FLAG, Scer\GAL4^elav.PU

(Sroka et al., 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by svr^EP356, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by g^EP514, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by ATP7[+]/ATP7^EY07895

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by EP330^EP330, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by MESR4^EP386, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mub^EP3108, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by UbcD4[+]/Ubc4^EY05497

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by P{EP}ATP7^EP308, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by P{EP}RhoBTB^EP3099, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by P{EP}Atg1^EP3348, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by P{EP}Prps^EP3603, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by P{EP}CG2924^EP1596, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor phenotype, suppressible by Akt^UAS.Exel, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has adult mushroom body gamma-lobe phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, suppressible by Akt^UAS.Exel, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has eye | progressive phenotype, suppressible by htt^81aa.UAS, Scer\GAL4^GMR.PF

(Mugat et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, suppressible by HDAC1^5-5/Rpd3[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by HDAC1^5-5/Rpd3[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, suppressible by Sirt1¹⁷/Sir2[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by Sirt1¹⁷/Sir2[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, suppressible by Sirt2^5B-2-35/Sirt2[+]

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, suppressible by Zzzz\scFv^{C4.UAS.Tag:HA}, Scer\GAL4^elav-C155

(Wolfgang et al., 2005)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye phenotype, suppressible by Sumo^unspecified/smt3[+]

(Steffan et al., 2004)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor phenotype, suppressible by Sumo^unspecified/smt3[+]

(Steffan et al., 2004)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible by Sin3A[+]/Sin3A⁰⁸²⁶⁹

(Steffan et al., 2001)

NOT suppressed by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Hsap\PPM1B^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye photoreceptor cell | adult stage | decreased number phenotype, non-suppressible by Hap40^ko3

(Xu et al., 2022)

Hsap\HTT^Q93.ex1.UAS, Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 has eye photoreceptor cell phenotype, non-suppressible by Pfk^UAS.cTa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, park¹/park[+] has eye photoreceptor cell phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Marf^RNAi.cUa.UAS, Scer\GAL4^elav.PU has eye photoreceptor cell phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has eye photoreceptor cell phenotype, non-suppressible by rl[+]/rl^10a

(Maher et al., 2011)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^ey-OK107 has adult mushroom body gamma-lobe phenotype, non-suppressible by Bmcp^UAS.cBa, Scer\GAL4^ey-OK107

(Besson et al., 2010)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, non-suppressible by htt^98E2

(Zhang et al., 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by EP1318^EP1318, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by EP1504^EP1504, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by CG2924[+]/CG2924^EY02142

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Sap130⁰⁶⁹²⁴/l(3)06924[+]

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Dyro^EP3405, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by cwo^EP3470, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Nep2^EP3549, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by P{EP}ckd^EP3041, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has adult mushroom body gamma-lobe phenotype, non-suppressible by Akt^UAS.Exel, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has adult mushroom body gamma-lobe phenotype, non-suppressible by rl^Sem.C.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, non-suppressible by rl^Sem.C.UAS, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, non-suppressible by HDAC3^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, non-suppressible by HDAC3^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, non-suppressible by HDAC4^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, non-suppressible by HDAC4^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, non-suppressible by HDAC11^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has rhabdomere phenotype, non-suppressible by HDAC11^RNAi.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has photoreceptor neuron phenotype, non-suppressible by Zzzz\scFv^{D10.UAS.Tag:HA}, Scer\GAL4^elav-C155

(Wolfgang et al., 2005)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155 has adult optic lobe neuron phenotype, non-suppressible by Zzzz\scFv^{D10.UAS.Tag:HA}, Scer\GAL4^elav-C155

(Wolfgang et al., 2005)

Other

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU, SkpA^GD16179 has eye phenotype

(Bhutani et al., 2012)

Cul1^KK100827, Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype

(Bhutani et al., 2012)

Cul1^GD9650, Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU has eye phenotype

(Bhutani et al., 2012)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155, htt^98E2 has mushroom body phenotype

(Zhang et al., 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155, htt^98E2 has adult brain phenotype

(Zhang et al., 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155, htt^98E2 has adult mushroom body beta-lobe phenotype

(Zhang et al., 2009)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155, htt^98E2 has adult mushroom body alpha-lobe phenotype

(Zhang et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The age-progressive retinal degeneration manifested by patchy depigmentation of the adult eye characteristic for flies expressing Hsap\HTT^{Q93.ex1.Scer\UAS} under the control of Scer\GAL4^GMR.PU is ameliorated by co-expression of jp^UAS and exacerbated by co-expression of jp^KK107921.

(Calpena et al., 2018)

Co-expression of Hsap\SLC2A3^Scer\UAS.cBa extends the lifespan and ameliorates the climbing defects in flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

The disruption of ommatidial arrangements is markedly rescued in flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS} when Hsap\SLC2A3^Scer\UAS.cBa is co-expressed.

Overexpression of Pfk^Scer\UAS.cTa under the control of Scer\GAL4^elav-C155 does not change the survival of flies also expressing Hsap\HTT^{Q93.ex1p.Scer\UAS}. However, statistical analysis of pseudopupil data shows that Pfk^Scer\UAS.cTa overexpression prevents neurodegeneration at day and day 4.

Co-expression of Pfk^Scer\UAS.cTa has no additional effect on the survival or degeneration of photoreceptors in flies co-expressing Hsap\SLC2A3^Scer\UAS.cBa and Hsap\HTT^{Q93.ex1p.Scer\UAS} using Scer\GAL4^elav-C155.

Overexpression of Zw^Scer\UAS.cLa significantly extends lifespan and suppresses eye photoreceptor neurodegeneration in flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

Overexpression of Zw^Scer\UAS.cLa does not statistically change the survival of flies co-expressing Hsap\SLC2A3^Scer\UAS.cBa and Hsap\HTT^{Q93.ex1p.Scer\UAS} using Scer\GAL4^elav-C155.

12 day-old flies co-expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} and Zw^Scer\UAS.cLa under the control of Scer\GAL4^elav-C155 display a significantly enhanced resistance to oxidative stress compared with wild-type.

Co-expression of dhd^Scer\UAS.cUa significantly extends the lifespan of flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

Co-expression of Jafrac1^Scer\UAS.cHa significantly extends the lifespan of flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

(Besson et al., 2015)

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} significantly reduces mitochondrial spheroid formation in photoreceptor neurons. Pseudo-pupil analysis reveal that Pink1^{Scer\UAS.T:Ivir\HA1} overexpression markedly reduces photoreceptor loss in 1-day-old flies.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} results in the reduction of the number of degenerative neurons showing cytoplasmic vacuolization in the olfactory lobes. Pink1^{Scer\UAS.T:Ivir\HA1} significantly increases both mean and median survival of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS}.

Heterozygous Pink1^B9 does not decrease life span in flies expressing Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} in heterozygous park¹ flies which also express Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} fails to increase life span.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} in heterozygous park¹ flies which also express Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} fails to provide protection against photoreceptor degeneration.

Overexpression of Drp1^Scer\UAS.cDa in flies also expressing Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} results in an about 23% further reduction in lifespan.

Co-expression of Marf^{miRNA.cUa.Scer\UAS} results in a significant reduction of Pink1^{Scer\UAS.T:Ivir\HA1}-mediated neuronal rescue in Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} in the presence of heterozygous porin^k05123 fails to extend lifespan or suppress neuronal loss in flies also expressing Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

(Khalil et al., 2015)

Co-expression of mav^GL01025 ameliorates the rhabdomere and photoreceptor neuron loss seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

(Varadarajan et al., 2015)

Co-expression of Hsf^GD16368 exacerbates the formation of aggregates in the eye disc seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Maheshwari et al., 2014)

Knockdown of Acn, through expression of Acn^KK111555 under the control of Scer\GAL4^GMR.PF enhances the neuronal degeneration and depolarization seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS}.

In two week-old flies, one copy of Acn^t.D527A significantly improves the neuronal depolarization seen in Hsap\HTT^{Q93.ex1p.Scer\UAS}-expressing flies.

The build up of aggregates seen in two week-old Hsap\HTT^{Q93.ex1p.Scer\UAS}-expressing flies is reduced by the presence of one copy of Acn^t.D527A.

The build up of aggregates seen in two week-old Hsap\HTT^{Q93.ex1p.Scer\UAS}-expressing flies is reduced by the presence of one copy of Acn^{t.S641D.S731D}.

One copy of Acn^t.D527A does not affect the neuronal depolarization seen in 2 week old Hsap\HTT^{Q93.ex1p.Scer\UAS}-expressing flies.

(Nandi et al., 2014)

Expression of DJ-1α^Scer\UAS.cMa suppresses the rhabdomere degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of dj-1β^Scer\UAS.cMa suppresses the rhabdomere degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

(Sajjad et al., 2014)

When Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}-expressing animals are also heterozygous for Sir2¹⁷, the extent of neuronal loss is reduced and show improved motor function compared with siblings wild type Sir2. However, homozygous Sir2¹⁷ enhances the neuronal loss phenotype and exacerbates the defects in motor function.

(Smith et al., 2014)

Glut1^17J does not significantly enhance the rhabdomere loss seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155. The reduction in eclosion frequency is significantly enhanced.

Expression of Glut1^KK108683 enhances the rhabdomere loss and reduction in lifespan seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Expression of Glut1^d05758 partially suppresses the rhabdomere loss seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155. Eclosion rate is not significantly altered compared to expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} alone.

(Vittori et al., 2014)

Co-expression of Mmus\Gpx1^Scer\UAS.cMa partially suppresses the progressive photoreceptor rhabdomere degeneration seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Co-expression of Mmus\Gpx1^Scer\UAS.cMa suppresses the reduced locomotor activity seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Co-expression of Mmus\Gpx1^Scer\UAS.cMa completely suppresses the loss of the small lateral ventral neurons seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^P2.4.Pdf.

(Mason et al., 2013)

The loss of rhabdomere phenotype seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU is partially suppressed by lid¹⁰⁴²⁴/+.

(Vashishtha et al., 2013)

Co-expression of Ctr1B^NIG.7459R partially suppresses the mobility defects of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU.

Co-expression of ATP7^GD3322 enhances the mobility defects of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU.

Co-expression of either Ctr1B^NIG.7459R or ATP7^EY07895 partially suppresses loss of eye pigmentation and progressive loss of rhabdomeres seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Co-expression of ATP7^GD3322 enhances loss of eye pigmentation and progressive loss of rhabdomeres seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Co-expression of either ATP7^EY07895 or Ctr1B^NIG.7459R suppresses the aggregation of Hsap\HTT^{Q93.ex1p.Scer\UAS} protein seen in the brains of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU.

Co-expression of ATP7^GD3322 enhances the aggregation of Hsap\HTT^{Q93.ex1p.Scer\UAS} protein seen in the brains of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU.

(Xiao et al., 2013)

One copy of Pcaf^E333st enhances the reduction in eclosion rate seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. These flies have a relative eclosion rate of 49.4%. Pcaf^E333st/+ also enhances rhabdomere loss, with an average of 4.32 rhabdomeres per ommatidium.

One copy of Df(3L)iro-2 enhances the reduction in eclosion rate seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. These flies have a relative eclosion rate of 54%. Df(3L)iro-2/+ also enhances rhabdomere loss, with an average of 4.42 rhabdomeres per ommatidium.

One copy of nej³ enhances the reduction in eclosion rate seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. These flies have a relative eclosion rate of 67.3%.

One copy of enok² does not enhance the reduction in eclosion rate seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

One copy of mof² does not enhance the reduction in eclosion rate seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

One copy of Df(3R)Exel6259 does not enhance the reduction in eclosion rate seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Pcaf^Scer\UAS.cBa does not significantly suppress either the reduction in eclosion rate or the rhabdomere loss seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

(Bodai et al., 2012)

arm³/+ or arm^G0192/+ significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU or Scer\GAL4^Eaat1.PR. wg¹/+ or wg^Sp-1/+ or Wnt2^O/+ or Wnt2^I/+ or Wnt2^RJ/+ or pan³/+ (but not shg^k03401/+) significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU. Co-expression of Axn^Scer\UAS.cUa or Apc2^Scer\UAS.cUa or sgg^{Y214F.Scer\UAS} significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU. Co-expression of sgg^Scer\UAS.cBa or sgg^S9A.Scer\UAS leads to lethality in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU. pan³/+ or pan²/+ (but not shg^k03401/+) or co-expression of Axn^Scer\UAS.cUa significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^Eaat1.PR. Co-expression of Axn^Scer\UAS.cUa significantly suppresses the locomotor defects and photoreceptor loss seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU. arm³/+ significantly suppresses photoreceptor loss seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU. Co-expression of Axn^Scer\UAS.cUa or arm³/+ significantly suppresses the locomotor defects and bang sensitivity seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^repo.PU. Co-expression of Axn^Scer\UAS.cUa significantly suppresses neurophysiological defects seen in the giant fiber pathway of Scer\GAL4^repo.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies. Co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} significantly enhances the short lifespan seen in Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies.

(Dupont et al., 2012)

Expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} suppresses the reduction in average synaptic vesicle diameter seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} suppresses the reduction in eEJP and mEJP amplitudes seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155 to levels comparable with controls. No significant difference is seen in mEJP decay kinetics, mEJP frequency, mean resting membrane potential or quantal content compared to controls.

Expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} suppresses the third instar larval crawling defects seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^C164. The number of turns and distance travelled is comparable to controls.

(Steinert et al., 2012)

Homozygous cn³ partially suppresses the rhabdomere degeneration seen in one day old flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155. Some rescue, albeit reduced, is also seen at seven days post-eclosion. No rescue is seen with heterozygous cn³. The increase in 3-hydroxykynurenine (3-HK)/kynurenic acid (KYNA) ratio is also significantly suppressed, with flies exhibiting ratios that are similar to those seen in cn³ mutant flies alone. Unlike when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed alone, treating these flies with Ro 61-8048 is unable to further rescue the rhabdomere degeneration. Feeding the flies 3-HK suppresses the protective effect of cn³ in a dose-dependent manner; at the highest dose the level of rhabdomere degeneration is similar to that seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed alone. The 3-HK/KYNA ratio is also restored.

Homozygous v^36f partially suppresses the rhabdomere degeneration seen in one day old flies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. Some rescue, albeit reduced, is also seen at seven days post-eclosion. Partial rescue is also seen with v^36f/+. The increase in 3-hydroxykynurenine (3-HK)/kynurenic acid (KYNA) ratio is also significantly suppressed with either homozygous or heterozygous v^36f, with flies exhibiting ratios that are similar to those seen in homozygous v^36f mutant flies alone.

Expression of cn^KK101938 partially suppresses the rhabdomere degeneration seen in one day old flies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. Some rescue is seen at seven days post-eclosion. The increase in 3-hydroxykynurenine (3-HK)/kynurenic acid (KYNA) ratio is also significantly suppressed.

Expression of v^KK108195 partially suppresses the rhabdomere degeneration seen in one day old flies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. Some rescue is seen at seven days post-eclosion. The increase in 3-hydroxykynurenine (3-HK)/kynurenic acid (KYNA) ratio is also significantly suppressed.

cd¹ partially suppresses the rhabdomere degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155 at both one day and seven days post-eclosion. 3-hydroxykynurenine (3-HK) levels are unchanged but kynurenic acid (KYNA) levels are significantly increased, resulting in a significant increase in the 3-HK/KYNA ratio.

(Campesan et al., 2011)

The neuronal degeneration phenotype and decreased survival of animals expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 is not suppressed in a rl^10a/+ mutant background.

The decreased survival phenotype of flies expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 is enhanced in a Dsor1^G42/+ mutant background.

The neuronal degeneration phenotype and decreased survival of animals expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 is partially suppressed in a PTP-ER^XE-2776/+ background. A modest but not-significant suppression is also observed in a mts^XE-2258/+ or bsk¹/+ mutant background.

(Maher et al., 2011)

Overexpression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} almost completely suppresses the Hsap\HTT^{Q93.ex1p.Scer\UAS} eclosion phenotype, with a greater than twofold increase in emergence.

Overexpression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} gives a highly significant 43% suppression of the rhadomere degeneration seen upon expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Overexpression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} increases median survival of Hsap\HTT^{Q93.ex1p.Scer\UAS} by 50% from 10 to 15 days.

(Richards et al., 2011)

When Bmcp^Scer\UAS.cBa is co-expressed in the Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^repo background, locomotor defects are suppressed: 52% of flies reach the top of the column after a startle while <22% remain at the bottom.

When Bmcp^Scer\UAS.cBa is co-expressed in the Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^repo background, bang sensitivity is suppressed: only 23% of flies are bang sensitive.

Co-expression of Bmcp^Scer\UAS.cBa improves extends the lifespan of Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^repo flies: >78% of these flies are alive at 16 days, and life expectancy is increased by 23-25%.

Co-expression of Bmcp^Scer\UAS.cBa increases the life expectancy of Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^Eaat1.PR flies by 20%.

Heterozygosity for Bmcp^BG02446 does not affect the short adult life span phenotype of Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^Eaat1.PR flies.

Co-expression of Bmcp^Scer\UAS.cBa does not improve the climbing ability or lifespan phenotypes of Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^elav-C155 flies.

Co-expression of Bmcp^Scer\UAS.cBa does not restore the loss of mushroom body gamma lobes seen in Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^ey-OK107 flies.

When Hsap\UCP2^Scer\UAS.cFa is co-expressed in the Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^repo background, the locomotor (climbing ability), bang sensitivity and reduced life span phenotypes are all suppressed.

When Hsap\UCP2^Scer\UAS.cFa is co-expressed in the Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^Eaat1.PR background, the reduced life span phenotype is suppressed.

The presence of Sod2^+t9 and Cat^T:mito1 does not prevent the early death of adult flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^Eaat1.PR, but does improve the survival of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

When Glut1^Scer\UAS.cBa is co-expressed in the Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^repo background, the locomotor (climbing ability) and reduced life span phenotypes are suppressed.

(Besson et al., 2010)

The rhabdomere loss observed upon expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU is partially rescued by Sirt2^5B-2-35 homozygosity or heterozygosity, in a dose-dependent manner.

(Luthi-Carter et al., 2010)

Co-expression of Psa^Scer\UAS.cSa increases the lifespan of flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

Co-expression of Psa^NIG.1009R further shortens the lifespan of flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

(Menzies et al., 2010)

The eye degeneration phenotype caused by expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU is suppressed by co-expression of Hsc70Cb^Scer\UAS.cZa.

The eye degeneration phenotype caused by expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU is enhanced if the flies are also heterozygous for one of Hsc70Cb⁰⁰⁰⁸², Hsc70Cb^S031820, Hsc70Cb^S064906, Hsc70Cb^S004112, Nipped-A^NC116 or Nipped-A^NC186.

(Zhang et al., 2010)

Co-expression of two copies of P{Sym-UAS-Hsrω} substantially inhibits the age dependant degeneration of rhabdomeres seen in Hsap\HD^{Q93.ex1p.Scer\UAS}, Scer\GAL4^GMR.PF flies.

Co-expression of one or two copies of P{Sym-UAS-Hsrω} restores normal phototactic behaviour to Hsap\HD^{Q93.ex1p.Scer\UAS}, Scer\GAL4^GMR.PF flies.

Co-expression of a single copy of P{Sym-UAS-Hsrω} prolongs the lifespan of Scer\GAL4^elav-C155, Hsap\HD^{Q93.ex1p.Scer\UAS} flies such that it becomes comparable with controls.

(Mallik and Lakhotia, 2009)

Co-expression of Mmus\Bag1^{Scer\UAS.T:Zzzz\FLAG} significantly alleviates the Scer\GAL4^elav.PU, Hsap\HTT^{Q93.ex1p.Scer\UAS} rhabdomere phenotype, resulting in higher numbers and an organization resembling that of controls.

(Sroka et al., 2009)

The eye degeneration phenotype caused by expression of Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 is not enhanced in a htt^98E2 background (Df(3R)98E2 homozygotes in which CG9990 function has been rescued by P{CG9990^+t24.7}).

The initial hyperactivity phenotype of adults expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 is not seen in a htt^98E2 background. The decrease in mobility that is seen as adults expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 as they age is enhanced in a htt^98E2 background. The double mutant flies also show earlier lethality than animals expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 in a wild-type background.

The brains of adults expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 in a htt^98E2 background show a more severe pathology at 5 days of age compared to adults expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 in a wild-type background. The mushroom bodies appear less organised (the characteristic bulged tip of the vertical α-lobes is largely unrecognizable in 95% of cases and the clear separation between the pair of medially projected β-lobes is less distinct and often appears to be merged) and they are reduced in size compared to animals expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 in a wild-type background. The double mutant brains also have larger areas that are devoid of neuronal cells.

(Zhang et al., 2009)

Expression of Akt1^{Scer\UAS.Exel} strongly suppresses the pigment cell degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Akt1^{Scer\UAS.Exel} markedly slows down the progressive photoreceptor degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Akt1^{Scer\UAS.Exel} does not suppress the γ-lobe kenyon cell degeneration seen in the mushroom bodies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Akt1^{Scer\UAS.Exel} does not suppress the reduction in lifespan seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of any of Scer\GAL4^elav-C155, Scer\GAL4^repo.PU or Scer\GAL4^Eaat1.PR.

Expression of Akt1^{Scer\UAS.Exel} does not suppress the locomotor defects seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. The locomotor defects seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^repo.PU are partially suppressed.

Expression of rl^{Sem.C.Scer\UAS} does not suppress the pigment cell degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of rl^{Sem.C.Scer\UAS} does not suppress the γ-lobe kenyon cell degeneration seen in the mushroom bodies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of rl^{Sem.C.Scer\UAS} does not suppress the reduction in lifespan seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of any of Scer\GAL4^elav-C155, Scer\GAL4^repo.PU or Scer\GAL4^Eaat1.PR.

Expression of Hsap\HSPA1L^Scer\UAS.cWa suppresses the pigment cell degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsap\HSPA1L^Scer\UAS.cWa significantly delays the progressive photoreceptor degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the reduction in life expectancy seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of any of Scer\GAL4^elav-C155, Scer\GAL4^repo.PU or Scer\GAL4^Eaat1.PR.

Expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the locomotor defects seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^repo.PU.

Expression of DnaJ-1^Scer\UAS.cKa partially suppresses the reduction in life expectancy seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^Eaat1.PR.

Expression of mrj^Scer\UAS.cFa partially suppresses the reduction in life expectancy seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^Eaat1.PR.

Expression of Tpr2^Scer\UAS.cKa partially suppresses the reduction in life expectancy seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^Eaat1.PR.

Expression of Hsap\HSPA1L^Scer\UAS.cWa suppresses the γ-lobe kenyon cell degeneration seen in the mushroom bodies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

(Liévens et al., 2008)

Co-expression of Hdac3^{dsRNA.Scer\UAS} does not affect the level of survival to eclosion or neurodegeneration in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Co-expression of HDAC4^{dsRNA.Scer\UAS} does not affect the level of survival to eclosion or neurodegeneration in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Co-expression of HDAC6^{dsRNA.Scer\UAS.cPa} does not affect the level of survival to eclosion or neurodegeneration in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Co-expression of HdacX^{dsRNA.Scer\UAS.cPa} does not affect the level of survival to eclosion or neurodegeneration in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

A heterozygous Rpd3^5-5 background markedly increases the survival rate of flies neuronally-expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} flies (from <10% to nearer 35% survival to eclosion). In addition, the level of neurodegeneration, as measured by the ratio of rhabdomeres per ommatidia, is also lowered in a Rpd3^5-5 heterozygous background.

A heterozygous Sir2¹⁷ background markedly increases the survival rate of flies neuronally-expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} flies (from <10% to nearer 35% survival to eclosion). In addition, the level of neurodegeneration, as measured by the ratio of rhabdomeres per ommatidia, is also lowered in a Sir2¹⁷ heterozygous background.

A reduction in the level of Sirt2, through a Sirt2^5B-2-35 heterozygous background, leads to greater survival of photoreceptor neurons in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155, although this background does not suppress lethality.

A Rpd3^5-5 heterozygous background does not affect the short lifespan found in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

Overexpression of Sir2^EP2300 does not reduce the lethality associated with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} (when both are driven by Scer\GAL4^elav-C155). Addition of resveratrol to food fed to these 'double mutant' flies rescues the neuronal degeneration phenotype found in these flies, in a dose-dependent manner.

(Pallos et al., 2008)

The eye degeneration phenotype caused by expression of Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by Hsrω⁰⁵²⁴¹/Hsrω⁰⁵²⁴¹.

(Sengupta and Lakhotia, 2006)

Co-expression with Zzzz\scFv^{C4.UAS.Tag:HA} rescues adult survival of Hsap\HTT^Q93.ex1.UAS; Scer\GAL4^elav-C155 animals to 100%. The mean and median survival time for Hsap\HTT^Q93.ex1.UAS adults co-expressing Zzzz\scFv^{C4.UAS.Tag:HA}, under the control of Scer\GAL4^elav-C155, compared to flies expressing solely Hsap\HTT^Q93.ex1.UAS is increased significantly, with increases ranging from 30% to 50%. Maximum lifespan is also significantly improved, although not to that of wild-type levels. Genetically doubling the dose of Zzzz\scFv^{C4.UAS.Tag:HA} produces no further improvement in survival.

Co-expression of Zzzz\scFv^{C4.UAS.Tag:HA} partially suppresses the age-dependent loss of photoreceptor cells seen in Hsap\HTT^Q93.ex1.UAS; Scer\GAL4^elav-C155 flies.

Co-expression of Zzzz\scFv^{D10.UAS.Tag:HA} does not suppress the age-dependent loss of photoreceptor cells caused by expression of Hsap\HTT^Q93.ex1.UAS under the control of Scer\GAL4^elav-C155.

(Wolfgang et al., 2005)

Neuropathology of Hsap\HD^{Q93.ex1p.Scer\UAS} is reduced when SUMO activity is reduced, and increased, though only slightly, when flies are heterozygous for a mutation in Ubi-p63E.

(Steffan et al., 2004)

Sin3A⁰⁸²⁶⁹/+ increases the viability of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 from 29% to 69% and reduces the extent and rate of neurodegeneration seen in these flies.

(Steffan et al., 2001)

Complementation and Rescue Data

Rescued by

Hsap\HTT^Q93.ex1.UAS is rescued by Scer\GAL4^elav-C155/Zzzz\scFv^{C4.UAS.Tag:HA}

(Bortvedt et al., 2010)

Comments

Co-expression of Hsap\HD^{C4sFv.Scer\UAS.T:Ivir\HA1} confers significantly improved survival on Hsap\HD^{Q93.ex1p.Scer\UAS} flies.

(Bortvedt et al., 2010)

Co-expression of Hsap\HD^{Q20.ex1p.Scer\UAS} with Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^ninaE.PD results in an increase of cells with nuclear inclusions at days 5 and 6, compared to expression of just Hsap\HD^{Q93.ex1p.Scer\UAS} alone. By day 10, almost all cell nuclei in flies expressing both Hsap\HD^{Q20.ex1p.Scer\UAS} and Hsap\HD^{Q93.ex1p.Scer\UAS} contain inclusions.

Co-expression of Hsap\HD^{Q20.ex1p.Scer\UAS} with Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^ninaE.PD increases the speed and severity of neuronal degeneration compared to expression of Hsap\HD^{Q93.ex1p.Scer\UAS} alone (under the control of Scer\GAL4^ninaE.PD), with an average of only 4.7 rhabdomeres per ommatidium remaining.

(Slepko et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

68418

w^*; P{UAS-HTT.ex1.Q93}4F1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

HTTex1

(Quinti et al., 2016)

Hsap\HD^{Q93.ex1p.Scer\UAS}

Hsap\HTT^{Q93.ex1.Scer\UAS}

Hsap\HTT^Q93.ex1.UAS

Hsap\HTT^{Q93.ex1p.Scer\UAS}

Httex1-93Q

(Steffan et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (95)

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