Allele Scer\GAL4^{elav.Switch.PO}

General Information
Symbol	Scer\GAL4^{elav.Switch.PO}	Species	S. cerevisiae
Name		FlyBase ID	FBal0128065
Feature type	allele	Associated gene	Scer\GAL4

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
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FB2013_03	New/Merged/Split Record This record was either newly added to FlyBase for this release or is the result of merging or splitting existing records in this release
FB2013_02	Controlled Vocabulary Terms nucleus
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Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Osterwalder et al., 2001, Osterwalder et al., 2001) in vitro construct - regulatory fusion (Osterwalder et al., 2001, Osterwalder et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: A 3.5kb fragment of the elav gene (including the elav promoter and the 5' UTR exons 0 and 1) drives expression of the "GeneSwitch" protein which consists of the Scer\GAL4 DNA binding domain tagged with T:Hsap\PGR^LBD (the ligand binding domain of T:Hsap\PGR) and T:Hsap\RELA^AD (the activation domain of T:Hsap\RELA). (Osterwalder et al., 2001)
Carried in construct	P{elav-Switch.O} (Martin-Lanneree et al., 2006, Murthy et al., 2003, Poirier et al., 2008, Sanyal et al., 2002, Kaufmann et al., 2002, Osterwalder et al., 2001, Osterwalder et al., 2001, Osterwalder et al., 2001, Mosca et al., 2005, Xu et al., 2008, van Swinderen, 2007, Pandey et al., 2007, Hwangbo et al., 2004, Bushey et al., 2009, Chang et al., 2003, Hekmat-Scafe et al., 2005, Rogina and Helfand, 2004, Sherwood et al., 2004, Wang et al., 2003, Joiner et al., 2006, Bauer et al., 2005, Bauer et al., 2005, Wu et al., 2005, Tian et al., 2011, Cheng et al., 2011, Kanao et al., 2010, Miguel et al., 2012, Chung et al., 2010, Kanao et al., 2012, Wang et al., 2012, Naganos et al., 2012, Wu et al., 2007, Tsuda et al., 2007, Furukawa et al., 2009, van Swinderen et al., 2009, Ford et al., 2007, Ingleby et al., 2009, Graf et al., 2009, Kurusu et al., 2009, Wu et al., 2009, Donlea et al., 2009, Haussmann et al., 2008, Ishimoto et al., 2009, Batlevi et al., 2010, Copeland et al., 2009, Khurana et al., 2006, Miguel et al., 2011, Tsurudome et al., 2010, Shen et al., 2009, Tricoire et al., 2009, Fridell et al., 2005, Ma et al., 2011, Liu et al., 2011, Bahadorani et al., 2010, Plyusnina et al., 2011, Lanson et al., 2011, Du et al., 2010, Murthy et al., 2005, Ball et al., 2010, Knight et al., 2010, Inagaki et al., 2012, Neckameyer, 2010, Neckameyer and Bhatt, 2012, Crocker et al., 2010, Luo and Sehgal, 2012, Sarkar et al., 2010, Pfeiffenberger and Allada, 2012, Rera et al., 2011, Brandt et al., 2008, Humphrey et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	behavior defective \| RU486 conditional, with Mmus\Pkaca^mC.Scer\UAS (Joiner et al., 2006) behavior defective \| RU486 conditional, with Pka-R1^BDK.Scer\UAS (Wu et al., 2009) cell cycle defective \| larval stage, with tll^Scer\UAS.cKa (Kurusu et al., 2009) cell cycle defective \| pupal stage, with tll^Scer\UAS.cKa (Kurusu et al., 2009) chemical resistant \| RU486 conditional, with hep^Scer\UAS.cBa (Wang et al., 2003) chemical resistant \| RU486 conditional, with p53^259H.GUS (Bauer et al., 2005) chemical resistant \| RU486 conditional, with p53^Ct.GUS (Bauer et al., 2005) courtship behavior defective \| RU486 conditional, with EcR^{dsRNA.Scer\UAS.cIa} (Ishimoto et al., 2009) hyperactive \| RU486 conditional, with Sh^{SDN.Scer\UAS.T:Avic\GFP-GL} (Mosca et al., 2005) increased cell death, with rpr^Scer\UAS.C (Khurana et al., 2006) learning defective \| RU486 conditional, with sra^Scer\UAS.cCa (Chang et al., 2003) lethal \| embryonic stage, with Hsap\TARDBP^{M.Scer\UAS.T:Zzzz\FLAG} (Miguel et al., 2011) lethal \| embryonic stage, with Hsap\TARDBP^{mutNES.Scer\UAS} (Miguel et al., 2011) lethal \| embryonic stage, with Hsap\TARDBP^{mutNLS.Scer\UAS} (Miguel et al., 2011) lethal \| pupal stage \| RU486 conditional, with ewg^Scer\UAS.cHa (Haussmann et al., 2008) lethal \| RU486 conditional, with Ctet\TeTxLC^TNT.Scer\UAS (Osterwalder et al., 2001) lethal \| RU486 conditional, with Hsap\UCP3^Scer\UAS.cHa (Humphrey et al., 2009) locomotor behavior defective \| adult stage \| RU486 conditional, with for^P1.Scer\UAS (Kanao et al., 2012) locomotor behavior defective \| adult stage \| RU486 conditional, with Mgat1^{dsRNA.h-h.Scer\UAS} (Sarkar et al., 2010) locomotor behavior defective \| adult stage \| RU486 conditional, with Mgat1^{dsRNA.t-t.Scer\UAS} (Sarkar et al., 2010) locomotor behavior defective \| RU486 conditional, with Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} (Lanson et al., 2011) locomotor behavior defective \| RU486 conditional, with Hsap\FUS^{Scer\UAS.T:Ivir\HA1} (Lanson et al., 2011) locomotor rhythm defective, with cyc^DN.Scer\UAS (Xu et al., 2008) locomotor rhythm defective \| RU486 conditional, with Gadd45^{Scer\UAS.P\T.cPa} (Plyusnina et al., 2011) locomotor rhythm defective \| RU486 conditional, with hop^Tum.Scer\UAS (Luo and Sehgal, 2012) locomotor rhythm defective \| RU486 conditional, with mir-279^Scer\UAS.L (Luo and Sehgal, 2012) locomotor rhythm defective \| RU486 conditional, with mir-279^Scer\UAS.S (Luo and Sehgal, 2012) locomotor rhythm defective \| RU486 conditional, with os^Scer\UAS.cUa (Luo and Sehgal, 2012) long lived \| female \| RU486 conditional, with CG9172^GD13310 (Copeland et al., 2009) long lived \| female \| RU486 conditional, with CG18809^GD9655 (Copeland et al., 2009) long lived \| female \| RU486 conditional, with l(3)neo18^GD3876 (Copeland et al., 2009) long lived \| RU486 conditional, with Eip71CD^Scer\UAS.cCa (Chung et al., 2010) long lived \| RU486 conditional, with Gadd45^{Scer\UAS.P\T.cPa} (Plyusnina et al., 2011) long lived \| RU486 conditional, with Hsap\UCP2^Scer\UAS.cFa (Fridell et al., 2005) long lived \| RU486 conditional, with Hsap\UCP3^Scer\UAS.cHa (Humphrey et al., 2009) long lived \| RU486 conditional, with Mgat1^Scer\UAS.cSa (Sarkar et al., 2010) long lived \| RU486 conditional, with p53^259H.GUS (Bauer et al., 2005) long lived \| RU486 conditional, with p53^Ct.GUS (Bauer et al., 2005) long lived \| RU486 conditional, with Scer\NDI1^Scer\UAS.cBa (Bahadorani et al., 2010) long lived \| RU486 conditional, with Sir2^EP2300 (Rogina and Helfand, 2004) memory defective \| RU486 conditional, with EcR^{dsRNA.Scer\UAS.cIa} (Ishimoto et al., 2009) neuroanatomy defective, with hiw^{Scer\UAS.T:Zzzz\TAP} (Wu et al., 2005) neuroanatomy defective, with hiw^{ΔRING.Scer\UAS.T:Zzzz\TAP} (Wu et al., 2005) neuroanatomy defective \| larval stage \| RU486 conditional, with ewg^Scer\UAS.cHa (Haussmann et al., 2008) neuroanatomy defective \| RU486 conditional, with Lar^{cyto.Scer\UAS} (Kaufmann et al., 2002) neuroanatomy defective \| third instar larval stage, with Rac1^{Scer\UAS.T:Hsap\MYC} (Ball et al., 2010) neurophysiology defective, with brp^{Scer\UAS.T:Avic\GFP} (Tsurudome et al., 2010) neurophysiology defective \| RU486 conditional, with Sh^{SDN.Scer\UAS.T:Avic\GFP-GL} (Mosca et al., 2005) oxidative stress response defective \| adult stage \| RU486 conditional, with Mgat1^Scer\UAS.cSa (Sarkar et al., 2010) short lived \| drug conditional, with SdhC^{I71E.Scer\UAS} (Tsuda et al., 2007) short lived \| RU486 conditional, with BacA\p35^Scer\UAS.cHa (Shen et al., 2009) short lived \| RU486 conditional, with for^P1.Scer\UAS (Kanao et al., 2012) short lived \| RU486 conditional, with Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} (Martin-Lanneree et al., 2006) short lived \| RU486 conditional, with Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} (Lanson et al., 2011) short lived \| RU486 conditional, with Hsap\FUS^{Scer\UAS.cMa.T:Ivir\HA1} (Miguel et al., 2012) short lived \| RU486 conditional, with Hsap\FUS^{Scer\UAS.T:Ivir\HA1} (Lanson et al., 2011) short lived \| RU486 conditional, with Hsap\TARDBP^{M.Scer\UAS.T:Zzzz\FLAG} (Miguel et al., 2011) short lived \| RU486 conditional, with Hsap\TARDBP^{mutNES.Scer\UAS} (Miguel et al., 2011) short lived \| RU486 conditional, with Hsap\TARDBP^{mutNLS.Scer\UAS} (Miguel et al., 2011) short lived \| RU486 conditional, with Hsap\UCP3^Scer\UAS.cHa (Humphrey et al., 2009) short lived \| RU486 conditional, with Mgat1^{dsRNA.h-h.Scer\UAS} (Sarkar et al., 2010) short lived \| RU486 conditional, with Mgat1^{dsRNA.t-t.Scer\UAS} (Sarkar et al., 2010) short lived \| RU486 conditional, with Pten^Scer\UAS.cGb (Ford et al., 2007) size defective \| third instar larval stage, with Rac1^{Scer\UAS.T:Hsap\MYC} (Ball et al., 2010) sleep defective \| RU486 conditional, with Cul-3^NIG.11861R, Dcr-2^Scer\UAS.cDa (Pfeiffenberger and Allada, 2012) sleep defective \| RU486 conditional, with inc^KK108908 (Pfeiffenberger and Allada, 2012) stress response defective \| RU486 conditional, with Hsap\UCP2^Scer\UAS.cFa (Fridell et al., 2005) uncoordinated \| RU486 conditional, with Sh^{SDN.Scer\UAS.T:Avic\GFP-GL} (Mosca et al., 2005) viable, with Ctet\TeTxLC^TNT.Scer\UAS (Osterwalder et al., 2001) viable, with Hsap\UCP3^Scer\UAS.cHa (Humphrey et al., 2009) viable \| RU486 conditional, with Sh^{SDN.Scer\UAS.T:Avic\GFP-GL} (Mosca et al., 2005)
Phenotype Manifest In
	adult brain, with rpr^Scer\UAS.C (Khurana et al., 2006) bouton \| supernumerary \| RU486 conditional, with Lar^{cyto.Scer\UAS} (Kaufmann et al., 2002) brain, with kuk^{Scer\UAS.P\T.cBa} (Brandt et al., 2008) brain, with Lam^Scer\UAS.cGa (Brandt et al., 2008) brain \| larval stage, with tll^Scer\UAS.cKa (Kurusu et al., 2009) brain \| pupal stage, with tll^Scer\UAS.cKa (Kurusu et al., 2009) embryonic/larval neuromuscular junction, with hiw^{HindIII.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^{HindIII.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, hiw^ND8 (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^ND8/hiw^{HindIII.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^ND8/hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^ND8/hiw^{ΔPHR.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^ND8/hiw^{ΔRCC1.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^{ΔN.Scer\UAS.T:Zzzz\TAP}, hiw^ND8 (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^{ΔPHR.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^{ΔPHR.Scer\UAS.T:Zzzz\TAP}, hiw^ND8 (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^{ΔRCC1.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) embryonic/larval neuromuscular junction, with hiw^{ΔRCC1.Scer\UAS.T:Zzzz\TAP}, hiw^ND8 (Tian et al., 2011) embryonic/larval neuromuscular junction \| RU486 conditional, with ewg^Scer\UAS.cHa (Haussmann et al., 2008) embryonic/larval neuromuscular junction \| third instar larval stage, with Rac1^{Scer\UAS.T:Hsap\MYC} (Ball et al., 2010) mitochondrion \| RU486 conditional, with Hsap\UCP2^Scer\UAS.cFa (Fridell et al., 2005) neuromuscular junction, with hiw^{Scer\UAS.T:Zzzz\TAP} (Wu et al., 2005) neuromuscular junction, with hiw^{ΔRING.Scer\UAS.T:Zzzz\TAP} (Wu et al., 2005) neuromuscular junction \| RU486 conditional, with Lar^{cyto.Scer\UAS} (Kaufmann et al., 2002) NMJ bouton, with hiw^{HindIII.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} (Tian et al., 2011) NMJ bouton, with hiw^{HindIII.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, hiw^ND8 (Tian et al., 2011) NMJ bouton, with hiw^ND8/hiw^{HindIII.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} (Tian et al., 2011) NMJ bouton, with hiw^ND8/hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) NMJ bouton, with hiw^ND8/hiw^{ΔPHR.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) NMJ bouton, with hiw^ND8/hiw^{ΔRCC1.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) NMJ bouton, with hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) NMJ bouton, with hiw^{ΔN.Scer\UAS.T:Zzzz\TAP}, hiw^ND8 (Tian et al., 2011) NMJ bouton, with hiw^{ΔPHR.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) NMJ bouton, with hiw^{ΔPHR.Scer\UAS.T:Zzzz\TAP}, hiw^ND8 (Tian et al., 2011) NMJ bouton, with hiw^{ΔRCC1.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) NMJ bouton, with hiw^{ΔRCC1.Scer\UAS.T:Zzzz\TAP}, hiw^ND8 (Tian et al., 2011) NMJ bouton \| RU486 conditional, with ewg^Scer\UAS.cHa (Haussmann et al., 2008) nucleus \| adult stage, with kuk^{Scer\UAS.P\T.cBa} (Brandt et al., 2008) nucleus \| adult stage, with Lam^Scer\UAS.cGa (Brandt et al., 2008) synapse, with hiw^{HindIII.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} (Tian et al., 2011) synapse, with hiw^{HindIII.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, hiw^ND8 (Tian et al., 2011) synapse, with hiw^ND8/hiw^{HindIII.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} (Tian et al., 2011) synapse, with hiw^ND8/hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) synapse, with hiw^ND8/hiw^{ΔPHR.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) synapse, with hiw^ND8/hiw^{ΔRCC1.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) synapse, with hiw^{Scer\UAS.T:Zzzz\TAP} (Wu et al., 2005) synapse, with hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) synapse, with hiw^{ΔN.Scer\UAS.T:Zzzz\TAP}, hiw^ND8 (Tian et al., 2011) synapse, with hiw^{ΔPHR.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) synapse, with hiw^{ΔPHR.Scer\UAS.T:Zzzz\TAP}, hiw^ND8 (Tian et al., 2011) synapse, with hiw^{ΔRCC1.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011) synapse, with hiw^{ΔRCC1.Scer\UAS.T:Zzzz\TAP}, hiw^ND8 (Tian et al., 2011) synapse, with hiw^{ΔRING.Scer\UAS.T:Zzzz\TAP} (Wu et al., 2005) terminal bouton, with hiw^{Scer\UAS.T:Zzzz\TAP} (Wu et al., 2005) terminal bouton, with hiw^{ΔRING.Scer\UAS.T:Zzzz\TAP} (Wu et al., 2005)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Scer\GAL4^{elav.Switch.PO}, for^P1.Scer\UAS, foxo^Scer\UAS.cPa has locomotor behavior defective \| adult stage \| RU486 conditional phenotype, enhanceable \| RU486 conditional by Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO} (Kanao et al., 2012, Kanao et al., 2012) Scer\GAL4^{elav.Switch.PO}, for^P1.Scer\UAS, foxo^Scer\UAS.cPa has neuroanatomy defective \| adult stage \| RU486 conditional phenotype, enhanceable \| RU486 conditional by Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO} (Kanao et al., 2012, Kanao et al., 2012)
Suppressed by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} has short lived \| RU486 conditional phenotype, suppressible \| partially by Mlf^Scer\UAS.cFa, Scer\GAL4^{elav.Switch.PO} (Martin-Lanneree et al., 2006, Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} has short lived \| RU486 conditional phenotype, suppressible \| partially by Mlf^Scer\UAS.cKa, Scer\GAL4^{elav.Switch.PO} (Martin-Lanneree et al., 2006, Martin-Lanneree et al., 2006) Hsap\FUS^{Scer\UAS.cMa.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} has short lived \| RU486 conditional phenotype, suppressible \| RU486 conditional by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^{elav.Switch.PO} (Miguel et al., 2012, Miguel et al., 2012) Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO}, foxo^Scer\UAS.cKb has neuroanatomy defective \| adult stage \| RU486 conditional phenotype, suppressible by W[+]/W¹ (Kanao et al., 2010) Rac1^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^{elav.Switch.PO} has neuroanatomy defective \| third instar larval stage phenotype, suppressible by Mad^k00237/Mad¹ (Ball et al., 2010) Scer\GAL4^{elav.Switch.PO}, brp^{Scer\UAS.T:Avic\GFP} has neurophysiology defective phenotype, suppressible by Df(2R)Exel6285/+ (Tsurudome et al., 2010) Scer\GAL4^{elav.Switch.PO}, for^P1.Scer\UAS has locomotor behavior defective \| adult stage \| RU486 conditional phenotype, suppressible \| partially by foxo²¹/foxo[+] (Kanao et al., 2012) Scer\GAL4^{elav.Switch.PO}, for^P1.Scer\UAS has short lived \| RU486 conditional phenotype, suppressible \| partially by foxo²¹/foxo[+] (Kanao et al., 2012) Scer\GAL4^{elav.Switch.PO}, pros^Scer\UAS.cMa has cell cycle defective \| larval stage phenotype, suppressible by Scer\GAL4^{elav.Switch.PO}, pros^Scer\UAS.cMa (Kurusu et al., 2009, Kurusu et al., 2009) Scer\GAL4^{elav.Switch.PO}, Sh^{SDN.Scer\UAS.T:Avic\GFP-GL} has hyperactive \| RU486 conditional phenotype, suppressible by mle^nap-ts1 (Mosca et al., 2005) Scer\GAL4^{elav.Switch.PO}, Sh^{SDN.Scer\UAS.T:Avic\GFP-GL} has uncoordinated \| RU486 conditional phenotype, suppressible by mle^nap-ts1 (Mosca et al., 2005) Scer\GAL4^{elav.Switch.PO}, tll^Scer\UAS.cKa has cell cycle defective \| larval stage phenotype, suppressible by Scer\GAL4^{elav.Switch.PO}/pros^Scer\UAS.cMa (Kurusu et al., 2009, Kurusu et al., 2009)
NOT suppressed by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} has short lived \| RU486 conditional phenotype, non-suppressible by Mlf[+]/Mlf^ΔC1 (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} has short lived \| RU486 conditional phenotype, non-suppressible by Mlf^Δ5-3/Mlf[+] (Martin-Lanneree et al., 2006)
Enhancer of
Statement Reference Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO} is an enhancer \| RU486 conditional of locomotor behavior defective \| adult stage \| RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, for^P1.Scer\UAS, foxo^Scer\UAS.cPa (Kanao et al., 2012, Kanao et al., 2012) Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO} is an enhancer \| RU486 conditional of neuroanatomy defective \| adult stage \| RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, for^P1.Scer\UAS, foxo^Scer\UAS.cPa (Kanao et al., 2012, Kanao et al., 2012) Scer\GAL4^{elav.Switch.PO}/dnc^Scer\UAS.cCa is an enhancer of neurophysiology defective \| recessive \| third instar larval stage phenotype of Ent2^P124 (Knight et al., 2010)
Suppressor of
Statement Reference Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^{elav.Switch.PO} is a suppressor \| RU486 conditional of short lived \| RU486 conditional phenotype of Hsap\FUS^{Scer\UAS.cMa.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} (Miguel et al., 2012, Miguel et al., 2012) Mlf^Scer\UAS.cFa, Scer\GAL4^{elav.Switch.PO} is a suppressor \| partially of short lived \| RU486 conditional phenotype of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} (Martin-Lanneree et al., 2006, Martin-Lanneree et al., 2006) Mlf^Scer\UAS.cKa, Scer\GAL4^{elav.Switch.PO} is a suppressor \| partially of short lived \| RU486 conditional phenotype of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} (Martin-Lanneree et al., 2006, Martin-Lanneree et al., 2006) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{L44.Scer\UAS.T:Avic\GFP-CFP}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of eclosion defective phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{L44.Scer\UAS.T:Avic\GFP-CFP}, Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of eclosion defective phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{L44.Scer\UAS.T:Avic\GFP-CFP}, Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of locomotor behavior defective \| adult stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus}, Hsap\SPAST^Q45.Scer\UAS is a suppressor \| partially of eclosion defective phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus}, Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of eclosion defective phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus}, Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of locomotor behavior defective \| adult stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, pros^Scer\UAS.cMa is a suppressor of cell cycle defective \| larval stage phenotype of Scer\GAL4^{elav.Switch.PO}, pros^Scer\UAS.cMa (Kurusu et al., 2009, Kurusu et al., 2009) Scer\GAL4^{elav.Switch.PO}/esg^EP2009 is a suppressor \| RU486 conditional \| partially of bang sensitive phenotype of eas² (Hekmat-Scafe et al., 2005) Scer\GAL4^{elav.Switch.PO}/Hsap\SPAST^{L44.Scer\UAS.T:Avic\GFP-CFP} is a suppressor \| partially of eclosion defective phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}/Hsap\SPAST^Q45.Scer\UAS is a suppressor \| partially of eclosion defective phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}/Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of eclosion defective phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}/Hsap\SPAST^{R431STOP.Scer\UAS} is a suppressor \| partially of eclosion defective phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}/Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of eclosion defective phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}/pros^Scer\UAS.cMa is a suppressor of cell cycle defective \| larval stage phenotype of Scer\GAL4^{elav.Switch.PO}, tll^Scer\UAS.cKa (Kurusu et al., 2009, Kurusu et al., 2009)
NOT Suppressor of
Statement Reference Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{L44.Scer\UAS.T:Avic\GFP-CFP}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus} is a non-suppressor of locomotor behavior defective \| adult stage phenotype of spas^5.75 (Du et al., 2010)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^{elav.Switch.PO}, for^P1.Scer\UAS, foxo^Scer\UAS.cPa has eye \| RU486 conditional phenotype, enhanceable \| RU486 conditional by Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO} (Kanao et al., 2012, Kanao et al., 2012)
Suppressed by
Statement Reference Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO}, foxo^Scer\UAS.cKb has dopaminergic neuron \| RU486 conditional phenotype, suppressible by W[+]/W¹ (Kanao et al., 2010) Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO}, foxo^Scer\UAS.cKb has dopaminergic PPL1 neuron \| RU486 conditional phenotype, suppressible by W[+]/W¹ (Kanao et al., 2010) Scer\GAL4^{elav.Switch.PO}, hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} has embryonic/larval neuromuscular junction phenotype, suppressible by Rae1^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^{elav.Switch.PO} (Tian et al., 2011, Tian et al., 2011) Scer\GAL4^{elav.Switch.PO}, hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} has NMJ bouton phenotype, suppressible by Rae1^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^{elav.Switch.PO} (Tian et al., 2011, Tian et al., 2011) Scer\GAL4^{elav.Switch.PO}, hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} has synapse phenotype, suppressible by Rae1^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^{elav.Switch.PO} (Tian et al., 2011, Tian et al., 2011) Scer\GAL4^{elav.Switch.PO}, pros^Scer\UAS.cMa has brain \| larval stage phenotype, suppressible by Scer\GAL4^{elav.Switch.PO}, pros^Scer\UAS.cMa (Kurusu et al., 2009, Kurusu et al., 2009) Scer\GAL4^{elav.Switch.PO}, tll^Scer\UAS.cKa has brain \| larval stage phenotype, suppressible by Scer\GAL4^{elav.Switch.PO}/pros^Scer\UAS.cMa (Kurusu et al., 2009, Kurusu et al., 2009)
Enhancer of
Statement Reference Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO} is an enhancer \| RU486 conditional of eye \| RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, for^P1.Scer\UAS, foxo^Scer\UAS.cPa (Kanao et al., 2012, Kanao et al., 2012) Scer\GAL4^{elav.Switch.PO}/dnc^Scer\UAS.cCa is an enhancer of synapse phenotype of Ent2^P124 (Knight et al., 2010)
Suppressor of
Statement Reference Rae1^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^{elav.Switch.PO} is a suppressor of embryonic/larval neuromuscular junction phenotype of Scer\GAL4^{elav.Switch.PO}, hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011, Tian et al., 2011) Rae1^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^{elav.Switch.PO} is a suppressor of NMJ bouton phenotype of Scer\GAL4^{elav.Switch.PO}, hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011, Tian et al., 2011) Rae1^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^{elav.Switch.PO} is a suppressor of synapse phenotype of Scer\GAL4^{elav.Switch.PO}, hiw^{ΔN.Scer\UAS.T:Zzzz\TAP} (Tian et al., 2011, Tian et al., 2011) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{L44.Scer\UAS.T:Avic\GFP-CFP}, Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of microtubule \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{L44.Scer\UAS.T:Avic\GFP-CFP}, Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of NMJ bouton \| supernumerary \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus}, Hsap\SPAST^Q45.Scer\UAS is a suppressor \| partially of microtubule \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus}, Hsap\SPAST^Q45.Scer\UAS is a suppressor \| partially of NMJ bouton \| supernumerary \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus}, Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of NMJ bouton \| supernumerary \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, pros^Scer\UAS.cMa is a suppressor of brain \| larval stage phenotype of Scer\GAL4^{elav.Switch.PO}, pros^Scer\UAS.cMa (Kurusu et al., 2009, Kurusu et al., 2009) Scer\GAL4^{elav.Switch.PO}/Hsap\ACSL4^{Scer\UAS.L.T:Hsap\MYC} is a suppressor of synapse phenotype of Acsl⁰⁵⁸⁴⁷/Acsl^KO (Liu et al., 2011) Scer\GAL4^{elav.Switch.PO}/Hsap\SPAST^Q45.Scer\UAS is a suppressor \| partially of microtubule \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}/Hsap\SPAST^Q45.Scer\UAS is a suppressor of NMJ bouton \| supernumerary \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}/Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of microtubule \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}/Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a suppressor \| partially of NMJ bouton \| supernumerary \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}/pros^Scer\UAS.cMa is a suppressor of brain \| larval stage phenotype of Scer\GAL4^{elav.Switch.PO}, tll^Scer\UAS.cKa (Kurusu et al., 2009, Kurusu et al., 2009)
NOT Suppressor of
Statement Reference Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{L44.Scer\UAS.T:Avic\GFP-CFP}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus} is a non-suppressor of microtubule \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{L44.Scer\UAS.T:Avic\GFP-CFP}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus} is a non-suppressor of NMJ bouton \| supernumerary \| larval stage phenotype of spas^5.75 (Du et al., 2010) Scer\GAL4^{elav.Switch.PO}, Hsap\SPAST^{R388.Scer\UAS.T:Avic\GFP-YFP.Venus}, Hsap\SPAST^{Scer\UAS.T:Avic\GFP-YFP.Venus} is a non-suppressor of microtubule \| larval stage phenotype of spas^5.75 (Du et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^{elav.Switch.PO}/dnc^Scer\UAS.cCa rescues dnc¹ (van Swinderen, 2007, van Swinderen et al., 2009) Scer\GAL4^{elav.Switch.PO}/hiw^{Scer\UAS.W.T:Avic\GFP-EGFP} rescues hiw^ND8 (Wu et al., 2005) Scer\GAL4^{elav.Switch.PO}/rut^Scer\UAS.cZa rescues rut²⁰⁸⁰ (Donlea et al., 2009) Scer\GAL4^{elav.Switch.PO}/spas^Scer\UAS.cSa rescues spas^5.75 (Sherwood et al., 2004) Scer\GAL4^{elav.Switch.PO}/trio^Scer\UAS.cBa rescues trio^6A/trio^S137203 (Ball et al., 2010)
Partially rescues	Scer\GAL4^{elav.Switch.PO}/Mgat1^Scer\UAS.cSa partially rescues Mgat1¹ (Sarkar et al., 2010) Scer\GAL4^{elav.Switch.PO}/spas^{Scer\UAS.T:Avic\GFP-CFP} partially rescues spas^5.75 (Du et al., 2010)
Fails to rescue	Scer\GAL4^{elav.Switch.PO}/chico^Scer\UAS.cNa fails to rescue chico¹ (Naganos et al., 2012)
Comments
Stocks ( 1 )
Bloomington	43642 y¹ w^*; P{elav-Switch.O}GSG301
Notes on Origin
Discoverer

Comments
	The Scer\GAL4[elav.Switch.PO] driver is leaky during the larval stages (driving expression of a UAS transgene in the absence of RU486). (Poirier et al., 2008) The "GeneSwitch" Scer\GAL4 protein produced by Scer\GAL4^{elav.Switch.PO} allows conditional expression of UAS transgenes, dependant on the presence of the activator RU486 (RU486 is thought to activate the protein produced by Scer\GAL4^{elav.Switch.PO} from a transcriptionally inactive to a transcriptionally active form). Expression of UAS transgenes by the Scer\GAL4^{elav.Switch.PO} protein is dose-dependent on RU486 concentration, with low background in the absence of RU486. (Osterwalder et al., 2001)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Scer\GAL4^{elav.Switch.PO}
Name Synonym
Secondary FlyBase IDs

References ( 71 )

Generate a list of	All references relating to this allele ( 71 )

List References by type	Research paper ( 65 ) Supplementary material ( 3 ) Review ( 1 ) Abstract ( 1 ) Letter ( 1 )
Recent research papers ( 16 )
	Inagaki et al., 2012, Cell 148(3): 583--595 Visualizing Neuromodulation In Vivo: TANGO-Mapping of Dopamine Signaling Reveals Appetite Control of Sugar Sensing. [FBrf0217362] Kanao et al., 2012, PLoS ONE 7(2): e30958 The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila. [FBrf0217639] Luo and Sehgal, 2012, Cell 148(4): 765--779 Regulation of Circadian Behavioral Output via a MicroRNA-JAK/STAT Circuit. [FBrf0217497] Miguel et al., 2012, Neurobiol. Aging 33(5): 1008.e1--1008.e15 Accumulation of insoluble forms of FUS protein correlates with toxicity in Drosophila. [FBrf0217826] Naganos et al., 2012, Neurosci. Res. 73(1): 49--55 Mutations in the Drosophila insulin receptor substrate, CHICO, impair olfactory associative learning. [FBrf0217997] Neckameyer and Bhatt, 2012, BMC Neurosci. 13: 26 Neurotrophic actions of dopamine on the development of a serotonergic feeding circuit in Drosophila melanogaster. [FBrf0218484] Pfeiffenberger and Allada, 2012, PLoS Genet. 8(10): e1003003 Cul3 and the BTB Adaptor Insomniac Are Key Regulators of Sleep Homeostasis and a Dopamine Arousal Pathway in Drosophila. [FBrf0219613] Wang et al., 2012, Aging Cell 11(1): 93--103 Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila. [FBrf0217184] Cheng et al., 2011, J. Cell Biol. 194(6): 921--935 S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development. [FBrf0216911] Lanson et al., 2011, Hum. Mol. Genet. 20(13): 2510--2523 A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. [FBrf0213887] Liu et al., 2011, J. Neurosci. 31(6): 2052--2063 Drosophila Acyl-CoA Synthetase Long-Chain Family Member 4 Regulates Axonal Transport of Synaptic Vesicles and Is Required for Synaptic Development and Transmission. [FBrf0212968] Ma et al., 2011, J. Gen. Physiol. 137(2): 225--238 Slob, a Slowpoke channel-binding protein, modulates synaptic transmission. [FBrf0212896] Miguel et al., 2011, Neurobiol. Disease 41(2): 398--406 Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies. [FBrf0212655] Plyusnina et al., 2011, Biogerontology 12(3): 211--226 Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system. [FBrf0213783] Rera et al., 2011, Cell Metab. 14(5): 623--634 Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog. [FBrf0216555] Tian et al., 2011, Nat. Neurosci. 14(10): 1267--1275 Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. [FBrf0216253] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Scer\GAL4elav.Switch.PO

Allele Scer\GAL4^{elav.Switch.PO}