FB2025_01 , released February 20, 2025
Allele: Dmel\RhoGAP93BRNAi.UAS.cBa
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General Information
Symbol
Dmel\RhoGAP93BRNAi.UAS.cBa
Species
D. melanogaster
Name
FlyBase ID
FBal0128103
Feature type
allele
Associated gene
Dmel\RhoGAP93B
Associated Insertion(s)
Carried in Construct
P{UAS-RhoGAP93B.RNAi.B}
Key Links
Transgenic product class
RNAi_reagent
(Billuart et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Billuart et al., 2001)
Mutagen
in vitro construct
(Billuart et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-RhoGAP93B.RNAi.B}
Cytology
Description

UAS regulatory sequences drive expression of two copies of RhoGAP93B sequence, arranged in an inverted repeat.

(Billuart et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
RhoGAP93B
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of RhoGAP93BdsRNA.Scer\UAS under the control of Scer\GAL4OK107 results in no obvious phenotype. Expression of RhoGAP93BdsRNA.Scer\UAS under the control of Scer\GAL4ey.PB results in a reduction in the size of the eye.

      (Billuart et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In robo5/+, sli1/+ transheterozygous embryos, the medial longitudinal pathway occasionally crosses the midline. The addition of RhoGAP93BdsRNA.Scer\UAS (driven by Scer\GAL4elav.PLu) significantly enhances this phenotype. The subsequent addition of RhoGAP93BScer\UAS.cHa suppresses this enhancement.

      (Hu et al., 2005)

      When RhoGAP93BdsRNA.Scer\UAS is driven by Scer\GAL4elav.PLu in a fraunspecified background no midline crossing defects are seen. When RhoGAP93BdsRNA.Scer\UAS is driven by Scer\GAL4elav.PLu in a Ptp69D4/Ptp10Dunspecified background no midline crossing defects are seen. When RhoGAP93BdsRNA.Scer\UAS is driven by Scer\GAL4elav.PLu in a Ptp69Dunspecified/Ptp10Dunspecified background no midline crossing defects are seen.

      (Hu, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Transcription from the P{UAS-RhoGAP93B-dsRNA} construct should produce RhoGAP93B dsRNA, resulting in dsRNA interference (RNAi) of the RhoGAP93B gene.

      (Billuart et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      RhoGAP93BRNAi.UAS.cBa
      RhoGAP93BdsRNA.Scer\UAS
      RhoGAP93BdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)