Allele Dmel\cv-c^{dsRNA.Scer\UAS}

General Information
Symbol	Dmel\cv-c^{dsRNA.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0128105
Feature type	allele	Associated gene	Dmel\cv-c

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - RNAi
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Billuart et al., 2001) in vitro construct - RNAi (Billuart et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of two copies of cv-c sequence, arranged in an inverted repeat. (Billuart et al., 2001)
Carried in construct	P{UAS-cv-c-dsRNA} (Denholm et al., 2005, Billuart et al., 2001, Pilgram et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	lethal, with Scer\GAL4^αTub84B.PL (Billuart et al., 2001) neurophysiology defective, with Scer\GAL4^G14 (Pilgram et al., 2011) visible, with Scer\GAL4^T80 (Billuart et al., 2001)
Phenotype Manifest In
	anterior crossvein, with Scer\GAL4^Bx-MS1096 (Denholm et al., 2005) neuromuscular junction, with Scer\GAL4^G14 (Pilgram et al., 2011) posterior crossvein, with Scer\GAL4^Bx-MS1096 (Denholm et al., 2005) wing vein L2, with Scer\GAL4^T80 (Billuart et al., 2001)
Detailed Description
	Statement Reference Expression of cv-c[dsRNA.Scer\UAS] in motoneurons under the control of Scer\GAL4[OK6] does not significantly increase quantal content (QC) at the neuromuscular junction. Expression of cv-c[dsRNA.Scer\UAS] in muscle under the control of Scer\GAL4[G14] significantly increase quantal content (QC) at the neuromuscular junction. (Pilgram et al., 2011) Expression of cv-c^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 causes a complete loss of the posterior crossvein and the detachment of the anterior crossvein from the fourth longitudinal vein of the wing. (Denholm et al., 2005) Expression of cv-c^{dsRNA.Scer\UAS} under the control of Scer\GAL4^ey.PB or Scer\GAL4^OK107 results in no obvious phenotype. Expression of cv-c^{dsRNA.Scer\UAS} under the control of Scer\GAL4^T80 results in reduction or absence of wing vein L2. (Billuart et al., 2001)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	6443 y¹ w^*; P{UAS-cv-c-dsRNA}4.1
Notes on Origin
Discoverer

Comments
	Transcription from the P{UAS-RhoGAP88C-dsRNA} construct should produce cv-c dsRNA, resulting in dsRNA interference (RNAi) of the cv-c gene. (Billuart et al., 2001)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cv-c^{dsRNA.Scer\UAS} RhoGAP88C^{dsRNA.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Denholm et al., 2005, Development 132(10): 2389--2400 crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis. [FBrf0187455] Billuart et al., 2001, Cell 107(2): 195--207 Regulating axon branch stability. The role of p190 RhoGAP in repressing a retraction signaling pathway. [FBrf0139610]

Allele Dmel\cv-cdsRNA.Scer\UAS

Allele Dmel\cv-c^{dsRNA.Scer\UAS}