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General Information
Symbol
Dmel\cv-cdsRNA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0128105
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of two copies of cv-c sequence, arranged in an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

cv-cdsRNA.Scer\UAS expression under the control of Scer\GAL4cv-c-C5 alone (the intrinsic Gal4 driver of cv-cC5), Scer\GAL4104Y alone, Scer\GAL4GMR23E10 alone, or Scer\GAL4GMR23E10 in combination with Gal80[ts] (in order to restrict expression to adulthood), induces a significant decrease in the mean sleep time of adults reared under 12h light:12h dark cycles, as compared to controls. Expression of cv-cdsRNA.Scer\UAS under the control of Scer\GAL4GMR23E10 alone also results in adults presenting a significantly lower sleep recovery after overnight sleep deprivation and a significant decrease in short-term olfactory memory under ad libitum sleep conditions, assessed by aversive tests to the 4-methylcyclohexanol odorant after electric shock-coupled training; these individuals, however present no significant changes in the sensitivity to electric shocks, as assessed by maximal motor velocities, and no changes in the preference score of naive individuals to the 4-methylcyclohexanol odorant in ad libitum sleep conditions, as compared to controls.

Expression of cv-cdsRNA.Scer\UAS in motoneurons under the control of Scer\GAL4OK6 does not significantly increase quantal content (QC) at the neuromuscular junction.

Expression of cv-cdsRNA.Scer\UAS in muscle under the control of Scer\GAL4G14 significantly increase quantal content (QC) at the neuromuscular junction.

Expression of cv-cdsRNA.Scer\UAS under the control of Scer\GAL4Bx-MS1096 causes a complete loss of the posterior crossvein and the detachment of the anterior crossvein from the fourth longitudinal vein of the wing.

Expression of cv-cdsRNA.Scer\UAS under the control of Scer\GAL4ey.PB or Scer\GAL4OK107 results in no obvious phenotype. Expression of cv-cdsRNA.Scer\UAS under the control of Scer\GAL4T80 results in reduction or absence of wing vein L2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Transcription from the P{UAS-RhoGAP88C-dsRNA} construct should produce cv-c dsRNA, resulting in dsRNA interference (RNAi) of the cv-c gene.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
RhoGAP88CdsRNA.Scer\UAS
cv-cdsRNA.Scer\UAS
cv-cdsRNA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (4)