FlyBase Allele Report: Dmel\wupA[PL87]

General Information

Symbol

Dmel\wupA^PL87

Species

D. melanogaster

Name

FlyBase ID

FBal0128959

Feature type

allele

Associated gene

Dmel\wupA

Associated Insertion(s)

P{lacW}wupA^PL87

Carried in Construct

Also Known As

PL87

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Sahota et al., 2009)

Mutagen

Delta2-3 transposase

(Bourbon et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{lacW}wupA^PL87

Cytology

Description

Re-mobilisation of the transposon causes the lethality phenotype to be lost.

(Bourbon et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:18,114,595..18,114,595

(Casas-Tintó and Ferrús, 2021, Marin et al., 2004, Bourbon et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic somatic muscle cell

(Marin et al., 2004)

germline cell | germline clone

(Sahota et al., 2009)

nucleus | embryonic stage 4

(Sahota et al., 2009)

Detailed Description

Statement

Reference

wupA^PL87 homozygous somatic clones in wandering third instar larval wing discs display significant apoptosis at 48h after clone induction as compared to control clones, and become undetectable at 72h after clone induction.

(Casas-Tintó et al., 2016)

Homozygous wupA^PL87 mutants show nuclear defects in the syncitial embryo. Nuclei in the anterior region of the wupA^PL87 mutant embryos either stop dividing or undergo one division less than nuclei at the posterior end.

The number of wupA^PL87 mutant clones, compared to controls, is reduced in germline mosaics.

(Sahota et al., 2009)

wupA^PL87 embryos show remnants of somatic muscles with poorly oriented thin filaments.

(Marin et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference