FlyBase Allele Report: Dmel\tou[2]

General Information

Symbol

Dmel\tou²

Species

D. melanogaster

Name

FlyBase ID

FBal0128995

Feature type

allele

Associated gene

Dmel\tou

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Fauvarque et al., 2001)

Progenitor genotype

tou¹

(Fauvarque et al., 2001)

Cytology

Description

Generated by imprecise excision of the P{lacW}tou¹, where 200bp of the intron was replaced by a 7kb sequence from the P-element.

(Vanolst et al., 2005)

Excision of the P{lacW} element.

(Fauvarque et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Fauvarque et al., 2001)

Phenotype Manifest In

dorsocentral bristle

(Vanolst et al., 2005)

dorsocentral bristle (with Df(2R)en-SFX31)

(Vanolst et al., 2005)

wing

(Fauvarque et al., 2001)

Detailed Description

Statement

Reference

Homozygous tou² mutants give rise to escapers lacking dorsocentral (DC) bristles (1.4 bristles per heminotum compared to 2.0). tou²/Df(2R)en-SFX31 mutants exhibit an average of 1.25 dorsocentral bristles per heminotum compared to 2.0 in wild-type controls.

(Vanolst et al., 2005)

tou² flies show the same wing defect as tou¹.

(Fauvarque et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

tou²/tou[+] is an enhancer of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

NOT Enhancer of

Statement

Reference

tou²/tou[+] is a non-enhancer of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

tou²/tou[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

tou²/tou[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

tou²/tou[+] is a suppressor of visible | recessive phenotype of ph-p⁴¹⁰

(Fauvarque et al., 2001)

NOT Suppressor of

Statement

Reference

tou²/tou[+] is a non-suppressor of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

tou² has dorsocentral bristle phenotype, enhanceable by Chi^E

(Vanolst et al., 2005)

tou² has dorsocentral bristle phenotype, enhanceable by Scer\GAL4^pnr-MD237/Iswi^{K159R.UAS.Tag:HA}

(Vanolst et al., 2005)

Suppressed by

Statement

Reference

tou² has dorsocentral bristle phenotype, suppressible by pnr^D1

(Vanolst et al., 2005)

tou² has dorsocentral bristle phenotype, suppressible by osa⁶¹⁶

(Vanolst et al., 2005)

tou² has dorsocentral bristle phenotype, suppressible by pnr^VX1

(Vanolst et al., 2005)

Enhancer of

Statement

Reference

tou²/tou[+] is an enhancer of wing phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

tou² is an enhancer of dorsocentral bristle phenotype of pnr^VX1

(Vanolst et al., 2005)

tou² is an enhancer of dorsocentral bristle phenotype of Chi^E

(Vanolst et al., 2005)

tou² is an enhancer of dorsocentral bristle phenotype of Iswi^{K159R.UAS.Tag:HA}, Scer\GAL4^pnr-MD237

(Vanolst et al., 2005)

NOT Enhancer of

Statement

Reference

tou²/tou[+] is a non-enhancer of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

tou²/tou[+] is a suppressor of first posterior wing cell phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

tou²/tou[+] is a suppressor of eye phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

tou² is a suppressor of dorsocentral bristle phenotype of pnr^D1

(Vanolst et al., 2005)

tou²/tou[+] is a suppressor of metathoracic leg phenotype of ph-p⁴¹⁰

(Fauvarque et al., 2001)

tou²/tou[+] is a suppressor of sex comb | ectopic phenotype of ph-p⁴¹⁰

(Fauvarque et al., 2001)

NOT Suppressor of

Statement

Reference

tou²/tou[+] is a non-suppressor of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

tou² ; pnr^D1/+ flies exhibit 2.17 dorsocentral bristles per heminotum compared to 3.34 per heminotum in pnr^D1 heterozygotes, indicating that tou² suppresses the phenotype. tou²/+ ; pnr^VX1/+ flies exhibit on average 1.57 dorsocentral bristles per heminotum, compared to 1.86 bristles per heminotum in pnr^VX1 heterozygotes, 1.4 bristles per heminotum in tou²/+ and 2.0 dorsocentral bristles per heminotum in wild-type. tou² Chi^E flies exhibit 1.11 dorsocentral bristles per heminotum compared to 2.0 in wild-type controls. tou²/+ heterozygotes, in which Iswi^{K159R.Scer\UAS.T:Ivir\HA1} is being expressed under the control of Scer\GAL4^pnr-MD237, exhibit a reduction in the number of dorsocentral bristles (an average of 1.14 bristles per heminotum compared to 2.0 in wild-type). tou² homozygotes, in which Iswi^{K159R.Scer\UAS.T:Ivir\HA1} is being expressed under the control of Scer\GAL4^pnr-MD237, exhibit a reduction in the number of dorsocentral bristles (an average of 0.75 bristles per heminotum compared to 2.0 in wild-type). tou² ; osa⁶¹⁶/+ flies exhibit an average of 1.97 dorsocentral bristles per heminotum, compared to 1.4 in tou²/+ flies and 2.0 in wild-type controls.

(Vanolst et al., 2005)

Has no effect on the arista to leg transformation phenotype seen in Df(2R)Dll-MP heterozygotes.

(Fauvarque et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6402

w¹¹¹⁸; tou²/CyO, P{sevRas1.V12}FK1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tou²

(Clarembaux-Badell et al., 2022, Bailetti et al., 2019, Ji et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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