FlyBase Allele Report: Dmel\tara[1]

General Information

Symbol

Dmel\tara¹

Species

D. melanogaster

Name

FlyBase ID

FBal0129007

Feature type

allele

Associated gene

Dmel\tara

Associated Insertion(s)

P{lacW}tara¹

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Afonso et al., 2015)

Mutagen

Delta2-3 transposase

(Fauvarque et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{lacW}tara¹

Cytology

Description

P{lacW} insertion in an intron.

(Calgaro et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal sleep (with tara^s132)

(Afonso et al., 2015)

abnormal sleep | dominant

(Afonso et al., 2015)

lethal

(Afonso et al., 2015)

lethal | recessive

(Calgaro et al., 2002)

lethal - all die during embryonic stage

(Dutta and Li, 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

tara^s132/tara¹ mutant males and females show a reduction in daily sleep that is more severe than that seen in tara^s132 homozygotes. A significant reduction in sleep is also seen in male and female heterozygotes and waking activity is significantly increased in tara¹/+ males.

Sleep bout duration is reduced in both males and female tara^s132/tara¹ mutant flies. The number of sleep bouts is reduced in female flies, although a reduction in the number of sleep bouts is also seen in female heterozygotes. No reduction is sleep bout number is seen in male flies. Sleep latency (the time between lights off to the first sleep) is increased in both males and females.

tara^s132/tara¹ mutant flies exhibit defects in locomotor rhythm in constant darkness.

tara^s132/tara¹ mutant flies show severely reduced sleep compared to controls when assayed in either constant light or constant dark.

(Afonso et al., 2015)

Homozygotes do not develop beyond the first larval instar. Heterozygotes do not have a held-out wing phenotype.

(Calgaro et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

tara¹/tara[+] is an enhancer of visible | dominant phenotype of Bx¹

(Bejarano et al., 2008)

NOT Enhancer of

Statement

Reference

tara¹/tara[+] is a non-enhancer of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

tara¹/tara[+] is a suppressor | partially of visible | recessive phenotype of sd^Fab-X

(Dutta and Li, 2017)

tara¹ is a suppressor of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

tara¹/tara[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

tara¹/tara[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

tara¹ is a suppressor of visible | dominant | homeotic phenotype of Pc¹⁶

(Calgaro et al., 2002)

tara¹ is a suppressor of visible | dominant | homeotic phenotype of ph-p⁴¹⁰

(Calgaro et al., 2002)

tara¹/tara[+] is a suppressor of visible | dominant phenotype of Pc¹⁶

(Fauvarque et al., 2001)

tara¹/tara[+] is a suppressor of visible | recessive phenotype of ph-p⁴¹⁰

(Fauvarque et al., 2001)

NOT Suppressor of

Statement

Reference

tara¹/tara[+] is a non-suppressor of visible | dominant phenotype of sd¹

(Dutta and Li, 2017)

tara¹/tara[+] is a non-suppressor of bang sensitive | semidominant phenotype of para^bss1

(Howlett et al., 2013)

tara¹/tara[+] is a non-suppressor of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Other

Statement

Reference

brm², tara¹/tara[+] has visible | dominant phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara¹, trx[+]/trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara¹/tara[+], trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

brm², tara¹/tara[+], trx[+]/trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

osa¹, tara¹/tara[+] has visible | dominant phenotype

(Calgaro et al., 2002)

brm², tara¹ has visible | dominant phenotype

(Calgaro et al., 2002)

osa¹, tara¹ has visible | dominant phenotype

(Calgaro et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

tara¹/tara[+] is an enhancer of wing margin phenotype of Bx¹

(Bejarano et al., 2008)

NOT Enhancer of

Statement

Reference

tara¹/tara[+] is a non-enhancer of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

tara¹/tara[+] is a suppressor | partially of wing phenotype of sd^Fab-X

(Dutta and Li, 2017)

tara¹ is a suppressor of wing margin phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

tara¹/tara[+] is a suppressor of first posterior wing cell phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

tara¹/tara[+] is a suppressor of eye phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

tara¹ is a suppressor of mesothoracic leg phenotype of Pc¹⁶

(Calgaro et al., 2002)

tara¹ is a suppressor of metathoracic leg phenotype of Pc¹⁶

(Calgaro et al., 2002)

tara¹ is a suppressor of sex comb | ectopic phenotype of Pc¹⁶

(Calgaro et al., 2002)

tara¹ is a suppressor of mesothoracic leg phenotype of ph-p⁴¹⁰

(Calgaro et al., 2002)

tara¹ is a suppressor of metathoracic leg phenotype of ph-p⁴¹⁰

(Calgaro et al., 2002)

tara¹ is a suppressor of sex comb | ectopic phenotype of ph-p⁴¹⁰

(Calgaro et al., 2002)

tara¹/tara[+] is a suppressor of mesothoracic leg phenotype of Pc¹⁶

(Fauvarque et al., 2001)

tara¹/tara[+] is a suppressor of sex comb | ectopic phenotype of Pc¹⁶

(Fauvarque et al., 2001)

tara¹/tara[+] is a suppressor of metathoracic leg phenotype of ph-p⁴¹⁰

(Fauvarque et al., 2001)

tara¹/tara[+] is a suppressor of sex comb | ectopic phenotype of ph-p⁴¹⁰

(Fauvarque et al., 2001)

NOT Suppressor of

Statement

Reference

tara¹/tara[+] is a non-suppressor of wing phenotype of sd¹

(Dutta and Li, 2017)

tara¹/tara[+] is a non-suppressor of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Other

Statement

Reference

brm², tara¹/tara[+] has wing phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara¹, trx[+]/trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara¹/tara[+], trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm², tara¹/tara[+], trx[+]/trx^E2 has wing phenotype

(Calgaro et al., 2002)

osa¹, tara¹/tara[+] has wing phenotype

(Calgaro et al., 2002)

brm², tara¹ has wing phenotype

(Calgaro et al., 2002)

osa¹, tara¹ has wing phenotype

(Calgaro et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The bang sensitive phenotype seen in para^bss1/+ mutant females is not suppressed by one copy of tara¹.

(Howlett et al., 2013)

The wing nicking phenotype caused by expression of dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 is suppressed if the flies are also carrying tara¹.

(Kwon et al., 2013)

28% of osa¹ tara¹ double heterozygotes have a held-out wing phenotype. 1% of trx^E2 tara¹ double heterozygotes have a held-out wing phenotype. 10% of brm² tara¹ double heterozygotes have a held-out wing phenotype. 38% of trx^E2 brm² tara¹ triple heterozygotes have a held-out wing phenotype.

(Calgaro et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6403

w¹¹¹⁸; tara¹/TM3, Sb¹

Notes on Origin

Discoverer

Selected as: a suppressor of the meta- to pro-thoracic leg transformation seen in ph-p⁴¹⁰/Y flies.

(Fauvarque et al., 2001)

Comments

Excision of the P{lacW} element reverts the phenotype.

(Fauvarque et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tara¹

(Akpoghiran et al., 2024, Dutta et al., 2021, Tian and Smith-Bolton, 2021, Dutta and Li, 2017, Afonso et al., 2015, Afonso et al., 2015, Kwon et al., 2013, Manansala et al., 2013, Ji et al., 2012, Bejarano et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (14)

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