Allele Dmel\rdgC^I12E

General Information
Symbol	Dmel\rdgC^I12E	Species	D. melanogaster
Name		FlyBase ID	FBal0129125
Feature type	allele	Associated gene	Dmel\rdgC

Allele class
Mutagen	in vitro construct - site directed mutagenesis
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Genes rdgC
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - site directed mutagenesis (Lee and Montell, 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	rdgC^+t7.0 (Lee and Montell, 2001)
Nature of the lesion	Statement Reference Construct: Amino acid replacement: I12E. (Lee and Montell, 2001)
Carried in construct	P{rdgC.I12E} (Lee and Montell, 2001)
Cytology
Phenotypic Data
Phenotypic Class
	neurophysiology defective (Lee and Montell, 2001)
Phenotype Manifest In
	rhabdomere (Lee and Montell, 2001)
Detailed Description
	Statement Reference One-day old mutant flies maintained under a 12hr light/12hr dark cycle show little if any decrease in the size of the rhabdomeres. After rearing mutant flies for 7 days under such a cycle, the rhabdomeres almost completely degenerate. When the retina of mutant animals are exposed to 0.5 sec pulses of orange light and the photoresponse measured, A significant delay is seen in the deactivation of the light response. These flies also exhibit a defective, prolonged depolarisation afterpotential (PDA), that is less than 10% seen in controls. (Lee and Montell, 2001)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	rdgC^I12E
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Lee and Montell, 2001, Neuron 32(6): 1097--1106 Regulation of the Rhodopsin Protein Phosphatase, RDGC, through Interaction with Calmodulin. [FBrf0141683]

Allele Dmel\rdgCI12E

Allele Dmel\rdgC^I12E