|Feature type||allele||Associated gene||Dmel\hbs|
|Map ( GBrowse )|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Nucleotide substitution: A?T. Amino acid replacement: K554@.
|Phenotype Manifest In|
hbs/+ dominantly enhances the Scer\GAL4[hs.2sev]>hbs[VDRC.cUa]-induced planar cell polarity phenotype in the eye. hbs/Df(2R)ED2423 mutants display a reduction in the number of notal microchaetae compared with wild-type.
Stage 12 hbs459/Df(2R)X28 or hbs459/hbs2593 embryos have a reduction in the number of visceral muscle progenitors. hbs459/Df(2R)X28, or hbs459/hbs2593 embryos The overall pattern or somatic muscles is normal, though there is a partial fusion block in embryos (especially around the heart). The unfused myoblasts can still extend filopodia. Mutant embryos also show a gut phenotype consisting of an enlarged first gut chamber, which pushes the dorsal muscles and heart upwards.
|Phenotype Manifest In|
hbs459 is a suppressor of ommatidium phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.Scer\UAS
hbs459 is a suppressor of pigment cell phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.Scer\UAS
hbs459 is a suppressor of primary pigment cell phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.Scer\UAS
hbs459 is a suppressor of secondary pigment cell phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.Scer\UAS
The patterning defects in retinas co-expressing Arf51F[GD13822] and Dcr-2[Scer\UAS.cDa] under the control of Scer\GAL4[GMR.PF] is enhanced by heterozygosity for hbs.
sns[XB3], hbs / sns[D1], hbs embryos have a relatively low number of eve-expressing DA1 founder cells - fewer than in sns[XB3] embryos. The limited number of unfused myoblasts in hbs/hbs embryos increases when embryos are also heterozygous for sns[XB3] or sns[D1].
Pupae heterozygous for hbs exhibit mild but consistent suppression of the Scer\GAL4[GMR.PF]>cindr[dsRNA.PC.PD.Scer\UAS] phenotype. The prevalence of cone and 1[o] cell defects is decreased and the number of 2[o] and 3[o] cells is reduced to slightly below normal.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 8 )|