FlyBase Allele Report: Dmel\eff[mer4]

General Information

Symbol

Dmel\eff^mer4

Species

D. melanogaster

Name

FlyBase ID

FBal0130384

Feature type

allele

Associated gene

Dmel\eff

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3R)ry506-85C)

(Fauvarque et al., 2001)

lethal (with eff^s1782)

(Fauvarque et al., 2001)

lethal - all die during embryonic stage | recessive

(Fauvarque et al., 2001)

male sterile (with eff⁸)

(Fauvarque et al., 2001)

some die during embryonic stage | recessive

(Fauvarque et al., 2001)

visible | dominant

(Fauvarque et al., 2001)

Phenotype Manifest In

female germline stem cell (with eff⁸)

(Chen et al., 2009)

larval dorsal multidendritic neuron ddaC

(Lu et al., 2009)

mesothoracic leg

(Fauvarque et al., 2001)

sex comb | ectopic

(Fauvarque et al., 2001)

Detailed Description

Statement

Reference

The average number of germline stem cells per germarium is reduced in 7 and 14 day old eff⁸/eff^mer4 females compared to controls.

(Chen et al., 2009)

Heterozygous males have a small but significant number of additional sex comb teeth on the mesothoracic legs.

(Fauvarque et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

eff^mer4 has abnormal neuroanatomy phenotype, enhanceable by Ube3a^Δ15-8

(Lu et al., 2009)

Enhancer of

Statement

Reference

eff^mer4 is an enhancer of abnormal neuroanatomy phenotype of Ube3a^Δ15-8

(Lu et al., 2009)

eff[+]/eff^mer4 is an enhancer of visible | dominant phenotype of Pc¹⁶

(Fauvarque et al., 2001)

eff[+]/eff^mer4 is an enhancer of visible | recessive phenotype of ph-p⁴¹⁰

(Fauvarque et al., 2001)

NOT Enhancer of

Statement

Reference

eff[+]/eff^mer4 is a non-enhancer of chemical sensitive | adult stage phenotype of Otud6^C183A

(Villa et al., 2024)

eff[+]/eff^mer4 is a non-enhancer of increased mortality | adult stage phenotype of Otud6^C183A

(Villa et al., 2024)

eff[+]/eff^mer4 is a non-enhancer of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

eff[+]/eff^mer4 is a non-enhancer of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

eff[+]/eff^mer4 is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

eff[+]/eff^mer4 is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

NOT Suppressor of

Statement

Reference

eff[+]/eff^mer4 is a non-suppressor of chemical sensitive | adult stage phenotype of Otud6^C183A

(Villa et al., 2024)

eff[+]/eff^mer4 is a non-suppressor of increased mortality | adult stage phenotype of Otud6^C183A

(Villa et al., 2024)

eff[+]/eff^mer4 is a non-suppressor of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

eff[+]/eff^mer4 is a non-suppressor of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

eff^mer4 has larval dorsal multidendritic neuron ddaC phenotype, enhanceable by Ube3a^Δ15-8

(Lu et al., 2009)

Enhancer of

Statement

Reference

eff^mer4 is an enhancer of larval dorsal multidendritic neuron ddaC phenotype of Ube3a^Δ15-8

(Lu et al., 2009)

eff[+]/eff^mer4 is an enhancer of mesothoracic leg phenotype of Pc¹⁶

(Fauvarque et al., 2001)

eff[+]/eff^mer4 is an enhancer of sex comb | ectopic phenotype of Pc¹⁶

(Fauvarque et al., 2001)

eff[+]/eff^mer4 is an enhancer of metathoracic leg phenotype of ph-p⁴¹⁰

(Fauvarque et al., 2001)

eff[+]/eff^mer4 is an enhancer of sex comb | ectopic phenotype of ph-p⁴¹⁰

(Fauvarque et al., 2001)

NOT Enhancer of

Statement

Reference

eff[+]/eff^mer4 is a non-enhancer of wing phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

eff[+]/eff^mer4 is a non-enhancer of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

eff[+]/eff^mer4 is a suppressor of eye phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

eff[+]/eff^mer4 is a suppressor of first posterior wing cell phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

NOT Suppressor of

Statement

Reference

eff[+]/eff^mer4 is a non-suppressor of wing phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

eff[+]/eff^mer4 is a non-suppressor of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Third-instar larva transheterozygous for As^Δ15-8 and eff^mer4 exhibit a severe reduction in the number of terminal dendritic branches of ddaC neurons compared to the single mutant heterozygotes.

(Lu et al., 2009)

Dominantly suppresses the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes.

(Fauvarque et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

eff^s1782

(Fauvarque et al., 2001)

eff⁸

(Fauvarque et al., 2001)

Comments

eff^{MI05507-FF.PT-EGFP}/eff^mer4 flies are viable while eff^{MI05507-FF.GT-mCh}/eff^mer4 flies are lethal in the eff^mer4 lethality complementation test.

in a lethality complementation test.

(Nagarkar-Jaiswal et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6401

w¹¹¹⁸; eff^mer4/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

UbcD1^mer4

(Fauvarque et al., 2001)

eff^mer4

(Villa et al., 2024, Nagarkar-Jaiswal et al., 2017, Ji et al., 2012, Chen et al., 2009, Cook et al., 2009.11.9, Lu et al., 2009, Cook et al., 2008.12.28)

mer⁴

(Fauvarque et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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