|Feature type||allele||Associated gene||Dmel\Stat92E|
|Also Known As||stat397|
|Map ( GBrowse )|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified).
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: W594@. Nucleotide substitution: G?A.
|Phenotype Manifest In|
30% of Stat92E/Df(3R)H-B79 animals die during embryogenesis and the remainder die during the first larval instar. Mosaic animals in which the eye-antennal disc is almost completely homozygous for Stat92E show a reduced eye phenotype.
Stat92E/+ third instar larval lymph glands show hyperplasia and increased plasmatocyte differentiation. There is no marked increase in lamellocyte differentiation.
Stat92E wing disc clones average 6.4% of the wing pouch area, compared to 28% for wild-type clones. When wing discs are subjected to x-irradiation (5,000 rad daily for 3 days), Stat92E clones take up 1.1% of the total pouch area. The level of apoptosis observed is increased in mutant wing discs subjected to x-irradiation compared to controls.
In Stat92EEP3391/Stat92E397 egg chambers, border cell migration is reduced but border cell number is not affected.
Homozygous mutant mosaic egg chambers display severe border cell migration defects. Border cells frequently fail to penetrate into the nurse cell clusters and can be found at the anterior tip or along the sides of the egg chamber. Alternatively the cells migrate partially, but fail top reach the oocyte by stage 10.
|Phenotype Manifest In|
When th[Scer\UAS.cBa] is over-expressed in the wing disc under the control of Scer\GAL4[tub.PU] from first instar larval stage (by heat-shock induction to inactivate Scer\GAL80[αTub84B.PL]), Stat92E mutant clones take up 7.7% of the wing pouch after x-irradiation treatment (5,000 rads daily for 3 days). Low levels of cell death are observed.
|Complementation & Rescue Data|
|Fails to complement|
|Not rescued by|
The mutant eye phenotype seen in mosaic animals in which the eye-antennal disc is almost completely homozygous for Stat92E is rescued by Stat92E[Scer\UAS.P\T.T:Ivir\HA1], Stat92E[ΔN.Scer\UAS.P\T.T:Ivir\HA1] or Stat92E[ΔC.Scer\UAS.P\T.T:Ivir\HA1] expressed under the control of Scer\GAL4[ey.PH]. The mutant eye phenotype seen in mosaic animals in which the eye-antennal disc is almost completely homozygous for Stat92E is not rescued by Stat92E[Y711F.Scer\UAS.P\T.T:Ivir\HA1] or Stat92E[R442P.Scer\UAS.P\T.T:Ivir\HA1] expressed under the control of Scer\GAL4[ey.PH].
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 4 )|
|Secondary FlyBase IDs|
|References ( 9 )|