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General Information
Symbol
Dmel\RanGAPEP1173
Species
D. melanogaster
Name
FlyBase ID
FBal0130612
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP(2)1173
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{EP}RanGAPEP1173
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

RanGAPEP1173 homozygous third instar larvae display brain lobes with a normal glossy physical appearance, but there is a significant decrease in the number of central brain neuroblasts only in females, which does not show at second instar or early third instar (i.e. 48h and 72h after larval hatching, respectively), as compared to controls. At the pre-pupal stage (i.e. at 120h afer larval hatching) males also start showing a significant decrease in the number of central brain neuroblasts, as compared to controls. Female third instar neuroblasts show a severe decrease in the frequency of cell division (phospho-H3 and EdU stainings), despite of identical levels of apoptosis (Caspase 3 staining) in the brain.

Both male and female RanGAPEP1173/RanGAP327 show a progressive decrease in the number of central brain neuroblasts from early third instar larval stage into prepupal stage (i.e. at 72h-120h after larval hatching, but not at 48h after larval hatching).

Expression via Scer\GAL4fkh.PH results in strongly penetrant gland shape/lumen ('shepherd's crook') and positioning ('hook') phenotypes in the embryonic salivary gland.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
RanGAPEP1173
RanGapEP1173
SdEP1173
rangapEP1173
rangapEP
Name Synonyms
Secondary FlyBase IDs
    References (5)