FB2025_01 , released February 20, 2025
Allele: Dmel\Nmdar1EP3511
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General Information
Symbol
Dmel\Nmdar1EP3511
Species
D. melanogaster
Name
FlyBase ID
FBal0130852
Feature type
allele
Associated gene
Dmel\Nmdar1
Associated Insertion(s)
P{EP}Nmdar1EP3511
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Xia et al., 2005)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EP}Nmdar1EP3511
Cytology
Description

P{EP} element inserted in the first intron of the Nmdar1 gene, 718bp upstream of the start codon in exon 2.

(Xia et al., 2005)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nmdar1EP3511 mutants exhibit a significant reduction of acquired tolerance to ethanol vapor-induced sedation, in both acute and chronic tolerance assays, and a significant increase in ethanol sensitivity, as compared to controls.

      (Maiya et al., 2012)

      Mutant flies show defects in learning (memory measured immediately after conditioning) in an aversive olfactory conditioning assay. Short-term memory (assayed 1 hour after training) is also defective compared to controls. One-day memory after spaced training (long-term memory) is reduced compared to wild type, while one-day memory after massed training (anesthesia-resistant memory) is normal.

      (Miyashita et al., 2012)

      Nmdar1EP3511 mutants exhibit reduced short-term and long-term memory. Extinction learning appears to be normal in these mutants.

      (Qin and Dubnau, 2010)

      Olfactory learning is reduced in Nmdar1EP3511 mutants. Sensorimotor responses to odors and foot shock stimuli are not affected.

      (Xia et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Nmdar1EP3511 is rescued by Nmdar1+tCosmidC

      (Xia et al., 2005)

      Nmdar1EP3511 is rescued by Nmdar1+tCosmidB

      (Xia et al., 2005)
      Not rescued by

      Nmdar1EP3511 is not rescued by Nmdar1tCosmidA

      (Xia et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      NR1EP3511
      (Maiya et al., 2012)
      Nmdar1EP3511
      dNR1EP3511
      (Miyashita et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)