Allele Dmel\Fmr1^{I307N.Z.Scer\UAS}

General Information
Symbol	Dmel\Fmr1^{I307N.Z.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0131028
Feature type	allele	Associated gene	Dmel\Fmr1

Allele class
Mutagen	in vitro construct - amino acid replacement
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Zhang et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Fmr1^Scer\UAS.cZa (Zhang et al., 2001)
Nature of the lesion	Statement Reference Construct: Amino acid replacement: I307N. (Zhang et al., 2001)
Carried in construct	P{UAS-Fmr1.I307N.Z} (Zhang et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	flightless, with Scer\GAL4^elav-C155 (Zhang et al., 2001) flightless, with Scer\GAL4^Mhc.PW (Zhang et al., 2001) lethal, with Fmr1^Scer\UAS.cZa, Scer\GAL4^elav-C155 (Zhang et al., 2001) lethal \| adult stage, with Scer\GAL4^elav-C155 (Zhang et al., 2001) lethal \| pupal stage, with Scer\GAL4^G7 (Zhang et al., 2001) neurophysiology defective, with Scer\GAL4^hs.2sev (Zhang et al., 2001) uncoordinated, with Scer\GAL4^elav-C155 (Zhang et al., 2001) visible, with Scer\GAL4^elav-C155 (Zhang et al., 2001)
Phenotype Manifest In
	ommatidium, with Scer\GAL4^hs.2sev (Zhang et al., 2001) photoreceptor cell, with Scer\GAL4^hs.2sev (Zhang et al., 2001) photoreceptor cell & synapse & lamina receptor cell, with Scer\GAL4^hs.2sev (Zhang et al., 2001) rhabdomere, with Scer\GAL4^hs.2sev (Zhang et al., 2001) wing, with Scer\GAL4^elav-C155 (Zhang et al., 2001) wing, with Scer\GAL4^Mhc.PW (Zhang et al., 2001)
Detailed Description
	Statement Reference The phenotypes produced by Fmr1^{I307N.Z.Scer\UAS} are similar but consistently weaker than those produced by Fmr1^Scer\UAS.cZa. When expression is driven by Scer\GAL4^elav-C155 flies show abnormally outspread wings and cannot fly. Flies are uncoordinated and show adult lethality - dying 5-10 days post-eclosion. When expression is driven by Scer\GAL4^Mhc.PW flies' wings are droopy or held up and they cannot fly. When expression is driven by Scer\GAL4^G7 flies show pupal lethality. When expression is driven by Scer\GAL4^hs.2sev the retina is disordered with misshapen rhabdomeres, abnormal rhabdomere numbers and fused ommatidia. Phototransduction is normal, however synaptic transmission is reduced (as indicated by a reduction in off-transient mean amplitude as assayed by ERG). (Zhang et al., 2001)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Fmr1^{I307N.Z.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Zhang et al., 2001, Cell 107(5): 591--603 Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. [FBrf0141416]

Allele Dmel\Fmr1I307N.Z.Scer\UAS

Allele Dmel\Fmr1^{I307N.Z.Scer\UAS}