FlyBase Allele Report: Dmel\Dif[2]

General Information

Symbol

Dmel\Dif²

Species

D. melanogaster

Name

FlyBase ID

FBal0131264

Feature type

allele

Associated gene

Dmel\Dif

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

(Rutschmann et al., 2000)

Amino acid replacement: S245F.

(Rutschmann et al., 2000)

Nucleotide substitution: C1296T.

(Rutschmann et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:17,418,260..17,418,260 [-]

Nucleotide change:

C17418260T

Reported nucleotide change:

C1296T

Amino acid change:

S245F | Dif-PA; S245F | Dif-PB; S245F | Dif-PC; S245F | Dif-PD

Reported amino acid change:

S245F

(Rutschmann et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Bischoff et al., 2004, Gottar et al., 2002, Ligoxygakis et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

Dif²/Df(2L)J4 and Dif¹/Dif² larvae do not show R2-R5 photoreceptor axon targeting defects in the developing visual system.

(Minidorff et al., 2007)

Mutant flies show reduced survival compared to wild-type controls after infection with S. pyogenes or with Cryptococcus neoformans.

(Bischoff et al., 2004)

Dif² flies are highly susceptible to infection by Gram-positive bacteria (E.faecalis previously known as 'Streptococcus faecalis').

(Ligoxygakis et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Df(2L)J4/Dif² is a suppressor | partially of increased cell number | larval stage phenotype of lwr⁵/lwr^4-3

(Huang et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Df(2L)J4/Dif² is a suppressor of lamellocyte | increased number phenotype of lwr⁵/lwr^4-3

(Huang et al., 2005)

Df(2L)J4/Dif² is a suppressor | partially of embryonic/larval hemocyte | increased number phenotype of lwr⁵/lwr^4-3

(Huang et al., 2005)

Df(2L)J4/Dif² is a suppressor | partially of embryonic/larval plasmatocyte | increased number phenotype of lwr⁵/lwr^4-3

(Huang et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

In lwr^4-3/lwr⁵; Dif²/Df(2L)J4 double mutants the number of lamellocytes are the same as in wild-type larvae, while the number of plasmatocytes is reduced compared to lwr^4-3/lwr⁵ single mutants, but remain higher than in wild type.

(Huang et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36558

P{Dipt2.2-lacZ}1, P{Drs-GFP.JM804}1, y¹ w^*; Dif² cn¹ bw¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dif²

(Nagai et al., 2021, Martin et al., 2018, Gao et al., 2016, Nakamoto et al., 2012, Clark et al., 2011, Minidorff et al., 2007, Bischoff et al., 2004, Rutschmann et al., 2000)

dif²

(Peng et al., 2005, Ligoxygakis et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

Open Close