FB2025_01 , released February 20, 2025
Allele: Dmel\mrvaEP3102
Open Close
General Information
Symbol
Dmel\mrvaEP3102
Species
D. melanogaster
Name
FlyBase ID
FBal0131362
Feature type
allele
Associated gene
Dmel\mrva
Associated Insertion(s)
P{EP}mrvaEP3102
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EP}mrvaEP3102
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Stage 12 mrvaEP3102 homozygous and GlcAT-PMI05251/Df(3L)BSC117 transheterozygous embryos exhibit significantly fewer macrophages within the germband, as compared to controls; mrvaEP3102 homozygotes also show significantly fewer macrophages on the yolk, but show no changes in the number of macrophages along the ventral nerve cord and no changes in the overall number of macrophages compared to controls.

      In mrvaEP3102 embryos, macrophages migrating from their initial position in the delaminated mesoderm up to the germband are significantly slower, take much longer to start invading the germ band, and are significantly slower migrating along the germ band, but there are no changes in macrophage persistence in the head, as compared to controls; macrophages migrating along the unner ventral nerve cord show no change in speed or directionality compared to controls.

      mrvaEP3102 embryos show no changes in the timing of germ band retraction initiation despite a delay in its completion, and show no changes in germ cell migration from the midgut, as compared to controls. Likewise, there is no obvious defect in border cell migration in mrvaEP3102 stage 10 egg chambers compared to controls.

      (Valoskova et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mmus\Mfsd1srpHemo.PV and shgk03401 fully suppress and partially suppress, respectively, the decreased number of macrophages within the germ band of mrvaEP3102 stage 12 embryos.

      (Valoskova et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference

      Mmus\Mfsd1srpHemo.PV fully suppresses the decreased number of macrophages within the germ band of mrvaEP3102 stage 12 embryos.

      (Valoskova et al., 2019)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG8602EP3102
      mrva3102
      (Valoskova et al., 2019)
      mrvaEP3102
      Name Synonyms
      Secondary FlyBase IDs
        References (3)