Allele Dmel\kibra^EP747

General Information
Symbol	Dmel\kibra^EP747	Species	D. melanogaster
Name		FlyBase ID	FBal0131390
Feature type	allele	Associated gene	Dmel\kibra
Also Known As	CG7552^EP747

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Gene Disruption Project members, 2001-, Pena-Rangel et al., 2002, Tseng and Hariharan, 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:10,549,562..10,549,562 (Gene Disruption Project members, 2001-, Genevet et al., 2010, Pena-Rangel et al., 2002, Tseng and Hariharan, 2002, Genevet et al., 2010)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion in the 5' UTR. (Genevet et al., 2010)
Caused by insertion	P{EP}kibra^EP747 (Gene Disruption Project members, 2001-, Genevet et al., 2010, Pena-Rangel et al., 2002, Tseng and Hariharan, 2002, Genevet et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^ey.PH (Tseng and Hariharan, 2002) visible, with Scer\GAL4^GMR.PF (Genevet et al., 2010)
Phenotype Manifest In
	eye, with Scer\GAL4^ey.PH (Tseng and Hariharan, 2002) eye, with Scer\GAL4^GMR.PF (Genevet et al., 2010)
Detailed Description
	Statement Reference Expression of CG33967^EP747 under the control of Scer\GAL4^ey.PH results in eyes that are somewhat reduced in size. Flies expressing CG33967^EP747 under the control of Scer\GAL4^hs.2sev have wild-type eyes. Flies expressing CG33967^EP747 under the control of Scer\GAL4^en-e16E have wild-type wings. (Tseng and Hariharan, 2002)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^GMR.PF, kibra^EP747 has visible phenotype, suppressible \| partially by hpo^5.1/hpo[+] (Genevet et al., 2010)
NOT suppressed by
Statement Reference kibra^EP747, Scer\GAL4^ey.PH has visible phenotype, non-suppressible by CycE^Scer\UAS.cLa, Scer\GAL4^ey.PH (Tseng and Hariharan, 2002)
Enhancer of
Statement Reference kibra^EP747/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237 (Pena-Rangel et al., 2002)
Suppressor of
Statement Reference kibra^EP747/Scer\GAL4^tub.PU is a suppressor \| partially of visible \| somatic clone phenotype of ex^e1 (Genevet et al., 2010)
NOT Suppressor of
Statement Reference kibra^EP747/Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, yki^Scer\UAS.cHa (Genevet et al., 2010)
Other
Statement Reference kibra^EP747, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has lethal \| pupal stage phenotype (Pena-Rangel et al., 2002) kibra^EP747, Scer\GAL4^pnr-MD237, pnr^MD237 has lethal \| pupal stage phenotype (Pena-Rangel et al., 2002)
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4^GMR.PF, kibra^EP747 has eye phenotype, suppressible \| partially by hpo^5.1/hpo[+] (Genevet et al., 2010)
NOT suppressed by
Statement Reference kibra^EP747, Scer\GAL4^ey.PH has eye phenotype, non-suppressible by CycE^Scer\UAS.cLa, Scer\GAL4^ey.PH (Tseng and Hariharan, 2002)
Enhancer of
Statement Reference kibra^EP747/Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of pnr^MD237 (Pena-Rangel et al., 2002)
Suppressor of
Statement Reference kibra^EP747/Scer\GAL4^tub.PU is a suppressor \| partially of eye \| somatic clone phenotype of ex^e1 (Genevet et al., 2010)
NOT Suppressor of
Statement Reference kibra^EP747/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, yki^Scer\UAS.cHa (Genevet et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of CycE^Scer\UAS.cLa does not suppress the small eye phenotype caused by expression of CG33967^EP747 under the control of Scer\GAL4^ey.PH. (Tseng and Hariharan, 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237. (Pena-Rangel et al., 2002)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG7552^EP747 (Tseng and Hariharan, 2002, Pena-Rangel et al., 2002, ) CG33967^EP747 kibra^EP747 (Genevet et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Genevet et al., 2010, Dev. Cell 18(2): 300--308 Kibra is a regulator of the Salvador/Warts/Hippo signaling network. [FBrf0211094] Pena-Rangel et al., 2002, Genetics 160(3): 1035--1050 A misexpression study examining dorsal thorax formation in Drosophila melanogaster. [FBrf0147055] Tseng and Hariharan, 2002, Genetics 162(1): 229--243 An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. [FBrf0152035]
Supplementary material	Genevet et al., 2010, Dev. Cell 18(2): Supplemental Information. [FBrf0211483]
Personal communication to FlyBase	Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]

Allele Dmel\kibraEP747

Allele Dmel\kibra^EP747