A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\CG7231EP2510

General Information
SymbolDmel\CG7231EP2510SpeciesD. melanogaster
NameFlyBase IDFBal0131405
Feature typealleleAssociated geneDmel\CG7231
Map ( GBrowse ) Untitled Document detailed view FBti0105164 FBti0072443 FBti0111071 FBti0011195 FBti0104968 FBti0110063 FBti0035371 FBti0057799
Allele class
MutagenP-element activity
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Description
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
transposable element insertion site
2L:7,984,198..7,984,198
 
(Gene Disruption Project members, 2001-, Zhu et al., 2005, Shulman and Feany, 2003, Ramel et al., 2007, Cao et al., 2008, Ghosh and Feany, 2004)
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
The orientation of the P{EP} element is opposite to the direction of CG7231 transcription.
(Shulman and Feany, 2003)
Caused by insertion
P{EP}CG7231EP2510
(Gene Disruption Project members, 2001-, Zhu et al., 2005, Shulman and Feany, 2003, Ramel et al., 2007, Cao et al., 2008, Ghosh and Feany, 2004)
Cytology
hide Phenotypic Data
hide Phenotypic Class
viable
(Ramel et al., 2007)
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
Expression using Scer\GAL4[ey.PU] does not induce a rough eye phenotype.
(Cao et al., 2008)
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideEnhancer of
Statement
Reference
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of eye color defective phenotype of Hsap\ATXN182.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Shulman and Feany, 2003)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of visible phenotype of Cdc42L89.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Zhu et al., 2005)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of visible phenotype of Hsap\ATXN182.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Shulman and Feany, 2003)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of visible phenotype of Hsap\MAPTV337M.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Shulman and Feany, 2003)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of visible phenotype of PvrScer\UAS.T:λ\cI-DD, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Zhu et al., 2005)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of visible phenotype of Rac1N17.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Zhu et al., 2005)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of visible phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, btl::EgfrScer\UAS.T:λ\cI-DD
(Zhu et al., 2005)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of visible phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, btlScer\UAS.T:λ\cI-DD, stumpsScer\UAS.T:Zzzz\FLAG
(Zhu et al., 2005)
hideOther
Statement
Reference
CG7231EP2510, Hsap\ATXN182.Scer\UAS, Scer\GAL4Cha.7.4 has lethal phenotype
(Ghosh and Feany, 2004)
hide Phenotype Manifest In
hideEnhancer of
Statement
Reference
CG7231EP2510, Scer\GAL430Y is an enhancer of adult brain phenotype of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1, Scer\GAL430Y
(Ghosh and Feany, 2004)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of eye phenotype of Hsap\ATXN182.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Shulman and Feany, 2003)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of eye phenotype of Hsap\MAPTV337M.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Shulman and Feany, 2003)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of eye phenotype of PvrScer\UAS.T:λ\cI-DD, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Zhu et al., 2005)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of eye phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, btl::EgfrScer\UAS.T:λ\cI-DD
(Zhu et al., 2005)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of eye phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, btlScer\UAS.T:λ\cI-DD, stumpsScer\UAS.T:Zzzz\FLAG
(Zhu et al., 2005)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of ommatidium phenotype of Hsap\MAPTV337M.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Shulman and Feany, 2003)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of pigment cell phenotype of Hsap\ATXN182.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Shulman and Feany, 2003)
CG7231EP2510, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of retina phenotype of Hsap\ATXN182.Scer\UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Ghosh and Feany, 2004)
CG7231EP2510, Scer\GAL4GMR.PF is an enhancer of retina phenotype of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
(Ghosh and Feany, 2004)
CG7231EP2510, Scer\GAL4GMR.PF is an enhancer of retina phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1
(Ghosh and Feany, 2004)
CG7231EP2510/Scer\GAL4ey.PU is an enhancer of eye phenotype of Hsap\APPAβ42.GMR
(Cao et al., 2008)
hide Additional Comments
hide Genetic Interactions
Statement
Reference
hide Xenogenetic Interactions
Statement
Reference
The rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is enhanced by CG7231EP2510. Co-expression of CG7231EP2510 enhances the eye phenotype caused by expression of Hsap\ATX182.Scer\UAS under the control of Scer\GAL4GMR.PF; loss of eye pigmentation is enhanced and necrotic black spots are induced.
(Shulman and Feany, 2003)
hide Complementation & Rescue Data
Comments
hide Stocks ( 0 )
hide Notes on Origin
Discoverer
hide Comments
Precise excision of the P{EP} element reverts the modifying effect of CG7231EP2510 on the rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF.
(Shulman and Feany, 2003)
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym
CG7231EP2510
 
Name Synonym
Secondary FlyBase IDs
hide References ( 6 )
Research paper
Cao et al., 2008, Genetics 178(3): 1457--1471
Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. [FBrf0205107]
Ramel et al., 2007, Mech. Dev. 124(4): 304--317
Drosophila SnoN modulates growth and patterning by antagonizing TGF-beta signalling. [FBrf0199308]
Zhu et al., 2005, Genetics 170(2): 767--777
A screen for genes that influence fibroblast growth factor signal transduction in Drosophila. [FBrf0187664]
Ghosh and Feany, 2004, Hum. Mol. Genet. 13(18): 2011--2018
Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. [FBrf0180337]
Shulman and Feany, 2003, Genetics 165(3): 1233--1242
Genetic modifiers of tauopathy in Drosophila. [FBrf0167629]
Personal communication to FlyBase
Gene Disruption Project members, 2001-, (Computer file)
(Computer file) [FBrf0132177]