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General Information
Symbol
Dmel\seaEP3364
Species
D. melanogaster
Name
FlyBase ID
FBal0131420
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion 437bp upstream of the putative start codon.

The P{EP}seaEP3364 insertion maps within a dicistronic processed transcript that encodes two non-overlapping open reading frames (fabp and sea).

Insertion components
P{EP}seaEP3364
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

seaEP3364 homozygous larval neuroblasts show a high frequency of chromosome breaks, which are almost absent in wild-type controls.

Brain neuroblasts of homozygous and seaEP3364/Df(3R)Mx-1 larvae show defects in mitosis; approximately 40% have chromatid and chromosome breaks, and approximately 3% show chromosome exchanges. In addition, approximately 10% of the mutant cells show a more complex breakage phenotype consisting of multiple chromosome splinters. The mutant neuroblasts show an approximately 3-fold reduction in the mitotic index compared to controls, although the frequency of anaphases is indistinguishable from wild type.

Brain neuroblasts of seaΔ24/seaEP3364 larvae show defects in mitosis, with a high frequency of chromosome breaks. Mutant cells with highly fragmented nuclei containing chromosome "splinters" are also seen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

rad50Δ5.1 does not override the reduced mitotic index of seaEP3364 single mutants.

mre11unspecified does not override the reduced mitotic index of seaEP3364 single mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
CG6782EP3364
Name Synonyms
Secondary FlyBase IDs
    References (4)