seaEP3364 homozygous larval neuroblasts show a high frequency of chromosome breaks, which are almost absent in wild-type controls.
Brain neuroblasts of homozygous and seaEP3364/Df(3R)Mx-1 larvae show defects in mitosis; approximately 40% have chromatid and chromosome breaks, and approximately 3% show chromosome exchanges. In addition, approximately 10% of the mutant cells show a more complex breakage phenotype consisting of multiple chromosome splinters. The mutant neuroblasts show an approximately 3-fold reduction in the mitotic index compared to controls, although the frequency of anaphases is indistinguishable from wild type.
Brain neuroblasts of seaΔ24/seaEP3364 larvae show defects in mitosis, with a high frequency of chromosome breaks. Mutant cells with highly fragmented nuclei containing chromosome "splinters" are also seen.