Allele Dmel\CG3776^EP835

General Information
Symbol	Dmel\CG3776^EP835	Species	D. melanogaster
Name		FlyBase ID	FBal0131499
Feature type	allele	Associated gene	Dmel\CG3776

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Gene Disruption Project members, 2001-, Pena-Rangel et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2R:20,857,336..20,857,336 (Gene Disruption Project members, 2001-, Pena-Rangel et al., 2002, Liu et al., 2007, Liu et al., 2008)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{EP}CG3776^EP835 (Gene Disruption Project members, 2001-, Pena-Rangel et al., 2002, Liu et al., 2007, Liu et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	courtship behavior defective \| male \| heat sensitive, with Scer\GAL4^hs.PB (Liu et al., 2008) female fertile (Liu et al., 2008) female sterile \| heat sensitive, with Scer\GAL4^hs.PB (Liu et al., 2008) lethal \| heat sensitive, with Scer\GAL4^hs.PB (Liu et al., 2008) locomotor behavior defective, with Scer\GAL4^hs.PB (Liu et al., 2008) male fertile, with Scer\GAL4^hs.PB (Liu et al., 2008) short lived \| female (Liu et al., 2008) short lived \| female, with Scer\GAL4^hs.PB (Liu et al., 2008) short lived \| male (Liu et al., 2008) short lived \| male, with Scer\GAL4^hs.PB (Liu et al., 2008) small body \| heat sensitive, with Scer\GAL4^hs.PB (Liu et al., 2008)
Phenotype Manifest In

Detailed Description
	Statement Reference Expression of CG3776[EP835] under the control of Scer\GAL4[hs.PB] using heat shock during the first or second larval instar results in lethality, while heat shock during the third larval instar results in eclosion of small adults. Expression of CG3776[EP835] under the control of Scer\GAL4[hs.PB] using heat shock in males does not affect the number of adult progeny from these flies. These males show a high frequency of mating behaviour and also show male-male courtship behaviour. Expression of CG3776[EP835] under the control of Scer\GAL4[hs.PB] using heat shock in newly eclosed female flies results in a reduced number of adult progeny flies even when the females are mated with normal males. Newly eclosed females expressing CG3776[EP835] under the control of Scer\GAL4[hs.PB] lay significantly fewer eggs than control females (this effect is seen both when they are mated to wild-type males and when they are mated to males expressing CG3776[EP835] under the control of Scer\GAL4[hs.PB]). These females have significantly fewer eggs in their ovaries 4 days after eclosion compared to control females (egg production in these females can be recovered by application of methoprene). Fecundity is not affected if females carrying CG3776[EP835] under the control of Scer\GAL4[hs.PB] are heat shocked 7 days after eclosion. CG3776[EP835] females (in the absence of a Scer\GAL4 driver) lay significantly more eggs than control females (this effect is seen both when they are mated to wild-type males and when they are mated to CG3776[EP835] males). CG3776[EP835] males (in the absence of a Scer\GAL4 driver) show a 38.8% reduction in lifespan compared to controls, while males expressing CG3776[EP835] under the control of Scer\GAL4[hs.PB] show a 42.6% reduction in lifespan compared to controls. CG3776[EP835] females (in the absence of a Scer\GAL4 driver) show a 31.6% reduction in lifespan compared to controls, while females expressing CG3776[EP835] under the control of Scer\GAL4[hs.PB] show a 35% reduction in lifespan compared to controls. Flies expressing CG3776[EP835] under the control of Scer\GAL4[hs.PB] show increased locomotor activity compared to controls. (Liu et al., 2008)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Scer\GAL4^pnr-MD237/CG3776^EP835 is a suppressor of visible phenotype of pnr^MD237 (Pena-Rangel et al., 2002)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	32051 w¹¹¹⁸; P{EP}CG3776^EP835
Notes on Origin
Discoverer
	Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237. (Pena-Rangel et al., 2002)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG3776^EP835 Jhebp29^EP835 l(2)k03704^EP835
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Liu et al., 2008, Gen. Comp. Endocrinol. 156(1): 164--172 Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance. [FBrf0205371] Liu et al., 2007, Insect Biochem. Mol. Biol. 37(8): 838--846 Potential ligands of DmP29, a putative juvenile hormone esterase binding protein of Drosophila melanogaster. [FBrf0200109] Pena-Rangel et al., 2002, Genetics 160(3): 1035--1050 A misexpression study examining dorsal thorax formation in Drosophila melanogaster. [FBrf0147055]
Personal communication to FlyBase	Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]

Allele Dmel\CG3776EP835

Allele Dmel\CG3776^EP835