|Feature type||allele||Associated gene||Dmel\Drp1|
|Map ( GBrowse )||
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
autophagic vacuole & larval fat body | somatic clone | cell autonomous
lysosome & larval fat body | somatic clone | cell autonomous
mitochondrion & primary spermatocyte | germ-line clone
Drp1[KG03815] clones in fat bodies from well-fed early third instar larvae accumulate lysosomes, as indicated by elevated LysoTracker staining, and show redistribution of the Atg8a product into autophagosomes.
Primary spermatocytes in homozygous germline clones induced in males contain abnormally clustered mitochondria. 52% of early round spermatids derived from these spermatocytes retain mitochondrial material and in all cases the mitochondria appear not to have separated properly during meiosis, remaining connected and appearing to pass through the cytoplasmic bridges between spermatids. The remaining 48% of the mutant spermatids have little or no mitochondrial material. At later stages of flagellar elongation, the mutant spermatids have defects in unfurling and elongation of mitochondria, with the spermatids containing spaghetti-like interconnected masses of mitochondria that fail to elongate properly and are associated with multiple nuclei. The ratio of the observed mitochondrial masses to nuclei is 8:34, consistent with each mass typically representing the mitochondrial material from all four meiotic products of a single spermatocyte.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to complement|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 5 )|
|Secondary FlyBase IDs|
|References ( 6 )|
|Personal communication to FlyBase|