A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\Drp1KG03815

General Information
SymbolDmel\Drp1KG03815SpeciesD. melanogaster
NameFlyBase IDFBal0131515
Feature typealleleAssociated geneDmel\Drp1
Map ( GBrowse ) Untitled Document detailed view FBti0050624 FBti0021561
Allele class
MutagenP-element activity
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Description
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
transposable element insertion site
2L:2,584,872..2,584,872
 
(Gene Disruption Project members, 2001-, Ly, 2005.3.2, Verstreken et al., 2005)
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
 
 
Caused by insertion
P{SUPor-P}Drp1KG03815
(Gene Disruption Project members, 2001-, Ly, 2005.3.2, Verstreken et al., 2005)
Cytology
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hide Phenotypic Class
hide Phenotype Manifest In
autophagic vacuole & larval fat body | somatic clone | cell autonomous
(Arsham and Neufeld, 2009)
lysosome & larval fat body | somatic clone | cell autonomous
(Arsham and Neufeld, 2009)
mitochondrial derivative | germline clone
(Aldridge et al., 2007)
mitochondrion & primary spermatocyte | germ-line clone
(Aldridge et al., 2007)
Nebenkern | germline clone
(Aldridge et al., 2007)
hide Detailed Description
Statement
Reference
Drp1[KG03815] clones in fat bodies from well-fed early third instar larvae accumulate lysosomes, as indicated by elevated LysoTracker staining, and show redistribution of the Atg8a product into autophagosomes.
(Arsham and Neufeld, 2009)
Primary spermatocytes in homozygous germline clones induced in males contain abnormally clustered mitochondria. 52% of early round spermatids derived from these spermatocytes retain mitochondrial material and in all cases the mitochondria appear not to have separated properly during meiosis, remaining connected and appearing to pass through the cytoplasmic bridges between spermatids. The remaining 48% of the mutant spermatids have little or no mitochondrial material. At later stages of flagellar elongation, the mutant spermatids have defects in unfurling and elongation of mitochondria, with the spermatids containing spaghetti-like interconnected masses of mitochondria that fail to elongate properly and are associated with multiple nuclei. The ratio of the observed mitochondrial masses to nuclei is 8:34, consistent with each mass typically representing the mitochondrial material from all four meiotic products of a single spermatocyte.
(Aldridge et al., 2007)
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Linkouts
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hide Phenotypic Class
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hide Additional Comments
hide Genetic Interactions
Statement
Reference
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Fails to complement
Drp11
(Ly, 2005.3.2, Verstreken et al., 2005)
Drp12
(Ly, 2005.3.2, Verstreken et al., 2005)
Drp1H7
(Verstreken et al., 2005)
Drp1T26
(Verstreken et al., 2005)
Comments
hide Stocks ( 2 )
Bloomington
13510
y1; P{SUPor-P}Drp1KG03815/CyO; ry506
Kyoto
111549
yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}Drp1KG03815 P{neoFRT}40A/CyO y+
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Discoverer
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Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym
CG3210KG03815
 
drp1KG03185
(Deng et al., 2008)
Drp1KG03815
(Aldridge et al., 2007, Arsham and Neufeld, 2009)
drp1KG
(Ly, 2005.3.2)
noodleKG03815
 
Name Synonym
Secondary FlyBase IDs
hide References ( 6 )
Research paper
Arsham and Neufeld, 2009, PLoS ONE 4(6): e6068
A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. [FBrf0208155]
Deng et al., 2008, Proc. Natl. Acad. Sci. U.S.A. 105(38): 14503--14508
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. [FBrf0206104]
Aldridge et al., 2007, Fly 1(1): 38--46
Roles for Drp1, a dynamin-related protein, and milton, a kinesin-associated protein, in mitochondrial segregation, unfurling, and elongation during Drosophila spermatogenesis. [FBrf0200064]
Verstreken et al., 2005, Neuron 47(3): 365--378
Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. [FBrf0188182]
Personal communication to FlyBase
Ly, 2005.3.2, Helping FlyBase: ADRC-50399.
Helping FlyBase: ADRC-50399. [FBrf0183137]
Gene Disruption Project members, 2001-, (Computer file)
(Computer file) [FBrf0132177]