Allele Dmel\beag^EP3260

General Information
Symbol	Dmel\beag^EP3260	Species	D. melanogaster
Name		FlyBase ID	FBal0131563
Feature type	allele	Associated gene	Dmel\beag

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Gene Disruption Project members, 2001-)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:4,890,586..4,890,586 (Gene Disruption Project members, 2001-, Schulz et al., 2004, Beck et al., 2012)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{EP}beag^EP3260 (Gene Disruption Project members, 2001-, Schulz et al., 2004, Beck et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| third instar larval stage (with beag¹) (Beck et al., 2012) neuroanatomy defective \| third instar larval stage (with Df(3R)Exel6151) (Beck et al., 2012) neurophysiology defective \| third instar larval stage (with beag¹) (Beck et al., 2012)
Phenotype Manifest In
	germline cell \| male, with Scer\GAL4^ptc-559.1 (Schulz et al., 2004) NMJ bouton \| third instar larval stage (with beag¹) (Beck et al., 2012) NMJ bouton \| third instar larval stage (with Df(3R)Exel6151) (Beck et al., 2012)
Detailed Description
	Statement Reference beag[1]/beag[EP3260] larvae have decreased numbers of NMJ synaptic boutons compared to wild type. Df(3R)Exel6151/beag[EP3260] larvae have decreased numbers of NMJ synaptic boutons compared to wild type. beag[1]/beag[EP3260] animals have a 47% decrease in EJP amplitude at the larval NMJ compared with wild type. mEJP amplitude and frequency are unchanged, leading to a 34% decrease in quantal content compared with wild type. (Beck et al., 2012) Expression of CG18005^EP3260 under the control of Scer\GAL4^ptc-559.1 (the animals are initially raised at 18^oC and then shifted to 29^oC after 10 days) results in a reduced number of early germ cells (stem cells, gonialblasts and spermatogonia) in the testis. (Schulz et al., 2004)
External Data
Linkouts
Interactions
Phenotypic Class
NOT Enhanced by
Statement Reference Df(3R)Exel6151/beag^EP3260 has neuroanatomy defective \| third instar larval stage phenotype, non-enhanceable by Smu1^f03090/Df(3R)Exel6182 (Beck et al., 2012)
NOT Enhancer of
Statement Reference Df(3R)Exel6151/beag^EP3260 is a non-enhancer of neuroanatomy defective \| third instar larval stage phenotype of Smu1^f03090/Df(3R)Exel6182 (Beck et al., 2012)
Phenotype Manifest In
NOT Enhanced by
Statement Reference Df(3R)Exel6151/beag^EP3260 has NMJ bouton \| third instar larval stage phenotype, non-enhanceable by Smu1^f03090/Df(3R)Exel6182 (Beck et al., 2012)
NOT Enhancer of
Statement Reference Df(3R)Exel6151/beag^EP3260 is a non-enhancer of NMJ bouton \| third instar larval stage phenotype of Smu1^f03090/Df(3R)Exel6182 (Beck et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference The decrease in synaptic bouton number in beag[EP3260]/Df(3R)Exel6151, Smu1[f03090]/Df(3R)Exel6182 double mutants is not significantly different from that observed in either single hemizygous mutant. (Beck et al., 2012)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	beag¹/beag^EP3260 is rescued by Scer\GAL4^Rapgap1-OK6/beag^Scer\UAS.cBa (Beck et al., 2012)
Comments	Expression of beag[Scer\UAS.cBa] using Scer\GAL4[Rapgap1-OK6] fully rescues the reduction in EJP amplitude and quantal content in beag[1]/beag[EP3260] mutants. (Beck et al., 2012)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Complements: ird1[unspecified]. (Wu et al., 2007)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	beag^EP3260 (Beck et al., 2012) CG18005^EP3260 EP3260 (Wu et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Beck et al., 2012, J. Neurosci. 32(20): 7058--7073 Regulation of Fasciclin II and Synaptic Terminal Development by the Splicing Factor Beag. [FBrf0218385] Wu et al., 2007, Cell. Microbiol. 9(4): 1073--1085 ird1 is a Vps15 homologue important for antibacterial immune responses in Drosophila. [FBrf0201559] Schulz et al., 2004, Genetics 167(2): 707--723 A misexpression screen reveals effects of bag-of-marbles and TGF beta class signaling on the Drosophila male germ-line stem cell lineage. [FBrf0179436]
Personal communication to FlyBase	Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]

Allele Dmel\beagEP3260

Allele Dmel\beag^EP3260