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General Information
Symbol
Dmel\Arp3EP3640
Species
D. melanogaster
Name
FlyBase ID
FBal0131796
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
arp66BEP3640, Arp3EP(3)3640, EP(3)3640
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{EP}Arp3EP3640
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Arp3EP3640/+ mutants embryos show no defects in development or survival.

Cultured primary neurons derived from mutant embryos show a significant reduction in the number of filopodia compared to control neurons.

Arp66BEP3640 heterozygous neuromuscular junctions do not exhibit any morphological changes.

Homozygous Arp66BEP3640 mutant embryos do not exhibit a strong myoblast-fusion defect.

Trans-heterozygous Arp66BEP3640/Arp66Bschwachling exhibit a clear myoblast-fusion defect.

Arp66BEP3640 mutants reveal a moderate myoblast fusion defect. Arp66BEP3640 mutants show a dramatic increase in the size and number of actin foci.

Germ-line clones of Arp66BEP3640 lead to defects in nurse cell dumping: late stage oocytes are abnormally small, while late stage nurse cells are abnormally large. By stage 10B the arrangement of actin filament bundles in the cytoplasm of mutant nurse cells is abnormally uneven, and the diameter and shape of ring canals between these cells is severely compromised. There are approximately twice as many longitudinal ridges on anterior dorso-central bristles in Arp66BEP3640 homozygous pharate adults, as in wild-type. A similar phenotype is seen in all other macrochaete.

Arp66BEP3640/Df(3L)pbl-X1 embryos have breaks in ventral nerve cord commissures.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Arp3EP3640 has neuroanatomy defective phenotype, enhanceable by Cip41/Cip4[+]

Enhancer of
Statement
Reference

Arp3EP3640/Arp66B[+] is an enhancer of neuroanatomy defective phenotype of Cip41

Suppressor of
Phenotype Manifest In
Enhanced by
Statement
Reference

Arp3EP3640 has NMJ bouton phenotype, enhanceable by Cip41/Cip4[+]

Arp3EP3640 has neuromuscular junction phenotype, enhanceable by Cip41/Cip4[+]

Enhancer of
Statement
Reference

Arp3EP3640/Arp66B[+] is an enhancer of NMJ bouton phenotype of Cip41

Arp3EP3640/Arp66B[+] is an enhancer of neuromuscular junction phenotype of Cip41

Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Arp3EP3640/+ partially suppresses the embryonic lethality and dorsal closure defects seen in embryos expressing crbY10A in a crbGX24w-/crb11A22 background.

Arp3EP3640/+ does not lead to any dorsal closure defects in embryos expressing crb+tfos in a crbGX24w-/crb11A22 background.

One copy of Arp3EP3640 partially suppresses the cuticle defects seen in α-Cat1 mutant embryos. Embryos show less severe defects on average and a fraction of embryos have normal heads.

One copy of Arp3EP3640 partially suppresses the cuticle defects seen in arm3 mutant embryos.

One copy of Arp3EP3640 partially suppresses the cuticle defects seen in arm043A01 mutant embryos.

Arp66BEP3640/Cip41 double heterozygotes exhibit an increase in total bouton number, satellite bouton formation and neuromuscular junction length.

Myoblast fusion does not occur in DA1 muscles in Arp66BEP3640, WASp3D3-035 double mutants.

Ectopic expression of Arp66BEP3640 suppresses the patterning defects found in Scer\GAL4GMR.PF>cindrdsRNA.PC.PD.Scer\UAS mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

In Sop2Q25sd/Df(2L)b84a9; Arp66BEP3640/+ embryos, commissural axons are severely reduced.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (12)