Arp3EP3640/+ mutants embryos show no defects in development or survival.
Cultured primary neurons derived from mutant embryos show a significant reduction in the number of filopodia compared to control neurons.
Arp66BEP3640 heterozygous neuromuscular junctions do not exhibit any morphological changes.
Arp66BEP3640 mutants reveal a moderate myoblast fusion defect. Arp66BEP3640 mutants show a dramatic increase in the size and number of actin foci.
Germ-line clones of Arp66BEP3640 lead to defects in nurse cell dumping: late stage oocytes are abnormally small, while late stage nurse cells are abnormally large. By stage 10B the arrangement of actin filament bundles in the cytoplasm of mutant nurse cells is abnormally uneven, and the diameter and shape of ring canals between these cells is severely compromised. There are approximately twice as many longitudinal ridges on anterior dorso-central bristles in Arp66BEP3640 homozygous pharate adults, as in wild-type. A similar phenotype is seen in all other macrochaete.