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General Information
Symbol
Dmel\Arf51FEP2612
Species
D. melanogaster
Name
FlyBase ID
FBal0131798
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Arf6P2, EP2612, EP(2)2612
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion in the first intron.

Insertion components
P{EP}Arf51FEP2612
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Arf51FEP2612 homozygotes and Arf51FEP2612/Arf51FNP5226 transheterozygotes are more sensitive (lower survival) to ethanol than heterozygotes or wild-type controls; Arf51FEP2612/Arf51FNP5226 transheterozygotes do not develop much tolerance from previous exposures.

Naive Arf51FEP2612/Arf51FNP5226 mutants show preference for ethanol-laced food, unlike the aversion normally observed in wild-type controls. Arf51FEP2612/Arf51FNP5226 mutants previously exposed to ethanol show the same preference for ethanol-laced food as wild-type controls.

Homozygotes are sensitive to ethanol-induced sedation compared to heterozygous siblings and wild-type controls.

Arf51FNP5226/Arf51FEP2612 and Arf51FKG02753/Arf51FEP2612 flies are sensitive to ethanol-induced sedation compared to wild-type controls.

Arf51FNP5226/Arf51FEP2612 flies show a small but significant increase in sensitivity to sedation with CO[[2]] compared to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The sensitivity to ethanol-induced sedation seen in Arf51FNP5226/Arf51FEP2612 flies is not enhanced if they are also homozygous for Arfip12.

The sensitivity to ethanol-induced sedation seen in Arf51FNP5226/Arf51FEP2612 flies is enhanced if they also carry amnchpd.

The sensitivity to ethanol-induced sedation seen in Arf51FKG02753/Arf51FEP2612 flies is not altered if they also carry RhoGAP18B1.

The sensitivity to ethanol-induced sedation seen in Arf51FKG02753/Arf51FEP2612 flies is not altered if they express Rac1CA.Scer\UAS under the control of Scer\GAL4RhoGAP18B-NP1514 specifically in the adult (using the heat sensitive Scer\GAL80ts.αTub84B allele to limit expression).

The ommatidial patterning errors resulting from the expression of cindrdsRNA.PC.PD.Scer\UAS via Scer\GAL4GMR.PF are strongly enhanced in Arf51FEP2612 heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Arf51FScer\UAS.cCa under the control of Scer\GAL4Arf51F-NP5226 rescues the sensitivity of Arf51FNP5226/Arf51FEP2612 flies to ethanol-induced sedation. This rescue is suppressed in the presence of Scer\GAL80elav.PY.

Expression of Arf51FScer\UAS.cCa under the control of Scer\GAL4elav.PLu rescues the sensitivity of Arf51FKG02753/Arf51FEP2612 flies to ethanol-induced sedation.

Expression of Arf51FScer\UAS.cCa under the control of Scer\GAL4RhoGAP18B-NP1514 throughout development but not in the adult (using the heat sensitive Scer\GAL80ts.αTub84B allele to limit expression) does not rescue the sensitivity of Arf51FKG02753/Arf51FEP2612 flies to ethanol-induced sedation.

Expression of Arf51FScer\UAS.cCa under the control of Scer\GAL4RhoGAP18B-NP1514 specifically in the adult (using the heat sensitive Scer\GAL80ts.αTub84B allele to limit expression) does rescue the sensitivity of Arf51FKG02753/Arf51FEP2612 flies to ethanol-induced sedation.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Separable from: a lethal mutation on the same chromosome.

Selected as: a P{EP} insertion line that modifies the pnrMD237/+ phenotype when expressed using Scer\GAL4pnr-MD237.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)