FB2025_01 , released February 20, 2025
Allele: Dmel\witHA1
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General Information
Symbol
Dmel\witHA1
Species
D. melanogaster
Name
FlyBase ID
FBal0133967
Feature type
allele
Associated gene
Dmel\wit
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Aberle et al., 2002)
Mutagen
ethyl methanesulfonate
(Aberle et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: E413K. Mutation is within the coiled-coil/leucine zipper domain.

(Aberle et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:4,066,781..4,066,781 [-]
Nucleotide change:

G4066781A

Amino acid change:

E413K | wit-PA; E413K | wit-PB

Reported amino acid change:

E413K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Aberle et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      witHA1 has abnormal neuroanatomy phenotype, enhanceable by Impβ1170

      (Higashi-Kovtun et al., 2010)
      Suppressed by
      Statement
      Reference

      Impβ1170, wit[+]/witHA1 has abnormal neuroanatomy phenotype, suppressible by witUAS.cMa/Scer\GAL4elav.PLu

      (Higashi-Kovtun et al., 2010)
      Enhancer of
      Statement
      Reference

      wit[+]/witHA1 is an enhancer of abnormal neuroanatomy phenotype of Impβ1170

      (Higashi-Kovtun et al., 2010)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      witHA1 has bouton phenotype, enhanceable by Ranbp11[+]/Impβ1170

      (Higashi-Kovtun et al., 2010)
      Suppressed by
      Statement
      Reference

      Impβ1170, wit[+]/witHA1 has bouton phenotype, suppressible by witUAS.cMa/Scer\GAL4elav.PLu

      (Higashi-Kovtun et al., 2010)
      Enhancer of
      Statement
      Reference

      wit[+]/witHA1 is an enhancer of bouton phenotype of Impβ1170

      (Higashi-Kovtun et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ranbp1170/+; witHA1/+ double heterozygous larvae exhibit significantly fewer boutons than either wild-type or each heterozygous allele alone.

      Neuronal expression of witScer\UAS.cMa (under the control of Scer\GAL4elav.PLu reverses the reduction in bouton number in Ranbp1170/+ ; witHA1/+ larvae.

      (Higashi-Kovtun et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      witHA1
      (Higashi-Kovtun et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)