Co-expression of BHDdsRNA.Sym.Scer\UAS significantly suppresses the testis phenotype caused by expression of upd1Scer\UAS.cCa under the control of Scer\GAL4nos.PG; the number of germline stem cells is significantly reduced, and the overall shape of the testis is closer to that of wild type.
The eye and eye disc overgrowth phenotypes seen in upd1Scer\UAS.cCa; Scer\GAL4GMR.PF flies, are dramatically enhanced by CycDScer\UAS.cDa with Cdk4Scer\UAS.T:Hsap\MYC : All ommatidia are dramatically enlarged in these eyes, and the entire eye bulges out of the head. The increase in ommatidial numbers seen in upd1Scer\UAS.cCa; Scer\GAL4GMR.PF eye discs is also enhanced. The block in photoreceptor differentiation seen in third instar CycDScer\UAS.cDa; Cdk4Scer\UAS.T:Hsap\MYC; Scer\GAL4GMR.PF eye discs, is suppressed by upd1Scer\UAS.cCa. However, the similar phenotype seen in third instar Cdk2Scer\UAS.T:Hsap\MYC; CycEScer\UAS.cLa; Scer\GAL4GMR.PF eye discs is largely unaffected by upd1Scer\UAS.cCa.
The extra number of ommatidia caused by expression of upd1Scer\UAS.cCa under the control of Scer\GAL4GMR.PF is partially suppressed by hop2/+; the flies have an average of 854 +/- 9 ommatidia. The extra number of ommatidia caused by expression of upd1Scer\UAS.cCa under the control of Scer\GAL4GMR.PF is partially suppressed by domeG0441/+; the flies have an average of 813 +/- 10 ommatidia.