A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\lmdA388

General Information
SymbolDmel\lmdA388SpeciesD. melanogaster
NameFlyBase IDFBal0134061
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\lmd
Allele classamorph
Mutagenethyl methanesulfonate
hide Nature of the Allele
Allele class
amorph
(Ruiz-Gomez et al., 2002)
Mutagen
ethyl methanesulfonate
(Ruiz-Gomez et al., 2002)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      Amino acid replacement: W320@. Amino acid replacement: F140I. Nucleotide substitution: G959A.
      (Ruiz-Gomez et al., 2002)
      Assay mode
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      hide Phenotype Manifest In
      embryonic somatic muscle
      (Ruiz-Gomez et al., 2002)
      embryonic myoblast
      (Ruiz-Gomez et al., 2002)
      pharyngeal muscle
      (Ruiz-Gomez et al., 2002)
      embryonic visceral muscle
      (Ruiz-Gomez et al., 2002)
      hide Detailed Description
      Statement
      Reference
      The heart develops normally in mutant embryos. Mutant embryos show a complete lack of myoblast fusion and all somatic muscles are mononucleated. Fusion also does not occur in the pharynx muscles. The somatic founder myoblasts appear to differentiate normally, elongating and attaching to the epidermis at the correct insertion sites. Fusion-competent myoblasts are not detected at any stage with Myosin staining. Syncytial visceral muscles are not formed in mutant embryos.
      (Ruiz-Gomez et al., 2002)
      hide Interactions
      hide Phenotypic Class
      hide Phenotype Manifest In
      hideNOT suppressed by
      Statement
      Reference
      lmdA388 has embryonic myoblast phenotype, non-suppressible by Scer\GAL4twi.PB/Mef2III.Scer\UAS
      (Ruiz-Gomez et al., 2002)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Partially rescued by
      lmdA388 is partially rescued by Scer\GAL4twi.PB/lmdScer\UAS.cRa
      (Ruiz-Gomez et al., 2002)
      Comments
      hide Stocks ( 0 )
      hide Notes on Origin
      Discoverer
      hide Synonyms & Secondary IDs ( 2 )
      Reported As
      Symbol Synonym
      lmdA388
       
      mincA388
      (Marin et al., 2004, Ruiz-Gomez et al., 2002)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 2 )
        Research paper
        Marin et al., 2004, Molec. Biol. Cell 15(3): 1185--1196
        Transcription of Drosophila Troponin I gene is regulated by two conserved, functionally identical, synergistic elements. [FBrf0174929]
        Ruiz-Gomez et al., 2002, Development 129(1): 133--141
        myoblasts incompetent encodes a zinc finger transcription factor required to specify fusion-competent myoblasts in Drosophila. [FBrf0141504]