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General Information
Symbol
Dmel\CblKG03080
Species
D. melanogaster
Name
FlyBase ID
FBal0134284
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
kg03080
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{SUPor-P}CblKG03080
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

CblKG03080 homozygous mutant third instar larvae have significantly increased concentration of circulating hemocytes compared to wild-type controls due to an increase in their mitotic activity (higher percentage of pH3-positive hemocytes). Primary hemocytes from these mutant larvae show strongly reduced internalization of sSpi-GFP protein (spi encodes the principal ligand of the EGFR pathway) at high sSpi-GFP conditions (treatment with 30 ng/ml sSpi-GFP), as compared to controls.

Homozygous CblKG03080 flies show poor survival to adulthood.

Less than half of CblEY11427/CblKG03080 mutant males survive to adulthood.

Pupation is delayed by approximately 24 hours in CblEY11427/CblKG03080 larvae compared with wild-type controls.

CblEY11427/CblKG03080 males show increased sensitivity to starvation, exhibiting an approximately 20% decrease in the median survival time upon food deprivation.

CblEY11427/CblKG03080 males display a dramatically shortened lifespan, with an approximately 67% reduction in the median lifespan compared with wild-type controls.

Heterozygotes show a direct effect on the shape of the wing.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference

CblKG03080/Cbl[+] is a non-enhancer of visible phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

NOT Suppressor of
Statement
Reference

CblKG03080/Cbl[+] is a non-suppressor of visible phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

Phenotype Manifest In
NOT Enhancer of
Statement
Reference

CblKG03080/Cbl[+] is a non-enhancer of wing vein | ectopic phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

NOT Suppressor of
Statement
Reference

CblKG03080/Cbl[+] is a non-suppressor of wing vein | ectopic phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The increased concentration of circulating hemocytes in CblKG03080 homozygous mutant third instar larvae along with the strongly reduced internalization of sSpi-GFP protein (spi encodes the principal ligand of the EGFR pathway) at high sSpi-GFP conditions (treatment with 30 ng/ml sSpi-GFP) seen in primary hemocytes isolated form the mutant larvae is fully rescued by expression of CblL.Scer\UAS but not CblL.Δ70Z.Scer\UAS under the control of Scer\GAL4crq.PO in the CblKG03080 mutants.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)