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General Information
Symbol
Dmel\Atg18aKG03090
Species
D. melanogaster
Name
FlyBase ID
FBal0134302
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
atg18KG03090
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{SUPor-P}Atg18aKG03090
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Atg18KG03090 mutants display basal autophagy defects in larval fat body cells.

Atg18KG03090 heterozygous neuromuscular junctions exhibit wild-type bouton levels.

Atg18KG03090/Df(3L)Exel6112 animals analysed at +4 hours relative to puparium formation show a significant delay in midgut histolysis compared to controls. At +12 hours relative to puparium formation, larval midgut contraction is dramatically delayed in the mutants compared to controls.

Larvae homozygous for Atg18KG03090 show abnormal autophagic response to starvation.

Atg18KG03090/+ mutants exhibit a neuromuscular junction undergrowth phenotype but do not exhibit defects in axonal transport.

At 24 hours after puparium formation, Atg18KG03090/Df(3L)66C-G28 animals expressing still contain vacuolated salivary gland fragments, in contrast to wild-type animals, where the salivary glands have completely degraded by this stage.

DNA fragmentation is detected by TUNEL in salivary glands of Atg18KG03090/Df(3L)Exel6112 animals at 13.5 hours after puparium formation, as occurs in control salivary glands at this stage.

Mutants show disruption of autophagy.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

Atg18aKG03090/Atg18a[+] is a non-enhancer of adult external thorax phenotype of parkΔ21/park25

Suppressor of
Statement
Reference

Atg18aKG03090, maskUAS.cZa, Atg18a[+], Scer\GAL4how-24B is a suppressor | partially of pupal thorax | heat sensitive phenotype of Prosβ61.B.UAS, Scer\GAL4how-24B

Atg18aKG03090/Atg18a[+] is a suppressor of adult external thorax phenotype of mask10.22, parkΔ21/park25

Atg18aKG03090/Atg18[+] is a suppressor of synapse phenotype of Rae1EX28

Atg18aKG03090/Atg18[+] is a suppressor of NMJ bouton phenotype of Rae1EX28

NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The indentations on the thorax phenotype characteristic for adult park25/parkΔ21 transheterozygotes is not changed by combination with Atg18aKG03090 in heterozygous state: the penetrance of the indentation phenotype is comparable to park25/parkΔ21 mutants alone.

The partial suppression of the indentations on the thorax phenotype characteristic for adult park25/parkΔ21 transheterozygotes that results from combination with mask10.22 allele in heterozygous state is reverted again by addition of Atg18aKG03090 in heterozygous state: the penetrance of the indentation phenotype in park25/parkΔ21;mask10.22/+;Atg18aKG03090/+ triple mutants is comparable to park25/parkΔ21 mutants alone.

An Atg18KG03090 heterozygous background dominantly suppresses the increase in bouton number seen in Rae1EX28 homozygous mutant neuromuscular junction.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (16)