Allele Dmel\14-3-3ζ^LII.2.hs

General Information
Symbol	Dmel\14-3-3ζ^LII.2.hs	Species	D. melanogaster
Name		FlyBase ID	FBal0134435
Feature type	allele	Associated gene	Dmel\14-3-3ζ

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Philip et al., 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of a 14-3-3ζ cDNA exons 1-6',7 is driven by a heat shock promoter. (Philip et al., 2001)
Carried in construct	P{hs-14-3-3ζ.LII.2} (Philip et al., 2001, Acevedo et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	learning defective, with 14-3-3ζ^LI.15.hs, 14-3-3ζ^P1375 (Philip et al., 2001) learning defective, with 14-3-3ζ^LI.15.hs, 14-3-3ζ^P1375/14-3-3ζ^P1188 (Philip et al., 2001) learning defective, with 14-3-3ζ^LI.15.hs, 14-3-3ζ^P2335/14-3-3ζ^P1188 (Philip et al., 2001) viable, with 14-3-3ζ^LI.15.hs, 14-3-3ζ^P1375 (Philip et al., 2001) viable, with 14-3-3ζ^LI.15.hs, 14-3-3ζ^P1375/14-3-3ζ^P1188 (Philip et al., 2001) viable, with 14-3-3ζ^LI.15.hs, 14-3-3ζ^P2335/14-3-3ζ^P1188 (Philip et al., 2001) wild-type (Philip et al., 2001)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference 14-3-3ζ^LII.2.hs is a suppressor \| heat sensitive of partially lethal - majority die \| recessive phenotype of 14-3-3ε^ex4 (Acevedo et al., 2007) 14-3-3ζ^LII.2.hs is a suppressor \| heat sensitive of partially lethal - majority die \| recessive phenotype of 14-3-3ε^j2B10 (Acevedo et al., 2007)
NOT Suppressor of
Statement Reference 14-3-3ζ^LII.2.hs is a non-suppressor of visible phenotype of 14-3-3ε^ex4 (Acevedo et al., 2007)
Phenotype Manifest In
NOT Suppressor of
Statement Reference 14-3-3ζ^LII.2.hs is a non-suppressor of anterior crossvein phenotype of 14-3-3ε^ex4 (Acevedo et al., 2007) 14-3-3ζ^LII.2.hs is a non-suppressor of posterior crossvein phenotype of 14-3-3ε^ex4 (Acevedo et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	14-3-3ζ^LII.2.hs rescues 14-3-3ζ^2.3 (Philip et al., 2001) 14-3-3ζ^LII.2.hs rescues 14-3-3ζ^P1375 (Philip et al., 2001) 14-3-3ζ^LII.2.hs rescues 14-3-3ζ^X1 (Philip et al., 2001)
Fails to rescue	14-3-3ζ^LII.2.hs fails to rescue 14-3-3ζ^P1188 (Philip et al., 2001) 14-3-3ζ^LII.2.hs fails to rescue 14-3-3ζ^P2335 (Philip et al., 2001)
Comments	Induction with two 30 min heat shocks daily through embryonic, larval and pupal stages rescues the lethal phenotype of 14-3-3ζ^P1375. A single heat shock daily can also rescue to adulthood. Shows heat-shock specific rescue of the learning and memory defects of 14-3-3ζ^X1 and 14-3-3ζ^2.3. Flies rescued from lethality by 14-3-3ζ^LI.15.hs and 14-3-3ζ^LII.2.hs show a 25-30% decrement in olfactory learning, comparable to that of (rescued) 14-3-3ζ^2.3. The restoration of learning by the transgenes decays back to mutant levels 60-70 hr later. (Philip et al., 2001)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	14-3-3ζ^LII.2.hs
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Acevedo et al., 2007, Genetics 177(1): 239--253 In vivo functional specificity and homeostasis of Drosophila 14-3-3 proteins. [FBrf0201747] Philip et al., 2001, J. Neurosci. 21(21): 8417--8425 Conditional rescue of olfactory learning and memory defects in mutants of the 14-3-3 gene leonardo. [FBrf0139731]

Allele Dmel\14-3-3ζLII.2.hs

Allele Dmel\14-3-3ζ^LII.2.hs