Allele Dmel\sub²²

General Information
Symbol	Dmel\sub²²	Species	D. melanogaster
Name		FlyBase ID	FBal0135611
Feature type	allele	Associated gene	Dmel\sub

Allele class	loss of function allele
Mutagen	Delta2-3
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Giunta et al., 2002)
Mutagen	Delta2-3 (Giunta et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EP}sub^EP616 (Giunta et al., 2002)
Nature of the lesion	Statement Reference Deletion from site of P{EP}sub^EP616 (located 105bp upstream of the sub ATG) removing P{EP}sub^EP616 and the majority of the sub transcription unit. (Giunta et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (with sub^Dub) (Giunta et al., 2002) female sterile \| recessive (Giunta et al., 2002) lethal \| maternal effect \| recessive (Giunta et al., 2002) meiotic cell cycle defective \| recessive (Giunta et al., 2002) mitotic cell cycle defective \| maternal effect \| recessive (Giunta et al., 2002) visible (with sub^Dub) (Giunta et al., 2002)
Phenotype Manifest In
	eye (with sub^Dub) (Giunta et al., 2002) spindle (Giunta et al., 2002) wing (with sub^Dub) (Giunta et al., 2002) wing margin (with sub^Dub) (Giunta et al., 2002)
Detailed Description
	Statement Reference Sterile females show rough eyes and clipped wings. Mutant males show elevated levels of X-Y chromosome non-disjunction in male meiosis. Embryos derived from mutant mothers show early mitotic abnormalities including arrest before embryonic mitoses begin, a polar body near one end and the development of one or two spindles in the middle. Structure of spindles in the embryos is abnormal, and their size variable. (Giunta et al., 2002)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	sub^Dub (Giunta et al., 2002)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Allelic series (strongest to weakest phenotype): sub¹³¹/sub^Dub = sub²⁰²/sub^Dub = sub²¹⁸/sub^Dub = sub²²/sub^Dub = sub⁷²/sub^Dub = sub¹⁰⁴/sub^Dub = sub¹⁵⁸/sub^Dub > sub¹⁷⁹⁴/sub^Dub > +/sub^Dub. (Giunta et al., 2002)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	sub²²
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Giunta et al., 2002, Genetics 160(4): 1489--1501 subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster. [FBrf0147060]

Allele Dmel\sub22

Allele Dmel\sub²²