FlyBase Allele Report: Dmel\sub[158]

General Information

Symbol

Dmel\sub¹⁵⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0135615

Feature type

allele

Associated gene

Dmel\sub

Associated Insertion(s)

Carried in Construct

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Giunta et al., 2002)

Mutagen

Delta2-3 transposase

(Giunta et al., 2002)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

P{EP}sub^EP616

(Giunta et al., 2002)

Cytology

Nature of the lesion

Statement

Reference

Deletion removing P{EP}sub^EP616 (located 105bp upstream of the sub ATG), and sequence flanking the insertion, 5' of sub (approaching 1kb) as well as more than half of the sub transcription unit.

(Giunta et al., 2002)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

female sterile (with sub^Dub)

(Giunta et al., 2002)

female sterile | recessive

(Giunta et al., 2002)

lethal | maternal effect | recessive

(Giunta et al., 2002)

meiotic cell cycle defective | recessive

(Giunta et al., 2002)

mitotic cell cycle defective | maternal effect | recessive

(Giunta et al., 2002)

visible (with sub^Dub)

(Giunta et al., 2002)

Phenotype Manifest In

eye (with sub^Dub)

(Giunta et al., 2002)

spindle

(Giunta et al., 2002)

wing (with sub^Dub)

(Giunta et al., 2002)

wing margin (with sub^Dub)

(Giunta et al., 2002)

Detailed Description

Statement

Reference

Sterile females show rough eyes and clipped wings. Mutant males show elevated levels of X-Y chromosome non-disjunction in male meiosis. Embryos derived from mutant mothers show early mitotic abnormalities including arrest before embryonic mitoses begin, a polar body near one end and the development of one or two spindles in the middle. Structure of spindles in the embryos is abnormal, and their size variable.

(Giunta et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sub^Dub

(Giunta et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Allelic series (strongest to weakest phenotype): sub¹³¹/sub^Dub = sub²⁰²/sub^Dub = sub²¹⁸/sub^Dub = sub²²/sub^Dub = sub⁷²/sub^Dub = sub¹⁰⁴/sub^Dub = sub¹⁵⁸/sub^Dub > sub¹⁷⁹⁴/sub^Dub > +/sub^Dub.

(Giunta et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sub¹⁵⁸

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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