Allele Dmel\homer^{Scer\UAS.T:Hsap\MYC}

General Information
Symbol	Dmel\homer^{Scer\UAS.T:Hsap\MYC}	Species	D. melanogaster
Name		FlyBase ID	FBal0135704
Feature type	allele	Associated gene	Dmel\homer

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Diagana et al., 2002) in vitro construct - regulatory fusion (Diagana et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Six copies of T:Hsap\MYC are fused in-frame to the C-terminus of the homer full length cDNA LD03156 - the expression of the resulting protein is governed by Scer\UAS regulatory sequences. (Diagana et al., 2002)
Carried in construct	P{UAS-homer.Myc} (Sanchez-Soriano et al., 2005, Diagana et al., 2002, Bottenberg et al., 2009, Urizar et al., 2007)
Tagged with	T:Hsap\MYC (Diagana et al., 2002, Sanchez-Soriano et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Overexpression of homer[Scer\UAS.T:Hsap\MYC] in the nervous system under the control of Scer\GAL4[elav-C155] does not alter ethanol sensitivity nor does it alter rapid ethanol tolerance. (Urizar et al., 2007) When expression is driven by Scer\GAL4^elav-C155 no pathfinding errors occur in the embryonic ventral nerve cord. (Diagana et al., 2002)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	homer^{Scer\UAS.T:Hsap\MYC}/Scer\GAL4^c819 rescues homer^R102 (Urizar et al., 2007) Scer\GAL4^c42/homer^{Scer\UAS.T:Hsap\MYC} rescues homer^R102 (Urizar et al., 2007) Scer\GAL4^elav-C155/homer^{Scer\UAS.T:Hsap\MYC} rescues homer^R102 (Urizar et al., 2007)
Fails to rescue	homer^{Scer\UAS.T:Hsap\MYC}/Scer\GAL4^103Y fails to rescue homer^R102 (Urizar et al., 2007) homer^{Scer\UAS.T:Hsap\MYC}/Scer\GAL4²⁴⁷ fails to rescue homer^R102 (Urizar et al., 2007) homer^{Scer\UAS.T:Hsap\MYC}/Scer\GAL4^c107 fails to rescue homer^R102 (Urizar et al., 2007) homer^{Scer\UAS.T:Hsap\MYC}/Scer\GAL4^c302 fails to rescue homer^R102 (Urizar et al., 2007) homer^{Scer\UAS.T:Hsap\MYC}/Scer\GAL4^Ilp2.PR fails to rescue homer^R102 (Urizar et al., 2007) homer^{Scer\UAS.T:Hsap\MYC}/Scer\GAL4^lilli-189Y fails to rescue homer^R102 (Urizar et al., 2007) Scer\GAL4^078Y/homer^{Scer\UAS.T:Hsap\MYC} fails to rescue homer^R102 (Urizar et al., 2007) Scer\GAL4^121Y/homer^{Scer\UAS.T:Hsap\MYC} fails to rescue homer^R102 (Urizar et al., 2007) Scer\GAL4^Aph-4-c232/homer^{Scer\UAS.T:Hsap\MYC} fails to rescue homer^R102 (Urizar et al., 2007) Scer\GAL4^c105/homer^{Scer\UAS.T:Hsap\MYC} fails to rescue homer^R102 (Urizar et al., 2007) Scer\GAL4^c481/homer^{Scer\UAS.T:Hsap\MYC} fails to rescue homer^R102 (Urizar et al., 2007) Scer\GAL4^c522/homer^{Scer\UAS.T:Hsap\MYC} fails to rescue homer^R102 (Urizar et al., 2007)
Comments	Pan-neuronal expression of homer[Scer\UAS.T:Hsap\MYC] restores the ethanol sensitivity and rapid tolerance phenotypes of homer[R102] homozygous males to control levels. Expression of homer[Scer\UAS.T:Hsap\MYC] in various subsections of the brain under the control of Scer\GAL4[c522], Scer\GAL4[121Y], Scer\GAL4[247], Scer\GAL4[103Y], Scer\GAL4[c107], Scer\GAL4[Ilp2.PR], Scer\GAL4[078Y], Scer\GAL4[Aph-4-c232], Scer\GAL4[c105], Scer\GAL4[c481], Scer\GAL4[lilli-189Y] or Scer\GAL4[c302] does not affect ethanol sensitivity in homer[R102] mutant male flies. Expression of homer[Scer\UAS.T:Hsap\MYC] in the R2 and R4m Ring neurons of the ellipsoid body under the control of Scer\GAL4[c819] or Scer\GAL4[c42] results in significant rescue of the homer[R102] ethanol sensitivity and rapid tolerance phenotype. (Urizar et al., 2007)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	homer^{Scer\UAS.T:Hsap\MYC}
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Bottenberg et al., 2009, Mech. Dev. 126(7): 489--502 Context-specific requirements of functional domains of the Spectraplakin Short stop in vivo. [FBrf0209450] Urizar et al., 2007, J. Neurosci. 27(17): 4541--4551 Drosophila Homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance. [FBrf0201158] Sanchez-Soriano et al., 2005, Dev. Biol. 288(1): 126--138 Are dendrites in Drosophila homologous to vertebrate dendrites? [FBrf0190157] Diagana et al., 2002, J. Neurosci. 22(2): 428--436 Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity. [FBrf0141617]

Allele Dmel\homerScer\UAS.T:Hsap\MYC

Allele Dmel\homer^{Scer\UAS.T:Hsap\MYC}