FlyBase Allele Report: Dmel\Rac1[J11]

General Information

Symbol

Dmel\Rac1^J11

Species

D. melanogaster

Name

FlyBase ID

FBal0135835

Feature type

allele

Associated gene

Dmel\Rac1

Associated Insertion(s)

Carried in Construct

Also Known As

Rac^J11

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Stramer et al., 2005, Woolner et al., 2005, Hakeda-Suzuki et al., 2002, Ng et al., 2002)

Mutagen

ethyl methanesulfonate

(Ng et al., 2002)

Progenitor genotype

Cytology

Description

Amino acid replacement: G60E.

(Ng et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:1,302,168..1,302,168 [-]

Nucleotide change:

G1302168A

Amino acid change:

G60E | Rac1-PA; G60E | Rac1-PB

Reported amino acid change:

G?E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ng et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates transthyretin amyloidosis

modeled by Hsap\TTR^{V30M.UAS.Tag:HA}

(Oliveira da Silva et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | larval stage

(Sampson et al., 2012)

abnormal neuroanatomy

(Soba et al., 2015, Ng et al., 2002)

abnormal neuroanatomy | adult stage

(Yang et al., 2024)

abnormal neuroanatomy | dominant

(Higuchi et al., 2009, Reeve et al., 2005)

abnormal neuroanatomy | somatic clone

(Srahna et al., 2006, Ng et al., 2002)

male semi-sterile

(Raymond et al., 2004)

Phenotype Manifest In

adult mushroom body

(Ng et al., 2002)

adult mushroom body (with Df(3L)Rac1)

(Ng et al., 2002)

adult mushroom body | somatic clone

(Yang et al., 2024, Ng et al., 2002)

axon & dorsal cluster neuron | somatic clone

(Srahna et al., 2006)

axon | adult stage | somatic clone

(Yang et al., 2024)

dendritic arborizing neuron

(Lee et al., 2003)

larval dorsal multidendritic neuron ddaC

(Lee et al., 2003)

larval multidendritic class IV neuron

(Soba et al., 2015)

LNv neuron

(Reeve et al., 2005)

lobe system of adult mushroom body

(Yang et al., 2024, Higuchi et al., 2009)

PNS glial cell

(Sepp and Auld, 2003)

presumptive embryonic salivary gland

(Pirraglia et al., 2006)

ventral adult lateral neuron & commissure

(Reeve et al., 2005)

Detailed Description

Statement

Reference

Bouton numbers are unaffected at the NMJ of Rac1^J11/+ third instar larvae.

(Kim et al., 2019)

Rac1^J11 mutant larvae exhibit strong ECM detachment and epithelial enclosure of dendrites in class IV dendritic arborizing neurons.

(Soba et al., 2015)

Homozygous larvae show a strongly reduced rate of encapsulation (11%) of eggs of the avirulent wasp strain L. boulardi G486 compared to the rate seen in wild-type larvae.

(Sampson et al., 2012)

65% of heterozygotes have normal alpha/beta mushroom body lobes and 35% have branching defects in the lobes.

(Higuchi et al., 2009)

Heterozygous and Rac1^J11/Rac1^J10 flies show normal resistance to infection with P.aeruginosa by septic injury.

(Avet-Rochex et al., 2007)

The salivary gland cells invaginate in Rac1^J11 mutant embryos, but the gland does not complete its posterior migration, but instead is abnormally shaped and appears attached to the ventral surface.

(Pirraglia et al., 2006)

In contrast to wild-type animals, where only 38% of dorsal cluster neuron axons innervate the medulla, 87% of axons from Rac1^J11 neuron clones innervate this region.

(Srahna et al., 2006)

An ectopic collateral branch is observed on the small LNv projections in 17% of Rac1^J11/+ adult brains. The posterior tract of the LNv neurons shows a defasciculation phenotype in 33% of brains.

(Reeve et al., 2005)

46% of homozygous males are sterile in individual crosses with wild-type females, although the testes appear normal and the seminal vesicle is full of motile sperm.

(Raymond et al., 2004)

No gross defects are seen in dendritic branching patterns are seen in later embryogenesis stages. however, when single cell mutant clones are made during larval stages, dendritic arborising neurons (DA neurons) exhibit fewer dendritic branches than wild-type. ddaC neurons exhibit a 23% reduction in the number of dendritic branches.

(Lee et al., 2003)

Homozygous mutant embryos show lack of peripheral glial coverage of lateral axon tracts and abnormal glial profiles are seen in the ventral region. The motor neuron projections and the lateral chordotonal sensory neurons are sometimes seen to be stalled.

(Sepp and Auld, 2003)

Heterozygous adults show significant defects in branching of the mushroom body axons and some guidance defects in the mushroom body axons. Homozygotes show mainly guidance defects in the mushroom body axons. In mosaic animals, 21% of neuroblast clones show defective guidance.

(Ng et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rac1^J11 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Remo^1A3

(Yang et al., 2024)

DAAM^Ex68, Rac1^J11 has abnormal neuroanatomy phenotype, enhanceable by Rac2^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11, Rac2^Δ has abnormal neuroanatomy phenotype, enhanceable by Mtl^Δ

(Matusek et al., 2008)

Mtl^Δ, Rac1^J11, Rac2^Δ has abnormal planar polarity | somatic clone phenotype, enhanceable by Cdc42⁵

(Muñoz-Descalzo et al., 2007)

Rac1^J11 has abnormal neuroanatomy phenotype, enhanceable by Fmr1^Δ113M/Fmr1[+]

(Reeve et al., 2005)

Rac1^J11 has abnormal neuroanatomy phenotype, enhanceable by Dp(2;2)C619/+

(Reeve et al., 2005)

Rac1^J11 has male semi-sterile phenotype, enhanceable by cdi^R47/cdi[+]

(Raymond et al., 2004)

NOT Enhanced by

Statement

Reference

Rac1^J11/Rac1[+], Scer\GAL4^GMR.PFa, egr^UAS.cMa has visible | adult stage phenotype, non-enhanceable by Rac2^Δ/Rac2[+]

(Ruan et al., 2016)

GluRIIA^SP16, Rac1^J11/Rac1[+] has abnormal neurophysiology | third instar larval stage | recessive phenotype, non-enhanceable by Exn^EY01953/Exn[+]

(Frank et al., 2009)

Suppressed by

Statement

Reference

Rac1^J11 has abnormal neuroanatomy | adult stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Remo^UAS.Tag:HA

(Yang et al., 2024)

Mtl^Δ, Rac1^J11, Rac2^Δ has lethal | embryonic stage phenotype, suppressible | partially by hep^CA.UAS

(Woolner et al., 2005)

Enhancer of

Statement

Reference

Rac1^J11/Rac1[+] is an enhancer of abnormal neuroanatomy | adult stage phenotype of Remo^1A3

(Yang et al., 2024)

Rac1^J11/Rac1[+] is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex1

(Gombos et al., 2015)

Rac1^J11/Rac1[+] is an enhancer of abnormal neuroanatomy phenotype of PsGEF^Δ21

(Higuchi et al., 2009)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Johnson et al., 2008)

Rac1^J11 is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11/Rac1[+] is an enhancer of abnormal planar polarity phenotype of Mtl^UAS.cMa, Scer\GAL4^hs.2sev

(Muñoz-Descalzo et al., 2007)

Rac1^J11/Rac1[+] is an enhancer of abnormal neuroanatomy phenotype of Fmr1^Δ113M

(Reeve et al., 2005)

Rac1^J11/Rac1[+] is an enhancer of abnormal neuroanatomy phenotype of LIMK1^UAS.Tag:HA, Scer\GAL4^ey-OK107

(Ng and Luo, 2004)

NOT Enhancer of

Statement

Reference

Rac1^J11, Rac2^Δ, Rac2[+], Rac1[+] is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Rac1^J11 is a non-enhancer of abnormal neuroanatomy phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Rac1^J10 is a non-enhancer of abnormal neuroanatomy phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is a non-enhancer of abnormal neuroanatomy phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is a non-enhancer of abnormal neuroanatomy phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Rac1[+] is a non-enhancer of visible | dominant phenotype of Sb⁷⁰

(Chen et al., 2004)

Rac1^J11/Rac1[+] is a non-enhancer of visible | dominant phenotype of br¹

(Chen et al., 2004)

Rac1^J11/Rac1[+] is a non-enhancer of visible | dominant phenotype of Sb^63b

(Chen et al., 2004)

Rac1^J11, Rac2^Δ, Mtl^Δ is a non-enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Suppressor of

Statement

Reference

Rac1^J11/Rac2^Δ is a suppressor of visible | adult stage phenotype of Hsap\TTR^{V30M.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Oliveira da Silva et al., 2020)

Rac1^J11/Rac2^Δ is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Hsap\TTR^{V30M.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Oliveira da Silva et al., 2020)

Rac1^J11/Rac1[+] is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, egr^UAS.cMa

(Ruan et al., 2016)

Rac1^J11 is a suppressor | partially of abnormal neuroanatomy phenotype of Scer\GAL4^ey-OK107, Vang^UAS.mGFP6

(Gombos et al., 2015)

Rac1^J11 is a suppressor | partially of abnormal neuroanatomy phenotype of Scer\GAL4^ey-OK107, Wnt5^UAS.cFa

(Gombos et al., 2015)

NOT Suppressor of

Statement

Reference

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is a non-suppressor | somatic clone of abnormal developmental rate | somatic clone | larval stage phenotype of Ras85D^G12V.UAS, RhoGEF2^RE.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

Rac1^J11/Rac1[+] is a non-suppressor of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Rac1^J11, Rac2^Δ, Rac2[+], Rac1[+] is a non-suppressor of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Rac1^J11, Rac2^Δ, Rac2[+], Rac1[+] is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Rac1^J11, Rac2^Δ, Mtl^Δ is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Other

Statement

Reference

Rac1^J11, Remo^1G5 has abnormal neuroanatomy | adult stage phenotype

(Yang et al., 2024)

Rac1^J11, Remo^1G9 has abnormal neuroanatomy | adult stage phenotype

(Yang et al., 2024)

Abi⁵, Rac1^J11/Rac1[+] has abnormal neuroanatomy | dominant | third instar larval stage phenotype

(Kim et al., 2019)

Fmr1^Δ50M, Rac1^J11 has abnormal neuroanatomy | third instar larval stage phenotype

(Kim et al., 2019)

Rac1^J11/Rac1[+], dsh¹ has abnormal neuroanatomy phenotype

(Gombos et al., 2015)

Mtl^Δ, Rac1^J11, Rac2^Δ has increased cell number | pupal stage phenotype

(Martín-Bermudo et al., 2015)

Rac1^J11/Rac1[+], mys¹ has abnormal neuroanatomy phenotype

(Soba et al., 2015)

Rac1^J11/Rac1[+], mew¹ has abnormal neuroanatomy phenotype

(Soba et al., 2015)

Mtl^Δ, Rac1^J11/Rac1^J10, Rac2^Δ has abnormal neuroanatomy phenotype

(Soba et al., 2015)

Mtl[+]/Mtl^Δ, Nav^Δ, Rac1^J11, Rac2^Δ/Rac2[+], tsr[+]/tsr^N96A has abnormal neuroanatomy phenotype

(Abe et al., 2014)

Mtl[+]/Mtl^Δ, Rac1^J11, Rac2^Δ/Rac2[+] has abnormal neuroanatomy phenotype

(Abe et al., 2014, Ng et al., 2002)

Mtl^Δ, Rac1^J11, Rac2^Δ has abnormal neuroanatomy phenotype

(Pinal and Pichaud, 2011)

GluRIIA^SP16, Rac1^J11/Rac1[+] has abnormal neurophysiology | recessive | third instar larval stage phenotype

(Frank et al., 2009)

GluRIIA^SP16, Rac1^J11/Rac1[+], cac^S/cac[+] has abnormal neurophysiology | recessive | third instar larval stage phenotype

(Frank et al., 2009)

Mtl^Δ, Rac1^J11, Rac2^Δ has abnormal planar polarity | somatic clone phenotype

(Muñoz-Descalzo et al., 2007)

Rac1^J11, Rac2^Δ/Rac2[+] has abnormal neuroanatomy phenotype

(Rodriguez Moncalvo and Campos, 2005, Ng et al., 2002)

Rac1^J11/Rac1[+], Rac2^Δ has abnormal neuroanatomy phenotype

(Rodriguez Moncalvo and Campos, 2005)

Rac1^J11, Rac2^Δ has abnormal neuroanatomy phenotype

(Rodriguez Moncalvo and Campos, 2005, Ng et al., 2002)

Mtl^Δ, Rac1^J11, Rac2^Δ has lethal | embryonic stage phenotype

(Woolner et al., 2005)

Mtl^Δ, Rac1^J11, Rac2^Δ has lethal | germline clone | embryonic stage phenotype

(Woolner et al., 2005)

Rac1^J11, sli² has abnormal neuroanatomy phenotype

(Fan et al., 2003)

Mtl^Δ, Rac1^J11/Rac1[+], Rac2^Δ has abnormal neuroanatomy phenotype

(Ng et al., 2002)

Mtl[+]/Mtl^Δ, Rac1^J11/Rac1[+], Rac2^Δ has abnormal neuroanatomy phenotype

(Ng et al., 2002)

Rac1^J11/Df(3L)Rac1, Rac2^Δ has viable phenotype

(Ng et al., 2002)

Rac1^J11/Df(3L)Rac1, Rac2^Δ has lethal phenotype

(Ng et al., 2002)

Rac1^J11/Df(3L)Rac1, Rac2^Δ/Rac2[+] has viable phenotype

(Ng et al., 2002)

Mtl^Δ, Rac1^J11, Rac2^Δ has abnormal neuroanatomy | somatic clone phenotype

(Ng et al., 2002)

Mtl^Δ, Rac1^J11/Rac1[+], Rac2^Δ/Rac2[+] has abnormal neuroanatomy phenotype

(Ng et al., 2002)

Rac1^J11, Rac2^Δ has abnormal neuroanatomy | somatic clone phenotype

(Ng et al., 2002)

Mtl[+]/Mtl^Δ, Rac1^J11, Rac2^Δ has abnormal neuroanatomy | somatic clone phenotype

(Ng et al., 2002)

Mtl^Δ, Rac1^J11, Rac2^Δ/Rac2[+] has abnormal neuroanatomy phenotype

(Ng et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rac1^J11 has lobe system of adult mushroom body phenotype, enhanceable by Remo^1A3

(Yang et al., 2024)

DAAM^Ex68, Rac1^J11 has neuropil phenotype, enhanceable by Rac2^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11 has fascicle phenotype, enhanceable by Rac2^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11 has connective phenotype, enhanceable by Rac2^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11 has lateral longitudinal fascicle phenotype, enhanceable by Rac2^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11 has embryo phenotype, enhanceable by Rac2^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11, Rac2^Δ has neuropil phenotype, enhanceable by Mtl^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11, Rac2^Δ has fascicle phenotype, enhanceable by Mtl^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11, Rac2^Δ has connective phenotype, enhanceable by Mtl^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11, Rac2^Δ has lateral longitudinal fascicle phenotype, enhanceable by Mtl^Δ

(Matusek et al., 2008)

DAAM^Ex68, Rac1^J11, Rac2^Δ has embryo phenotype, enhanceable by Mtl^Δ

(Matusek et al., 2008)

Mtl^Δ, Rac1^J11, Rac2^Δ has ommatidium | somatic clone phenotype, enhanceable by Cdc42⁵

(Muñoz-Descalzo et al., 2007)

Rac1^J11 has presumptive embryonic salivary gland phenotype, enhanceable by Rac2^Δ

(Pirraglia et al., 2006)

Rac1^J11 has ventral adult lateral neuron & commissure phenotype, enhanceable by Fmr1^Δ113M/Fmr1[+]

(Reeve et al., 2005)

Rac1^J11 has LNv neuron phenotype, enhanceable by Fmr1^Δ113M/Fmr1[+]

(Reeve et al., 2005)

Rac1^J11 has ventral adult lateral neuron & commissure phenotype, enhanceable by Dp(2;2)C619/+

(Reeve et al., 2005)

Rac1^J11 has LNv neuron phenotype, enhanceable by Dp(2;2)C619/+

(Reeve et al., 2005)

Rac1^J11, Rac2^Δ/Rac2[+] has dorsal group tracheal branch precursor phenotype, enhanceable by bnl[+]/bnl⁰⁰⁸⁵⁷

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ/Rac2[+] has tracheal branch primordium phenotype, enhanceable by bnl[+]/bnl⁰⁰⁸⁵⁷

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ/Rac2[+] has tracheal dorsal trunk primordium phenotype, enhanceable by bnl[+]/bnl⁰⁰⁸⁵⁷

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ/Rac2[+] has dorsal group tracheal branch precursor phenotype, enhanceable by btl[+]/btl^ΔOh10

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ/Rac2[+] has tracheal branch primordium phenotype, enhanceable by btl[+]/btl^ΔOh10

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ/Rac2[+] has tracheal dorsal trunk primordium phenotype, enhanceable by btl[+]/btl^ΔOh10

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ/Rac2[+] has dorsal group tracheal branch precursor phenotype, enhanceable by stumps^09904b/stumps[+]

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ/Rac2[+] has tracheal branch primordium phenotype, enhanceable by stumps^09904b/stumps[+]

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ/Rac2[+] has tracheal dorsal trunk primordium phenotype, enhanceable by stumps^09904b/stumps[+]

(Chihara et al., 2003)

NOT Enhanced by

Statement

Reference

Rac1^J11/Rac1[+], Scer\GAL4^GMR.PFa, egr^UAS.cMa has eye phenotype, non-enhanceable by Rac2^Δ/Rac2[+]

(Ruan et al., 2016)

GluRIIA^SP16, Rac1^J11/Rac1[+] has embryonic/larval neuromuscular junction phenotype, non-enhanceable by Exn^EY01953/Exn[+]

(Frank et al., 2009)

Suppressed by

Statement

Reference

Rac1^J11 has lobe system of adult mushroom body phenotype, suppressible | partially by Scer\GAL4^elav-C155/Remo^UAS.Tag:HA

(Yang et al., 2024)

Rac1^J11, Rac2^Δ has embryo | dorsal closure stage phenotype, suppressible by cv-c^M62

(Denholm et al., 2005)

Mtl^Δ, Rac1^J11, Rac2^Δ has embryo | dorsal closure stage phenotype, suppressible | partially by hep^CA.UAS

(Woolner et al., 2005)

Mtl^Δ, Rac1^J11, Rac2^Δ has embryonic/first instar larval cuticle phenotype, suppressible | partially by hep^CA.UAS

(Woolner et al., 2005)

Rac1^J11, Rac2^Δ has ganglionic tracheal branch primordium phenotype, suppressible | partially by RhoGAP93B¹

(Lundstrom et al., 2004)

Rac1^J11, Rac2^Δ has ganglionic tracheal branch primordium phenotype, suppressible | partially by robo1⁴

(Lundstrom et al., 2004)

Enhancer of

Statement

Reference

Rac1^J11/Rac1[+] is an enhancer of lobe system of adult mushroom body phenotype of Remo^1A3

(Yang et al., 2024)

Rac1^J11/Rac1[+] is an enhancer of adult mushroom body alpha-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

Rac1^J11/Rac1[+] is an enhancer of adult mushroom body beta-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

Rac1^J11/Rac1[+] is an enhancer of mushroom body phenotype of PsGEF^Δ21

(Higuchi et al., 2009)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is an enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Johnson et al., 2008)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is an enhancer of pigment cell phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Johnson et al., 2008)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is an enhancer of cone cell phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Johnson et al., 2008)

Rac1^J11 is an enhancer of neuropil phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11 is an enhancer of fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11 is an enhancer of connective phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11 is an enhancer of lateral longitudinal fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11 is an enhancer of embryo phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is an enhancer of neuropil phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is an enhancer of fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is an enhancer of connective phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is an enhancer of lateral longitudinal fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is an enhancer of embryo phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is an enhancer of neuropil phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is an enhancer of fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is an enhancer of connective phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is an enhancer of lateral longitudinal fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is an enhancer of embryo phenotype of DAAM^Ex68

(Matusek et al., 2008)

Rac1^J11/Rac1[+] is an enhancer of ommatidium phenotype of Mtl^UAS.cMa, Scer\GAL4^hs.2sev

(Muñoz-Descalzo et al., 2007)

Rac1^J11/Rac2^Δ is an enhancer of posterior spiracle primordium phenotype of cv-c^M62

(Denholm et al., 2005)

Rac1^J11/Rac1[+] is an enhancer of wing hair | increased number phenotype of Scer\GAL4^ap-md544, trc^T453A.UAS.L

(He et al., 2005)

Rac1^J11/Rac1[+] is an enhancer of ventral adult lateral neuron & commissure phenotype of Fmr1^Δ113M

(Reeve et al., 2005)

Rac1^J11/Rac1[+] is an enhancer of LNv neuron phenotype of Fmr1^Δ113M

(Reeve et al., 2005)

Rac1^J11/Rac1[+] is an enhancer of adult mushroom body phenotype of LIMK1^UAS.Tag:HA, Scer\GAL4^ey-OK107

(Ng and Luo, 2004)

NOT Enhancer of

Statement

Reference

Rac1^J11, Rac2^Δ, Rac2[+], Rac1[+] is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Rac1^J11 is a non-enhancer of neuropil | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11 is a non-enhancer of symmetrical commissure | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Rac1^J10 is a non-enhancer of symmetrical commissure | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is a non-enhancer of neuropil | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is a non-enhancer of fascicle | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Rac2^Δ is a non-enhancer of symmetrical commissure | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is a non-enhancer of neuropil | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is a non-enhancer of fascicle | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11, Rac2^Δ, Mtl^Δ is a non-enhancer of symmetrical commissure | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Mtl^Δ is a non-enhancer of fascicle | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Rac1^J10, Scer\GAL4^elav-C155 is a non-enhancer of neuropil | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11, Mtl^Δ, Rac1^J10 is a non-enhancer of fascicle | embryonic stage phenotype of DAAM^C.UASp, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Rac1^J11/Rac1[+] is a non-enhancer of leg phenotype of Sb⁷⁰

(Chen et al., 2004)

Rac1^J11/Rac1[+] is a non-enhancer of leg phenotype of br¹

(Chen et al., 2004)

Rac1^J11/Rac1[+] is a non-enhancer of leg phenotype of Sb^63b

(Chen et al., 2004)

Rac1^J11, Rac2^Δ, Mtl^Δ is a non-enhancer of photoreceptor cell & axon phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Suppressor of

Statement

Reference

Rac1^J11/Rac2^Δ is a suppressor of eye phenotype of Hsap\TTR^{V30M.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Oliveira da Silva et al., 2020)

Rac1^J11/Rac2^Δ is a suppressor of eye disc | third instar larval stage phenotype of Hsap\TTR^{V30M.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Oliveira da Silva et al., 2020)

Rac1^J11/Rac2^Δ is a suppressor of axon | third instar larval stage phenotype of Hsap\TTR^{V30M.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Oliveira da Silva et al., 2020)

Rac1^J11/Rac2^Δ is a suppressor of larval brain | third instar larval stage phenotype of Hsap\TTR^{V30M.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Oliveira da Silva et al., 2020)

Rac1^J11/Rac1[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PFa, egr^UAS.cMa

(Ruan et al., 2016)

Rac1^J11 is a suppressor | partially of mushroom body medial lobe phenotype of Scer\GAL4^ey-OK107, Vang^UAS.mGFP6

(Gombos et al., 2015)

Rac1^J11 is a suppressor | partially of mushroom body medial lobe phenotype of Scer\GAL4^ey-OK107, Wnt5^UAS.cFa

(Gombos et al., 2015)

Rac1^J11, Rac2^Δ, Rac2[+], Rac1[+] is a suppressor of visceral muscle fiber | embryonic stage phenotype of Ced-12^UAS.cGa, Scer\GAL4^Mef2.PR, mbc^UAS.cBa

(Liu et al., 2013)

Rac1^J11, Rac2^Δ, Rac2[+], Rac1[+] is a suppressor of tendon cell | embryonic stage phenotype of Ced-12^UAS.cGa, Scer\GAL4^Mef2.PR, mbc^UAS.cBa

(Liu et al., 2013)

Rac1^J11, Rac2^Δ, Rac2[+], Rac1[+] is a suppressor of eye phenotype of Ced-12^UAS.cGa, Scer\GAL4^Mef2.PR, mbc^UAS.cBa

(Geisbrecht et al., 2008)

Rac1^J11/Rac1[+] is a suppressor of NMJ bouton phenotype of Vps35^EY14200

(Korolchuk et al., 2007)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is a suppressor of eye phenotype of Scer\GAL4^ey.PB, sti^RNAi.Sym.UAS

(D'Avino et al., 2004)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is a suppressor of ommatidium phenotype of Scer\GAL4^ey.PB, sti^RNAi.Sym.UAS

(D'Avino et al., 2004)

NOT Suppressor of

Statement

Reference

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is a non-suppressor | somatic clone of eye-antennal disc | somatic clone | third instar larval stage phenotype of Ras85D^G12V.UAS, RhoGEF2^RE.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is a non-suppressor | somatic clone of eye photoreceptor cell | somatic clone | third instar larval stage phenotype of Ras85D^G12V.UAS, RhoGEF2^RE.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

Rac1^J11/Rac1[+] is a non-suppressor of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Rac1^J11, Rac2^Δ, Rac2[+], Rac1[+] is a non-suppressor of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Rac1^J11, Rac2^Δ, Rac2[+], Rac1[+] is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Rac1^J11, Rac2^Δ, Mtl[+], Mtl^Δ, Rac2[+], Rac1[+] is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Rac1^J11, Rac2^Δ, Mtl^Δ is a non-suppressor of photoreceptor cell & axon phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Other

Statement

Reference

Rac1^J11, Rac2^Δ has interommatidial bristle | P-stage phenotype

(Malin et al., 2024)

Rac1^J11, Rac2^Δ has ommatidium | P-stage phenotype

(Malin et al., 2024)

Rac1^J11, Rac2^Δ has interommatidial cell | P-stage phenotype

(Malin et al., 2024)

Rac1^J11, Remo^1G5 has lobe system of adult mushroom body phenotype

(Yang et al., 2024)

Rac1^J11, Remo^1G9 has lobe system of adult mushroom body phenotype

(Yang et al., 2024)

Abi⁵, Rac1^J11/Rac1[+] has NMJ bouton | third instar larval stage phenotype

(Kim et al., 2019)

Abi⁵, Rac1^J11/Rac1[+] has embryonic/larval neuromuscular junction | third instar larval stage phenotype

(Kim et al., 2019)

Fmr1^Δ50M, Rac1^J11 has NMJ bouton | third instar larval stage phenotype

(Kim et al., 2019)

Fmr1^Δ50M, Rac1^J11 has embryonic/larval neuromuscular junction | third instar larval stage phenotype

(Kim et al., 2019)

Rac1^J11/Rac1[+], dsh¹ has mushroom body phenotype

(Gombos et al., 2015)

Mtl^Δ, Rac1^J11, Rac2^Δ has retina | somatic clone | pupal stage phenotype

(Martín-Bermudo et al., 2015)

Mtl^Δ, Rac1^J11, Rac2^Δ has interommatidial cell | increased number | somatic clone | pupal stage phenotype

(Martín-Bermudo et al., 2015)

Rac1^J11/Rac1[+], mys¹ has larval multidendritic class IV neuron phenotype

(Soba et al., 2015)

Rac1^J11/Rac1[+], mew¹ has larval multidendritic class IV neuron phenotype

(Soba et al., 2015)

Mtl^Δ, Rac1^J11/Rac1^J10, Rac2^Δ has larval multidendritic class IV neuron phenotype

(Soba et al., 2015)

Mtl[+]/Mtl^Δ, Rac1^J11, Rac2^Δ/Rac2[+] has adult mushroom body beta-lobe phenotype

(Abe et al., 2014)

Mtl[+]/Mtl^Δ, Rac1^J11, Rac2^Δ/Rac2[+] has adult mushroom body alpha-lobe phenotype

(Abe et al., 2014)

Mtl[+]/Mtl^Δ, Nav^Δ, Rac1^J11, Rac2^Δ/Rac2[+], tsr[+]/tsr^N96A has mushroom body pedunculus phenotype

(Abe et al., 2014)

Mtl[+]/Mtl^Δ, Nav^Δ, Rac1^J11, Rac2^Δ/Rac2[+], tsr[+]/tsr^N96A has adult mushroom body beta-lobe phenotype

(Abe et al., 2014)

Mtl[+]/Mtl^Δ, Nav^Δ, Rac1^J11, Rac2^Δ/Rac2[+], tsr[+]/tsr^N96A has adult mushroom body alpha-lobe phenotype

(Abe et al., 2014)

Rac1^J11, Rac2^Δ has visceral muscle fiber | embryonic stage phenotype

(Liu et al., 2013)

Rac1^J11, Rac2^Δ has embryonic myoblast phenotype

(Haralalka et al., 2011)

Mtl^Δ, Rac1^J11, Rac2^Δ has adult optic lobe phenotype

(Pinal and Pichaud, 2011)

GluRIIA^SP16, Rac1^J11/Rac1[+] has embryonic/larval neuromuscular junction phenotype

(Frank et al., 2009)

GluRIIA^SP16, Rac1^J11/Rac1[+], cac^S/cac[+] has embryonic/larval neuromuscular junction phenotype

(Frank et al., 2009)

Rac1^J11/Rac1[+], Rac2^Δ/Rac2[+], prtp^Δ1 has embryonic/larval hemocyte phenotype

(Kuraishi et al., 2009)

Mtl^Δ, Rac1^J11, Rac2^Δ has ommatidium | somatic clone phenotype

(Muñoz-Descalzo et al., 2007)

Mtl^Δ, Rac1^J11, Rac2^Δ has embryonic myoblast phenotype

(Richardson et al., 2007)

Mtl[+]/Mtl^Δ, Rac1^J11/Rac1[+], Rac2^Δ/Rac2[+], shi² has presumptive embryonic salivary gland | heat sensitive phenotype

(Pirraglia et al., 2006)

Rac1^J11, Rac2^Δ has posterior spiracle primordium phenotype

(Denholm et al., 2005)

Rac1^J11, Rac2^Δ has embryo | dorsal closure stage phenotype

(Denholm et al., 2005)

Rac1^J11, Rac2^Δ has embryonic Malpighian tubule phenotype

(Pütz et al., 2005)

Rac1^J11, Rac2^Δ has embryonic anterior Malpighian tubule phenotype

(Pütz et al., 2005)

Rac1^J11, Rac2^Δ has Malpighian tubule main body primordium phenotype

(Pütz et al., 2005)

Rac1^J11/Rac1[+], Rac2^Δ has serotonergic neuron phenotype

(Rodriguez Moncalvo and Campos, 2005)

Rac1^J11, Rac2^Δ has serotonergic neuron phenotype

(Rodriguez Moncalvo and Campos, 2005)

Rac1^J11, Rac2^Δ/Rac2[+] has serotonergic neuron phenotype

(Rodriguez Moncalvo and Campos, 2005)

Mtl^Δ, Rac1^J11, Rac2^Δ has embryonic/larval hemocyte phenotype

(Stramer et al., 2005)

Mtl^Δ, Rac1^J11, Rac2^Δ has embryonic leading edge cell & actin filament phenotype

(Woolner et al., 2005)

Mtl^Δ, Rac1^J11, Rac2^Δ has embryo | dorsal closure stage phenotype

(Woolner et al., 2005)

Mtl^Δ, Rac1^J11, Rac2^Δ has embryonic/first instar larval cuticle phenotype

(Woolner et al., 2005)

Mtl^Δ, Rac1^J11, Rac2^Δ has embryonic leading edge cell phenotype

(Woolner et al., 2005)

Mtl^Δ, Rac1^J11, Rac2^Δ has amnioserosa phenotype

(Woolner et al., 2005)

Rac1^J11, Rac2^Δ has ganglionic tracheal branch primordium phenotype

(Lundstrom et al., 2004)

Rac1^J11, cdi^R47/cdi[+] has testis phenotype

(Raymond et al., 2004)

Rac1^J11, Rac2^Δ has embryonic epidermis phenotype

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ has tracheal branch primordium phenotype

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ has dorsal group tracheal branch precursor phenotype

(Chihara et al., 2003)

Rac1^J11, Rac2^Δ has tracheal dorsal trunk primordium phenotype

(Chihara et al., 2003)

Rac1^J11, sli² has larval longitudinal connective phenotype

(Fan et al., 2003)

Rac1^J11, Rac2^Δ has photoreceptor cell & axon phenotype

(Hakeda-Suzuki et al., 2002)

Mtl^Δ, Rac1^J11, Rac2^Δ has photoreceptor cell & axon phenotype

(Hakeda-Suzuki et al., 2002)

Rac1^J11, Rac2^Δ has adult mushroom body phenotype

(Ng et al., 2002)

Mtl^Δ, Rac1^J11/Rac1[+], Rac2^Δ has adult mushroom body phenotype

(Ng et al., 2002)

Mtl[+]/Mtl^Δ, Rac1^J11/Rac1[+], Rac2^Δ has adult mushroom body phenotype

(Ng et al., 2002)

Mtl^Δ, Rac1^J11, Rac2^Δ has adult mushroom body | somatic clone phenotype

(Ng et al., 2002)

Mtl^Δ, Rac1^J11/Rac1[+], Rac2^Δ/Rac2[+] has adult mushroom body phenotype

(Ng et al., 2002)

Rac1^J11, Rac2^Δ/Rac2[+] has adult mushroom body phenotype

(Ng et al., 2002)

Rac1^J11, Rac2^Δ has adult mushroom body | somatic clone phenotype

(Ng et al., 2002)

Mtl[+]/Mtl^Δ, Rac1^J11, Rac2^Δ has adult mushroom body | somatic clone phenotype

(Ng et al., 2002)

Mtl[+]/Mtl^Δ, Rac1^J11, Rac2^Δ/Rac2[+] has adult mushroom body phenotype

(Ng et al., 2002)

Mtl^Δ, Rac1^J11, Rac2^Δ/Rac2[+] has adult mushroom body phenotype

(Ng et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The dot-like small eye phenotype characteristic for flies expressing egr^Scer\UAS.cMa under the control of Scer\GAL4^GMR.PFa is partially suppressed by combination with Rac1^J11 in heterozygous state.

(Ruan et al., 2016)

One copy of Rac1^J11 enhances the axonal growth defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies.

Hemizygous dsh¹ mutant males with one copy of Rac1^J11 exhibit an early growth termination phenotype in the mushroom body axons that is not observed in either dsh¹/Y or Rac1^J11/+ males alone.

Hemizygous Rac1^J11 partially suppresses the medial lobe fusion phenotype seen when Vang^{Scer\UAS.T:Avic\GFP-m6} is expressed in male flies under the control of Scer\GAL4^ey-OK107.

Hemizygous Rac1^J11 partially suppresses the medial lobe fusion phenotype seen when Wnt5^Scer\UAS.cFa is expressed in male flies under the control of Scer\GAL4^ey-OK107.

(Gombos et al., 2015)

Pupal retina constituting almost entirely of somatic clones (induced specifically in the eye) triple homozygous for Rac2^Δ,Rac1^J11,Mtl^Δ do not show any extra cone cells or primary pigment cells, only extra inter-ommatidial cells are observed.

(Martín-Bermudo et al., 2015)

Rac1^J11/Rac1^J10, Rac2^Δ, Mtl^Δ triple mutant larvae exhibit strong ECM detachment and epithelial enclosure of dendrites in class IV dendritic arborizing neurons.

Ret^C168 Rac1^J11 transheterozygous third instar larvae exhibit defects in class IV dendritic arborizing neuron dendrite-ECM interaction. The phenotype is not observed in either heterozygote alone.

mew¹ Rac1^J11 transheterozygous third instar larvae exhibit defects in class IV dendritic arborizing neuron dendrite-ECM interaction. The phenotype is not observed in either heterozygote alone.

mys¹ Rac1^J11 transheterozygous third instar larvae exhibit defects in class IV dendritic arborizing neuron dendrite-ECM interaction. The phenotype is not observed in either heterozygote alone.

(Soba et al., 2015)

The mushroom bodies of Rac1^J11 Rac2^Δ Mtl^Δ triple heterozygotes display short α/β axonal lobes compared with those of controls. The peduncle and ellipsoid body form normally.

The mushroom body axons of flies that are heterozygous for Rac1^J11, Rac2^Δ tsr^N96A sick^Δ and Mtl^Δ fail to extend to form peduncles and lobe structures (the 'posterior arrest' phenotype).

(Abe et al., 2014)

The presence of Rac2^Δ/+, Rac1^J11/+ and Mtl^Δ/+ mutations fails to suppress the reduction of differentiation seen in eye-antennal disc clones expressing both RhoGEF2^RE.Scer\UAS and Ras85D^{G12V.Scer\UAS} under the control of Scer\GAL4^tub.PU, and also fails to suppress the developmental delay shown by larvae containing these clones.

(Khoo et al., 2013)

Only small amounts of muscle fibers form in Rac1^J11, Rac2^Δ mutant embryos - these myofibers round up upon muscle contraction, indicating detachment.

Co-expression of Ced-12^Scer\UAS.cGa and mbc^Scer\UAS.cBa via Scer\GAL4^Mef2.PR results in prevalent myoblast fusion, muscle attachment, and tendon cell identity phenotypes in embryos. The muscle attachment and tendon cell phenotypes are largely rescued in a Rac1^J11/+, Rac2^Δ/+ background.

(Liu et al., 2013)

Myoblast fusion is defective in Rac1^J11 Rac2^Δ double mutant embryos, although some fusion does occur. Binucleate muscle precursors that have undergone a single fusion event between a founder cell and a fusion competent myoblast are seen in the mutant embryos as follows: DA1 (64.2% of segments), DO1 (68.3% of segments), LO1 (26.3% of segments), VT1 (66.7%) of segments.

(Haralalka et al., 2011)

A mild, though not significant enhancement of the ommatidium-phenotype resulting from the co-expression of Arf51F^GD13822 with Dcr-2^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PF is observed in a Rac1^J11, Rac2^Δ, Mtl^Δ heterozygous background.

(Johnson et al., 2011)

Expression of psidin^Scer\UAS.cKa under the control of Scer\GAL4^slbo.2.6 in a Rac1^J11 Rac2^Δ double heterozygous background has little or no effect on border cell migration.

(Kim et al., 2011)

No rhabdomeric defect is seen at the base of the rhabdomere at eclosion in flies in which the eyes are triply mutant for Rac1^J11 Rac2^Δ Mtl^Δ, although there is an axon guidance defect in the optic lobe.

(Pinal and Pichaud, 2011)

The Rac1^J11/+ heterozygous mutation causes a mild suppression of the GluRIIA^SP16 NMJ synaptic homeostatic response.

The Exn^EY01953/+ heterozygous mutation does not enhance the Rac1^J11/+, GluRIIA^SP16 double mutant NMJ synaptic homeostasis phenotype.

(Frank et al., 2009)

Larval hemocytes prepared from flies simultaneously heterozygous for drpr^Δ5, Rac1^J11 and Rac2^Δ show a significant reduction in the level of phagocytosis of S. aureus.

(Hashimoto et al., 2009)

Heterozygosity for Rac1^J11 enhances the phenotype in the alpha lobes of the mushroom bodies that is seen in PsGEF^Δ21 animals; a pair of alpha/beta lobes is missing in 90% of the double mutants.

(Higuchi et al., 2009)

prtp^Δ1/+ ; Rac1^J11 Rac2^Δ/+ triple heterozygotes show a reduced level of phagocytosis in embryonic hemocytes (neither prtp^Δ1/+ single heterozygotes nor Rac1^J11 Rac2^Δ/+ double heterozygotes show a reduction in phagocytosis compared to wild type).

(Kuraishi et al., 2009)

The rough eye phenotype resulting from Scer\GAL4^GMR.PU-mediated expression of Ced-12^Scer\UAS.cGa and mbc^Scer\UAS.cBa is suppressed by heterozygosity for Rac1^J11, Rac2^Δ.

(Geisbrecht et al., 2008)

A Rac1^J11 Rac2^Δ Mtl^Δ heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

(Johnson et al., 2008)

The Scer\GAL4^elav-C155/DAAM^{C.Scer\UAS.P\T} gain-of-function phenotype (i.e the appearance of thicker commissures and nerve roots) is not affected by Rac1 gene dose (i.e. a Rac1^J11/+ or Rac1^J11/Rac1^J10 background), a Rac1^J11, Rac2^Δ background or a Rac1^J10, Rac2^Δ, Mtl^Δ background.

A Rac1^J11 background enhances the zygotic DAAM^Ex68 CNS phenotype, with the severity of the phenotype correlating with the number of Rac1 copies removed. A DAAM^Ex68 heterozygous background strongly enhances the axonal growth defects exhibited by Rac1^J11 mutants.

A Rac1^J11/+; Rac2^Δ/+ background enhances both the zygotic DAAM^Ex68 and DAAM^Ex68; Rac1^J11/+ CNS phenotypes.

A Rac1^J11; Rac2^Δ, Mtl[Δ] heterozygous background enhances the zygotic DAAM^Ex68, DAAM^Ex68; Rac1^J11/+ and DAAM^Ex68; Rac1^J11/+; Rac2^Δ/+CNS phenotypes.

(Matusek et al., 2008)

The increased bouton number at the neuromuscular junction that is seen in Vps35^EY14200/Df(2R)ED3952 larvae is suppressed by Rac1^J11/+.

(Korolchuk et al., 2007)

Rac1^J11, Rac2^Δ, Mtl^Δ triple mutant clones in the eye result in a low frequency (approximately 5%) of planar polarity defects (such as achiral or misrotated ommatidia). Cdc42⁵, Rac1^J11, Rac2^Δ, Mtl^Δ quadruple mutant clones in the eye result in a higher frequency of (14.2%) of planar polarity defects.

(Muñoz-Descalzo et al., 2007)

Rac1^J11 Rac2^Δ Mtl^Δ triple mutant myoblasts show enlarged foci, as well as increased numbers of actin foci. Enlarged foci are seen in these mutants from the earliest stages of fusion and foci persist after fusion would be complete in wild-type.

(Richardson et al., 2007)

The salivary gland defects seen in Rac1^J11 embryos are enhanced in Rac1^J11 Rac2^Δ mutants; more cells remain at the ventral surface of the embryo and the gland fails to migrate posteriorly. In addition, the lumen of the salivary gland is disrupted, with breaks in the lumen being seen during posterior migration of the gland, and cyst-like lumena being seen in the mature gland.

shi² Rac1^J11 Rac2^Δ Mtl^Δ heterozygous embryos form normal salivary glands at the permissive temperature of 25[o]C. However, at the restrictive temperature of 30[o]C, posterior migration of the salivary gland is disrupted.

(Pirraglia et al., 2006)

The Rac1^J11 mutation fails to modify the cv-c^M62 phenotype in the Malpighian tubules. Dorsal closure defects occur in 82% of Rac1^J11, Rac2^Δ double mutant embryos. If these mutants also carry the cv-c^M62 mutation , 37 % of these embryos are rescued. In cv-c^M62, Rac1^J11, Rac2^Δ triple mutants, the posterior spiracle phenotype is enhanced compared to cv-c^M62 mutants. Posterior spiracle phenotypes are seen in Rac1^J11, Rac2^Δ embryos, but with low penetrance.

(Denholm et al., 2005)

A Rac1^J11/+ background enhances the splitting wing hair phenotype of flies that express trc^{T453A.Scer\UAS} under the control of Scer\GAL4^ap-md544.

(He et al., 2005)

In Rac1^J11; Rac2^Δ double homozygous embryos, rearrangement of tubule cells to produce elongated, 2 cell wide tubules is partially disrupted and tubule migration is defective. The anterior tubules follow an erratic path, doubling back on themselves to form loops and knots.

(Pütz et al., 2005)

The penetrance of the LNv ectopic branch phenotype is increased to 100% and the posterior tract defasciculation phenotype is increased to 93% when Fmr1^Δ113M/+ flies are also heterozygous for Rac1^J11. Likewise, the LNv ectopic branch phenotype is increased to 100% and the posterior tract defasciculation phenotype is increased to 93% when Rac1^J11/+ flies are also heterozygous for Fmr1^Δ113M.

(Reeve et al., 2005)

Both Rac1^J11, Rac2^Δ/Rac2^Δ mutants and Rac2^Δ, Rac1^J11/Rac1^J11 mutants show a reduction of 5-HT arborization in the larval brain.

(Rodriguez Moncalvo and Campos, 2005)

Developmental dispersal of hemocytes is abnormal in embryos triply mutant for Rac1^J11, Rac2^Δ and Mtl^Δ.

One hour after laser-induced wounding, approximately half the number of hemocytes are recruited to the wound in embryos triply mutant for Rac1^J11, Rac2^Δ and Mtl^Δ compared to wild type embryos. Hemocytes that are recruited in the triple mutant embryos have significantly reduced lamellar protrusions.

(Stramer et al., 2005)

Germ line clones of the Rac1^J11 Rac2^Δ Mtl^Δ triple mutant fail to produce embryos. Zygotic Rac1^J11 Rac2^Δ Mtl^Δ triple mutants, that have wild-type maternal contribution of Rac1, survive beyond early dorsal closure, but still show 100% embryonic lethality. These embryos achieve dorsal closure, but show puckering along the dorsal side. The dorsal hole becomes a long slit-like shape as it closes in the triple mutants, while the hole has an oval shape in wild-type embryos. Although amnioserosa cells are significantly larger in the mutants than in wild type, these cells are able to contract at a similar rate to wild type. The leading edge of zygotic Rac1^J11 Rac2^Δ Mtl^Δ triple mutants is disorganized and, unlike in wild-type embryos, is not taut. Many of the triple mutant leading edge cells are polygonal in shape, instead of being dorsally-ventrally elongated, like in wild type. Some of the cells in the mutant edge assemble the actin cable and actin projections, while other cells fail to do so. Leaky expression of hep^CA.Scer\UAS, with no GAL4 driver, partially rescues the lethality and dorsal puckering phenotype of Rac1^J11 Rac2^Δ Mtl^Δ triple mutants.

(Woolner et al., 2005)

Rac1^J11/+ has very little effect on the mutant wing phenotype caused by expression of LIMK1^Scer\UAS.cCa under the control of Scer\GAL4^en-e16E (the % of wings with normal morphology at 18^oC is 23% compared to 9% for control flies expressing LIMK1^Scer\UAS.cCa under the control of Scer\GAL4^en-e16E in an otherwise wild-type background). The frequency of the malformed leg phenotype seen in Sb^63b/+ heterozygotes (8%) is not increased if the flies are also heterozygous for Rac1^J11/+ (3%). The frequency of the malformed leg phenotype seen in Sb⁷⁰/+ heterozygotes (7%) is not increased if the flies are also heterozygous for Rac1^J11/+ (2%). The frequency of the malformed leg phenotype seen in br¹/Y males (1%) is not increased if the flies are also heterozygous for Rac1^J11/+ (0%).

(Chen et al., 2004)

Rac1^J11, Rac2^Δ mutant embryos exhibit arrested ganglionic branches (GBs), and GBs turning prematurely away from the midline. robo⁴ partially suppresses the ganglionic branch phenotype seen in Rac1^J11, Rac2^Δ embryos.

(Lundstrom et al., 2004)

74% of Rac1^J11 cdi^R47/Rac1^J11 males are sterile in individual crosses with females. The males have an abnormal accumulation of dense material in the distal part of the testis.

(Raymond et al., 2004)

Double mutant clones of Rac1^J11 and Rac2^Δ do not affect F-actin enrichment in rhabdomeres.

(Zelhof and Hardy, 2004)

In a subset of the epidermal cells of stage 15 Rac1^J11, Rac2^Δ double homozygous embryos, the distinction between apical and basolateral domains is compromised. At stage 16 the columnar epithelial cells are shorter than wild-type and parts of the epidermis become multilayered. Reducing the maternal and zygotic gene dosage of Rac1^J11 and Rac2^Δ together produces embryos exhibiting tracheal defects of increasing severity: the mildest phenotype is a mis-routing of the dorsal branches toward the anteroposterior direction, whereas more severely affected embryos also exhibit truncations of the dorsal trunk. Order of severity: maternal(M) +/+ zygotic(Z) +/- =WT. M -/+ Z +/+ < M -/+, Z -/+ < M +/-, Z -/-. The proportion of M -/+, Z -/+ embryos with severely affected tracheal systems is enhanceable by heterozygosity for bnl⁰⁰⁸⁵⁷, btl^ΔOh10, or stumps^09904b.

In a subset of the epidermis of stage 15 Rac1^J11, Rac2^Δ double homozygous embryos the distinction between apical and basolateral domains is compromised. At stage 16 the columnar epithelial cells are shorter than wild-type and parts of the epidermis become multilayered. Reducing the maternal and zygotic gene dosage of Rac1^J11 and Rac2^Δ together produces embryos exhibiting tracheal defects of increasing severity: The mildest phenotype is a misrouting of the dorsal branches toward the anteroposterior direction, whereas more severely effected embryos also exhibit truncations of the dorsal trunk. Order of severity: maternal(M) +/+ zygotic(Z) +/- =WT. M -/+ Z +/+ < M -/+, Z -/+ < M +/-, Z -/-. The proportion of M -/+, Z -/+ embryos with severely effected tracheal systems is enhanceable by heterozygosity for bnl⁰⁰⁸⁵⁷, btl^ΔOh10, or stumps^09904b.

(Chihara et al., 2003)

The combination of heterozygous sli² and Rac1^J11 leads to an enhancement of the longitudinal axon ectopic midline crossing defects. An average of 4.8 defects are seen per animal, and an average of 44% of segments have defects.

(Fan et al., 2003)

Rac1^J11 Rac2^Δ Mtl^Δ triple mutant clones in the wing and eye do not show planar cell polarity defects. Mosaic flies in which the eye is doubly mutant for Rac1^J11 and Rac2^Δ show mild defects in the projection pattern of photoreceptor cell axons. Mosaic flies in which the eye is triply mutant for Mtl^Δ, Rac1^J11 and Rac2^Δ show severe defects in the projection pattern of photoreceptor cell axons, showing a medulla bypass phenotype. Specification of photoreceptor cell fate appears to be normal.

(Hakeda-Suzuki et al., 2002)

55% of Rac1^J11 Rac2^Δ double mutant neuroblast clones show defective guidance. 55% of Rac1^J11 Rac2^Δ Mtl^Δ single-cell γ neuron clones in the mushroom body show axon-stalling defects, mostly at the peduncle. There is a significant reduction in total dendritic length and number of dendritic segments per neuron compared to wild type. Mushroom body axon growth defects in single-cell Rac1^J11 Rac2^Δ Mtl^Δ γ neuron clones are largely rescued by expression of Rac1^{Scer\UAS.T:Hsap\MYC} or Rac1^{Y40C.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^OK107. Mushroom body axon growth defects in single-cell Rac1^J11 Rac2^Δ Mtl^Δ γ neuron clones are not rescued by expression of Rac1^{F37A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^OK107. 81% of axons in Rac1^J11 Rac2^Δ mushroom body clones show mutant phenotypes, predominantly guidance (55%) and branching (24%) defects. Expression of Rac1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^OK107 markedly rescues these defects. Expression of Rac1^{Y40C.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^OK107 does not reduce the total percentage of axonal defects in Rac1^J11 Rac2^Δ mushroom body clones, but results in a marked shift in the distribution of defects, with most showing branching (45%) rather than guidance (31%) defects. Analysis of Rac1^J11 Rac2^Δ mushroom body clones indicates cell non-autonomous effects in axon guidance and branching caused by defective "Rac" activity.

(Ng et al., 2002)

The phenotype caused by expression of msn^EP549 under the control of Scer\GAL4^GMR.PF is not modified by the addition of the triple mutant combination Rac1^J11 Rac2^Δ Mtl^Δ.

(Ruan et al., 2002)

Xenogenetic Interactions

Statement

Reference

Rac1^J11/+ does not suppress the wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1.

The presence of Rac1^J11/+ and Rac2^Δ/+ in double heterozygous combination does not suppress the wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1.

(Marchal et al., 2012)

Complementation and Rescue Data

Rescued by

Rac1^J11/Df(3L)Rac1 is rescued by Rac1^+t3.6

(Ng et al., 2002)

Comments

Expression of Rac1^Scer\UAS.cLa under the control of Scer\GAL4^sns.PK strongly rescues the myoblast fusion defects of Rac1^J11 Rac2^Δ double mutant embryos, resulting in a near normal somatic muscle pattern. In contrast, expression of Rac1^Scer\UAS.cLa under the control of Scer\GAL4^kirre-rP298 rescues the myoblast fusion defects of Rac1^J11 Rac2^Δ double mutant embryos much less efficiently.

(Haralalka et al., 2011)

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Mutant

Wild-type

Stocks (2)

Bloomington

6677

y¹ w^*; Rac1^J11 Rac2^Δ P{FRT(w^hs)}2A/TM6B, Tb⁺

6678

y¹ w^*; Rac1^J11 Rac2^Δ P{FRT(w^hs)}2A Mtl^Δ/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Drac1^J11

(He et al., 2005)

Rac1^j11

(Bothe et al., 2014, Marchal et al., 2012, Neisch et al., 2010, Srahna et al., 2006, Raymond et al., 2004)

Rac^J11

(Park et al., 2022, Geisbrecht et al., 2013)

rac1^J11

(Malin et al., 2024, Oliveira da Silva et al., 2020, Wang et al., 2020, Dollar et al., 2016, Hamp et al., 2016, Ruan et al., 2016, Kamiyama et al., 2015, Soba et al., 2015, Herszterg et al., 2013, Liu et al., 2013, Haralalka et al., 2011, Kim et al., 2011, Pinal and Pichaud, 2011, Higuchi et al., 2009, Johnson et al., 2008, Yang and Bashaw, 2006, Lundstrom et al., 2004, Chihara et al., 2003, Fan et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (75)

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