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General Information
Symbol
Dmel\Rab11ex1
Species
D. melanogaster
Name
FlyBase ID
FBal0135841
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{lacW} insertion in Rab11j2D1 has created a deletion that removes the second intron of the Rab11 gene.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Rab11ex1 heterozygous flies show no significant border cell migration defects.

Rab11ex1/+ flies show no eye phenotype.

Rab11ex1/Rab1193Bi transheterozygotes are mostly lethal but a few survive to adulthood.

The posterior abdomens of Rab11ex1/Rab1193Bi flies have empty sockets that are missing microchaetae. Additionally, posterior scutellar bristles are shortened in these mutants.

The synapse of muscle 6/7 shows an increase in boutons by about 60% in Rab11ex1/Rab1193Bi mutants compared to controls. The boutons of Rab11ex1/Rab1193Bi mutants are often clustered resulting in a 'bunch of grapes' morphology instead of the wild-type 'beads-on-a-string' morphology. The aberrant morphology may reflect increased branching (by 2.6 fold) of Rab11ex1/Rab1193Bi boutons.

Oogenesis is arrested before oocyte determination in Rab11ex1 germ-line clones.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

A Rab11ex1 heterozygous background enhances the restriction on border cell migration seen upon expression of Evi5Scer\UAS.T:Disc\RFP-mCherry in border cells under the control of Scer\GAL4c306. The number of clusters unable to initiate migration is strongly increased.

Rab11ex1 heterozygotes act as dominant enhancers of the Scer\GAL4GMR.PF>bchsEP2299 eye phenotype, resulting in adults with severely reduced eyes.

The viability of Rab11ex1/Rab1193Bi is increased when flies are also mutant for either Df(2L)cl7/+, Df(2L)cl7/bchs17, bchs17/bchs12 or bchs17/+.

The microchaeta loss of Rab11ex1/Rab1193Bi flies is significantly suppressed by Df(2L)cl7/+ or bchs17/+ and is completely suppressed by Df(2L)cl7/bchs17 or bchs17/bchs12. Further, posterior scutellar bristle length of Rab11ex1/Rab1193Bi flies is restored partially by Df(2L)cl7/+ or bchs17/+ and more fully by Df(2L)cl7/bchs17 or bchs17/bchs12.

The bouton density and branching defects of Rab11ex1/Rab1193Bi larval NMJs at muscle 6/7 are significantly suppressed in bchs17/bchs12; Rab11ex1/Rab1193Bi double mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)