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General Information
Symbol
Dmel\Atx2EP3145
Species
D. melanogaster
Name
FlyBase ID
FBal0136144
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP(3)3145
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{EP} insertion upstream of Atx2.

The orientation of the P{EP} element is the same as the direction of Atx2 transcription.

P{EP} insertion in the 5' untranslated region, 667bp upstream of the putative start codon. The P{EP} insertion is oriented such that overexpression from the element can drive overexpression of Atx2.

Insertion components
P{EP}Atx2EP3145
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Other
Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Enhancer of
NOT Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

The rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is enhanced by Atx2EP3145. Atx2EP3145 enhances the eye phenotype caused by expression of Hsap\ATX182.Scer\UAS under the control of Scer\GAL4GMR.PF; loss of eye pigmentation is enhanced and necrotic black spots are induced.

pnrMD237/+ adults expressing Atx2EP3145 under the control of Scer\GAL4pnr-MD237 have a deformed scutellum.

Xenogenetic Interactions
Statement
Reference

Overexpression of Atx2EP3145 via Scer\GAL4GMR.PF enhances the toxicity of Hsap\TARDBPScer\UAS.cEa in a markedly dose-dependent manner resulting in more severe retinal degeneration.

Overexpression of Atx2EP3145 via Scer\GAL4elav-C155 enhances the toxicity of Hsap\TARDBPScer\UAS.cEa in a markedly dose-dependent manner resulting in a further reduction of lifespan.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a P{EP} insertion line that modifies the pnrMD237/+ phenotype when expressed using Scer\GAL4pnr-MD237.

Separable from: a recessive lethal mutation unrelated to the P{EP}Atx2EP3145 insertion.

Comments
Comments

Precise excision of the P{EP} element reverts the modifying effect of Atx2EP3145 on the rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (9)