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General Information
Symbol
Dmel\lolaORE120
Species
D. melanogaster
Name
FlyBase ID
FBal0137145
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C10533366T

Reported nucleotide change:

C9922T

Amino acid change:

A107V | lola-PA; A107V | lola-PAA; A107V | lola-PB; A107V | lola-PC; A107V | lola-PD; A107V | lola-PE; A107V | lola-PF; A107V | lola-PG; A107V | lola-PH; A107V | lola-PI; A107V | lola-PJ; A107V | lola-PK; A107V | lola-PL; A107V | lola-PM; A107V | lola-PO; A107V | lola-PP; A107V | lola-PQ; A107V | lola-PR; A107V | lola-PT; A107V | lola-PU; A107V | lola-PV; A107V | lola-PW; A107V | lola-PX; A107V | lola-PY; A107V | lola-PZ

Reported amino acid change:

A107V

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: T9922C. Amino acid replacement: A107V.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Females containing homozygous germline clones show defects in stage 14 egg chambers, including dumpless egg chambers (egg chambers in which the nurse cells have failed to transfer their cytoplasmic contents to the oocyte, have intact nuclei and do not appear to be undergoing programmed cell death) and egg chambers with persisting nurse cell nuclei (egg chambers in which nurse cells have transferred their cytoplasmic contents to the oocyte, but their nuclei have failed to undergo programmed cell death including nuclear condensation).

Fas2-expressing axons cross the midline in only 25% of homozygous stage 16/17 embryos, with one or two segments per embryo usually being affected.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

lolaORE120 has neuroanatomy defective phenotype, enhanceable by robo[+]/robo13

lolaORE120 has neuroanatomy defective phenotype, enhanceable by sli2/sli[+]

Phenotype Manifest In
Enhanced by
Statement
Reference

lolaORE120 has longitudinal connective phenotype, enhanceable by robo[+]/robo13

lolaORE120 has longitudinal connective phenotype, enhanceable by sli2/sli[+]

Enhancer of
Statement
Reference

lolaORE120/lola[+] is an enhancer of wing margin phenotype of ct53d

Additional Comments
Genetic Interactions
Statement
Reference

98% of lolaORE120 sli2/lolaORE120 embryos show Fas2-expressing axons crossing the midline. There are an average of 4.8 crossovers per affected embryo. 93% of lolaORE120 robo3/lolaORE120 embryos show Fas2-expressing axons crossing the midline. There are an average of 4.4 crossovers per affected embryo.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)