FB2025_01 , released February 20, 2025
Allele: Dmel\gcmPyx
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General Information
Symbol
Dmel\gcmPyx
Species
D. melanogaster
Name
Polythryx
FlyBase ID
FBal0137244
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Progenitor genotype
Caused by aberration
Cytology
Description

gcm has maintained its integrity and at least 2kb 3' to gcm is intact in the Tp(2;2)Pyx chromosome, however, the Tp(2;2)Pyx aberration results in precocious expression of gcm in the notum in larvae.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

mesothoracic tergum & macrochaeta | supernumerary (with gcmN7-4)

metathoracic laterotergite & macrochaeta | supernumerary

scutellum & macrochaeta | supernumerary

scutum & macrochaeta | supernumerary

Detailed Description
Statement
Reference

Heterozygotes have supernumerary bristles on the notum (average 18.5 per heminotum compared to the wild type number of 11).

Heterozygous females have on average 18.5 bristles per heminotum (compared to the wild-type 11 per heminotum).

Heterozygotes have supernumerary macrochaetae, with an average of 19 large bristles per heminotum (wild-type number is 11 macrochaetae per heminotum). Heterozygous females have an average of 21 large bristles per heminotum and heterozygous males have an average of 17 large bristles per heminotum. Bristle number and position vary, even within the two heminota of a single animal. Extra bristles are found only on the scutum and on the scutellum. Adjacent supernumerary bristles are never seen. gcmPyx homozygotes (Tp(2;2)Pyx homozygotes in which the lethality of the ftPyx allele associated with the 24D breakpoint has been rescued by Dp(2;Y)odd4.13) are viable and have a bristle phenotype stronger than that of heterozygous adults. gcmPyx/gcmN7-4 adults have the same phenotype as gcmPyx/+ flies (extra macrochaetae on the notum). Embryos do not show defects in glial development.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

gcmPyx has visible | dominant phenotype, enhanceable by Df(2R)rl10a/+

gcmPyx has visible | dominant phenotype, enhanceable by +/Df(3L)ED4079

gcmPyx has visible | dominant phenotype, enhanceable by Df(3L)ED4177/+

gcmPyx has visible | dominant phenotype, enhanceable by Df(3L)RM5-2/+

gcmPyx has visible | dominant phenotype, enhanceable by Df(3L)th102/+

gcmPyx has visible | dominant phenotype, enhanceable by Df(3R)Z1/+

gcmPyx has visible | dominant phenotype, enhanceable by Df(3R)ED5066/+

gcmPyx has visible | dominant phenotype, enhanceable by Df(3R)DG2/+

gcmPyx has visible | dominant phenotype, enhanceable by Df(3R)Exel6178/+

gcmPyx has visible | dominant phenotype, enhanceable by Df(3R)ED2/+

gcmPyx has visible | dominant phenotype, enhanceable by Df(3R)Exel6179/+

gcmPyx has visible | dominant phenotype, enhanceable by Df(3R)E40/+

gcmPyx has visible | dominant phenotype, enhanceable by E(bx)ry122/E(bx)[+]

gcmPyx has visible | dominant phenotype, enhanceable by brm[+]/brm2

gcmPyx has visible | dominant phenotype, enhanceable by repo[+]/repounspecified

gcmPyx has visible | dominant phenotype, enhanceable by fru[+]/fru3

gcmPyx has visible | dominant phenotype, enhanceable by ttk[+]/ttk1e11

gcmPyx has visible | dominant phenotype, enhanceable by +/Df(3L)brm11

gcmPyx has visible | dominant phenotype, enhanceable by osa2/osa[+]

gcmPyx has visible | dominant phenotype, enhanceable by osa2/osa[+]/brm[+]/brm2

gcmPyx has visible | dominant phenotype, enhanceable by Pc1/Pc[+]

gcmPyx has visible | dominant phenotype, enhanceable by Pc3/Pc[+]

gcmPyx has visible | dominant phenotype, enhanceable by Pc[+]/Pc15

gcmPyx has visible | dominant phenotype, enhanceable by E(z)[+]/E(z)731

gcmPyx has visible | dominant phenotype, enhanceable by esc1/esc[+]

gcmPyx has visible | dominant phenotype, enhanceable by psqE39/psq[+]

NOT Enhanced by
Statement
Reference

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(1)ED418/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(2L)ED746/+

gcmPyx has visible | dominant phenotype, non-enhanceable by +/Df(2L)Exel8026

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(2L)Exel7049/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(2L)Exel8034/+

gcmPyx has visible | dominant phenotype, non-enhanceable by +/Df(2L)ED1231

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(2L)ED1305/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(2R)Exel6062/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(3L)Exel6084/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(3L)ED4543/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(3L)Exel6123/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(1)ED7265/+

gcmPyx has visible | dominant phenotype, non-enhanceable by +/Df(3R)ED5021

gcmPyx has visible | dominant phenotype, non-enhanceable by +/Df(3R)Exel6210

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(3R)Exel6211/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(2L)Exel6016/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Ubc2k13206/UbcD2[+]

gcmPyx has visible | dominant phenotype, non-enhanceable by wor[+]/wor1

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(2L)J3/+

gcmPyx has visible | dominant phenotype, non-enhanceable by Df(2L)J1/+

Suppressed by
Statement
Reference

gcmPyx has visible | dominant phenotype, suppressible | partially by AGO1k08121/AGO1[+]

gcmPyx has visible | dominant phenotype, suppressible by +/Df(2L)Exel6046

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)DS6/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2R)ED2076/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2R)Exel6059/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2R)Exel7128/+

gcmPyx has visible | dominant phenotype, suppressible by Df(3L)Exel6083/+

gcmPyx has visible | dominant phenotype, suppressible by Df(3L)Exel6085/+

gcmPyx has visible | dominant phenotype, suppressible by Df(3L)Exel6122/+

gcmPyx has visible | dominant phenotype, suppressible | partially by Df(3L)Brd12/+

gcmPyx has visible | dominant phenotype, suppressible by Df(3L)ED217/+

gcmPyx has visible | dominant phenotype, suppressible | partially by Df(3L)Brd15/+

gcmPyx has visible | dominant phenotype, suppressible by Df(3L)Exel6125/+

gcmPyx has visible | dominant phenotype, suppressible by Df(3R)XM3/+

gcmPyx has visible | dominant phenotype, suppressible by lilli[+]/lilliA17-2

gcmPyx has visible | dominant phenotype, suppressible by mid1/mid[+]

gcmPyx has visible | dominant phenotype, suppressible by pimIL/pim[+]

gcmPyx has visible | dominant phenotype, suppressible by l(2)gd1EY04750/l(2)gd1[+]

gcmPyx has visible | dominant phenotype, suppressible by crol[+]/crolk05205

gcmPyx has visible | dominant phenotype, suppressible by esg35Ce-1/esg[+]

gcmPyx has visible | dominant phenotype, suppressible by sna18/sna[+]

gcmPyx has visible | dominant phenotype, suppressible by Su(H)[+]/Su(H)1

gcmPyx has visible | dominant phenotype, suppressible by brat[+]/brat1

gcmPyx has visible | dominant phenotype, suppressible by E2f2[+]/E2f276Q1

gcmPyx has visible | dominant phenotype, suppressible by lola[+]/lola00642

gcmPyx has visible | dominant phenotype, suppressible by AGO1k08121/AGO1[+]

gcmPyx has visible | dominant phenotype, suppressible | partially by hkb2/hkb[+]

gcmPyx has visible | dominant phenotype, suppressible by trx[+]/trxE2

gcmPyx has visible | dominant phenotype, suppressible by ash1[+]/ash122

gcmPyx has visible | dominant phenotype, suppressible by nej[+]/nej3

gcmPyx has visible | dominant phenotype, suppressible | partially by Df(2L)N6/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)JS17/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)cl7/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)J2/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)esc-P2-0/+

gcmPyx has visible | dominant phenotype, suppressible by +/Df(2L)el80f1

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)r10/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)ED3/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)ED1050/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)Exel7063/+

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)E71/+

gcmPyx has visible | dominant phenotype, suppressible | partially by Df(2L)Sd77/+

gcmPyx has visible | dominant phenotype, suppressible by +/Df(2L)ED1303

gcmPyx has visible | dominant phenotype, suppressible by Df(2L)ED1315/+

gcmPyx has visible | dominant phenotype, suppressible by Df(1)sc10-1

NOT suppressed by
Statement
Reference

gcmPyx has visible | dominant phenotype, non-suppressible by Df(1)ED418/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(1)ED7265/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(2L)Exel6016/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(2L)J3/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(2L)J1/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(2L)ED746/+

gcmPyx has visible | dominant phenotype, non-suppressible by +/Df(2L)Exel8026

gcmPyx has visible | dominant phenotype, non-suppressible by Df(2L)Exel7049/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(2L)Exel8034/+

gcmPyx has visible | dominant phenotype, non-suppressible by +/Df(2L)ED1231

gcmPyx has visible | dominant phenotype, non-suppressible by Df(2L)ED1305/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(2R)Exel6062/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(3L)Exel6084/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(3L)ED4543/+

gcmPyx has visible | dominant phenotype, non-suppressible by Df(3L)Exel6123/+

gcmPyx has visible | dominant phenotype, non-suppressible by +/Df(3R)ED5021

gcmPyx has visible | dominant phenotype, non-suppressible by +/Df(3R)Exel6210

gcmPyx has visible | dominant phenotype, non-suppressible by Df(3R)Exel6211/+

gcmPyx has visible | dominant phenotype, non-suppressible by Ubc2k13206/UbcD2[+]

gcmPyx has visible | dominant phenotype, non-suppressible by wor[+]/wor1

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

gcmPyx has chaeta | increased number phenotype, enhanceable by Df(3R)Z1/+

gcmPyx has chaeta | increased number phenotype, enhanceable by Df(3R)DG2/+

gcmPyx has chaeta | increased number phenotype, enhanceable by Df(3R)ED2/+

gcmPyx has chaeta | increased number phenotype, enhanceable by Df(3R)E40/+

gcmPyx has chaeta | increased number phenotype, enhanceable by E(bx)ry122/E(bx)[+]

gcmPyx has chaeta | increased number phenotype, enhanceable by brm[+]/brm2

gcmPyx has chaeta | increased number phenotype, enhanceable by repo[+]/repounspecified

gcmPyx has chaeta | increased number phenotype, enhanceable by fru[+]/fru3

gcmPyx has chaeta | increased number phenotype, enhanceable by ttk[+]/ttk1e11

gcmPyx has chaeta | increased number phenotype, enhanceable by osa2/osa[+]

gcmPyx has chaeta | increased number phenotype, enhanceable by osa2/osa[+]/brm[+]/brm2

gcmPyx has chaeta | increased number phenotype, enhanceable by Pc1/Pc[+]

gcmPyx has chaeta | increased number phenotype, enhanceable by Pc3/Pc[+]

gcmPyx has chaeta | increased number phenotype, enhanceable by Pc[+]/Pc15

gcmPyx has chaeta | increased number phenotype, enhanceable by E(z)[+]/E(z)731

gcmPyx has chaeta | increased number phenotype, enhanceable by esc1/esc[+]

gcmPyx has chaeta | increased number phenotype, enhanceable by psqE39/psq[+]

NOT Enhanced by
Statement
Reference

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(1)ED418/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(2L)ED746/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by +/Df(2L)Exel8026

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(2L)Exel7049/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(2L)Exel8034/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by +/Df(2L)ED1231

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(1)ED7265/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(2L)ED1305/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(2R)Exel6062/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(3L)Exel6084/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(3L)ED4543/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(3L)Exel6123/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by +/Df(3R)ED5021

gcmPyx has chaeta | increased number phenotype, non-enhanceable by +/Df(3R)Exel6210

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(3R)Exel6211/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(2L)Exel6016/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(2L)J3/+

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Ubc2k13206/UbcD2[+]

gcmPyx has chaeta | increased number phenotype, non-enhanceable by wor[+]/wor1

gcmPyx has chaeta | increased number phenotype, non-enhanceable by Df(2L)J1/+

Suppressed by
Statement
Reference

gcmPyx has macrochaeta | increased number phenotype, suppressible | partially by AGO1k08121/AGO1[+]

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2L)JS17/+

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2L)cl7/+

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2L)J2/+

gcmPyx has chaeta | increased number phenotype, suppressible by +/Df(2L)el80f1

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2L)r10/+

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2L)ED3/+

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2L)ED1050/+

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2L)E71/+

gcmPyx has chaeta | increased number phenotype, suppressible by +/Df(2L)ED1303

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2L)ED1315/+

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2L)DS6/+

gcmPyx has chaeta | increased number phenotype, suppressible by Df(2R)ED2076/+

gcmPyx has chaeta | increased number phenotype, suppressible by Df(3L)ED217/+

gcmPyx has chaeta | increased number phenotype, suppressible by Df(3R)XM3/+

gcmPyx has chaeta | increased number phenotype, suppressible by lilli[+]/lilliA17-2

gcmPyx has chaeta | increased number phenotype, suppressible by mid1/mid[+]

gcmPyx has chaeta | increased number phenotype, suppressible by pimIL/pim[+]

gcmPyx has chaeta | increased number phenotype, suppressible by l(2)gd1EY04750/l(2)gd1[+]

gcmPyx has chaeta | increased number phenotype, suppressible by crol[+]/crolk05205

gcmPyx has chaeta | increased number phenotype, suppressible by esg35Ce-1/esg[+]

gcmPyx has chaeta | increased number phenotype, suppressible by sna18/sna[+]

gcmPyx has chaeta | increased number phenotype, suppressible by Su(H)[+]/Su(H)1

gcmPyx has chaeta | increased number phenotype, suppressible by brat[+]/brat1

gcmPyx has chaeta | increased number phenotype, suppressible by E2f2[+]/E2f276Q1

gcmPyx has chaeta | increased number phenotype, suppressible by lola[+]/lola00642

gcmPyx has chaeta | increased number phenotype, suppressible by AGO1k08121/AGO1[+]

gcmPyx has chaeta | increased number phenotype, suppressible | partially by hkb2/hkb[+]

gcmPyx has chaeta | increased number phenotype, suppressible by trx[+]/trxE2

gcmPyx has chaeta | increased number phenotype, suppressible by ash1[+]/ash122

gcmPyx has chaeta | increased number phenotype, suppressible by nej[+]/nej3

gcmPyx has metathoracic laterotergite & macrochaeta | supernumerary phenotype, suppressible by Df(1)sc10-1

NOT suppressed by
Statement
Reference

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(1)ED418/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(1)ED7265/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(2L)ED1305/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(2R)Exel6062/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(3L)Exel6084/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(3L)ED4543/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(3L)Exel6123/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by +/Df(3R)ED5021

gcmPyx has chaeta | increased number phenotype, non-suppressible by +/Df(3R)Exel6210

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(3R)Exel6211/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Ubc2k13206/UbcD2[+]

gcmPyx has chaeta | increased number phenotype, non-suppressible by wor[+]/wor1

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(2L)Exel6016/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(2L)J3/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(2L)J1/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(2L)ED746/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by +/Df(2L)Exel8026

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(2L)Exel7049/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by Df(2L)Exel8034/+

gcmPyx has chaeta | increased number phenotype, non-suppressible by +/Df(2L)ED1231

Additional Comments
Genetic Interactions
Statement
Reference

AGO1k08121 dominantly partially suppresses the supernumerary bristle phenotype seen on the notum of gcmPyx heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)