Expression of ctScer\UAS.cPa under the control of Scer\GAL4221 in a sn36a background in class I vpda neurons results in an expansion of the dendrite tree. In addition, the formation of ectopic spiked protrusions is reduced by more than 40% compared to the expression of ctScer\UAS.cPa under the control of Scer\GAL4221 in a wild-type background.
Expression of ctScer\UAS.cPa almost completely suppresses the ectopic eye phenotype seen in adult flies expressing eyScer\UAS.cHa under the control of Scer\GAL4dpp.blk1. The photoreceptor induction seen in the wing discs is also suppressed.
Ectopic expression of Rac1Scer\UAS.cLa along with ctScer\UAS.cPa in class I neurons under the control of Scer\GAL4221 leads to the formation of an arbor with many filpodia/spikes, which shows a significant enhancement of branching as compared to either Rac1Scer\UAS.cLa or ctScer\UAS.cPa expression alone.
Co-expression of knScer\UAS.cMa and ctScer\UAS.cPa under the control of Scer\GAL4221 increases the number of dendritic branching points to 409% of wild-type. Similarly, the total length is increased by 130% and the arbor area by 89%.
Expression of ctScer\UAS.cPa under the control of Scer\GAL4ppk.PG in class IV neurons in a kn1/knKN2 results in the formation of many additional filpodia/spikes that closely resemble those of class III neurons. The overall level of branching in class IV neuron dendritic arbors appears similar to those of class III neurons.
In acj66 homozygous somatic clones in animals carrying ctScer\UAS.cPa; Scer\GAL4GH146, DL1 adPN have diffuse dendrites which fail to innervate antennal lobe glomerulus DL1 and instead occupy the medial to dorso-medial antennal lobe: typically VM2, DM6 and DC1.
Coexpression of ctScer\UAS.cPa and abScer\UAS.cBa, under the control of Scer\GAL4221, does not suppress the increased dendritic branching of vpda neurons, seen when ctScer\UAS.cPa is expressed, but did partially rescue the total dendritic length phenotype.
Coexpression of ctScer\UAS.cPa with abScer\UAS.S.cSa, under the control of Scer\GAL4109(2)80 and Scer\GAL4IG1-2, partially suppresses the reduction of field size and terminal number of ddA neurons seen when abScer\UAS.L.cSa is expressed alone. This coexpression also leads to a partial suppression of the dendritic overgrowth and overbranching of ddaE neurons, seen when ctScer\UAS.cPa is expressed under the control of Scer\GAL4109(2)80 and Scer\GAL4IG1-2.
ctScer\UAS.cPa; Scer\GAL4GH146 completely rescues the Targeting of DMA, DM2 and VA5 antennal glomeruli by lateral projection neurons (lPN) in ctdb3 or ctC145 homozygous clones, but fails to rescue the decrease in vPN cell number and only partially rescues ventral projection neuron (vPN) Targeting of VA1lm but not of DA1.