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General Information
Symbol
Dmel\bwkΔ11
Species
D. melanogaster
Name
FlyBase ID
FBal0137293
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Caused by a deletion that has a breakpoint just upstream of the cic start site and removes the whole of the cic open reading frame.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Stages 10B and early 11 of dorsal appendage morphogenesis proceed normally in bwk151/bwkΔ11 egg chambers. Defects in both roof and floor formation become evident in the developing dorsal appendage shortly after morphogenesis begins. Although apical constriction occurs normally in roof cells, the roof cell apices fail to reorganise from an almond shape into a normal triangular array by late stage 11. Instead, the roof cells form a blunt array, that even in stage 12, is abnormally short and/or wide. Floor cells begin to elongate normally, extending beneath the nascent roof in late stage 11, but they show defects in several subsequent stages; they frequently separate along their basolateral margins during tube formation, extend far too laterally and have apical gaps that result in an incomplete tube floor. Even when the roof population attains a normal length, the floor cells of the dorsal appendage primordium often extend too far laterally and have basal discontinuities. During anterior extension, the floor cell population becomes increasingly disorganised, often forking into large clefts. The roof cell population can also bifurcate. This bifurcation correlates with the secretion of prongs and spurs of chorion that project off the main dorsal appendage in the mutant. Defects are also seen in paddle formation; the mutant cells remain 27% more elongated during paddle formation than wild-type cells.

    bwkΔ11/bwk08482 animals have an extra veins phenotype.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    NOT Enhanced by
    Statement
    Reference

    bwkΔ11, cicD49 has wing vein | ectopic phenotype, non-enhanceable by rhove-1/vn1

    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    bwkΔ11 combined with cic1 produces animals with a terminal phenotype. bwkΔ11, cicD49 animals are 'almost lethal' and have abnormal wings. These wings can have an extra wing vein tissue phenotype, where intervein cells acquire morphological features of vein cells at least partially. This extra tissue is usually close to the normal veins. This wings also have wing blisters. These animals also have defects in the male genitalia. The cuticle plates forming the genitalia are oriented in the opposite direction to those of wild-type. The addition of bwkΔ11 and vn1 fails to enhance the extra wing vein phenotype seen in cicD49/bwkΔ11 animals.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    bwkΔ11
    Name Synonyms
    Secondary FlyBase IDs
      References (2)